Loosemore, Michael P; Butler, Charles F; Khadri, Abdelhamid; McDonagh, David; Patel, Vimal A; Bailes, Julian E
Use of Head Guards in AIBA Boxing Tournaments--A Cross-Sectional Observational Study Journal Article
In: Clinical Journal of Sport Medicine, vol. 27, no. 1, pp. 86–88, 2017, ISBN: 1050642X.
Abstract | BibTeX | Tags: acute brain injuries, Boxing, BOXING injuries, Concussion, CONFIDENCE intervals, CROSS-sectional method, DISEASE incidence, Head Protective Devices, LONGITUDINAL method, Poisson distribution, PREVENTION, PROBABILITY theory, Relative risk (Medicine), SAFETY hats, SPORTS events, STATISTICAL hypothesis testing, traumatic brain injury, WOUNDS & injuries
@article{Loosemore2017,
title = {Use of Head Guards in AIBA Boxing Tournaments--A Cross-Sectional Observational Study},
author = {Loosemore, Michael P and Butler, Charles F and Khadri, Abdelhamid and McDonagh, David and Patel, Vimal A and Bailes, Julian E},
isbn = {1050642X},
year = {2017},
date = {2017-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {27},
number = {1},
pages = {86--88},
abstract = {Objective: This study looks at the changes in injuries after the implementation of a new rule by the International Boxing Association (AIBA) to remove head guards from its competitions. Design: A cross-sectional observational study performed prospectively. This brief report examines the removal of head guards in 2 different ways. The first was to examine the stoppages due to blows to the head by comparing World Series Boxing (WSB), without head guards, to other AIBA competitions with head guards. Secondly, we examined the last 3 world championships: 2009 and 2011 (with head guards) and 2013 (without head guards). Setting: World Series Boxing and AIBA world championship boxing. Participants: Boxers from WSB and AIBA world championships. Interventions: The information was recorded by ringside medical physicians. Main Outcome Measures: Stoppages per 10 000 rounds; stoppages per 1000 hours. Results: Both studies show that the number of stoppages due to head blows was significantly decreased without head guards. The studies also showed that there was a notable increase in cuts. Conclusions: Removing head guards may reduce the already small risk of acute brain injury in amateur boxing. [ABSTRACT FROM AUTHOR]},
keywords = {acute brain injuries, Boxing, BOXING injuries, Concussion, CONFIDENCE intervals, CROSS-sectional method, DISEASE incidence, Head Protective Devices, LONGITUDINAL method, Poisson distribution, PREVENTION, PROBABILITY theory, Relative risk (Medicine), SAFETY hats, SPORTS events, STATISTICAL hypothesis testing, traumatic brain injury, WOUNDS \& injuries},
pubstate = {published},
tppubtype = {article}
}
Hwang, Sungjae; Ma, Lei; Kawata, Keisuke; Tierney, Ryan; Jeka, John J
Vestibular dysfunction after subconcussive head impact Journal Article
In: Journal of Neurotrauma, vol. 34, no. 1, pp. 8–15, 2017, ISBN: 0897-7151 1557-9042.
Abstract | Links | BibTeX | Tags: 2017, BEHAVIORAL assessment, Behavioral assessments, Head trauma, Human studies, Outcome measures, Sensory Feedback, sensory function, Soccer, traumatic brain injury
@article{Hwang2017,
title = {Vestibular dysfunction after subconcussive head impact},
author = {Hwang, Sungjae and Ma, Lei and Kawata, Keisuke and Tierney, Ryan and Jeka, John J},
doi = {10.1089/neu.2015.4238},
isbn = {0897-7151
1557-9042},
year = {2017},
date = {2017-01-01},
journal = {Journal of Neurotrauma},
volume = {34},
number = {1},
pages = {8--15},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Current thinking views mild head impact (i.e., subconcussion) as an underrecognized phenomenon that has the ability to cause significant current and future detrimental neurological effects. Repeated mild impacts to the head, however, often display no observable behavioral deficits based on standard clinical tests, which may lack sensitivity. The current study investigates the effects of subconcussive impacts from soccer heading with innovative measures of vestibular function and walking stability in a pre- 0\textendash2 h, post- 24 h post-heading repeated measures design. The heading group (n = 10) executed 10 headers with soccer balls projected at a velocity of 25 mph (11.2 m/sec) over 10 min. Subjects were evaluated 24 h before, immediately after, and 24 h after soccer heading with: the modified Balance Error Scoring System (mBESS); a walking stability task with visual feedback of trunk movement; and galvanic vestibular stimulation (GVS) while standing with eyes closed on foam. A control group (n = 10) followed the same protocol with no heading. The results showed significant decrease in trunk angle, leg angle gain, and center of mass gain relative to GVS for the heading group compared with controls. Medial-lateral trunk orientation displacement and velocity during treadmill walking increased immediately after mild head impact for the heading group compared with controls. Controls showed an improvement in mBESS scores over time, indicating a learning effect, which was not observed with the heading group. These results suggest that mild head impact leads to a transient dysfunction in vestibular processing, which deters walking stability during task performance. (PsycINFO Database Record (c) 2017 APA, all rights reserved)},
keywords = {2017, BEHAVIORAL assessment, Behavioral assessments, Head trauma, Human studies, Outcome measures, Sensory Feedback, sensory function, Soccer, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Zusman, E E; Zopfi, P; Kuluva, J; Zuckerman, S
Can Ideas From United States Youth Sports Reduce Judo-Related Head Injuries in Japan? Journal Article
In: World Neurosurgery, vol. 97, pp. 725–727, 2017.
Links | BibTeX | Tags: Concussion, head injury, judo, Secondary impact syndrome, Soccer, traumatic brain injury, Youth sports
@article{Zusman2017,
title = {Can Ideas From United States Youth Sports Reduce Judo-Related Head Injuries in Japan?},
author = {Zusman, E E and Zopfi, P and Kuluva, J and Zuckerman, S},
doi = {10.1016/j.wneu.2016.05.096},
year = {2017},
date = {2017-01-01},
journal = {World Neurosurgery},
volume = {97},
pages = {725--727},
keywords = {Concussion, head injury, judo, Secondary impact syndrome, Soccer, traumatic brain injury, Youth sports},
pubstate = {published},
tppubtype = {article}
}
Connery, A K; Peterson, R L; Baker, D A; Randolph, C; Kirkwood, M W
The Role of Neuropsychological Evaluation in the Clinical Management of Concussion Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 475–486, 2016.
Links | BibTeX | Tags: brain concussion, childhood injury, CONVALESCENCE, health care access, health care delivery, human, medical history, mild TBI, Neuropsychological assessment, neuropsychological test, postconcussion syndrome, priority journal, return to sport, Review, risk factor, traumatic brain injury, validity
@article{Connery2016a,
title = {The Role of Neuropsychological Evaluation in the Clinical Management of Concussion},
author = {Connery, A K and Peterson, R L and Baker, D A and Randolph, C and Kirkwood, M W},
doi = {10.1016/j.pmr.2015.12.001},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {475--486},
keywords = {brain concussion, childhood injury, CONVALESCENCE, health care access, health care delivery, human, medical history, mild TBI, Neuropsychological assessment, neuropsychological test, postconcussion syndrome, priority journal, return to sport, Review, risk factor, traumatic brain injury, validity},
pubstate = {published},
tppubtype = {article}
}
Brett, Benjamin L; Smyk, Nathan; Solomon, Gary; Baughman, Brandon C; Schatz, Philip
In: Archives of Clinical Neuropsychology, vol. 31, no. 8, pp. 904–914, 2016, ISBN: 08876177.
Abstract | Links | BibTeX | Tags: assessment, Childhood brain insult, Cognitive Ability, COGNITIVE testing, head injury, HIGH school athletes, Intraclass correlation, Norms/normative studies, Practice effects/reliable change, psychology, STATISTICAL reliability, Test construction, traumatic brain injury
@article{Brett2016,
title = {Long-term Stability and Reliability of Baseline Cognitive Assessments in High School Athletes Using ImPACT at 1-, 2-, and 3-year Test-Retest Intervals},
author = {Brett, Benjamin L and Smyk, Nathan and Solomon, Gary and Baughman, Brandon C and Schatz, Philip},
doi = {10.1093/arclin/acw055},
isbn = {08876177},
year = {2016},
date = {2016-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {31},
number = {8},
pages = {904--914},
abstract = {Objective: The ImPACT (Immediate Post-Concussion Assessment and Cognitive Testing) neurocognitive testing battery is a widely used tool used for the assessment and management of sports-related concussion. Research on the stability of ImPACT in high school athletes at a 1- and 2-year intervals have been inconsistent, requiring further investigation. We documented 1-, 2-, and 3-year test-retest reliability of repeated ImPACT baseline assessments in a sample of high school athletes, using multiple statistical methods for examining stability. Methods: A total of 1,510 high school athletes completed baseline cognitive testing using online ImPACT test battery at three time periods of approximately 1- (N = 250), 2- (N = 1146), and 3-year (N = 114) intervals. No participant sustained a concussion between assessments. Results: Intraclass correlation coefficients (ICCs) ranged in composite scores from 0.36 to 0.90 and showed little change as intervals between assessments increased. Reliable change indices and regression-based measures (RBMs) examining the test-retest stability demonstrated a lack of significant change in composite scores across the various time intervals, with very few cases (0%-6%) falling outside of 95% confidence intervals. Conclusion: The results suggest ImPACT composites scores remain considerably stability across 1-, 2-, and 3-year test-retest intervals in high school athletes, when considering both ICCs and RBM. Annually ascertaining baseline scores continues to be optimal for ensuring accurate and individualized management of injury for concussed athletes. For instances in which more recent baselines are not available (1-2 years), clinicians should seek to utilize more conservative range estimates in determining the presence of clinically meaningful change in cognitive performance.},
keywords = {assessment, Childhood brain insult, Cognitive Ability, COGNITIVE testing, head injury, HIGH school athletes, Intraclass correlation, Norms/normative studies, Practice effects/reliable change, psychology, STATISTICAL reliability, Test construction, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Lin, K; Tung, C
Acupuncture for Recovery from Pediatric Sport-Related Concussion Journal Article
In: Medical Acupuncture, vol. 28, no. 4, pp. 217–222, 2016.
Abstract | Links | BibTeX | Tags: Acupuncture, Pediatric Pain, pediatrics, postconcussive symptoms, Sport-related, traumatic brain injury
@article{Lin2016,
title = {Acupuncture for Recovery from Pediatric Sport-Related Concussion},
author = {Lin, K and Tung, C},
doi = {10.1089/acu.2016.1181},
year = {2016},
date = {2016-01-01},
journal = {Medical Acupuncture},
volume = {28},
number = {4},
pages = {217--222},
abstract = {Background: Sport-related concussion is a major concern for young athletes because a growing number of children participate in sport-related activities. Postconcussive symptoms can lead to physical, academic, and social impairment. There is no definitive treatment for sport-related postconcussive symptoms, and most available pharmacologic therapies have potential side-effects. Cases: The aim of this case report is to describe the use of acupuncture in the management of sport-related postconcussive symptoms in 3 pediatric patients. All 3 patients presented with chronic postconcussive symptoms that did not improve with conventional treatments alone. A retrospective chart review was performed from 2012 to 2015 on the 3 patients who received acupuncture in a tertiary pediatric pain clinic for postconcussive symptoms. Demographics and results from the Numerical Rating Scale, a postconcussive symptoms questionnaire, and the Brief Pain Inventory were included in the review. Results: All 3 patients experienced satisfactory symptomatic reduction following acupuncture treatment. Conclusions: Acupuncture with conventional medication appeared to reduce the postconcussive symptoms in the 3 patients. © Copyright 2016, Mary Ann Liebert, Inc.},
keywords = {Acupuncture, Pediatric Pain, pediatrics, postconcussive symptoms, Sport-related, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Haran, F J; Slaboda, J C; King, L A; Wright, W G; Houlihan, D; Norris, J N
Sensitivity of the Balance Error Scoring System and the Sensory Organization Test in the Combat Environment Journal Article
In: Journal of Neurotrauma, vol. 33, no. 7, pp. 705–711, 2016.
Abstract | Links | BibTeX | Tags: adult, Afghanistan, Article, Balance Error Scoring System, BESS, body posture, brain injury assessment, controlled study, CONVALESCENCE, human, integration, major clinical study, Male, Military, military deployment, mTBI, scoring system, Sensory Organization Test, SOT, traumatic brain injury, visual disorder, War
@article{Haran2016,
title = {Sensitivity of the Balance Error Scoring System and the Sensory Organization Test in the Combat Environment},
author = {Haran, F J and Slaboda, J C and King, L A and Wright, W G and Houlihan, D and Norris, J N},
doi = {10.1089/neu.2015.4060},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurotrauma},
volume = {33},
number = {7},
pages = {705--711},
abstract = {This study evaluated the utility of the Balance Error Scoring System (BESS) and the Sensory Organization Test (SOT) as tools for the screening and monitoring of Service members (SMs) with mild traumatic brain injury (mTBI) in a deployed setting during the acute and subacute phases of recovery. Patient records (N = 699) were reviewed for a cohort of SMs who sustained a blast-related mTBI while deployed to Afghanistan and were treated at the Concussion Restoration Care Center (CRCC) at Camp Leatherneck. On initial intake into the CRCC, participants completed two assessments of postural control, the BESS, and SOT. SMs with mTBI performed significantly worse on the BESS and SOT when compared with comparative samples. When the SOT data were further examined using sensory ratios, the results indicated that postural instability was primarily a result of vestibular and visual integration dysfunction (r \> 0.62). The main finding of this study was that the sensitivity of the SOT composite score (50-58%) during the acute phase was higher than previous sensitivities found in the sports medicine literature for impact-related trauma. Copyright © 2016 Mary Ann Liebert, Inc.},
keywords = {adult, Afghanistan, Article, Balance Error Scoring System, BESS, body posture, brain injury assessment, controlled study, CONVALESCENCE, human, integration, major clinical study, Male, Military, military deployment, mTBI, scoring system, Sensory Organization Test, SOT, traumatic brain injury, visual disorder, War},
pubstate = {published},
tppubtype = {article}
}
Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
Abstract | Links | BibTeX | Tags: amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Leddy, J J; Baker, J G; Willer, B
Active Rehabilitation of Concussion and Post-concussion Syndrome Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 437–454, 2016.
Links | BibTeX | Tags: Active, aerobic exercise, athlete, autonomic dysfunction, brain blood flow, Buffalo Concussion Treadmill Test, cognition, cognitive behavioral therapy, Cognitive rehabilitation, Concussion, DISEASE exacerbation, disease severity, exercise tolerance, functional assessment, functional magnetic resonance imaging, head injury, human, motor dysfunction, nerve cell plasticity, nonhuman, ocular motor dysfunction, ocular therapy, oculomotor training therapy, Pathophysiology, PHYSICAL ACTIVITY, Physical Examination, PHYSIOLOGY, physiotherapy, post concussion syndrome, Post-Concussion Syndrome, priority journal, Psychoeducation, psychologic assessment, Rehabilitation, rehabilitation care, rest, Review, Social behavior, social psychology, sport related concussion, traumatic brain injury, Treatment, treatment contraindication, vestibular disorder, Vestibular therapy
@article{Leddy2016a,
title = {Active Rehabilitation of Concussion and Post-concussion Syndrome},
author = {Leddy, J J and Baker, J G and Willer, B},
doi = {10.1016/j.pmr.2015.12.003},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {437--454},
keywords = {Active, aerobic exercise, athlete, autonomic dysfunction, brain blood flow, Buffalo Concussion Treadmill Test, cognition, cognitive behavioral therapy, Cognitive rehabilitation, Concussion, DISEASE exacerbation, disease severity, exercise tolerance, functional assessment, functional magnetic resonance imaging, head injury, human, motor dysfunction, nerve cell plasticity, nonhuman, ocular motor dysfunction, ocular therapy, oculomotor training therapy, Pathophysiology, PHYSICAL ACTIVITY, Physical Examination, PHYSIOLOGY, physiotherapy, post concussion syndrome, Post-Concussion Syndrome, priority journal, Psychoeducation, psychologic assessment, Rehabilitation, rehabilitation care, rest, Review, Social behavior, social psychology, sport related concussion, traumatic brain injury, Treatment, treatment contraindication, vestibular disorder, Vestibular therapy},
pubstate = {published},
tppubtype = {article}
}
Keener, A B
Tackling the brain: Clues emerge about the pathology of sports-related brain trauma Journal Article
In: Nature Medicine, vol. 22, no. 4, pp. 326–329, 2016.
Links | BibTeX | Tags: amnesia, Article, astrocyte, athlete, Athletic Injuries, behavior change, blood vessel injury, brain, Brain Injuries, Brain Injury, cognitive defect, Concussion, confusion, degenerative disease, Epilepsy, head injury, headache, hearing impairment, human, Humans, Neck pain, nerve cell, nervous system inflammation, neurofibrillary tangle, nonhuman, Pathophysiology, postconcussion syndrome, priority journal, sport injury, traumatic brain injury, unsteadiness, Vision, wrestling
@article{Keener2016,
title = {Tackling the brain: Clues emerge about the pathology of sports-related brain trauma},
author = {Keener, A B},
doi = {10.1038/nm0416-326},
year = {2016},
date = {2016-01-01},
journal = {Nature Medicine},
volume = {22},
number = {4},
pages = {326--329},
keywords = {amnesia, Article, astrocyte, athlete, Athletic Injuries, behavior change, blood vessel injury, brain, Brain Injuries, Brain Injury, cognitive defect, Concussion, confusion, degenerative disease, Epilepsy, head injury, headache, hearing impairment, human, Humans, Neck pain, nerve cell, nervous system inflammation, neurofibrillary tangle, nonhuman, Pathophysiology, postconcussion syndrome, priority journal, sport injury, traumatic brain injury, unsteadiness, Vision, wrestling},
pubstate = {published},
tppubtype = {article}
}
Bressan, S; Babl, F E
Diagnosis and management of paediatric concussion Journal Article
In: Journal of Paediatrics & Child Health, vol. 52, no. 2, pp. 151–157, 2016.
Abstract | Links | BibTeX | Tags: Article, brain concussion, brain injury assessment, Child, child care, childhood injury, chronic brain disease, clinical feature, Concussion, conservative treatment, Glasgow Coma Scale, glial fibrillary acidic protein, human, neuroimaging, neuron specific enolase, patient care, Post Concussive Symptom Scale, post-concussive syndrome, priority journal, protein S100B, Second impact syndrome, Sport Concussion Assessment Tool 3, traumatic brain injury
@article{Bressan2016,
title = {Diagnosis and management of paediatric concussion},
author = {Bressan, S and Babl, F E},
doi = {10.1111/jpc.12967},
year = {2016},
date = {2016-01-01},
journal = {Journal of Paediatrics \& Child Health},
volume = {52},
number = {2},
pages = {151--157},
abstract = {Heightened recognition of concussions and concerns about their sequelae in children has become an increasing community and public health concern. Biomarkers and clinical tests are being explored, but the diagnosis of concussion in the emergency department continues to be based on clinical signs and symptoms. While the majority of children go on to recover from post-concussive symptoms within 2 weeks, it is unclear which patients with concussion will go on to develop short- or long-term sequelae. A number of more or less evidence-based guidelines have become available which seek to guide clinicians on how to manage children post-concussion. In general, care after the emergency department is focused on reducing the risk of re-injury and rest until cerebral recovery with a graduated return to school and then play. © 2015 The Authors. Journal of Paediatrics and Child Health © 2015 Paediatrics and Child Health Division (Royal Australasian College of Physicians).},
keywords = {Article, brain concussion, brain injury assessment, Child, child care, childhood injury, chronic brain disease, clinical feature, Concussion, conservative treatment, Glasgow Coma Scale, glial fibrillary acidic protein, human, neuroimaging, neuron specific enolase, patient care, Post Concussive Symptom Scale, post-concussive syndrome, priority journal, protein S100B, Second impact syndrome, Sport Concussion Assessment Tool 3, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Sussman, E S; Ho, A L; Pendharkar, A V; Ghajar, J
Clinical evaluation of concussion: The evolving role of oculomotor assessments Journal Article
In: Neurosurgical Focus, vol. 40, no. 4, 2016.
Abstract | Links | BibTeX | Tags: Concussion diagnosis, Concussion screening, Eye tracking, Oculomotor tracking, traumatic brain injury, Vision tracking
@article{Sussman2016,
title = {Clinical evaluation of concussion: The evolving role of oculomotor assessments},
author = {Sussman, E S and Ho, A L and Pendharkar, A V and Ghajar, J},
doi = {10.3171/2016.1.FOCUS15610},
year = {2016},
date = {2016-01-01},
journal = {Neurosurgical Focus},
volume = {40},
number = {4},
abstract = {Sports-related concussion is a change in brain function following a direct or an indirect force to the head, identified in awake individuals and accounting for a considerable proportion of mild traumatic brain injury. Although the neurological signs and symptoms of concussion can be subtle and transient, there can be persistent sequelae, such as impaired attention and balance, that make affected patients particularly vulnerable to further injury. Currently, there is no accepted definition or diagnostic criteria for concussion, and there is no single assessment that is accepted as capable of identifying all patients with concussion. In this paper, the authors review the available screening tools for concussion, with particular emphasis on the role of visual function testing. In particular, they discuss the oculomotor assessment tools that are being investigated in the setting of concussion screening. © AANS, 2016.},
keywords = {Concussion diagnosis, Concussion screening, Eye tracking, Oculomotor tracking, traumatic brain injury, Vision tracking},
pubstate = {published},
tppubtype = {article}
}
Kania, K; Shaikh, K A; White, I K; Ackerman, L L
Follow-up issues in children with mild traumatic brain injuries Journal Article
In: Journal of Neurosurgery: Pediatrics, vol. 18, no. 2, pp. 224–230, 2016.
Abstract | Links | BibTeX | Tags: Acute Concussion Evaluation, Concussion, head injury, Patient Outcome Assessment, Trauma, traumatic brain injury
@article{Kania2016,
title = {Follow-up issues in children with mild traumatic brain injuries},
author = {Kania, K and Shaikh, K A and White, I K and Ackerman, L L},
doi = {10.3171/2016.1.PEDS15511},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurosurgery: Pediatrics},
volume = {18},
number = {2},
pages = {224--230},
abstract = {OBJECTIVE: Concerns about mild traumatic brain injury (mTBI) have increased in recent years, and neurosurgical consultation is often requested for patients with radiographic abnormalities or clinical findings suspicious for mTBI. However, to the authors' knowledge, no study has used the Acute Concussion Evaluation (ACE) tool to systematically evaluate the evolution of symptoms in patients with mTBI during neurosurgical follow-up. The goal in this study was to evaluate symptom progression in pediatric patients referred for neurosurgical consultation by using the ACE, as endorsed by the Centers for Disease Control and Prevention. METHODS: The authors performed a retrospective review of records of consecutive pediatric patients who had presented to the emergency department, were diagnosed with possible mTBI, and were referred for neurosurgical consultation. Outpatient follow-up for these patients included serial assessment using the ACE. Data collected included the mechanisms of the patients' injuries, symptoms, follow-up duration, and premorbid conditions that might potentially contribute to protracted recovery. RESULTS: Of 91 patients identified with mTBI, 58 met the inclusion criteria, and 33 of these had sufficient follow-up data to be included in the study. Mechanisms of injury included sports injury (15 patients), isolated falls (10), and motor vehicle collisions (8). Ages ranged from 5 to 17 years (mean age 11.6 years), and 29 of the 33 patients were male. Six patients had preinjury developmental and/or psychiatric diagnoses such as attention deficit hyperactivity disorder. Seventeen had negative findings on head CT scans. The first follow-up evaluation occurred at a mean of 30 days after injury. The mean number of symptoms reported on the ACE inventory at first follow-up were 3.2; 12 patients were symptom free. Patients with positive head CT findings required longer follow-up: these patients needed 14.59 weeks, versus 7.87 weeks of follow-up in patients with negative findings on head CT scans (p \< 0.05). CONCLUSIONS: The data suggest that patients with mTBI, particularly those with developmental and/or psychiatric comorbidities and concurrent cerebral or extracranial injury, often report symptoms for several weeks after their initial injury. Serial ACE assessment permits systematic identification of patients who are experiencing continued symptoms, leading to appropriate patient management and referral. ©AANS, 2016.},
keywords = {Acute Concussion Evaluation, Concussion, head injury, Patient Outcome Assessment, Trauma, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Sanghera, Navjit K; Baas, Eric A; Bakkum, Barclay W; Foreman, Katie; Beckerman, Stephen
Sports vision evaluation findings in an elite athlete population Journal Article
In: Optometry & Visual Performance, vol. 4, no. 3, pp. 137–146, 2016, ISBN: 2325-3479 2325-3487.
Abstract | BibTeX | Tags: 2016, Binocular Vision, binocular vision disorder, brain concussion, Concussion, Sports, sports vision, traumatic brain injury, Vision Disorders
@article{Sanghera2016,
title = {Sports vision evaluation findings in an elite athlete population},
author = {Sanghera, Navjit K and Baas, Eric A and Bakkum, Barclay W and Foreman, Katie and Beckerman, Stephen},
isbn = {2325-3479
2325-3487},
year = {2016},
date = {2016-01-01},
journal = {Optometry \& Visual Performance},
volume = {4},
number = {3},
pages = {137--146},
publisher = {Optometric Extension Program Foundation, Inc.},
address = {US},
abstract = {Background: Epidemiological studies suggest that the athletic population has a significant need for vision care. Recently, there has been an increased awareness and discussion of sports-related concussion, which can have a negative impact on athletic performance. The goal of this investigation is to characterize baseline performance of a cohort of elite athletes on a battery of sports vision tests. This information can: 1) serve as a baseline for comparison after an athlete is concussed, 2) help evaluate the effects of concussion on the visual system as it relates to athletic performance, and 3) help establish vision-related criteria for determining if and when an athlete is ready to return to play and perform at pre-concussive levels. Methods: Twenty-one male Major League Soccer athletes ages 18-35 were tested on 20 sports vision-related tests. Results: Eighteen of 21 subjects (86%) demonstrated one or more clinically significant problems with visual acuity, ocular health, binocular vision, and/or exhibited visual symptoms. The screening results indicate that 17% failed visual acuity, 26% displayed abnormal ocular health findings, 6% exhibited binocular vision problems, and 29% complained of at least one visual symptom related to a previous incident involving head trauma or concussion. Conclusion: This visual performance testing characterized baseline findings for this population and may help determine how deficits may interfere with optimum athletic performance at the elite level. The baseline testing could also serve as an indicator of recovery in acute vs. chronic stages and help determine if and when a concussed athlete is ready to return to play. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2016, Binocular Vision, binocular vision disorder, brain concussion, Concussion, Sports, sports vision, traumatic brain injury, Vision Disorders},
pubstate = {published},
tppubtype = {article}
}
Stieg, P E; Perrine, K
Helmet Use and Traumatic Brain Injury in Snowboarding Journal Article
In: World Neurosurgery, vol. 86, pp. 65–68, 2016.
Links | BibTeX | Tags: brain hemorrhage, Concussion, disability, emergency ward, Female, head injury, Head Protective Devices, Helmet, human, Humans, Injuries, Male, Morbidity, MORTALITY, Neuroprotection, Review, skiing, skull fracture, Snowboarding, Traumatic, traumatic brain injury, UNITED States, winter sport
@article{Stieg2016,
title = {Helmet Use and Traumatic Brain Injury in Snowboarding},
author = {Stieg, P E and Perrine, K},
doi = {10.1016/j.wneu.2015.07.044},
year = {2016},
date = {2016-01-01},
journal = {World Neurosurgery},
volume = {86},
pages = {65--68},
keywords = {brain hemorrhage, Concussion, disability, emergency ward, Female, head injury, Head Protective Devices, Helmet, human, Humans, Injuries, Male, Morbidity, MORTALITY, Neuroprotection, Review, skiing, skull fracture, Snowboarding, Traumatic, traumatic brain injury, UNITED States, winter sport},
pubstate = {published},
tppubtype = {article}
}
Sullivan, K A; Edmed, S L
New vignettes for the experimental manipulation of injury cause in prospective mild traumatic brain injury research Journal Article
In: Brain Injury, vol. 30, no. 13-14, pp. 1699–1707, 2016.
Abstract | Links | BibTeX | Tags: Concussion, mild brain, survey, traumatic brain injury, vignette
@article{Sullivan2016a,
title = {New vignettes for the experimental manipulation of injury cause in prospective mild traumatic brain injury research},
author = {Sullivan, K A and Edmed, S L},
doi = {10.1080/02699052.2016.1202448},
year = {2016},
date = {2016-01-01},
journal = {Brain Injury},
volume = {30},
number = {13-14},
pages = {1699--1707},
abstract = {Purpose: This study developed standardized vignettes that depict a mild traumatic brain injury (TBI) from one of several causes and subjected them to formal expert review. Method: A base vignette was developed using the World Health Organization operational criteria for mild TBI. Eight specific causes (e.g. sport vs assault) were examined. A convenience sample of mild TBI experts with a discipline background of Neuropsychology from North America, Australasia and Europe (n = 21) used an online survey to evaluate the vignettes and rated the role of cause on outcome. Results: The vignette suite was rated as fitting the mild TBI WHO operational diagnostic criteria at least moderately well. When compared to other factors, cause was not rated as significantly contributing to outcome. When evaluated in isolation, approximately half of the sample rated cause as important or very important and at least two of three clinical outcomes were associated with a different cause. Discussion: The vignettes may be useful in experimental mild TBI research. They enable the injury parameters to be controlled so that the effects of cause can be isolated and examined empirically. Such studies should advance understanding of the role of this factor in mild TBI outcome. © 2016 Taylor \& Francis Group, LLC.},
keywords = {Concussion, mild brain, survey, traumatic brain injury, vignette},
pubstate = {published},
tppubtype = {article}
}
Kawata, K; Rubin, L H; Lee, J H; Sim, T; Takahagi, M; Szwanki, V; Bellamy, A; Darvish, K; Assari, S; Henderer, J D; Tierney, R; Langford, D
Association of football subconcussive head impacts with ocular near point of convergence Journal Article
In: JAMA Ophthalmology, vol. 134, no. 7, pp. 763–769, 2016.
Abstract | Links | BibTeX | Tags: Acceleration, accelerometer, adult, Article, binocular convergence, Concussion, eye movement, follow up, football, head movement, human, KINEMATICS, major clinical study, Male, mouth protector, observational study, priority journal, prospective study, traumatic brain injury, Young Adult
@article{Kawata2016,
title = {Association of football subconcussive head impacts with ocular near point of convergence},
author = {Kawata, K and Rubin, L H and Lee, J H and Sim, T and Takahagi, M and Szwanki, V and Bellamy, A and Darvish, K and Assari, S and Henderer, J D and Tierney, R and Langford, D},
doi = {10.1001/jamaophthalmol.2016.1085},
year = {2016},
date = {2016-01-01},
journal = {JAMA Ophthalmology},
volume = {134},
number = {7},
pages = {763--769},
abstract = {IMPORTANCE An increased understanding of the relationship between subconcussive head impacts and near point of convergence (NPC) ocular-motor function may be useful in delineating traumatic brain injury. OBJECTIVE To investigate whether repetitive subconcussive head impacts during preseason football practice cause changes in NPC. DESIGN, SETTING, AND PARTICIPANTS This prospective, observational study of 29 National Collegiate Athletic Association Division I football players included baseline and preseason practices (1 noncontact and 4 contact), and postseason follow-up and outcome measures were obtained for each time. An accelerometer-embedded mouthguard measured head impact kinematics. Based on the sum of head impacts from all 5 practices, players were categorized into lower (n = 7) or higher (n = 22) impact groups. EXPOSURES Players participated in regular practices, and all head impacts greater than 10g from the 5 practices were recorded using the i1Biometerics Vector mouthguard (i1 Biometrics Inc). MAIN OUTCOMES AND MEASURES Near point of convergence measures and symptom scores. RESULTS A total of 1193 head impacts were recorded from 5 training camp practices in the 29 collegiate football players; 22 were categorized into the higher-impact group and 7 into the lower-impact group. Therewere significant differences in head impact kinematics between lower- and higher-impact groups (number of impacts, 6 vs 41 [lower impact minus higher impact = 35; 95%CI, 21-51; P \< .001]; linear acceleration, 99g vs 1112g [lower impact minus higher impact= 1013; 95%CI, 621 - 1578; P \< .001]; angular acceleration, 7589 radian/s2 vs 65016 radian/s2 [lower impact minus higher impact= 57 427; 95%CI , 31 123-80 498; P \< .001], respectively). The trajectory and cumulative burden of subconcussive impacts on NPC differed by group (F for group × linear trend1},
keywords = {Acceleration, accelerometer, adult, Article, binocular convergence, Concussion, eye movement, follow up, football, head movement, human, KINEMATICS, major clinical study, Male, mouth protector, observational study, priority journal, prospective study, traumatic brain injury, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Papa, L; Brophy, G M; Welch, R D; Lewis, L M; Braga, C F; Tan, C N; Ameli, N J; Lopez, M A; Haeussler, C A; Mendez Giordano, D I; Silvestri, S; Giordano, P; Weber, K D; Hill-Pryor, C; Hack, D C
In: JAMA Neurology, vol. 73, no. 5, pp. 551–560, 2016.
Abstract | Links | BibTeX | Tags: adult, aged, American Indian, amnesia, area under the curve, Article, Asian, assault, bicycle, Black person, blood sampling, blunt trauma, brain concussion, Caucasian, cohort analysis, computer assisted tomography, controlled study, diagnostic accuracy, diagnostic test accuracy study, disorientation, emergency ward, falling, Female, Glasgow Coma Scale, glial fibrillary acidic protein, Hispanic, human, limit of detection, limit of quantitation, major clinical study, Male, mild to moderate traumatic brain injury, neurosurgery, pedestrian, priority journal, prospective study, sport injury, traffic accident, traumatic brain injury, traumatic intracranial lesion, ubiquitin, ubiquitin carboxy terminal hydrolase L1, unclassified drug, unconsciousness, very elderly
@article{Papa2016a,
title = {Time course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic brain injury},
author = {Papa, L and Brophy, G M and Welch, R D and Lewis, L M and Braga, C F and Tan, C N and Ameli, N J and Lopez, M A and Haeussler, C A and {Mendez Giordano}, D I and Silvestri, S and Giordano, P and Weber, K D and Hill-Pryor, C and Hack, D C},
doi = {10.1001/jamaneurol.2016.0039},
year = {2016},
date = {2016-01-01},
journal = {JAMA Neurology},
volume = {73},
number = {5},
pages = {551--560},
abstract = {Importance: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been widely studied and show promise for clinical usefulness in suspected traumatic brain injury (TBI) and concussion. Understanding their diagnostic accuracy over time will help translate them into clinical practice. Objectives: To evaluate the temporal profiles of GFAP and UCH-L1 in a large cohort of trauma patients seen at the emergency department and to assess their diagnostic accuracy over time, both individually and in combination, for detecting mild to moderate TBI (MMTBI), traumatic intracranial lesions on head computed tomography (CT), and neurosurgical intervention. Design, Setting, and Participants: This prospective cohort study enrolled adult trauma patients seen at a level I trauma center from March 1, 2010, to March 5, 2014. All patients underwent rigorous screening to determine whether they had experienced an MMTBI (blunt head trauma with loss of consciousness, amnesia, or disorientation and a Glasgow Coma Scale score of 9-15). Of 3025 trauma patients assessed, 1030 met eligibility criteria for enrollment, and 446 declined participation. Initial blood samples were obtained in 584 patients enrolled within 4 hours of injury. Repeated blood sampling was conducted at 4, 8, 12, 16, 20, 24, 36, 48, 60, 72, 84, 96, 108, 120, 132, 144, 156, 168, and 180 hours after injury. Main Outcomes and Measures: Diagnosis of MMTBI, presence of traumatic intracranial lesions on head CT scan, and neurosurgical intervention. Results: A total of 1831 blood samples were drawn from 584 patients (mean [SD] age, 40 [16] years; 62.0%[362 of 584] male) over 7 days. Both GFAP and UCH-L1 were detectible within 1 hour of injury. GFAP peaked at 20 hours after injury and slowly declined over 72 hours. UCH-L1 rose rapidly and peaked at 8 hours after injury and declined rapidly over 48 hours. Over the course of 1 week, GFAP demonstrated a diagnostic range of areas under the curve for detecting MMTBI of 0.73 (95%CI, 0.69-0.77) to 0.94 (95%CI, 0.78-1.00), and UCH-L1 demonstrated a diagnostic range of 0.30 (95%CI, 0.02-0.50) to 0.67 (95%CI, 0.53-0.81). For detecting intracranial lesions on CT, the diagnostic ranges of areas under the curve were 0.80 (95%CI, 0.67-0.92) to 0.97 (95%CI, 0.93-1.00)for GFAP and 0.31 (95%CI, 0-0.63) to 0.77 (95%CI, 0.68-0.85) for UCH-L1. For distinguishing patients with and without a neurosurgical intervention, the range for GFAP was 0.91 (95%CI, 0.79-1.00) to 1.00 (95% CI, 1.00-1.00), and the range for UCH-L1 was 0.50 (95%CI, 0-1.00) to 0.92 (95%CI, 0.83-1.00). Conclusions and Relevance: GFAP performed consistently in detecting MMTBI, CT lesions, and neurosurgical intervention across 7 days. UCH-L1 performed best in the early postinjury period. © Copyright 2016 American Medical Association. All rights reserved.},
keywords = {adult, aged, American Indian, amnesia, area under the curve, Article, Asian, assault, bicycle, Black person, blood sampling, blunt trauma, brain concussion, Caucasian, cohort analysis, computer assisted tomography, controlled study, diagnostic accuracy, diagnostic test accuracy study, disorientation, emergency ward, falling, Female, Glasgow Coma Scale, glial fibrillary acidic protein, Hispanic, human, limit of detection, limit of quantitation, major clinical study, Male, mild to moderate traumatic brain injury, neurosurgery, pedestrian, priority journal, prospective study, sport injury, traffic accident, traumatic brain injury, traumatic intracranial lesion, ubiquitin, ubiquitin carboxy terminal hydrolase L1, unclassified drug, unconsciousness, very elderly},
pubstate = {published},
tppubtype = {article}
}
Naeser, M A; Martin, P I; Ho, M D; Krengel, M H; Bogdanova, Y; Knight, J A; Yee, M K; Zafonte, R; Frazier, J; Hamblin, M R; Koo, B B
Transcranial, red/near-infrared light-emitting diode therapy to improve cognition in chronic traumatic brain injury Journal Article
In: Photomedicine and Laser Surgery, vol. 34, no. 12, pp. 610–626, 2016.
Abstract | Links | BibTeX | Tags: Accidents, Adenosinetriphosphate, brain, Cognitive dysfunction, Diodes, Explosives, Head Injuries, Hemodynamics, Infrared devices, LED, Light, Light emitting diodes, Lightemitting diodes, LLLT, Nitric oxide, Patient monitoring, Patient treatment, PBM, Photobiomodulation, postconcussion syndrome, PTSD, Sports, Sports head injury, TBI, TBI treatment, Traumatic Brain Injuries, traumatic brain injury
@article{Naeser2016,
title = {Transcranial, red/near-infrared light-emitting diode therapy to improve cognition in chronic traumatic brain injury},
author = {Naeser, M A and Martin, P I and Ho, M D and Krengel, M H and Bogdanova, Y and Knight, J A and Yee, M K and Zafonte, R and Frazier, J and Hamblin, M R and Koo, B B},
doi = {10.1089/pho.2015.4037},
year = {2016},
date = {2016-01-01},
journal = {Photomedicine and Laser Surgery},
volume = {34},
number = {12},
pages = {610--626},
abstract = {Objective: We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM improves mitochondrial function increasing oxygen consumption, production of adenosine triphosphate (ATP), and improving cellular energy stores. Nitric oxide is released from the cells increasing regional blood flow in the brain. Review of published studies: In our previously published study, 11 chronic TBI patients with closed-head TBI caused by different accidents (motor vehicle accident, sports-related, improvised explosive device blast injury) and exhibiting long-lasting cognitive dysfunction received 18 outpatient treatments (Monday, Wednesday, Friday for 6 weeks) starting at 10 months to 8 years post-TBI. LED therapy is nonthermal, painless, and noninvasive. An LED-based device classified as nonsignificant risk (FDA cleared) was used. Each LED cluster head (5.35 cm diameter, 500mW, 22.2 mW/cm2) was applied for 9 min 45 sec (13 J/cm2) using 11 locations on the scalp: midline from front-to-back hairline and bilaterally on frontal, parietal, and temporal areas. Testing was performed before and after transcranial LED (tLED; at 1 week, 1 month, and at 2 months after the 18th treatment) and showed significant improvements in executive function and verbal memory. There were also fewer post-traumatic stress disorder (PTSD) symptoms reported. Ongoing studies: Ongoing, current studies involve TBI patients who have been treated with tLED using either 26 J/cm2 per LED location on the head or treated with intranasal only (iLED) using red (633 nm) and NIR (810 nm) diodes placed into the nostrils. The NIR iLED is hypothesized to deliver photons to the hippocampus, and the red 633 nm iLED is believed to increase melatonin. Results have been similar to the previously published tLED study. Actigraphy sleep data showed increased time asleep (on average one additional hour per night) after the 18th tLED or iLED treatment. LED treatments may be performed in the home. Sham-controlled studies with veterans who have cognitive dysfunction from Gulf War Illness, blast TBI, and TBI/PTSD are currently ongoing. © Mary Ann Liebert, Inc.},
keywords = {Accidents, Adenosinetriphosphate, brain, Cognitive dysfunction, Diodes, Explosives, Head Injuries, Hemodynamics, Infrared devices, LED, Light, Light emitting diodes, Lightemitting diodes, LLLT, Nitric oxide, Patient monitoring, Patient treatment, PBM, Photobiomodulation, postconcussion syndrome, PTSD, Sports, Sports head injury, TBI, TBI treatment, Traumatic Brain Injuries, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Tierney, Gregory J; Lawler, John; Denvir, Karl; McQuilkin, Kurt; Simms, Ciaran K
Risks associated with significant head impact events in elite rugby union Journal Article
In: Brain Injury, vol. 30, no. 11, pp. 1350–1361, 2016, ISBN: 0269-9052 1362-301X.
Abstract | Links | BibTeX | Tags: 2016, brain concussion, Sport, statistical analysis, traumatic brain injury, Video analysis
@article{Tierney2016,
title = {Risks associated with significant head impact events in elite rugby union},
author = {Tierney, Gregory J and Lawler, John and Denvir, Karl and McQuilkin, Kurt and Simms, Ciaran K},
doi = {10.1080/02699052.2016.1193630},
isbn = {0269-9052
1362-301X},
year = {2016},
date = {2016-01-01},
journal = {Brain Injury},
volume = {30},
number = {11},
pages = {1350--1361},
publisher = {Taylor \& Francis},
address = {United Kingdom},
abstract = {Primary objectives: To conduct video and statistical analysis on Rugby Union play, focusing mainly on the tackle, to establish the player to player configurations for significant direct head impacts and non-direct head impacts. Research design: Quantitative, observational cohort study. Methods and procedures: Video analysis of 52 significant direct head impacts (31 Tackle, 10 Ruck, 7 Dive and 4 Ground) and 40 non-direct head impact tackles from 2014/15 International Rugby Union matches. Relative risk, 95% CI and p-values were calculated for a range of tackle variables. Main outcome and results: Upper body tackles and lower body tackles accounted for 37% (19) and 23% (12) of cases, respectively, with the tackler as the head impacted player for 97% (30) of cases. The majority (81%) of tackle-related significant direct head impacts occurred in the second half of the game, with 63% of upper body tackle significant direct head impacts occurring in the final quarter. Tackler head placement and high speed tackles had statistical significance for causing tackle related significant direct head impacts as well as foot planting and difference in tackler and ball carrier mass for upper body tackles and ball carrier change in direction for lower body tackles. Conclusion: Tackle variables that statistically increased the risk of significant direct head impact were identified, which can aid player protection strategies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2016, brain concussion, Sport, statistical analysis, traumatic brain injury, Video analysis},
pubstate = {published},
tppubtype = {article}
}
Bonfield, C M; Kondziolka, D
Beyond the game: The legacy of Bill Masterton Journal Article
In: Neurosurgical Focus, vol. 41, no. 1, 2016.
Abstract | Links | BibTeX | Tags: Bill Masterton, Hockey, neurosurgery, traumatic brain injury
@article{Bonfield2016,
title = {Beyond the game: The legacy of Bill Masterton},
author = {Bonfield, C M and Kondziolka, D},
doi = {10.3171/2016.2.FOCUS1558},
year = {2016},
date = {2016-01-01},
journal = {Neurosurgical Focus},
volume = {41},
number = {1},
abstract = {Bill Masterton is the only man to die of injuries sustained in a National Hockey League (NHL) game. He remains the last fatality in any professional team sport involving a direct in-game injury in North America. While Masterton was originally thought to have suffered a fatal brain injury while being checked on the ice, later analysis of the case revealed evidence of second-impact syndrome and the effects of prior concussions. Masterton's death sparked both an immediate debate in the NHL on whether helmets should be compulsory and the NHL's first vote on mandatory helmet use. Although the subject of mandated helmet use met with resistance in the 10 years after Masterton's death, especially from hockey owners and coaches, the NHL finally legislated helmet use by all players entering the league beginning in the 1979-1980 season. Several awards, including one recognizing the NHL player who best exemplifies the qualities of perseverance, sportsmanship, and dedication to hockey, have been created in memory of Masterton. However, his legacy extends far beyond the awards that bear his name. His death was the seminal event bringing head safety to the forefront of a game that was both unready and unwilling to accept change. An increase in mainstream media attention in recent years has led to unprecedented public awareness of brain injury and concussion in hockey and other sports. Advances in the diagnosis and treatment of head injury in sports have occurred recently, the impetus for which started over 45 years ago, when Bill Masterton died.},
keywords = {Bill Masterton, Hockey, neurosurgery, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Talavage, T M; Nauman, E A; Leverenz, L J
The role of medical imaging in the recharacterization of mild traumatic brain injury using youth sports as a laboratory Journal Article
In: Frontiers in Neurology, vol. 6, no. JAN, 2016.
Abstract | Links | BibTeX | Tags: Article, cognition assessment, Concussion, DIAGNOSTIC imaging, functional magnetic resonance imaging, Functional MRI, human, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Neuroanatomy, neuroimaging, neuromonitoring, nonhuman, NUCLEAR magnetic resonance spectroscopy, Patient monitoring, population risk, prediction, protective equipment, sport injury, Subconcussive, traumatic brain injury, validation process
@article{Talavage2016,
title = {The role of medical imaging in the recharacterization of mild traumatic brain injury using youth sports as a laboratory},
author = {Talavage, T M and Nauman, E A and Leverenz, L J},
doi = {10.3389/fneur.2015.00273},
year = {2016},
date = {2016-01-01},
journal = {Frontiers in Neurology},
volume = {6},
number = {JAN},
abstract = {The short- and long-term impact of mild traumatic brain injury (TBI) is an increasingly vital concern for both military and civilian personnel. Such injuries produce significant social and financial burdens and necessitate improved diagnostic and treatment methods. Recent integration of neuroimaging and biomechanical studies in youth collision-sport athletes has revealed that significant alterations in brain structure and function occur even in the absence of traditional clinical markers of "concussion." While task performance is maintained, athletes exposed to repetitive head accelerations exhibit structural changes to the underlying white matter, altered glial cell metabolism, aberrant vascular response, and marked changes in functional network behavior. Moreover, these changes accumulate with accrued years of exposure, suggesting a cumulative trauma mechanism that may culminate in categorization as "concussion" and long-term neurological deficits. The goal of this review is to elucidate the role of medical imaging in recharacterizing TBI, as a whole, to better identify at-risk individuals and improve the development of preventative and interventional approaches. © 2016 Talavage, Nauman and Leverenz.},
keywords = {Article, cognition assessment, Concussion, DIAGNOSTIC imaging, functional magnetic resonance imaging, Functional MRI, human, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Neuroanatomy, neuroimaging, neuromonitoring, nonhuman, NUCLEAR magnetic resonance spectroscopy, Patient monitoring, population risk, prediction, protective equipment, sport injury, Subconcussive, traumatic brain injury, validation process},
pubstate = {published},
tppubtype = {article}
}
Holtkamp, M D; Grimes, J; Ling, G
Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache Journal Article
In: Current Pain & Headache Reports, vol. 20, no. 6, 2016.
Abstract | Links | BibTeX | Tags: apolipoprotein E4, assessment, biological marker, botulinum toxin, brain concussion, calcitonin gene related peptide receptor antagonis, comorbidity, Concussion, depression, DIAGNOSTIC imaging, disease course, genetic polymorphism, genetic predisposition, glial fibrillary acidic protein, headache, Headache disorder, human, MANAGEMENT, migraine, Military personnel, mTBI, neuroimaging, Pathophysiology, postconcussion syndrome, posttraumatic headache, posttraumatic stress disorder, Prognosis, Review, serotonin 1 agonist, serotonin 1F agonist, soldier, traumatic brain injury, Treatment, tricyclic antidepressant agent, triptan derivative, unclassified drug, UNITED States
@article{Holtkamp2016,
title = {Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache},
author = {Holtkamp, M D and Grimes, J and Ling, G},
doi = {10.1007/s11916-016-0572-x},
year = {2016},
date = {2016-01-01},
journal = {Current Pain \& Headache Reports},
volume = {20},
number = {6},
abstract = {Traumatic brain injury (TBI) is defined as an alteration in brain function caused by an external force. Mild TBI or concussion is now well recognized to be a risk of military service as well as participation in athletic sports such as football. Posttraumatic headache (PTH) is the most common symptom after mTBI in US service members. PTH most commonly presents with migraine-like headache features. The following is an overview of the epidemiology, pathophysiology, clinical course, prognosis, complications, and treatment of mTBI and associated comorbidities with a focus on PTH. There is a particular emphasis on emerging evidence-based clinical practice. One important medical consequence of the recognition that mTBI is a highly prevalent among military service members is that the Department of Defense (DoD) is dedicating significant financial and intellectual resources to better understanding and developing treatments for TBI. The identification of the importance of TBI among the US military population has had the added benefit of increasing awareness of this condition among civilian populations, particularly those engaged in both professional and youth sports. The NIH and NSF are also supporting important TBI research. President Obama’s Brain Initiative is also providing additional impetus for these efforts. Unfortunately, the understanding of the acute and chronic effects of mTBI on the brain remains limited. Gratefully, there is hope that through innovative research, there will be advances in elucidating the underlying pathophysiology, which will lead to clinical and prognostic indicators, ultimately resulting in new treatment options for this very complicated set of disorders. © 2016, Springer Science+Business Media New York (outside the USA).},
keywords = {apolipoprotein E4, assessment, biological marker, botulinum toxin, brain concussion, calcitonin gene related peptide receptor antagonis, comorbidity, Concussion, depression, DIAGNOSTIC imaging, disease course, genetic polymorphism, genetic predisposition, glial fibrillary acidic protein, headache, Headache disorder, human, MANAGEMENT, migraine, Military personnel, mTBI, neuroimaging, Pathophysiology, postconcussion syndrome, posttraumatic headache, posttraumatic stress disorder, Prognosis, Review, serotonin 1 agonist, serotonin 1F agonist, soldier, traumatic brain injury, Treatment, tricyclic antidepressant agent, triptan derivative, unclassified drug, UNITED States},
pubstate = {published},
tppubtype = {article}
}
Schulte, S; Rasmussen, N N; McBeth, J W; Richards, P Q; Yochem, E; Petron, D J; Strathmann, F G
In: EPMA Journal, vol. 7, no. 1, 2016.
Abstract | Links | BibTeX | Tags: adult, Article, athlete-derived reference interval, biological marker, Biomarker panel, Blood test, clinical decision making, clinical laboratory, college, collegiate athletes, Concussion, controlled study, diagnostic test accuracy study, follow up, football, health program, human, Male, neuron specific enolase, NSE, prediction, Predictive diagnostics, priority journal, protein blood level, protein S100B, rating scale, reference value, S100B, Sport-related concussion, Sports-related concussion, traumatic brain injury, validation study
@article{Schulte2016b,
title = {Utilization of the clinical laboratory for the implementation of concussion biomarkers in collegiate football and the necessity of personalized and predictive athlete specific reference intervals},
author = {Schulte, S and Rasmussen, N N and McBeth, J W and Richards, P Q and Yochem, E and Petron, D J and Strathmann, F G},
doi = {10.1186/s13167-016-0050-x},
year = {2016},
date = {2016-01-01},
journal = {EPMA Journal},
volume = {7},
number = {1},
abstract = {Background: A continued interest in concussion biomarkers makes the eventual implementation of identified biomarkers into routine concussion assessment an eventual reality. We sought to develop and test an interdisciplinary approach that could be used to integrate blood-based biomarkers into the established concussion management program for a collegiate football team. Methods: We used a CLIA-certified laboratory for all testing and chose biomarkers where clinically validated testing was available as would be required for results used in clinical decision making. We summarized the existing methods and results for concussion assessment across an entire season to identify and demonstrate the challenges with the eventual integration of a parallel process using blood-based tests for concussion management. We analyzed the results of the biomarkers chosen for trends consistent with the outcome assessments provided from the current concussion management protocols. Results: Baseline samples were collected with three additional post-concussion samples collected at three separate time points from players with a diagnosed concussion (n = 12). A summary of results from currently used concussion assessment tools were compared to the representative biomarkers S100B and NSE results. Nine sport-related concussions occurred during practice and three during play. For S100B, 50% had follow-up testing results lower than the post-injury result. In contrast, 92% of NSE follow-up results were lower than post-injury. One hundred percent of the results for S100B and NSE were within the athlete-derived reference intervals upon return-to-play and season end. Conclusions: The reported workflow provides a framework for the eventual implementation of biomarkers for concussion assessment into existing assessment protocols and strengthens the need for reliance on clinical laboratory testing. Athlete-specific reference intervals will be required to adequately interpret results. © 2016 Schulte et al.},
keywords = {adult, Article, athlete-derived reference interval, biological marker, Biomarker panel, Blood test, clinical decision making, clinical laboratory, college, collegiate athletes, Concussion, controlled study, diagnostic test accuracy study, follow up, football, health program, human, Male, neuron specific enolase, NSE, prediction, Predictive diagnostics, priority journal, protein blood level, protein S100B, rating scale, reference value, S100B, Sport-related concussion, Sports-related concussion, traumatic brain injury, validation study},
pubstate = {published},
tppubtype = {article}
}
Moon, K; Theodore, N
Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists? Journal Article
In: World Neurosurgery, vol. 89, pp. 720–721, 2016.
Links | BibTeX | Tags: Alzheimer disease, amyloid beta protein, amyloid plaque, anxiety disorder, apolipoprotein E, Article, behavior disorder, Boxing, brain atrophy, brain concussion, brain degeneration, chronic disease, Chronic traumatic encephalopathy, cognitive defect, degenerative disease, depression, environmental factor, football, frontotemporal dementia, genetic predisposition, genetic risk, genetic susceptibility, human, motor control, Neuroanatomy, opiate addiction, Parkinson disease, protein phosphorylation, scar formation, septum pellucidum, sport injury, substantia nigra, suicide, TAR DNA binding protein, tau protein, tauopathy, traumatic brain injury
@article{Moon2016,
title = {Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists?},
author = {Moon, K and Theodore, N},
doi = {10.1016/j.wneu.2016.03.073},
year = {2016},
date = {2016-01-01},
journal = {World Neurosurgery},
volume = {89},
pages = {720--721},
keywords = {Alzheimer disease, amyloid beta protein, amyloid plaque, anxiety disorder, apolipoprotein E, Article, behavior disorder, Boxing, brain atrophy, brain concussion, brain degeneration, chronic disease, Chronic traumatic encephalopathy, cognitive defect, degenerative disease, depression, environmental factor, football, frontotemporal dementia, genetic predisposition, genetic risk, genetic susceptibility, human, motor control, Neuroanatomy, opiate addiction, Parkinson disease, protein phosphorylation, scar formation, septum pellucidum, sport injury, substantia nigra, suicide, TAR DNA binding protein, tau protein, tauopathy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Johnson, K L; Chowdhury, S; Lawrimore, W B; Mao, Y; Mehmani, A; Prabhu, R; Rush, G A; Horstemeyer, M F
Constrained topological optimization of a football helmet facemask based on brain response Journal Article
In: Materials and Design, vol. 111, pp. 108–118, 2016.
Abstract | Links | BibTeX | Tags: Accident prevention, ALGORITHMS, brain, Concussion, Constrained optimization, Design, Design optimization, finite element analysis, Finite element method, football helmet, Fuel additives, Genetic algorithms, Multiobjective optimization, Optimization, Safety devices, Shear strain, Sports, Surrogate model, Surrogate modeling, Topology, Traumatic Brain Injuries, traumatic brain injury
@article{Johnson2016a,
title = {Constrained topological optimization of a football helmet facemask based on brain response},
author = {Johnson, K L and Chowdhury, S and Lawrimore, W B and Mao, Y and Mehmani, A and Prabhu, R and Rush, G A and Horstemeyer, M F},
doi = {10.1016/j.matdes.2016.08.064},
year = {2016},
date = {2016-01-01},
journal = {Materials and Design},
volume = {111},
pages = {108--118},
abstract = {Surrogate model-based multi-objective design optimization was performed to reduce concussion risk during frontal football helmet impacts. In particular, a topological decomposition of the football helmet facemask was performed to formulate the design problem, and brain injury metrics were exploited as objective functions. A validated finite element model of a helmeted human head was used to recreate facemask impacts. Due to the prohibitive computational expense of the full scale simulations, a surrogate modeling approach was employed. An optimal surrogate model selection framework, called Concurrent Surrogate Model Selection, or COSMOS, was utilized to identify the surrogate models best suited to approximate each objective function. The resulting surrogate models were implemented in the Non-dominated Sorting Genetic Algorithm II (NSGA-II) optimization algorithm. Constraints were implemented to control the solid material fraction in the facemask design space, and binary variables were used to control the placement of the facemask bars. The optimized facemask designs reduced the maximum tensile pressure in the brain by 7.5% and the maximum shear strain by a remarkable 39.5%. This research represents a first-of-its-kind approach to multi-objective design optimization on a football helmet, and demonstrates the possibilities that are achievable in improving human safety by using such a simulation-based design optimization. © 2016 Elsevier Ltd},
keywords = {Accident prevention, ALGORITHMS, brain, Concussion, Constrained optimization, Design, Design optimization, finite element analysis, Finite element method, football helmet, Fuel additives, Genetic algorithms, Multiobjective optimization, Optimization, Safety devices, Shear strain, Sports, Surrogate model, Surrogate modeling, Topology, Traumatic Brain Injuries, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Laker, S R; Meron, A; Greher, M R; Wilson, J
Retirement and Activity Restrictions Following Concussion Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 487–501, 2016.
Links | BibTeX | Tags: Activity restrictions, athlete, attention deficit disorder, brain concussion, Concussion, CONVALESCENCE, depression, human, learning disorder, migraine, neuropsychological test, nonhuman, PHYSICAL ACTIVITY, postconcussion syndrome, practice guideline, priority journal, Retirement, return to sport, Review, risk factor, sleep disorder, sport injury, Sport-related concussion, subarachnoid hemorrhage, symptom, traumatic brain injury, unconsciousness
@article{Laker2016,
title = {Retirement and Activity Restrictions Following Concussion},
author = {Laker, S R and Meron, A and Greher, M R and Wilson, J},
doi = {10.1016/j.pmr.2016.01.001},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {487--501},
keywords = {Activity restrictions, athlete, attention deficit disorder, brain concussion, Concussion, CONVALESCENCE, depression, human, learning disorder, migraine, neuropsychological test, nonhuman, PHYSICAL ACTIVITY, postconcussion syndrome, practice guideline, priority journal, Retirement, return to sport, Review, risk factor, sleep disorder, sport injury, Sport-related concussion, subarachnoid hemorrhage, symptom, traumatic brain injury, unconsciousness},
pubstate = {published},
tppubtype = {article}
}
Blennow, K; Brody, D L; Kochanek, P M; Levin, H; McKee, A; Ribbers, G M; Yaffe, K; Zetterberg, H
Traumatic brain injuries Journal Article
In: Nature Reviews Disease Primers, vol. 2, 2016.
Abstract | Links | BibTeX | Tags: amyloid beta protein, Article, axonal injury, biological marker, BIOPHYSICS, blood, brain, BRAIN damage, cerebrospinal fluid, Chronic traumatic encephalopathy, computer assisted tomography, disease severity, endocrine disease, heredity, human, molecular pathology, neuropathology, nonhuman, nuclear magnetic resonance imaging, Pathophysiology, positron emission tomography, postconcussion syndrome, priority journal, protein aggregation, quality of life, screening, tau protein, traumatic brain injury
@article{Blennow2016,
title = {Traumatic brain injuries},
author = {Blennow, K and Brody, D L and Kochanek, P M and Levin, H and McKee, A and Ribbers, G M and Yaffe, K and Zetterberg, H},
doi = {10.1038/nrdp.2016.84},
year = {2016},
date = {2016-01-01},
journal = {Nature Reviews Disease Primers},
volume = {2},
abstract = {Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe. Mild TBI (the least severe form) is synonymous with concussion and is typically caused by blunt non-penetrating head trauma. The trauma causes stretching and tearing of axons, which leads to diffuse axonal injury-the best-studied pathogenetic mechanism of this disorder. However, mild TBI is defined on clinical grounds and no well-validated imaging or fluid biomarkers to determine the presence of neuronal damage in patients with mild TBI is available. Most patients with mild TBI will recover quickly, but others report persistent symptoms, called post-concussive syndrome, the underlying pathophysiology of which is largely unknown. Repeated concussive and subconcussive head injuries have been linked to the neurodegenerative condition chronic traumatic encephalopathy (CTE), which has been reported post-mortem in contact sports athletes and soldiers exposed to blasts. Insights from severe injuries and CTE plausibly shed light on the underlying cellular and molecular processes involved in mild TBI. MRI techniques and blood tests for axonal proteins to identify and grade axonal injury, in addition to PET for tau pathology, show promise as tools to explore CTE pathophysiology in longitudinal clinical studies, and might be developed into diagnostic tools for CTE. Given that CTE is attributed to repeated head trauma, prevention might be possible through rule changes by sports organizations and legislators. © 2016 Macmillan Publishers Limited, part of Springer Nature.},
keywords = {amyloid beta protein, Article, axonal injury, biological marker, BIOPHYSICS, blood, brain, BRAIN damage, cerebrospinal fluid, Chronic traumatic encephalopathy, computer assisted tomography, disease severity, endocrine disease, heredity, human, molecular pathology, neuropathology, nonhuman, nuclear magnetic resonance imaging, Pathophysiology, positron emission tomography, postconcussion syndrome, priority journal, protein aggregation, quality of life, screening, tau protein, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Keays, G; Friedman, D; Gagnon, I
A 20-Year Comparison of Football-Related Injuries in American and Canadian Youth Aged 6 to 17 Years: A replication study Journal Article
In: Clinical Pediatrics, vol. 55, no. 7, pp. 603–613, 2016.
Abstract | Links | BibTeX | Tags: Adolescent, American, Article, CANADA, Canadian, Child, children, Concussion, dislocation, emergency care, Female, football, head injury, human, Injuries, major clinical study, Male, replication study, retrospective study, skull fracture, spine fracture, sport injury, Sports, sprain, traumatic brain injury, UNITED States
@article{Keays2016,
title = {A 20-Year Comparison of Football-Related Injuries in American and Canadian Youth Aged 6 to 17 Years: A replication study},
author = {Keays, G and Friedman, D and Gagnon, I},
doi = {10.1177/0009922815602631},
year = {2016},
date = {2016-01-01},
journal = {Clinical Pediatrics},
volume = {55},
number = {7},
pages = {603--613},
abstract = {Introduction. Little is known about Canadian youth football injuries. The objectives of this study were (a) to contrast the injuries in Canadian and American football players aged 6 to 17 years and (b) compare the injuries sustained during organized football with those in nonorganized football. Methods. Using a retrospective cohort design based on data from the Canadian Hospitals Injury Reporting and Prevention Program and the National Electronic Injury Surveillance System a comparison of injuries was made. Results. Trends in injuries were comparable. Proportions and odds of injuries were similar, except for a few exceptions. In Canada, more girls were injured and fractures were more prevalent. Compared with nonorganized football, organized football players were older, involved more males, and suffered more traumatic brain injuries and injuries to their lower extremities. Conclusion. Canadian and American youth football injuries were similar. The type of football, be it organized or nonorganized, has an impact on injuries. © 2016 The Author(s).},
keywords = {Adolescent, American, Article, CANADA, Canadian, Child, children, Concussion, dislocation, emergency care, Female, football, head injury, human, Injuries, major clinical study, Male, replication study, retrospective study, skull fracture, spine fracture, sport injury, Sports, sprain, traumatic brain injury, UNITED States},
pubstate = {published},
tppubtype = {article}
}
Baldwin, G; Breiding, M; Sleet, D
Using the public health model to address unintentional injuries and TBI: A perspective from the Centers for Disease Control and Prevention (CDC) Journal Article
In: NeuroRehabilitation, vol. 39, no. 3, pp. 345–349, 2016.
Abstract | Links | BibTeX | Tags: injury causes, Injury prevention, traumatic brain injury, unintentional injury
@article{Baldwin2016,
title = {Using the public health model to address unintentional injuries and TBI: A perspective from the Centers for Disease Control and Prevention (CDC)},
author = {Baldwin, G and Breiding, M and Sleet, D},
doi = {10.3233/NRE-161366},
year = {2016},
date = {2016-01-01},
journal = {NeuroRehabilitation},
volume = {39},
number = {3},
pages = {345--349},
abstract = {Traumatic brain injury (TBI) can have long term effects on mental and physical health, and can disrupt vocational, educational, and social functioning. TBIs can range from mild to severe and their effects can last many years after the initial injury. CDC seeks to reduce the burden of TBI from unintentional injuries through a focus on primary prevention, improved recognition and management, and intervening to improve health outcomes after TBI. CDC uses a 4-stage public health model to guide TBI prevention, moving from 1) surveillance of TBI, 2) identification of risk and protective factors for TBI, 3) development and testing of evidence-based interventions, to 4) bringing effective intervention to scale through widespread adoption. CDC's unintentional injury prevention activities focus on the prevention of sports-related concussions, motor vehicle crashes, and older adult falls. For concussion prevention, CDC developed Heads Up - an awareness initiative focusing on ways to prevent a concussion in sports, and identifying how to recognize and manage potential concussions. In motor vehicle injury prevention, CDC has developed a tool (MV PICCS) to calculate the expected number of injuries prevented and lives saved using various evidence-based motor vehicle crash prevention strategies. To help prevent TBI related to older adult falls, CDC has developed STEADI, an initiative to help primary care providers identify their patients' falls risk and provide effective interventions. In the future, CDC is focused on advancing our understanding of the public health burden of TBI through improved surveillance in order to produce more comprehensive estimates of the public health burden of TBI. © 2016 - IOS Press and the authors. All rights reserved.},
keywords = {injury causes, Injury prevention, traumatic brain injury, unintentional injury},
pubstate = {published},
tppubtype = {article}
}
Wallace, B; Lifshitz, J
Traumatic brain injury and vestibulo-ocular function: Current challenges and future prospects Journal Article
In: Eye and Brain, vol. 8, pp. 153–164, 2016.
Abstract | Links | BibTeX | Tags: Concussion, Ocular motor, Symptoms, traumatic brain injury, vestibular
@article{Wallace2016,
title = {Traumatic brain injury and vestibulo-ocular function: Current challenges and future prospects},
author = {Wallace, B and Lifshitz, J},
doi = {10.2147/EB.S82670},
year = {2016},
date = {2016-01-01},
journal = {Eye and Brain},
volume = {8},
pages = {153--164},
abstract = {Normal function of the vestibulo-ocular reflex (VOR) coordinates eye movement with head movement, in order to provide clear vision during motion and maintain balance. VOR is generated within the semicircular canals of the inner ear to elicit compensatory eye movements, which maintain stability of images on the fovea during brief, rapid head motion, otherwise known as gaze stability. Normal VOR function is necessary in carrying out activities of daily living (eg, walking and riding in a car) and is of particular importance in higher demand activities (eg, sports-related activities). Disruption or damage in the VOR can result in symptoms such as movement-related dizziness, blurry vision, difficulty maintaining balance with head movements, and even nausea. Dizziness is one of the most common symptoms following traumatic brain injury (TBI) and is considered a risk factor for a prolonged recovery. Assessment of the vestibular system is of particular importance following TBI, in conjunction with oculomotor control, due to the intrinsic neural circuitry that exists between the ocular and vestibular systems. The purpose of this article is to review the physiology of the VOR and the visual-vestibular symptoms associated with TBI and to discuss assessment and treatment guidelines for TBI. Current challenges and future prospects will also be addressed. © 2016 Wallace and Lifshitz.},
keywords = {Concussion, Ocular motor, Symptoms, traumatic brain injury, vestibular},
pubstate = {published},
tppubtype = {article}
}
Ikram, M Q; Sajjad, F H; Salardini, A
The head that wears the crown: Henry VIII and traumatic brain injury Journal Article
In: Journal of Clinical Neuroscience, vol. 28, pp. 16–19, 2016.
Abstract | Links | BibTeX | Tags: Henry VIII, HISTORY, sport concussion, traumatic brain injury
@article{Ikram2016,
title = {The head that wears the crown: Henry VIII and traumatic brain injury},
author = {Ikram, M Q and Sajjad, F H and Salardini, A},
doi = {10.1016/j.jocn.2015.10.035},
year = {2016},
date = {2016-01-01},
journal = {Journal of Clinical Neuroscience},
volume = {28},
pages = {16--19},
abstract = {Henry VIII of England is one of the most controversial figures in European history. He was born on 28 June 1491 as the second son of Henry VII and Elizabeth of York and became the heir to the English throne after his elder brother died prematurely. A contradictory picture of Henry's character emerges from history: the young Henry was a vigorous, generous and intelligent king who saw early military and naval successes. In contrast, in his later years he became cruel, petty and tyrannical. His political paranoia and military misjudgements are in direct contrast to his earlier successes and promise. Several hypotheses have been put forward regarding his transformation from a renaissance king to a later medieval tyrant, including endocrinopathies, psychiatric illnesses and traumatic brain injury. In this paper we examine the historical evidence linking the change in Henry's personality and health problems to traumatic brain injury. To our knowledge this is the first systematic neurological study of traumatic brain injury in Henry VIII. © 2016 Elsevier Ltd. All rights reserved.},
keywords = {Henry VIII, HISTORY, sport concussion, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Oliver, J M; Jones, M T; Kirk, K M; Gable, D A; Repshas, J T; Johnson, T A; Andréasson, U; Norgren, N; Blennow, K; Zetterberg, H
Serum Neurofilament Light in American Football Athletes over the Course of a Season Journal Article
In: Journal of Neurotrauma, vol. 33, no. 19, pp. 1784–1789, 2016.
Abstract | Links | BibTeX | Tags: adult brain injury, axonal injury, Biomarkers, Head trauma, traumatic brain injury
@article{Oliver2016,
title = {Serum Neurofilament Light in American Football Athletes over the Course of a Season},
author = {Oliver, J M and Jones, M T and Kirk, K M and Gable, D A and Repshas, J T and Johnson, T A and Andr\'{e}asson, U and Norgren, N and Blennow, K and Zetterberg, H},
doi = {10.1089/neu.2015.4295},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurotrauma},
volume = {33},
number = {19},
pages = {1784--1789},
abstract = {Despite being underreported, American football boasts the highest incidence of concussion among all team sports, likely due to exposure to head impacts that vary in number and magnitude over the season. This study compared a biological marker of head trauma in American football athletes with non-contact sport athletes and examined changes over the course of a season. Baseline serum neurofilament light polypeptide (NFL) was measured after 9 weeks of no contact and compared with a non-contact sport. Serum NFL was then measured over the course of the entire season at eight time-points coincident with expected changes in likelihood of increased head impacts. Data were compared between starters (n = 11) and non-starters (n = 9). Compared with non-starters (mean ± standard deviation) (7.30 ± 3.57 pg•mL-1) and controls (6.75 ± 1.68 pg•mL-1), serum NFL in starters (8.45 ± 5.90 pg•mL-1) was higher at baseline (mean difference; ±90% confidence interval) (1.69; ± 1.96 pg•mL-1 and 1.15; ± 1.4 pg•mL-1, respectively). Over the course of the season, an increase (effect size [ES] = 1.8; p \< 0.001) was observed post-camp relative to baseline (1.52 ± 1.18 pg•mL-1), which remained elevated until conference play, when a second increase was observed (ES = 2.6; p = 0.008) over baseline (4.82 ± 2.64 pg•mL-1). A lack of change in non-starters resulted in substantial differences between starters and non-starters over the course of the season. These data suggest that a season of collegiate American football is associated with elevations in serum NFL, which is indicative of axonal injury, as a result of head impacts. Copyright © 2016, Mary Ann Liebert, Inc.},
keywords = {adult brain injury, axonal injury, Biomarkers, Head trauma, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Vassilyadi, M; Macartney, G; Barrowman, N; Anderson, P; Dube, K
Symptom experience and quality of life in children after sport-related head injuries: A cross-sectional study Journal Article
In: Pediatric Neurosurgery, vol. 50, no. 4, pp. 196–203, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, adult, affect, Article, Athletic Injuries, behavior disorder, brain concussion, Child, clinical article, clinical assessment, cognitive defect, Cognitive Efficiency Index, complication, Concussion, Concussion Symptom Scale, controlled study, Craniocerebral Trauma, Cross-Sectional Studies, cross-sectional study, fatigue, Female, head injury, headache, human, Humans, Immediate Postconcussion Assessment and Cognitive, Likert scale, Male, memory disorder, mild traumatic brain injury, neuropsychological test, noise, Paediatric patients, Pediatric Quality of Life Inventory, postconcussion syndrome, priority journal, psychology, quality of life, rating scale, scoring system, Sport, sport injury, Sports, symptom, time factor, Time Factors, traumatic brain injury, trends
@article{Vassilyadi2015,
title = {Symptom experience and quality of life in children after sport-related head injuries: A cross-sectional study},
author = {Vassilyadi, M and Macartney, G and Barrowman, N and Anderson, P and Dube, K},
doi = {10.1159/000431232},
year = {2015},
date = {2015-01-01},
journal = {Pediatric Neurosurgery},
volume = {50},
number = {4},
pages = {196--203},
abstract = {Background: Sports are a major cause of concussions, and little is known about the symptom experience and health-related quality of life (HRQL) in children who remain symptomatic for over 3 months following such head injuries. Methods: A cross-sectional study of children aged 10-18 years was performed who were referred to the Neurosurgery Clinic at our centre following a head injury. Symptom experience was measured using the modified Concussion Symptom Scale, and HRQL was measured using the Pediatric Quality of Life Inventory (PedsQL). The Immediate Postconcussion Assessment and Cognitive Test (ImPACT) was administered to assess neurocognitive and neurobehavioural sequelae. Results: Symptoms with the highest mean symptom scores on a Likert scale of 0-6 in 35 children at the time of assessment included headaches (3.1), poor concentration (2.7), memory problems (2.1), fatigue (2.1) and sensitivity to noise (2.0). Compared with normative data, children in this study had ImPACT summary scores between the 28th and 38th percentiles and a comparably low Cognitive Efficiency Index score. Mean scores for females were consistently statistically significantly lower (p \< 0.05) than for males across all of the HRQL domains. Trouble falling asleep and memory problems explained 62% of the variance in the PedsQL total scores. Conclusions: Children continue to experience many symptoms at least 3 months following sport-related head injuries that significantly impact their HRQL and neurocognitive abilities. © 2015 S. Karger AG, Basel.},
keywords = {Adolescent, adult, affect, Article, Athletic Injuries, behavior disorder, brain concussion, Child, clinical article, clinical assessment, cognitive defect, Cognitive Efficiency Index, complication, Concussion, Concussion Symptom Scale, controlled study, Craniocerebral Trauma, Cross-Sectional Studies, cross-sectional study, fatigue, Female, head injury, headache, human, Humans, Immediate Postconcussion Assessment and Cognitive, Likert scale, Male, memory disorder, mild traumatic brain injury, neuropsychological test, noise, Paediatric patients, Pediatric Quality of Life Inventory, postconcussion syndrome, priority journal, psychology, quality of life, rating scale, scoring system, Sport, sport injury, Sports, symptom, time factor, Time Factors, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Daneshvar, Daniel H; Goldstein, Lee E; Kiernan, Patrick T; Stein, Thor D; McKee, Ann C
Post-traumatic neurodegeneration and chronic traumatic encephalopathy Journal Article
In: MCN: Molecular & Cellular Neuroscience, vol. 66, no. Part B, pp. 81–90, 2015, ISBN: 10447431.
Abstract | Links | BibTeX | Tags: A$beta$ beta-amyloid, AD Alzheimer's disease, APOE $epsilon$4 apolipoprotein $epsilon$4, axonal injury, Blast and impact neurotrauma, BRAIN -- Wounds & injuries, Brain trauma, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy NEURODEGENERATION, Concussion, CSF cerebrospinal fluid, CTE chronic traumatic encephalopathy, DIAGNOSIS, DISEASES -- Risk factors, DNA-binding proteins, MORTALITY, Motor neuron disease, mTBI mild traumatic brain injury, NERVOUS system -- Wounds & injuries, NFTs neurofibrillary tangles, p-tau hyperphosphorylated tau, PCS post-concussion syndrome, PET positron emission tomography, PHF-tau paired helical filament-tau, Posttraumatic neurodegeneration, tau protein, TBI traumatic brain injury, TDP-43 43 kDa TAR DNA-binding protein, traumatic brain injury
@article{Daneshvar2015,
title = {Post-traumatic neurodegeneration and chronic traumatic encephalopathy},
author = {Daneshvar, Daniel H and Goldstein, Lee E and Kiernan, Patrick T and Stein, Thor D and McKee, Ann C},
url = {http://search.ebscohost.com/login.aspx?direct=true\&db=aph\&AN=103136351\&site=ehost-live},
doi = {10.1016/j.mcn.2015.03.007},
isbn = {10447431},
year = {2015},
date = {2015-01-01},
journal = {MCN: Molecular \& Cellular Neuroscience},
volume = {66},
number = {Part B},
pages = {81--90},
abstract = {Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world. Concussive and subconcussive forms of closed-head injury due to impact or blast neurotrauma represent the most common types of TBI in civilian and military settings. It is becoming increasingly evident that TBI can lead to persistent, long-term debilitating effects, and in some cases, progressive neurodegeneration and chronic traumatic encephalopathy (CTE). The epidemiological literature suggests that a single moderate-to-severe TBI may be associated with accelerated neurodegeneration and increased risk of Alzheimer's disease, Parkinson's disease, or motor neuron disease. However, the pathologic phenotype of these post-traumatic neurodegenerations is largely unknown and there may be pathobiological differences between post-traumatic disease and the corresponding sporadic disorder. By contrast, the pathology of CTE is increasingly well known and is characterized by a distinctive pattern of progressive brain atrophy and accumulation of hyperphosphorylated tau neurofibrillary and glial tangles, dystrophic neurites, 43 kDa TAR DNA-binding protein (TDP-43) neuronal and glial aggregates, microvasculopathy, myelinated axonopathy, neuroinflammation, and white matter degeneration. Clinically, CTE is associated with behavioral changes, executive dysfunction, memory deficits, and cognitive impairments that begin insidiously and most often progress slowly over decades. Although research on the long-term effects of TBI is advancing quickly, the incidence and prevalence of post-traumatic neurodegeneration and CTE are unknown. Critical knowledge gaps include elucidation of pathogenic mechanisms, identification of genetic risk factors, and clarification of relevant variables\textemdashincluding age at exposure to trauma, history of prior and subsequent head trauma, substance use, gender, stress, and comorbidities\textemdashall of which may contribute to risk profiles and the development of post-traumatic neurodegeneration and CTE. This article is part of a Special Issue entitled 'Traumatic Brain Injury'. [ABSTRACT FROM AUTHOR] Copyright of MCN: Molecular \& Cellular Neuroscience is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)},
keywords = {A$beta$ beta-amyloid, AD Alzheimer's disease, APOE $epsilon$4 apolipoprotein $epsilon$4, axonal injury, Blast and impact neurotrauma, BRAIN -- Wounds \& injuries, Brain trauma, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy NEURODEGENERATION, Concussion, CSF cerebrospinal fluid, CTE chronic traumatic encephalopathy, DIAGNOSIS, DISEASES -- Risk factors, DNA-binding proteins, MORTALITY, Motor neuron disease, mTBI mild traumatic brain injury, NERVOUS system -- Wounds \& injuries, NFTs neurofibrillary tangles, p-tau hyperphosphorylated tau, PCS post-concussion syndrome, PET positron emission tomography, PHF-tau paired helical filament-tau, Posttraumatic neurodegeneration, tau protein, TBI traumatic brain injury, TDP-43 43 kDa TAR DNA-binding protein, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Dessy, A M; Rasouli, J; Choudhri, T F
Second Impact Syndrome: A Rare, Devastating Consequence of Repetitive Head Injuries Journal Article
In: Neurosurgery Quarterly, vol. 25, no. 3, pp. 423–426, 2015.
Abstract | Links | BibTeX | Tags: Article, brain concussion, clinical feature, Concussion, Dizziness, fatigue, headache, human, hyperemia, intracranial hypertension, memory disorder, Neck pain, neuropathology, neurosurgeon, neurosurgery, Pathophysiology, postconcussion syndrome, priority journal, respiratory failure, Second impact syndrome, sport injury, traumatic brain injury
@article{Dessy2015,
title = {Second Impact Syndrome: A Rare, Devastating Consequence of Repetitive Head Injuries},
author = {Dessy, A M and Rasouli, J and Choudhri, T F},
doi = {10.1097/WNQ.0000000000000085},
year = {2015},
date = {2015-01-01},
journal = {Neurosurgery Quarterly},
volume = {25},
number = {3},
pages = {423--426},
abstract = {Sports-related concussion has been viewed as a developing public health crisis in recent years. Underrecognition of concussions can lead to premature clearance for athletic participation. Second impact syndrome (SIS) represents a rare, yet devastating, potential outcome of premature return to play. SIS is a condition in which rapid brain swelling occurs as a result of a repeat head injury sustained before symptoms of a previous head injury have resolved. Within minutes of the second impact, diffuse cerebral swelling, brain herniation, and death can occur. There are \<20 documented cases of SIS in the world literature to date, and the general understanding of the syndrome is based largely on interpretation of anecdotal cases. This article reviews current understanding of the epidemiology and pathology of SIS. Given neurosurgeons' role in management of head trauma, it is essential that neurosurgeons acquire and maintain thorough knowledge of concussion diagnosis, treatment, and management. © 2014 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {Article, brain concussion, clinical feature, Concussion, Dizziness, fatigue, headache, human, hyperemia, intracranial hypertension, memory disorder, Neck pain, neuropathology, neurosurgeon, neurosurgery, Pathophysiology, postconcussion syndrome, priority journal, respiratory failure, Second impact syndrome, sport injury, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Russo, C R; Lathan, C E
An Evaluation of the Consistency and Reliability of the Defense Automated Neurocognitive Assessment Tool Journal Article
In: Applied Psychological Measurement, vol. 39, no. 7, pp. 566–572, 2015.
Abstract | Links | BibTeX | Tags: CNT, Cognitive Assessment, Concussion, reliability, screening, sports concussion, traumatic brain injury
@article{Russo2015,
title = {An Evaluation of the Consistency and Reliability of the Defense Automated Neurocognitive Assessment Tool},
author = {Russo, C R and Lathan, C E},
doi = {10.1177/0146621615577361},
year = {2015},
date = {2015-01-01},
journal = {Applied Psychological Measurement},
volume = {39},
number = {7},
pages = {566--572},
abstract = {A durable, portable, and field-hardened computerized neurocognitive test (CNT) called the Defense Automated Neurobehavioral Assessment (DANA) tool was recently developed to provide a practical means to conduct neurological and psychological assessment in situ. The psychometric properties of the DANA have been previously described. This present work discusses the test\textendashretest reliability of the DANA Rapid test battery, as administered to a homogeneous population of U.S. Air Force Academy football team players (N = 162) across the duration of the season. The intraclass correlation coefficient (ICC) metric of the DANA is compared with that from two different CNTs recently reported in Cole et al., and the implications of using the metric to interpret comparative test reliability among different CNTs are discussed. © 2015, © The Author(s) 2015.},
keywords = {CNT, Cognitive Assessment, Concussion, reliability, screening, sports concussion, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Kerr, Z Y; Mihalik, J P; Guskiewicz, K M; Rosamond, W D; Evenson, K R; Marshall, S W
Agreement between athlete-recalled and clinically documented concussion histories in former collegiate athletes Journal Article
In: American Journal of Sports Medicine, vol. 43, no. 3, pp. 606–613, 2015.
Abstract | Links | BibTeX | Tags: adult, athlete, Athletes, Athletic Injuries, brain concussion, cohort analysis, Cohort Studies, comparative study, concurrent validity, Concussion, EPIDEMIOLOGY, Female, human, Humans, injury, interpersonal communication, medical record, MEDICAL records, Mental Recall, psychology, recall, self report, sex difference, Sex Factors, traumatic brain injury, Truth Disclosure, Universities, university
@article{Kerr2015,
title = {Agreement between athlete-recalled and clinically documented concussion histories in former collegiate athletes},
author = {Kerr, Z Y and Mihalik, J P and Guskiewicz, K M and Rosamond, W D and Evenson, K R and Marshall, S W},
doi = {10.1177/0363546514562180},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Sports Medicine},
volume = {43},
number = {3},
pages = {606--613},
abstract = {Background: Athlete-recalled and clinically documented concussion histories have been used in research on former athletes, but both have limitations. Comparisons of these 2 types of concussion histories are needed to improve the accuracy of estimates of concussion history for future research and clinical care. Purpose: To estimate the agreement between athlete-recalled and clinically documented concussion histories during college and to explore reasons for differences. Study: Cohort study (diagnosis); Level of evidence, 3. Methods: Athlete-recalled concussion histories were provided by a convenience sample of 130 former collegiate athletes using an online questionnaire, and they were individually linked to previously collected clinical data that tracked medically diagnosed concussions at the host institution from 1996 to 2012. The intraclass correlation coefficient (ICC2,1) was used to assess agreement between athlete-recalled and clinically documented concussion histories. Descriptive analyses were performed to assess reasons for disagreement. Results: Agreement between athlete-recalled and clinically documented concussion histories was low (ICC2},
keywords = {adult, athlete, Athletes, Athletic Injuries, brain concussion, cohort analysis, Cohort Studies, comparative study, concurrent validity, Concussion, EPIDEMIOLOGY, Female, human, Humans, injury, interpersonal communication, medical record, MEDICAL records, Mental Recall, psychology, recall, self report, sex difference, Sex Factors, traumatic brain injury, Truth Disclosure, Universities, university},
pubstate = {published},
tppubtype = {article}
}
Phillips, S; Woessner, D
Sports-Related Traumatic Brain Injury Journal Article
In: Primary Care - Clinics in Office Practice, vol. 42, no. 2, pp. 243–248, 2015.
Abstract | Links | BibTeX | Tags: Anxiety, Athletic Injuries, attention deficit disorder, balance disorder, Balance Error Scoring System, benzodiazepine derivative, beta adrenergic receptor blocking agent, body equilibrium, brain concussion, Brain Injuries, clinical assessment tool, computer assisted tomography, Concussion, coordination disorder, depression, Dizziness, drowsiness, evaluation and follow up, headache, human, Humans, irritability, meclozine, memory disorder, mental concentration, Mild TBI guidelines, mild traumatic brain injury, mood change, mTBI, nausea, NFL Sideline Concussion Assessment Tool, nuclear magnetic resonance imaging, paracetamol, personal hygiene, postconcussion syndrome, Postconcussive syndrome, Primary Health Care, priority journal, procedures, recurrent disease, rest, Review, scoring system, Sideline Concussion Assessment Tool 3, Sideline concussion assessment tool 3 (SCAT3), sleep disorder, Sport, sport injury, Sports, Sports-related, Tomography, traumatic brain injury, tricyclic antidepressant agent, VERTIGO, visual disorder, vomiting, X-Ray Computed
@article{Phillips2015b,
title = {Sports-Related Traumatic Brain Injury},
author = {Phillips, S and Woessner, D},
doi = {10.1016/j.pop.2015.01.010},
year = {2015},
date = {2015-01-01},
journal = {Primary Care - Clinics in Office Practice},
volume = {42},
number = {2},
pages = {243--248},
abstract = {Concussions have garnered more attention in the medical literature, media, and social media. As such, in the nomenclature according to the Centers for Disease Control and Prevention, the term concussion has been supplanted by the term mild traumatic brain injury. Current numbers indicate that 1.7 million TBIs are documented annually, with estimates around 3 million annually (173,285 sports- and recreation-related TBIs among children and adolescents). The Sideline Concussion Assessment Tool 3 and the NFL Sideline Concussion Assessment Tool are commonly used sideline tools. © 2015 Elsevier Inc.},
keywords = {Anxiety, Athletic Injuries, attention deficit disorder, balance disorder, Balance Error Scoring System, benzodiazepine derivative, beta adrenergic receptor blocking agent, body equilibrium, brain concussion, Brain Injuries, clinical assessment tool, computer assisted tomography, Concussion, coordination disorder, depression, Dizziness, drowsiness, evaluation and follow up, headache, human, Humans, irritability, meclozine, memory disorder, mental concentration, Mild TBI guidelines, mild traumatic brain injury, mood change, mTBI, nausea, NFL Sideline Concussion Assessment Tool, nuclear magnetic resonance imaging, paracetamol, personal hygiene, postconcussion syndrome, Postconcussive syndrome, Primary Health Care, priority journal, procedures, recurrent disease, rest, Review, scoring system, Sideline Concussion Assessment Tool 3, Sideline concussion assessment tool 3 (SCAT3), sleep disorder, Sport, sport injury, Sports, Sports-related, Tomography, traumatic brain injury, tricyclic antidepressant agent, VERTIGO, visual disorder, vomiting, X-Ray Computed},
pubstate = {published},
tppubtype = {article}
}
Seidman, Daniel H; Burlingame, Jennifer; Yousif, Lina R; Donahue, Xinh P; Krier, Joshua; Rayes, Lydia J; Young, Rachel; Lilla, Muareen; Mazurek, Rochelle; Hittle, Kristie; McCloskey, Charles; Misra, Saroj; Shaw, Michael K
'Evaluation of the King–Devick Test as a concussion screening tool in high school football players' Corrigendum Journal Article
In: Journal of the Neurological Sciences, vol. 358, no. 1-2, pp. 540, 2015, ISBN: 0022-510X.
Abstract | Links | BibTeX | Tags: 2015, Athletes, diffuse axonal injury, football, High Schools, Neuropsychological assessment, Neuropsychological Tests, Post-Concussion Syndrome, screening, traumatic brain injury, Visual motor coordination
@article{Seidman2015a,
title = {'Evaluation of the King\textendashDevick Test as a concussion screening tool in high school football players' Corrigendum},
author = {Seidman, Daniel H and Burlingame, Jennifer and Yousif, Lina R and Donahue, Xinh P and Krier, Joshua and Rayes, Lydia J and Young, Rachel and Lilla, Muareen and Mazurek, Rochelle and Hittle, Kristie and McCloskey, Charles and Misra, Saroj and Shaw, Michael K},
doi = {10.1016/j.jns.2015.09.348},
isbn = {0022-510X},
year = {2015},
date = {2015-01-01},
journal = {Journal of the Neurological Sciences},
volume = {358},
number = {1-2},
pages = {540},
publisher = {Elsevier Science},
address = {Netherlands},
abstract = {Reports an error in 'Evaluation of the King\textendashDevick test as a concussion screening tool in high school football players' by Daniel H. Seidman, Jennifer Burlingame, Lina R. Yousif, Xinh P. Donahue, Joshua Krier, Lydia J. Rayes, Rachel Young, Muareen Lilla, Rochelle Mazurek, Kristie Hittle, Charles McCloskey, Saroj Misra and Michael K. Shaw (Journal of the Neurological Sciences, 2015[Sep][15], Vol 356[1-2], 97-101). In the original article, there was an error in the third paragraph. The sentence originally read 'The test subject reads a series of numbers in right-to-left and up-to-down order on three test cards.' This should read: 'The test subject reads a series of numbers in left-to-right and up-to-down order on three test cards.' The correction is present in the erratum. (The following abstract of the original article appeared in record [rid]2015-27894-001[/rid]). Objective: Concussion is the most common type of traumatic brain injury, and results from impact or impulsive forces to the head, neck or face. Due to the variability and subtlety of symptoms, concussions may go unrecognized or be ignored, especially with the pressure placed on athletes to return to competition. The King\textendashDevick (KD) test, an oculomotor test originally designed for reading evaluation, was recently validated as a concussion screening tool in collegiate athletes. A prospective study was performed using high school football players in an attempt to study the KD as a concussion screening tool in this younger population. Methods: 343 athletes from four local high school football teams were recruited to participate. These athletes were given baseline KD tests prior to competition. Individual demographic information was collected on the subjects. Standard team protocol was employed to determine if a concussion had occurred during competition. Immediately after diagnosis, the KD test was re-administered to the concussed athlete for comparison to baseline. Post-season testing was also performed in non-concussed individuals. Results: Of the 343 athletes, nine were diagnosed with concussions. In all concussed players, cumulative read times for the KD test were significantly increased (p \< 0.001). Post-season testing of non-concussed athletes revealed minimal change in read times relative to baseline. Univariate analysis revealed that history of concussion was the only demographic factor predictive of concussion in this cohort. Conclusion: The KD test is an accurate and easily administered sideline screening tool for concussion in adolescent football players. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2015, Athletes, diffuse axonal injury, football, High Schools, Neuropsychological assessment, Neuropsychological Tests, Post-Concussion Syndrome, screening, traumatic brain injury, Visual motor coordination},
pubstate = {published},
tppubtype = {article}
}
Morgan, C D; Zuckerman, S L; King, L E; Beaird, S E; Sills, A K; Solomon, G S
Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging Journal Article
In: Child's Nervous System, vol. 31, no. 12, pp. 2305–2309, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, arachnoid cyst, Article, brain, Brain Injury, Child, Computed tomography (CT) neuroimaging, computer assisted tomography, Computer-Assisted, Concussion, cost effectiveness analysis, cost utility analysis, DECISION making, diagnostic value, DSM-IV, Female, human, Humans, image processing, Magnetic Resonance Imaging, Magnetic resonance imaging (MRI), major clinical study, Male, mild traumatic brain injury, neuroimaging, neurosurgery, nuclear magnetic resonance, nuclear magnetic resonance imaging, pathology, Post-Concussion Syndrome, postconcussion syndrome, Preschool, preschool child, priority journal, Radiography, Retrospective Studies, retrospective study, Sports, STATISTICS, Tomography, traumatic brain injury, X ray, X-Ray Computed
@article{Morgan2015,
title = {Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging},
author = {Morgan, C D and Zuckerman, S L and King, L E and Beaird, S E and Sills, A K and Solomon, G S},
doi = {10.1007/s00381-015-2916-y},
year = {2015},
date = {2015-01-01},
journal = {Child's Nervous System},
volume = {31},
number = {12},
pages = {2305--2309},
abstract = {Purpose: Approximately 90% of concussions are transient, with symptoms resolving within 10\textendash14 days. However, a minority of patients remain symptomatic several months post-injury, a condition known as post-concussion syndrome (PCS). The treatment of these patients can be challenging. The goal of our study was to assess the utility and cost-effectiveness of neurologic imaging two or more weeks post-injury in a cohort of youth with PCS. Methods: We conducted a retrospective study of 52 pediatric patients with persistent post-concussion symptoms after 3 months. We collected demographics and neuroimaging results obtained greater than 2 weeks post-concussion. Neuroimaging ordered in the first 2 weeks post-concussion was excluded, except to determine the rate of re-imaging. Descriptive statistics and corresponding cost data were collected. Results: Of 52 patients with PCS, 23/52 (44 %) had neuroimaging at least 2 weeks after the initial injury, for a total of 32 diagnostic studies. In summary, 1/19 MRIs (5.3 %), 1/8 CTs (13 %), and 0/5 x-rays (0 %) yielded significant positive findings, none of which altered clinical management. Chronic phase neuroimaging estimated costs from these 52 pediatric patients totaled $129,025. We estimate the cost to identify a single positive finding was $21,000 for head CT and $104,500 for brain MRI. Conclusions: In this cohort of pediatric PCS patients, brain imaging in the chronic phase (defined as more than 2 weeks after concussion) was pursued in almost half the study sample, had low diagnostic yield, and had poor cost-effectiveness. Based on these results, outpatient management of pediatric patients with long-term post-concussive symptoms should rarely include repeat neuroimaging beyond the acute phase. © 2015, Springer-Verlag Berlin Heidelberg.},
keywords = {Adolescent, arachnoid cyst, Article, brain, Brain Injury, Child, Computed tomography (CT) neuroimaging, computer assisted tomography, Computer-Assisted, Concussion, cost effectiveness analysis, cost utility analysis, DECISION making, diagnostic value, DSM-IV, Female, human, Humans, image processing, Magnetic Resonance Imaging, Magnetic resonance imaging (MRI), major clinical study, Male, mild traumatic brain injury, neuroimaging, neurosurgery, nuclear magnetic resonance, nuclear magnetic resonance imaging, pathology, Post-Concussion Syndrome, postconcussion syndrome, Preschool, preschool child, priority journal, Radiography, Retrospective Studies, retrospective study, Sports, STATISTICS, Tomography, traumatic brain injury, X ray, X-Ray Computed},
pubstate = {published},
tppubtype = {article}
}
Wang, H; Wang, B; Jackson, K; Miller, C M; Hasadsri, L; Llano, D; Rubin, R; Zimmerman, J; Johnson, C; Sutton, B
A novel head-neck cooling device for concussion injury in contact sports Journal Article
In: Translational Neuroscience, vol. 6, pp. 20–31, 2015.
Abstract | Links | BibTeX | Tags: Acceleration, Article, brain concussion, Brain hypothermia, brain perfusion, brain temperature, brain tissue, clinical study, cognition, contact sport, cooling, diving, exercise, exercise induced hyperthermia, experimental study, government, head neck cooling device, Head-neck cooling, human, hyperthermia, induced hypothermia, mild traumatic brain injury, nonhuman, priority journal, randomized controlled trial (topic), sport injury, Sports, surface property, thermal regulating system, thermal stimulation, thermoregulation, traumatic brain injury
@article{Wang2015a,
title = {A novel head-neck cooling device for concussion injury in contact sports},
author = {Wang, H and Wang, B and Jackson, K and Miller, C M and Hasadsri, L and Llano, D and Rubin, R and Zimmerman, J and Johnson, C and Sutton, B},
doi = {10.1515/tnsci-2015-0004},
year = {2015},
date = {2015-01-01},
journal = {Translational Neuroscience},
volume = {6},
pages = {20--31},
abstract = {Emerging research on the long-term impact of concussions on athletes has allowed public recognition of the potentially devastating effects of these and other mild head injuries. Mild traumatic brain injury (mTBI) is a multifaceted disease for which management remains a clinical challenge. Recent pre-clinical and clinical data strongly suggest a destructive synergism between brain temperature elevation and mTBI; conversely, brain hypothermia, with its broader, pleiotropic effects, represents the most potent neuro-protectant in laboratory studies to date. Although well-established in selected clinical conditions, a systemic approach to accomplish regional hypothermia has failed to yield an effective treatment strategy in traumatic brain injury (TBI). Furthermore, although systemic hypothermia remains a potentially valid treatment strategy for moderate to severe TBIs, it is neither practical nor safe for mTBIs. Therefore, selective head-neck cooling may represent an ideal strategy to provide therapeutic benefits to the brain. Optimizing brain temperature management using a National Aeronautics and Space Administration (NASA) spacesuit spinoff head-neck cooling technology before and/or after mTBI in contact sports may represent a sensible, practical, and effective method to potentially enhance recover and minimize post-injury deficits. In this paper, we discuss and summarize the anatomical, physiological, preclinical, and clinical data concerning NASA spinoff head-neck cooling technology as a potential treatment for mTBIs, particularly in the context of contact sports. © 2015 Huan Wang et al., licensee De Gruyter Open.},
keywords = {Acceleration, Article, brain concussion, Brain hypothermia, brain perfusion, brain temperature, brain tissue, clinical study, cognition, contact sport, cooling, diving, exercise, exercise induced hyperthermia, experimental study, government, head neck cooling device, Head-neck cooling, human, hyperthermia, induced hypothermia, mild traumatic brain injury, nonhuman, priority journal, randomized controlled trial (topic), sport injury, Sports, surface property, thermal regulating system, thermal stimulation, thermoregulation, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Bondi, C O; Semple, B D; Noble-Haeusslein, L J; Osier, N D; Carlson, S W; Dixon, C E; Giza, C C; Kline, A E
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury Journal Article
In: Neuroscience and Biobehavioral Reviews, vol. 58, pp. 123–146, 2015.
Abstract | Links | BibTeX | Tags: 8 hydroxy 2 propylaminotetralin, Aggression, Attentional set-shifting test (AST), buspirone, Closed head injury, cognition, cognitive defect, cognitive function test, Concussion, conditioning, Controlled cortical impact (CCI), environmental enrichment, Environmental enrichment (EE), executive function, experimental disease, fear, Fluid percussion (FP), human, interpersonal communication, Memory, motor function test, nerve degeneration, neuropsychological test, Neurorehabilitation, nonhuman, outcome assessment, Pathophysiology, pediatrics, priority journal, rehabilitation care, Review, rodent, rotarod test, sensorimotor function, Social behavior, social disability, social interaction, spatial learning, TASK performance, traumatic brain injury
@article{Bondi2015,
title = {Found in translation: Understanding the biology and behavior of experimental traumatic brain injury},
author = {Bondi, C O and Semple, B D and Noble-Haeusslein, L J and Osier, N D and Carlson, S W and Dixon, C E and Giza, C C and Kline, A E},
doi = {10.1016/j.neubiorev.2014.12.004},
year = {2015},
date = {2015-01-01},
journal = {Neuroscience and Biobehavioral Reviews},
volume = {58},
pages = {123--146},
abstract = {The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided. © 2014 Elsevier Ltd.},
keywords = {8 hydroxy 2 propylaminotetralin, Aggression, Attentional set-shifting test (AST), buspirone, Closed head injury, cognition, cognitive defect, cognitive function test, Concussion, conditioning, Controlled cortical impact (CCI), environmental enrichment, Environmental enrichment (EE), executive function, experimental disease, fear, Fluid percussion (FP), human, interpersonal communication, Memory, motor function test, nerve degeneration, neuropsychological test, Neurorehabilitation, nonhuman, outcome assessment, Pathophysiology, pediatrics, priority journal, rehabilitation care, Review, rodent, rotarod test, sensorimotor function, Social behavior, social disability, social interaction, spatial learning, TASK performance, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Stone Jr., M E; Safadjou, S; Farber, B; Velazco, N; Man, J; Reddy, S H; Todor, R; Teperman, S
Utility of the Military Acute Concussion Evaluation as a screening tool for mild traumatic brain injury in a civilian trauma population Journal Article
In: Journal of Trauma and Acute Care Surgery, vol. 79, no. 1, pp. 147–151, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, adult, aged, Alcoholic Intoxication, amnesia, Article, assessment of humans, brain concussion, Brain Injuries, clinical assessment tool, computer assisted tomography, Concussion screening, Confounding Factors (Epidemiology), controlled study, DATA analysis, Demography, diagnostic test accuracy study, Dizziness, emergency health service, Female, Head, headache, hospital admission, human, Humans, injury severity, irritability, major clinical study, Male, middle aged, mild traumatic brain injury, Military Acute Concussion Evaluation, military medicine, nausea and vomiting, predictive value, priority journal, quality control, receiver operating characteristic, ROC Curve, screening test, Sensitivity and Specificity, traumatic brain injury, unconsciousness, Urban Population, visual disorder, Young Adult
@article{StoneJr.2015,
title = {Utility of the Military Acute Concussion Evaluation as a screening tool for mild traumatic brain injury in a civilian trauma population},
author = {{Stone Jr.}, M E and Safadjou, S and Farber, B and Velazco, N and Man, J and Reddy, S H and Todor, R and Teperman, S},
doi = {10.1097/TA.0000000000000679},
year = {2015},
date = {2015-01-01},
journal = {Journal of Trauma and Acute Care Surgery},
volume = {79},
number = {1},
pages = {147--151},
abstract = {BACKGROUND: Mild traumatic brain injury (mTBI) constitutes 75% of more than 1.5 million traumatic brain injuries annually. There exists no consensus on point-of-care screening for mTBI. The Military Acute Concussion Evaluation (MACE) is a quick and easy test used by the US Army to screen for mTBI; however, its utility in civilian trauma is unclear. It has two parts: a history section and the Standardized Assessment of Concussion (SAC) score (0-30) previously validated in sports injury. As a performance improvement project, our institution sought to evaluate the MACE as a concussion screening tool that could be used by housestaff in a general civilian trauma population. METHODS: From June 2013 to May 2014, patients 18 years to 65 years old with suspected concussion were given the MACE within 72 hours of admission to our urban Level I trauma center. Patients with a positive head computed tomography were excluded. Demographic data and MACE scores were recorded in prospect. Concussion was defined as loss of consciousness and/or posttraumatic amnesia; concussed patients were compared with those nonconcussed. Sensitivity and specificity for each respective MACE score were used to plot a receiver operating characteristic (ROC) curve. An ROC curve area of 0.8 was set as the benchmark for a good screening test to distinguish concussion from nonconcussion. RESULTS: There were 84 concussions and 30 nonconcussed patients. Both groups were similar; however, the concussion group had a lower mean MACE score than the nonconcussed patients. Data analysis demonstrated the sensitivity and specificity of a range of MACE scores used to generate an ROC curve area of only 0.65. CONCLUSION: The MACE showed a lower mean score for individuals with concussion, defined by loss of consciousness and/or posttraumatic amnesia. However, the ROC curve area of 0.65 highly suggests that MACE alone would be a poor screening test for mTBI in a general civilian trauma population. LEVEL OF EVIDENCE: Diagnostic study, level II. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {Adolescent, adult, aged, Alcoholic Intoxication, amnesia, Article, assessment of humans, brain concussion, Brain Injuries, clinical assessment tool, computer assisted tomography, Concussion screening, Confounding Factors (Epidemiology), controlled study, DATA analysis, Demography, diagnostic test accuracy study, Dizziness, emergency health service, Female, Head, headache, hospital admission, human, Humans, injury severity, irritability, major clinical study, Male, middle aged, mild traumatic brain injury, Military Acute Concussion Evaluation, military medicine, nausea and vomiting, predictive value, priority journal, quality control, receiver operating characteristic, ROC Curve, screening test, Sensitivity and Specificity, traumatic brain injury, unconsciousness, Urban Population, visual disorder, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Liu, C Y; Law, M; Romano, R
Rational approach to understanding and preventing sports-related traumatic brain injuries Journal Article
In: World Neurosurgery, vol. 84, no. 6, pp. 1556–1557, 2015.
Links | BibTeX | Tags: accelerometer, ACCELEROMETRY, biological marker, brain, brain concussion, brain hemorrhage, cognitive defect, Diffusion Tensor Imaging, Electroencephalography, emergency health service, Female, Head Protective Devices, Helmet, high risk patient, human, Humans, Injuries, Male, neuroimaging, neuromodulation, neuroprotective agent, nuclear magnetic resonance imaging, Occupational Exposure, protective equipment, Review, risk factor, risk reduction, SAFETY, skiing, Snowboarding, sport injury, Traumatic, traumatic brain injury, viscoelastic substance
@article{Liu2015,
title = {Rational approach to understanding and preventing sports-related traumatic brain injuries},
author = {Liu, C Y and Law, M and Romano, R},
doi = {10.1016/j.wneu.2015.07.076},
year = {2015},
date = {2015-01-01},
journal = {World Neurosurgery},
volume = {84},
number = {6},
pages = {1556--1557},
keywords = {accelerometer, ACCELEROMETRY, biological marker, brain, brain concussion, brain hemorrhage, cognitive defect, Diffusion Tensor Imaging, Electroencephalography, emergency health service, Female, Head Protective Devices, Helmet, high risk patient, human, Humans, Injuries, Male, neuroimaging, neuromodulation, neuroprotective agent, nuclear magnetic resonance imaging, Occupational Exposure, protective equipment, Review, risk factor, risk reduction, SAFETY, skiing, Snowboarding, sport injury, Traumatic, traumatic brain injury, viscoelastic substance},
pubstate = {published},
tppubtype = {article}
}
Caron, A M; Stephenson, R
Sleep deprivation does not affect neuronal susceptibility to mild traumatic brain injury in the rat Journal Article
In: Nature and Science of Sleep, vol. 7, pp. 63–72, 2015.
Abstract | Links | BibTeX | Tags: Concussion, Dark neuron, NEURODEGENERATION, Rat cortex, sleep deprivation, traumatic brain injury
@article{Caron2015b,
title = {Sleep deprivation does not affect neuronal susceptibility to mild traumatic brain injury in the rat},
author = {Caron, A M and Stephenson, R},
doi = {10.2147/NSS.S82888},
year = {2015},
date = {2015-01-01},
journal = {Nature and Science of Sleep},
volume = {7},
pages = {63--72},
abstract = {Mild and moderate traumatic brain injuries (TBIs) (and concussion) occur frequently as a result of falls, automobile accidents, and sporting activities, and are a major cause of acute and chronic disability. Fatigue and excessive sleepiness are associated with increased risk of accidents, but it is unknown whether prior sleep debt also affects the pathophysiological outcome of concussive injury. Using the "dark neuron" (DN) as a marker of reversible neuronal damage, we tested the hypothesis that acute (48 hours) total sleep deprivation (TSD) and chronic sleep restriction (CSR; 10 days, 6-hour sleep/day) affect DN formation following mild TBI in the rat. TSD and CSR were administered using a walking wheel apparatus. Mild TBI was administered under anesthesia using a weight-drop impact model, and the acute neuronal response was observed without recovery. DNs were detected using standard bright-field microscopy with toluidine blue stain following appropriate tissue fixation. DN density was low under home cage and sleep deprivation control conditions (respective median DN densities, 0.14% and 0.22% of neurons), and this was unaffected by TSD alone (0.1%). Mild TBI caused significantly higher DN densities (0.76%), and this was unchanged by preexisting acute or chronic sleep debt (TSD, 0.23%; CSR, 0.7%). Thus, although sleep debt may be predicted to increase the incidence of concussive injury, the present data suggest that sleep debt does not exacerbate the resulting neuronal damage. © 2015 Caron and Stephenson.},
keywords = {Concussion, Dark neuron, NEURODEGENERATION, Rat cortex, sleep deprivation, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
DiFazio, M; Silverberg, N D; Kirkwood, M W; Bernier, R; Iverson, G L
Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes? Journal Article
In: Clinical Pediatrics, vol. 55, no. 5, pp. 443–451, 2015.
Abstract | Links | BibTeX | Tags: activity restriction, Anxiety, Article, athletic trainer, brain concussion, case report, Concussion, daily life activity, depression, Dizziness, evolution, exercise, expectation, headache, human, Male, mood disorder, mTBI, nocebo effect, patient harm, PHYSICAL ACTIVITY, practice guideline, prolonged activity restriction, psychological aspect, Rehabilitation, rest, school, traumatic brain injury, Treatment, treatment outcome, wrestling
@article{DiFazio2015,
title = {Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes?},
author = {DiFazio, M and Silverberg, N D and Kirkwood, M W and Bernier, R and Iverson, G L},
doi = {10.1177/0009922815589914},
year = {2015},
date = {2015-01-01},
journal = {Clinical Pediatrics},
volume = {55},
number = {5},
pages = {443--451},
abstract = {The current treatment of concussion or mild traumatic brain injury (mTBI) is primarily based on expert consensus. Most clinical practice guidelines advise cognitive and physical rest after injury including withdrawal from normal life activities such as school attendance, sports participation, and technology use until symptoms resolve. Some individuals who sustain an mTBI experience persistent physical, cognitive, and mental health problems. Activity restriction itself may contribute to protracted recovery and other complications. Williamson's Activity Restriction Model of Depression, formulated more than 20 years ago, is central to this hypothesis. We review research evidence for potential harms of prolonged activity restriction and report an mTBI case as an example of how an "activity restriction cascade" can unfold. According to this model, psychological consequences of removal from validating life activities, combined with physical deconditioning, contribute to the development and persistence of postconcussive symptoms after mTBI in some youth. A modification to mTBI guidelines that emphasizes prompt reengagement in life activities as tolerated is encouraged. © SAGE Publications.},
keywords = {activity restriction, Anxiety, Article, athletic trainer, brain concussion, case report, Concussion, daily life activity, depression, Dizziness, evolution, exercise, expectation, headache, human, Male, mood disorder, mTBI, nocebo effect, patient harm, PHYSICAL ACTIVITY, practice guideline, prolonged activity restriction, psychological aspect, Rehabilitation, rest, school, traumatic brain injury, Treatment, treatment outcome, wrestling},
pubstate = {published},
tppubtype = {article}
}
Oeur, R A; Karton, C; Post, A; Rousseau, P; Hoshizaki, T B; Marshall, S; Brien, S E; Smith, A; Cusimano, M D; Gilchrist, M D
In: Journal of Neurosurgery, vol. 123, no. 2, pp. 415–422, 2015.
Abstract | Links | BibTeX | Tags: accident, Accident reconstruction, accidental injury, Accidents, Adolescent, adult, Article, Biomechanical Phenomena, Biomechanics, brain, brain concussion, brain stem, brain tissue, Cerebellum, clinical article, comparative study, Concussion, controlled study, Female, finite element analysis, Finite element modelling, gray matter, Hematoma, human, Humans, Hybrid iii headform, injury severity, laboratory test, Male, Mechanical, mechanical stress, middle aged, pathology, Pathophysiology, Persistent postconcussive symptoms, PHYSIOLOGY, Post Hoc Analysis, Post-Concussion Syndrome, postconcussion syndrome, priority journal, shear stress, simulation, SPORTS medicine, STATISTICAL significance, Stress, stress strain relationship, Subdural, subdural hematoma, traumatic brain injury, white matter, Young Adult
@article{Oeur2015,
title = {A comparison of head dynamic response and brain tissue stress and strain using accident reconstructions for concussion, concussion with persistent postconcussive symptoms, and subdural hematoma},
author = {Oeur, R A and Karton, C and Post, A and Rousseau, P and Hoshizaki, T B and Marshall, S and Brien, S E and Smith, A and Cusimano, M D and Gilchrist, M D},
doi = {10.3171/2014.10.JNS14440},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurosurgery},
volume = {123},
number = {2},
pages = {415--422},
abstract = {Object Concussions typically resolve within several days, but in a few cases the symptoms last for a month or longer and are termed persistent postconcussive symptoms (PPCS). These persisting symptoms may also be associated with more serious brain trauma similar to subdural hematoma (SDH). The objective of this study was to investigate the head dynamic and brain tissue responses of injury reconstructions resulting in concussion, PPCS, and SDH. Methods Reconstruction cases were obtained from sports medicine clinics and hospitals. All subjects received a direct blow to the head resulting in symptoms. Those symptoms that resolved in 9 days or fewer were defined as concussions (n = 3). Those with symptoms lasting longer than 18 months were defined as PPCS (n = 3), and 3 patients presented with SDHs (n = 3). A Hybrid III headform was used in reconstruction to obtain linear and rotational accelerations of the head. These dynamic response data were then input into the University College Dublin Brain Trauma Model to calculate maximum principal strain and von Mises stress. A Kruskal-Wallis test followed by Tukey post hoc tests were used to compare head dynamic and brain tissue responses between injury groups. Statistical significance was set at p \< 0.05. Results A significant difference was identified for peak resultant linear and rotational acceleration between injury groups. Post hoc analyses revealed the SDH group had higher linear and rotational acceleration responses (316 g and 23,181 rad/sec2, respectively) than the concussion group (149 g and 8111 rad/sec2, respectively; p \< 0.05). No significant differences were found between groups for either brain tissue measures of maximum principal strain or von Mises stress. Conclusions The reconstruction of accidents resulting in a concussion with transient symptoms (low severity) and SDHs revealed a positive relationship between an increase in head dynamic response and the risk for more serious brain injury. This type of relationship was not found for brain tissue stress and strain results derived by finite element analysis. Future research should be undertaken using a larger sample size to confirm these initial findings. Understanding the relationship between the head dynamic and brain tissue response and the nature of the injury provides important information for developing strategies for injury prevention. © AANS, 2015.},
keywords = {accident, Accident reconstruction, accidental injury, Accidents, Adolescent, adult, Article, Biomechanical Phenomena, Biomechanics, brain, brain concussion, brain stem, brain tissue, Cerebellum, clinical article, comparative study, Concussion, controlled study, Female, finite element analysis, Finite element modelling, gray matter, Hematoma, human, Humans, Hybrid iii headform, injury severity, laboratory test, Male, Mechanical, mechanical stress, middle aged, pathology, Pathophysiology, Persistent postconcussive symptoms, PHYSIOLOGY, Post Hoc Analysis, Post-Concussion Syndrome, postconcussion syndrome, priority journal, shear stress, simulation, SPORTS medicine, STATISTICAL significance, Stress, stress strain relationship, Subdural, subdural hematoma, traumatic brain injury, white matter, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Rapp, P E; Keyser, D O; Albano, A; Hernandez, R; Gibson, D B; Zambon, R A; David Hairston, W; Hughes, J D; Krystal, A; Nichols, A S
Traumatic brain injury detection using electrophysiological methods Journal Article
In: Frontiers in Human Neuroscience, vol. 9, no. FEB, 2015.
Abstract | Links | BibTeX | Tags: Article, brain electrophysiology, computer assisted tomography, Concussion, connectome, diagnostic accuracy, EEG, electroencephalogram, Electroencephalography, event related potential, Event-Related Potentials, evidence based medicine, executive function, human, intermethod comparison, latent period, neuroimaging, neuropathology, Non-linear dynamical analysis, nuclear magnetic resonance imaging, QEEG, Signal Processing, traumatic brain injury
@article{Rapp2015,
title = {Traumatic brain injury detection using electrophysiological methods},
author = {Rapp, P E and Keyser, D O and Albano, A and Hernandez, R and Gibson, D B and Zambon, R A and {David Hairston}, W and Hughes, J D and Krystal, A and Nichols, A S},
doi = {10.3389/fnhum.2015.00011},
year = {2015},
date = {2015-01-01},
journal = {Frontiers in Human Neuroscience},
volume = {9},
number = {FEB},
abstract = {Measuring neuronal activity with electrophysiological methods may be useful in detecting neurological dysfunctions, such as mild traumatic brain injury (mTBI).This approach may be particularly valuable for rapid detection in at-risk populations including military service members and athletes. Electrophysiological methods, such as quantitative electroencephalography (qEEG) and recording event-related potentials (ERPs) may be promising; however, the field is nascent and significant controversy exists on the efficacy and accuracy of the approaches as diagnostic tools. For example, the specific measures derived from an electroencephalogram (EEG) that are most suitable as markers of dysfunction have not been clearly established. A study was conducted to summarize and evaluate the statistical rigor of evidence on the overall utility of qEEG as an mTBI detection tool. The analysis evaluated qEEG measures/parameters that may be most suitable as fieldable diagnostic tools, identified other types of EEG measures and analysis methods of promise, recommended specific measures and analysis methods for further development as mTBI detection tools, identified research gaps in the field, and recommended future research and development thrust areas. The qEEG study group formed the following conclusions: (1) Individual qEEG measures provide limited diagnostic utility for mTBI. However, many measures can be important features of qEEG discriminant functions, which do show significant promise as mTBI detection tools. (2) ERPs offer utility in mTBI detection. In fact, evidence indicates that ERPs can identify abnormalities in cases where EEGs alone are non-disclosing. (3)The standard mathematical procedures used in the characterization of mTBI EEGs should be expanded to incorporate newer methods of analysis including non-linear dynamical analysis, complexity measures, analysis of causal interactions, graph theory, and information dynamics. (4) Reports of high specificity in qEEG evaluations of TBI must be interpreted with care. High specificities have been reported in carefully constructed clinical studies in which healthy controls were compared against a carefully selected TBI population. The published literature indicates, however, that similar abnormalities in qEEG measures are observed in other neuropsychiatric disorders. While it may be possible to distinguish a clinical patient from a healthy control participant with this technology, these measures are unlikely to discriminate between, for example, major depressive disorder, bipolar disorder, or TBI. The specificities observed in these clinical studies may well be lost in real world clinical practice. (5)The absence of specificity does not preclude clinical utility. The possibility of use as a longitudinal measure of treatment response remains. However, efficacy as a longitudinal clinical measure does require acceptable test-retest reliability. To date, very few test-retest reliability studies have been published with qEEG data obtained from TBI patients or from healthy controls. This is a particular concern because high variability is a known characteristic of the injured central nervous system. © 2015 Rapp, Keyser , Albano, Hernandez, Gibson, Zambon, Hairston, Hughes, Krystal and Nichols.},
keywords = {Article, brain electrophysiology, computer assisted tomography, Concussion, connectome, diagnostic accuracy, EEG, electroencephalogram, Electroencephalography, event related potential, Event-Related Potentials, evidence based medicine, executive function, human, intermethod comparison, latent period, neuroimaging, neuropathology, Non-linear dynamical analysis, nuclear magnetic resonance imaging, QEEG, Signal Processing, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Boddé, Tamar Roos Annemarie; Scheinberg, Adam; McKinlay, Audrey
A critical examination of mild traumatic brain injury management information distributed to parents Journal Article
In: Developmental Neuropsychology, vol. 40, no. 4, pp. 254–271, 2015, ISBN: 8756-5641 1532-6942.
Abstract | Links | BibTeX | Tags: 2015, MANAGEMENT, mild traumatic brain injury, Parents, pediatrics, traumatic brain injury
@article{Bodde2015,
title = {A critical examination of mild traumatic brain injury management information distributed to parents},
author = {Bodd\'{e}, Tamar Roos Annemarie and Scheinberg, Adam and McKinlay, Audrey},
doi = {10.1080/87565641.2015.1034864},
isbn = {8756-5641
1532-6942},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {4},
pages = {254--271},
publisher = {Taylor \& Francis},
address = {United Kingdom},
abstract = {Considerable confusion surrounds pediatric mild traumatic brain injury (mTBI) and its management. This study provides a comparison between mTBI management pamphlets distributed by Australasian hospitals and the Centers for Disease Control and Prevention (CDC) gold standard. Twenty-seven different pamphlets were collected from 96 hospitals in Australia and New Zealand and were assessed for readability, compliance with nine CDC criteria, and inclusion of confusing or incorrect information. None of the pamphlets completely complied with the CDC criteria and all included incorrect information. Findings demonstrate that mTBI management information in Australasia needs urgent revision, and evaluation in other countries is strongly advised. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2015, MANAGEMENT, mild traumatic brain injury, Parents, pediatrics, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Loosemore, Michael P; Butler, Charles F; Khadri, Abdelhamid; McDonagh, David; Patel, Vimal A; Bailes, Julian E
Use of Head Guards in AIBA Boxing Tournaments--A Cross-Sectional Observational Study Journal Article
In: Clinical Journal of Sport Medicine, vol. 27, no. 1, pp. 86–88, 2017, ISBN: 1050642X.
@article{Loosemore2017,
title = {Use of Head Guards in AIBA Boxing Tournaments--A Cross-Sectional Observational Study},
author = {Loosemore, Michael P and Butler, Charles F and Khadri, Abdelhamid and McDonagh, David and Patel, Vimal A and Bailes, Julian E},
isbn = {1050642X},
year = {2017},
date = {2017-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {27},
number = {1},
pages = {86--88},
abstract = {Objective: This study looks at the changes in injuries after the implementation of a new rule by the International Boxing Association (AIBA) to remove head guards from its competitions. Design: A cross-sectional observational study performed prospectively. This brief report examines the removal of head guards in 2 different ways. The first was to examine the stoppages due to blows to the head by comparing World Series Boxing (WSB), without head guards, to other AIBA competitions with head guards. Secondly, we examined the last 3 world championships: 2009 and 2011 (with head guards) and 2013 (without head guards). Setting: World Series Boxing and AIBA world championship boxing. Participants: Boxers from WSB and AIBA world championships. Interventions: The information was recorded by ringside medical physicians. Main Outcome Measures: Stoppages per 10 000 rounds; stoppages per 1000 hours. Results: Both studies show that the number of stoppages due to head blows was significantly decreased without head guards. The studies also showed that there was a notable increase in cuts. Conclusions: Removing head guards may reduce the already small risk of acute brain injury in amateur boxing. [ABSTRACT FROM AUTHOR]},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Zusman, E E; Zopfi, P; Kuluva, J; Zuckerman, S
Can Ideas From United States Youth Sports Reduce Judo-Related Head Injuries in Japan? Journal Article
In: World Neurosurgery, vol. 97, pp. 725–727, 2017.
@article{Zusman2017,
title = {Can Ideas From United States Youth Sports Reduce Judo-Related Head Injuries in Japan?},
author = {Zusman, E E and Zopfi, P and Kuluva, J and Zuckerman, S},
doi = {10.1016/j.wneu.2016.05.096},
year = {2017},
date = {2017-01-01},
journal = {World Neurosurgery},
volume = {97},
pages = {725--727},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hwang, Sungjae; Ma, Lei; Kawata, Keisuke; Tierney, Ryan; Jeka, John J
Vestibular dysfunction after subconcussive head impact Journal Article
In: Journal of Neurotrauma, vol. 34, no. 1, pp. 8–15, 2017, ISBN: 0897-7151 1557-9042.
@article{Hwang2017,
title = {Vestibular dysfunction after subconcussive head impact},
author = {Hwang, Sungjae and Ma, Lei and Kawata, Keisuke and Tierney, Ryan and Jeka, John J},
doi = {10.1089/neu.2015.4238},
isbn = {0897-7151
1557-9042},
year = {2017},
date = {2017-01-01},
journal = {Journal of Neurotrauma},
volume = {34},
number = {1},
pages = {8--15},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Current thinking views mild head impact (i.e., subconcussion) as an underrecognized phenomenon that has the ability to cause significant current and future detrimental neurological effects. Repeated mild impacts to the head, however, often display no observable behavioral deficits based on standard clinical tests, which may lack sensitivity. The current study investigates the effects of subconcussive impacts from soccer heading with innovative measures of vestibular function and walking stability in a pre- 0\textendash2 h, post- 24 h post-heading repeated measures design. The heading group (n = 10) executed 10 headers with soccer balls projected at a velocity of 25 mph (11.2 m/sec) over 10 min. Subjects were evaluated 24 h before, immediately after, and 24 h after soccer heading with: the modified Balance Error Scoring System (mBESS); a walking stability task with visual feedback of trunk movement; and galvanic vestibular stimulation (GVS) while standing with eyes closed on foam. A control group (n = 10) followed the same protocol with no heading. The results showed significant decrease in trunk angle, leg angle gain, and center of mass gain relative to GVS for the heading group compared with controls. Medial-lateral trunk orientation displacement and velocity during treadmill walking increased immediately after mild head impact for the heading group compared with controls. Controls showed an improvement in mBESS scores over time, indicating a learning effect, which was not observed with the heading group. These results suggest that mild head impact leads to a transient dysfunction in vestibular processing, which deters walking stability during task performance. (PsycINFO Database Record (c) 2017 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Kania, K; Shaikh, K A; White, I K; Ackerman, L L
Follow-up issues in children with mild traumatic brain injuries Journal Article
In: Journal of Neurosurgery: Pediatrics, vol. 18, no. 2, pp. 224–230, 2016.
@article{Kania2016,
title = {Follow-up issues in children with mild traumatic brain injuries},
author = {Kania, K and Shaikh, K A and White, I K and Ackerman, L L},
doi = {10.3171/2016.1.PEDS15511},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurosurgery: Pediatrics},
volume = {18},
number = {2},
pages = {224--230},
abstract = {OBJECTIVE: Concerns about mild traumatic brain injury (mTBI) have increased in recent years, and neurosurgical consultation is often requested for patients with radiographic abnormalities or clinical findings suspicious for mTBI. However, to the authors' knowledge, no study has used the Acute Concussion Evaluation (ACE) tool to systematically evaluate the evolution of symptoms in patients with mTBI during neurosurgical follow-up. The goal in this study was to evaluate symptom progression in pediatric patients referred for neurosurgical consultation by using the ACE, as endorsed by the Centers for Disease Control and Prevention. METHODS: The authors performed a retrospective review of records of consecutive pediatric patients who had presented to the emergency department, were diagnosed with possible mTBI, and were referred for neurosurgical consultation. Outpatient follow-up for these patients included serial assessment using the ACE. Data collected included the mechanisms of the patients' injuries, symptoms, follow-up duration, and premorbid conditions that might potentially contribute to protracted recovery. RESULTS: Of 91 patients identified with mTBI, 58 met the inclusion criteria, and 33 of these had sufficient follow-up data to be included in the study. Mechanisms of injury included sports injury (15 patients), isolated falls (10), and motor vehicle collisions (8). Ages ranged from 5 to 17 years (mean age 11.6 years), and 29 of the 33 patients were male. Six patients had preinjury developmental and/or psychiatric diagnoses such as attention deficit hyperactivity disorder. Seventeen had negative findings on head CT scans. The first follow-up evaluation occurred at a mean of 30 days after injury. The mean number of symptoms reported on the ACE inventory at first follow-up were 3.2; 12 patients were symptom free. Patients with positive head CT findings required longer follow-up: these patients needed 14.59 weeks, versus 7.87 weeks of follow-up in patients with negative findings on head CT scans (p \< 0.05). CONCLUSIONS: The data suggest that patients with mTBI, particularly those with developmental and/or psychiatric comorbidities and concurrent cerebral or extracranial injury, often report symptoms for several weeks after their initial injury. Serial ACE assessment permits systematic identification of patients who are experiencing continued symptoms, leading to appropriate patient management and referral. ©AANS, 2016.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Johnson, K L; Chowdhury, S; Lawrimore, W B; Mao, Y; Mehmani, A; Prabhu, R; Rush, G A; Horstemeyer, M F
Constrained topological optimization of a football helmet facemask based on brain response Journal Article
In: Materials and Design, vol. 111, pp. 108–118, 2016.
@article{Johnson2016a,
title = {Constrained topological optimization of a football helmet facemask based on brain response},
author = {Johnson, K L and Chowdhury, S and Lawrimore, W B and Mao, Y and Mehmani, A and Prabhu, R and Rush, G A and Horstemeyer, M F},
doi = {10.1016/j.matdes.2016.08.064},
year = {2016},
date = {2016-01-01},
journal = {Materials and Design},
volume = {111},
pages = {108--118},
abstract = {Surrogate model-based multi-objective design optimization was performed to reduce concussion risk during frontal football helmet impacts. In particular, a topological decomposition of the football helmet facemask was performed to formulate the design problem, and brain injury metrics were exploited as objective functions. A validated finite element model of a helmeted human head was used to recreate facemask impacts. Due to the prohibitive computational expense of the full scale simulations, a surrogate modeling approach was employed. An optimal surrogate model selection framework, called Concurrent Surrogate Model Selection, or COSMOS, was utilized to identify the surrogate models best suited to approximate each objective function. The resulting surrogate models were implemented in the Non-dominated Sorting Genetic Algorithm II (NSGA-II) optimization algorithm. Constraints were implemented to control the solid material fraction in the facemask design space, and binary variables were used to control the placement of the facemask bars. The optimized facemask designs reduced the maximum tensile pressure in the brain by 7.5% and the maximum shear strain by a remarkable 39.5%. This research represents a first-of-its-kind approach to multi-objective design optimization on a football helmet, and demonstrates the possibilities that are achievable in improving human safety by using such a simulation-based design optimization. © 2016 Elsevier Ltd},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Moon, K; Theodore, N
Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists? Journal Article
In: World Neurosurgery, vol. 89, pp. 720–721, 2016.
@article{Moon2016,
title = {Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists?},
author = {Moon, K and Theodore, N},
doi = {10.1016/j.wneu.2016.03.073},
year = {2016},
date = {2016-01-01},
journal = {World Neurosurgery},
volume = {89},
pages = {720--721},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bonfield, C M; Kondziolka, D
Beyond the game: The legacy of Bill Masterton Journal Article
In: Neurosurgical Focus, vol. 41, no. 1, 2016.
@article{Bonfield2016,
title = {Beyond the game: The legacy of Bill Masterton},
author = {Bonfield, C M and Kondziolka, D},
doi = {10.3171/2016.2.FOCUS1558},
year = {2016},
date = {2016-01-01},
journal = {Neurosurgical Focus},
volume = {41},
number = {1},
abstract = {Bill Masterton is the only man to die of injuries sustained in a National Hockey League (NHL) game. He remains the last fatality in any professional team sport involving a direct in-game injury in North America. While Masterton was originally thought to have suffered a fatal brain injury while being checked on the ice, later analysis of the case revealed evidence of second-impact syndrome and the effects of prior concussions. Masterton's death sparked both an immediate debate in the NHL on whether helmets should be compulsory and the NHL's first vote on mandatory helmet use. Although the subject of mandated helmet use met with resistance in the 10 years after Masterton's death, especially from hockey owners and coaches, the NHL finally legislated helmet use by all players entering the league beginning in the 1979-1980 season. Several awards, including one recognizing the NHL player who best exemplifies the qualities of perseverance, sportsmanship, and dedication to hockey, have been created in memory of Masterton. However, his legacy extends far beyond the awards that bear his name. His death was the seminal event bringing head safety to the forefront of a game that was both unready and unwilling to accept change. An increase in mainstream media attention in recent years has led to unprecedented public awareness of brain injury and concussion in hockey and other sports. Advances in the diagnosis and treatment of head injury in sports have occurred recently, the impetus for which started over 45 years ago, when Bill Masterton died.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Holtkamp, M D; Grimes, J; Ling, G
Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache Journal Article
In: Current Pain & Headache Reports, vol. 20, no. 6, 2016.
@article{Holtkamp2016,
title = {Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache},
author = {Holtkamp, M D and Grimes, J and Ling, G},
doi = {10.1007/s11916-016-0572-x},
year = {2016},
date = {2016-01-01},
journal = {Current Pain \& Headache Reports},
volume = {20},
number = {6},
abstract = {Traumatic brain injury (TBI) is defined as an alteration in brain function caused by an external force. Mild TBI or concussion is now well recognized to be a risk of military service as well as participation in athletic sports such as football. Posttraumatic headache (PTH) is the most common symptom after mTBI in US service members. PTH most commonly presents with migraine-like headache features. The following is an overview of the epidemiology, pathophysiology, clinical course, prognosis, complications, and treatment of mTBI and associated comorbidities with a focus on PTH. There is a particular emphasis on emerging evidence-based clinical practice. One important medical consequence of the recognition that mTBI is a highly prevalent among military service members is that the Department of Defense (DoD) is dedicating significant financial and intellectual resources to better understanding and developing treatments for TBI. The identification of the importance of TBI among the US military population has had the added benefit of increasing awareness of this condition among civilian populations, particularly those engaged in both professional and youth sports. The NIH and NSF are also supporting important TBI research. President Obama’s Brain Initiative is also providing additional impetus for these efforts. Unfortunately, the understanding of the acute and chronic effects of mTBI on the brain remains limited. Gratefully, there is hope that through innovative research, there will be advances in elucidating the underlying pathophysiology, which will lead to clinical and prognostic indicators, ultimately resulting in new treatment options for this very complicated set of disorders. © 2016, Springer Science+Business Media New York (outside the USA).},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Talavage, T M; Nauman, E A; Leverenz, L J
The role of medical imaging in the recharacterization of mild traumatic brain injury using youth sports as a laboratory Journal Article
In: Frontiers in Neurology, vol. 6, no. JAN, 2016.
@article{Talavage2016,
title = {The role of medical imaging in the recharacterization of mild traumatic brain injury using youth sports as a laboratory},
author = {Talavage, T M and Nauman, E A and Leverenz, L J},
doi = {10.3389/fneur.2015.00273},
year = {2016},
date = {2016-01-01},
journal = {Frontiers in Neurology},
volume = {6},
number = {JAN},
abstract = {The short- and long-term impact of mild traumatic brain injury (TBI) is an increasingly vital concern for both military and civilian personnel. Such injuries produce significant social and financial burdens and necessitate improved diagnostic and treatment methods. Recent integration of neuroimaging and biomechanical studies in youth collision-sport athletes has revealed that significant alterations in brain structure and function occur even in the absence of traditional clinical markers of "concussion." While task performance is maintained, athletes exposed to repetitive head accelerations exhibit structural changes to the underlying white matter, altered glial cell metabolism, aberrant vascular response, and marked changes in functional network behavior. Moreover, these changes accumulate with accrued years of exposure, suggesting a cumulative trauma mechanism that may culminate in categorization as "concussion" and long-term neurological deficits. The goal of this review is to elucidate the role of medical imaging in recharacterizing TBI, as a whole, to better identify at-risk individuals and improve the development of preventative and interventional approaches. © 2016 Talavage, Nauman and Leverenz.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Schulte, S; Rasmussen, N N; McBeth, J W; Richards, P Q; Yochem, E; Petron, D J; Strathmann, F G
In: EPMA Journal, vol. 7, no. 1, 2016.
@article{Schulte2016b,
title = {Utilization of the clinical laboratory for the implementation of concussion biomarkers in collegiate football and the necessity of personalized and predictive athlete specific reference intervals},
author = {Schulte, S and Rasmussen, N N and McBeth, J W and Richards, P Q and Yochem, E and Petron, D J and Strathmann, F G},
doi = {10.1186/s13167-016-0050-x},
year = {2016},
date = {2016-01-01},
journal = {EPMA Journal},
volume = {7},
number = {1},
abstract = {Background: A continued interest in concussion biomarkers makes the eventual implementation of identified biomarkers into routine concussion assessment an eventual reality. We sought to develop and test an interdisciplinary approach that could be used to integrate blood-based biomarkers into the established concussion management program for a collegiate football team. Methods: We used a CLIA-certified laboratory for all testing and chose biomarkers where clinically validated testing was available as would be required for results used in clinical decision making. We summarized the existing methods and results for concussion assessment across an entire season to identify and demonstrate the challenges with the eventual integration of a parallel process using blood-based tests for concussion management. We analyzed the results of the biomarkers chosen for trends consistent with the outcome assessments provided from the current concussion management protocols. Results: Baseline samples were collected with three additional post-concussion samples collected at three separate time points from players with a diagnosed concussion (n = 12). A summary of results from currently used concussion assessment tools were compared to the representative biomarkers S100B and NSE results. Nine sport-related concussions occurred during practice and three during play. For S100B, 50% had follow-up testing results lower than the post-injury result. In contrast, 92% of NSE follow-up results were lower than post-injury. One hundred percent of the results for S100B and NSE were within the athlete-derived reference intervals upon return-to-play and season end. Conclusions: The reported workflow provides a framework for the eventual implementation of biomarkers for concussion assessment into existing assessment protocols and strengthens the need for reliance on clinical laboratory testing. Athlete-specific reference intervals will be required to adequately interpret results. © 2016 Schulte et al.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sanghera, Navjit K; Baas, Eric A; Bakkum, Barclay W; Foreman, Katie; Beckerman, Stephen
Sports vision evaluation findings in an elite athlete population Journal Article
In: Optometry & Visual Performance, vol. 4, no. 3, pp. 137–146, 2016, ISBN: 2325-3479 2325-3487.
@article{Sanghera2016,
title = {Sports vision evaluation findings in an elite athlete population},
author = {Sanghera, Navjit K and Baas, Eric A and Bakkum, Barclay W and Foreman, Katie and Beckerman, Stephen},
isbn = {2325-3479
2325-3487},
year = {2016},
date = {2016-01-01},
journal = {Optometry \& Visual Performance},
volume = {4},
number = {3},
pages = {137--146},
publisher = {Optometric Extension Program Foundation, Inc.},
address = {US},
abstract = {Background: Epidemiological studies suggest that the athletic population has a significant need for vision care. Recently, there has been an increased awareness and discussion of sports-related concussion, which can have a negative impact on athletic performance. The goal of this investigation is to characterize baseline performance of a cohort of elite athletes on a battery of sports vision tests. This information can: 1) serve as a baseline for comparison after an athlete is concussed, 2) help evaluate the effects of concussion on the visual system as it relates to athletic performance, and 3) help establish vision-related criteria for determining if and when an athlete is ready to return to play and perform at pre-concussive levels. Methods: Twenty-one male Major League Soccer athletes ages 18-35 were tested on 20 sports vision-related tests. Results: Eighteen of 21 subjects (86%) demonstrated one or more clinically significant problems with visual acuity, ocular health, binocular vision, and/or exhibited visual symptoms. The screening results indicate that 17% failed visual acuity, 26% displayed abnormal ocular health findings, 6% exhibited binocular vision problems, and 29% complained of at least one visual symptom related to a previous incident involving head trauma or concussion. Conclusion: This visual performance testing characterized baseline findings for this population and may help determine how deficits may interfere with optimum athletic performance at the elite level. The baseline testing could also serve as an indicator of recovery in acute vs. chronic stages and help determine if and when a concussed athlete is ready to return to play. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Connery, A K; Peterson, R L; Baker, D A; Randolph, C; Kirkwood, M W
The Role of Neuropsychological Evaluation in the Clinical Management of Concussion Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 475–486, 2016.
@article{Connery2016a,
title = {The Role of Neuropsychological Evaluation in the Clinical Management of Concussion},
author = {Connery, A K and Peterson, R L and Baker, D A and Randolph, C and Kirkwood, M W},
doi = {10.1016/j.pmr.2015.12.001},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {475--486},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sussman, E S; Ho, A L; Pendharkar, A V; Ghajar, J
Clinical evaluation of concussion: The evolving role of oculomotor assessments Journal Article
In: Neurosurgical Focus, vol. 40, no. 4, 2016.
@article{Sussman2016,
title = {Clinical evaluation of concussion: The evolving role of oculomotor assessments},
author = {Sussman, E S and Ho, A L and Pendharkar, A V and Ghajar, J},
doi = {10.3171/2016.1.FOCUS15610},
year = {2016},
date = {2016-01-01},
journal = {Neurosurgical Focus},
volume = {40},
number = {4},
abstract = {Sports-related concussion is a change in brain function following a direct or an indirect force to the head, identified in awake individuals and accounting for a considerable proportion of mild traumatic brain injury. Although the neurological signs and symptoms of concussion can be subtle and transient, there can be persistent sequelae, such as impaired attention and balance, that make affected patients particularly vulnerable to further injury. Currently, there is no accepted definition or diagnostic criteria for concussion, and there is no single assessment that is accepted as capable of identifying all patients with concussion. In this paper, the authors review the available screening tools for concussion, with particular emphasis on the role of visual function testing. In particular, they discuss the oculomotor assessment tools that are being investigated in the setting of concussion screening. © AANS, 2016.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bressan, S; Babl, F E
Diagnosis and management of paediatric concussion Journal Article
In: Journal of Paediatrics & Child Health, vol. 52, no. 2, pp. 151–157, 2016.
@article{Bressan2016,
title = {Diagnosis and management of paediatric concussion},
author = {Bressan, S and Babl, F E},
doi = {10.1111/jpc.12967},
year = {2016},
date = {2016-01-01},
journal = {Journal of Paediatrics \& Child Health},
volume = {52},
number = {2},
pages = {151--157},
abstract = {Heightened recognition of concussions and concerns about their sequelae in children has become an increasing community and public health concern. Biomarkers and clinical tests are being explored, but the diagnosis of concussion in the emergency department continues to be based on clinical signs and symptoms. While the majority of children go on to recover from post-concussive symptoms within 2 weeks, it is unclear which patients with concussion will go on to develop short- or long-term sequelae. A number of more or less evidence-based guidelines have become available which seek to guide clinicians on how to manage children post-concussion. In general, care after the emergency department is focused on reducing the risk of re-injury and rest until cerebral recovery with a graduated return to school and then play. © 2015 The Authors. Journal of Paediatrics and Child Health © 2015 Paediatrics and Child Health Division (Royal Australasian College of Physicians).},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Keener, A B
Tackling the brain: Clues emerge about the pathology of sports-related brain trauma Journal Article
In: Nature Medicine, vol. 22, no. 4, pp. 326–329, 2016.
@article{Keener2016,
title = {Tackling the brain: Clues emerge about the pathology of sports-related brain trauma},
author = {Keener, A B},
doi = {10.1038/nm0416-326},
year = {2016},
date = {2016-01-01},
journal = {Nature Medicine},
volume = {22},
number = {4},
pages = {326--329},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Leddy, J J; Baker, J G; Willer, B
Active Rehabilitation of Concussion and Post-concussion Syndrome Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 437–454, 2016.
@article{Leddy2016a,
title = {Active Rehabilitation of Concussion and Post-concussion Syndrome},
author = {Leddy, J J and Baker, J G and Willer, B},
doi = {10.1016/j.pmr.2015.12.003},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {437--454},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Haran, F J; Slaboda, J C; King, L A; Wright, W G; Houlihan, D; Norris, J N
Sensitivity of the Balance Error Scoring System and the Sensory Organization Test in the Combat Environment Journal Article
In: Journal of Neurotrauma, vol. 33, no. 7, pp. 705–711, 2016.
@article{Haran2016,
title = {Sensitivity of the Balance Error Scoring System and the Sensory Organization Test in the Combat Environment},
author = {Haran, F J and Slaboda, J C and King, L A and Wright, W G and Houlihan, D and Norris, J N},
doi = {10.1089/neu.2015.4060},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurotrauma},
volume = {33},
number = {7},
pages = {705--711},
abstract = {This study evaluated the utility of the Balance Error Scoring System (BESS) and the Sensory Organization Test (SOT) as tools for the screening and monitoring of Service members (SMs) with mild traumatic brain injury (mTBI) in a deployed setting during the acute and subacute phases of recovery. Patient records (N = 699) were reviewed for a cohort of SMs who sustained a blast-related mTBI while deployed to Afghanistan and were treated at the Concussion Restoration Care Center (CRCC) at Camp Leatherneck. On initial intake into the CRCC, participants completed two assessments of postural control, the BESS, and SOT. SMs with mTBI performed significantly worse on the BESS and SOT when compared with comparative samples. When the SOT data were further examined using sensory ratios, the results indicated that postural instability was primarily a result of vestibular and visual integration dysfunction (r \> 0.62). The main finding of this study was that the sensitivity of the SOT composite score (50-58%) during the acute phase was higher than previous sensitivities found in the sports medicine literature for impact-related trauma. Copyright © 2016 Mary Ann Liebert, Inc.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lin, K; Tung, C
Acupuncture for Recovery from Pediatric Sport-Related Concussion Journal Article
In: Medical Acupuncture, vol. 28, no. 4, pp. 217–222, 2016.
@article{Lin2016,
title = {Acupuncture for Recovery from Pediatric Sport-Related Concussion},
author = {Lin, K and Tung, C},
doi = {10.1089/acu.2016.1181},
year = {2016},
date = {2016-01-01},
journal = {Medical Acupuncture},
volume = {28},
number = {4},
pages = {217--222},
abstract = {Background: Sport-related concussion is a major concern for young athletes because a growing number of children participate in sport-related activities. Postconcussive symptoms can lead to physical, academic, and social impairment. There is no definitive treatment for sport-related postconcussive symptoms, and most available pharmacologic therapies have potential side-effects. Cases: The aim of this case report is to describe the use of acupuncture in the management of sport-related postconcussive symptoms in 3 pediatric patients. All 3 patients presented with chronic postconcussive symptoms that did not improve with conventional treatments alone. A retrospective chart review was performed from 2012 to 2015 on the 3 patients who received acupuncture in a tertiary pediatric pain clinic for postconcussive symptoms. Demographics and results from the Numerical Rating Scale, a postconcussive symptoms questionnaire, and the Brief Pain Inventory were included in the review. Results: All 3 patients experienced satisfactory symptomatic reduction following acupuncture treatment. Conclusions: Acupuncture with conventional medication appeared to reduce the postconcussive symptoms in the 3 patients. © Copyright 2016, Mary Ann Liebert, Inc.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Brett, Benjamin L; Smyk, Nathan; Solomon, Gary; Baughman, Brandon C; Schatz, Philip
In: Archives of Clinical Neuropsychology, vol. 31, no. 8, pp. 904–914, 2016, ISBN: 08876177.
@article{Brett2016,
title = {Long-term Stability and Reliability of Baseline Cognitive Assessments in High School Athletes Using ImPACT at 1-, 2-, and 3-year Test-Retest Intervals},
author = {Brett, Benjamin L and Smyk, Nathan and Solomon, Gary and Baughman, Brandon C and Schatz, Philip},
doi = {10.1093/arclin/acw055},
isbn = {08876177},
year = {2016},
date = {2016-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {31},
number = {8},
pages = {904--914},
abstract = {Objective: The ImPACT (Immediate Post-Concussion Assessment and Cognitive Testing) neurocognitive testing battery is a widely used tool used for the assessment and management of sports-related concussion. Research on the stability of ImPACT in high school athletes at a 1- and 2-year intervals have been inconsistent, requiring further investigation. We documented 1-, 2-, and 3-year test-retest reliability of repeated ImPACT baseline assessments in a sample of high school athletes, using multiple statistical methods for examining stability. Methods: A total of 1,510 high school athletes completed baseline cognitive testing using online ImPACT test battery at three time periods of approximately 1- (N = 250), 2- (N = 1146), and 3-year (N = 114) intervals. No participant sustained a concussion between assessments. Results: Intraclass correlation coefficients (ICCs) ranged in composite scores from 0.36 to 0.90 and showed little change as intervals between assessments increased. Reliable change indices and regression-based measures (RBMs) examining the test-retest stability demonstrated a lack of significant change in composite scores across the various time intervals, with very few cases (0%-6%) falling outside of 95% confidence intervals. Conclusion: The results suggest ImPACT composites scores remain considerably stability across 1-, 2-, and 3-year test-retest intervals in high school athletes, when considering both ICCs and RBM. Annually ascertaining baseline scores continues to be optimal for ensuring accurate and individualized management of injury for concussed athletes. For instances in which more recent baselines are not available (1-2 years), clinicians should seek to utilize more conservative range estimates in determining the presence of clinically meaningful change in cognitive performance.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Loosemore, Michael P; Butler, Charles F; Khadri, Abdelhamid; McDonagh, David; Patel, Vimal A; Bailes, Julian E
Use of Head Guards in AIBA Boxing Tournaments--A Cross-Sectional Observational Study Journal Article
In: Clinical Journal of Sport Medicine, vol. 27, no. 1, pp. 86–88, 2017, ISBN: 1050642X.
Abstract | BibTeX | Tags: acute brain injuries, Boxing, BOXING injuries, Concussion, CONFIDENCE intervals, CROSS-sectional method, DISEASE incidence, Head Protective Devices, LONGITUDINAL method, Poisson distribution, PREVENTION, PROBABILITY theory, Relative risk (Medicine), SAFETY hats, SPORTS events, STATISTICAL hypothesis testing, traumatic brain injury, WOUNDS & injuries
@article{Loosemore2017,
title = {Use of Head Guards in AIBA Boxing Tournaments--A Cross-Sectional Observational Study},
author = {Loosemore, Michael P and Butler, Charles F and Khadri, Abdelhamid and McDonagh, David and Patel, Vimal A and Bailes, Julian E},
isbn = {1050642X},
year = {2017},
date = {2017-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {27},
number = {1},
pages = {86--88},
abstract = {Objective: This study looks at the changes in injuries after the implementation of a new rule by the International Boxing Association (AIBA) to remove head guards from its competitions. Design: A cross-sectional observational study performed prospectively. This brief report examines the removal of head guards in 2 different ways. The first was to examine the stoppages due to blows to the head by comparing World Series Boxing (WSB), without head guards, to other AIBA competitions with head guards. Secondly, we examined the last 3 world championships: 2009 and 2011 (with head guards) and 2013 (without head guards). Setting: World Series Boxing and AIBA world championship boxing. Participants: Boxers from WSB and AIBA world championships. Interventions: The information was recorded by ringside medical physicians. Main Outcome Measures: Stoppages per 10 000 rounds; stoppages per 1000 hours. Results: Both studies show that the number of stoppages due to head blows was significantly decreased without head guards. The studies also showed that there was a notable increase in cuts. Conclusions: Removing head guards may reduce the already small risk of acute brain injury in amateur boxing. [ABSTRACT FROM AUTHOR]},
keywords = {acute brain injuries, Boxing, BOXING injuries, Concussion, CONFIDENCE intervals, CROSS-sectional method, DISEASE incidence, Head Protective Devices, LONGITUDINAL method, Poisson distribution, PREVENTION, PROBABILITY theory, Relative risk (Medicine), SAFETY hats, SPORTS events, STATISTICAL hypothesis testing, traumatic brain injury, WOUNDS \& injuries},
pubstate = {published},
tppubtype = {article}
}
Hwang, Sungjae; Ma, Lei; Kawata, Keisuke; Tierney, Ryan; Jeka, John J
Vestibular dysfunction after subconcussive head impact Journal Article
In: Journal of Neurotrauma, vol. 34, no. 1, pp. 8–15, 2017, ISBN: 0897-7151 1557-9042.
Abstract | Links | BibTeX | Tags: 2017, BEHAVIORAL assessment, Behavioral assessments, Head trauma, Human studies, Outcome measures, Sensory Feedback, sensory function, Soccer, traumatic brain injury
@article{Hwang2017,
title = {Vestibular dysfunction after subconcussive head impact},
author = {Hwang, Sungjae and Ma, Lei and Kawata, Keisuke and Tierney, Ryan and Jeka, John J},
doi = {10.1089/neu.2015.4238},
isbn = {0897-7151
1557-9042},
year = {2017},
date = {2017-01-01},
journal = {Journal of Neurotrauma},
volume = {34},
number = {1},
pages = {8--15},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Current thinking views mild head impact (i.e., subconcussion) as an underrecognized phenomenon that has the ability to cause significant current and future detrimental neurological effects. Repeated mild impacts to the head, however, often display no observable behavioral deficits based on standard clinical tests, which may lack sensitivity. The current study investigates the effects of subconcussive impacts from soccer heading with innovative measures of vestibular function and walking stability in a pre- 0\textendash2 h, post- 24 h post-heading repeated measures design. The heading group (n = 10) executed 10 headers with soccer balls projected at a velocity of 25 mph (11.2 m/sec) over 10 min. Subjects were evaluated 24 h before, immediately after, and 24 h after soccer heading with: the modified Balance Error Scoring System (mBESS); a walking stability task with visual feedback of trunk movement; and galvanic vestibular stimulation (GVS) while standing with eyes closed on foam. A control group (n = 10) followed the same protocol with no heading. The results showed significant decrease in trunk angle, leg angle gain, and center of mass gain relative to GVS for the heading group compared with controls. Medial-lateral trunk orientation displacement and velocity during treadmill walking increased immediately after mild head impact for the heading group compared with controls. Controls showed an improvement in mBESS scores over time, indicating a learning effect, which was not observed with the heading group. These results suggest that mild head impact leads to a transient dysfunction in vestibular processing, which deters walking stability during task performance. (PsycINFO Database Record (c) 2017 APA, all rights reserved)},
keywords = {2017, BEHAVIORAL assessment, Behavioral assessments, Head trauma, Human studies, Outcome measures, Sensory Feedback, sensory function, Soccer, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Zusman, E E; Zopfi, P; Kuluva, J; Zuckerman, S
Can Ideas From United States Youth Sports Reduce Judo-Related Head Injuries in Japan? Journal Article
In: World Neurosurgery, vol. 97, pp. 725–727, 2017.
Links | BibTeX | Tags: Concussion, head injury, judo, Secondary impact syndrome, Soccer, traumatic brain injury, Youth sports
@article{Zusman2017,
title = {Can Ideas From United States Youth Sports Reduce Judo-Related Head Injuries in Japan?},
author = {Zusman, E E and Zopfi, P and Kuluva, J and Zuckerman, S},
doi = {10.1016/j.wneu.2016.05.096},
year = {2017},
date = {2017-01-01},
journal = {World Neurosurgery},
volume = {97},
pages = {725--727},
keywords = {Concussion, head injury, judo, Secondary impact syndrome, Soccer, traumatic brain injury, Youth sports},
pubstate = {published},
tppubtype = {article}
}
Connery, A K; Peterson, R L; Baker, D A; Randolph, C; Kirkwood, M W
The Role of Neuropsychological Evaluation in the Clinical Management of Concussion Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 475–486, 2016.
Links | BibTeX | Tags: brain concussion, childhood injury, CONVALESCENCE, health care access, health care delivery, human, medical history, mild TBI, Neuropsychological assessment, neuropsychological test, postconcussion syndrome, priority journal, return to sport, Review, risk factor, traumatic brain injury, validity
@article{Connery2016a,
title = {The Role of Neuropsychological Evaluation in the Clinical Management of Concussion},
author = {Connery, A K and Peterson, R L and Baker, D A and Randolph, C and Kirkwood, M W},
doi = {10.1016/j.pmr.2015.12.001},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {475--486},
keywords = {brain concussion, childhood injury, CONVALESCENCE, health care access, health care delivery, human, medical history, mild TBI, Neuropsychological assessment, neuropsychological test, postconcussion syndrome, priority journal, return to sport, Review, risk factor, traumatic brain injury, validity},
pubstate = {published},
tppubtype = {article}
}
Brett, Benjamin L; Smyk, Nathan; Solomon, Gary; Baughman, Brandon C; Schatz, Philip
In: Archives of Clinical Neuropsychology, vol. 31, no. 8, pp. 904–914, 2016, ISBN: 08876177.
Abstract | Links | BibTeX | Tags: assessment, Childhood brain insult, Cognitive Ability, COGNITIVE testing, head injury, HIGH school athletes, Intraclass correlation, Norms/normative studies, Practice effects/reliable change, psychology, STATISTICAL reliability, Test construction, traumatic brain injury
@article{Brett2016,
title = {Long-term Stability and Reliability of Baseline Cognitive Assessments in High School Athletes Using ImPACT at 1-, 2-, and 3-year Test-Retest Intervals},
author = {Brett, Benjamin L and Smyk, Nathan and Solomon, Gary and Baughman, Brandon C and Schatz, Philip},
doi = {10.1093/arclin/acw055},
isbn = {08876177},
year = {2016},
date = {2016-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {31},
number = {8},
pages = {904--914},
abstract = {Objective: The ImPACT (Immediate Post-Concussion Assessment and Cognitive Testing) neurocognitive testing battery is a widely used tool used for the assessment and management of sports-related concussion. Research on the stability of ImPACT in high school athletes at a 1- and 2-year intervals have been inconsistent, requiring further investigation. We documented 1-, 2-, and 3-year test-retest reliability of repeated ImPACT baseline assessments in a sample of high school athletes, using multiple statistical methods for examining stability. Methods: A total of 1,510 high school athletes completed baseline cognitive testing using online ImPACT test battery at three time periods of approximately 1- (N = 250), 2- (N = 1146), and 3-year (N = 114) intervals. No participant sustained a concussion between assessments. Results: Intraclass correlation coefficients (ICCs) ranged in composite scores from 0.36 to 0.90 and showed little change as intervals between assessments increased. Reliable change indices and regression-based measures (RBMs) examining the test-retest stability demonstrated a lack of significant change in composite scores across the various time intervals, with very few cases (0%-6%) falling outside of 95% confidence intervals. Conclusion: The results suggest ImPACT composites scores remain considerably stability across 1-, 2-, and 3-year test-retest intervals in high school athletes, when considering both ICCs and RBM. Annually ascertaining baseline scores continues to be optimal for ensuring accurate and individualized management of injury for concussed athletes. For instances in which more recent baselines are not available (1-2 years), clinicians should seek to utilize more conservative range estimates in determining the presence of clinically meaningful change in cognitive performance.},
keywords = {assessment, Childhood brain insult, Cognitive Ability, COGNITIVE testing, head injury, HIGH school athletes, Intraclass correlation, Norms/normative studies, Practice effects/reliable change, psychology, STATISTICAL reliability, Test construction, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Lin, K; Tung, C
Acupuncture for Recovery from Pediatric Sport-Related Concussion Journal Article
In: Medical Acupuncture, vol. 28, no. 4, pp. 217–222, 2016.
Abstract | Links | BibTeX | Tags: Acupuncture, Pediatric Pain, pediatrics, postconcussive symptoms, Sport-related, traumatic brain injury
@article{Lin2016,
title = {Acupuncture for Recovery from Pediatric Sport-Related Concussion},
author = {Lin, K and Tung, C},
doi = {10.1089/acu.2016.1181},
year = {2016},
date = {2016-01-01},
journal = {Medical Acupuncture},
volume = {28},
number = {4},
pages = {217--222},
abstract = {Background: Sport-related concussion is a major concern for young athletes because a growing number of children participate in sport-related activities. Postconcussive symptoms can lead to physical, academic, and social impairment. There is no definitive treatment for sport-related postconcussive symptoms, and most available pharmacologic therapies have potential side-effects. Cases: The aim of this case report is to describe the use of acupuncture in the management of sport-related postconcussive symptoms in 3 pediatric patients. All 3 patients presented with chronic postconcussive symptoms that did not improve with conventional treatments alone. A retrospective chart review was performed from 2012 to 2015 on the 3 patients who received acupuncture in a tertiary pediatric pain clinic for postconcussive symptoms. Demographics and results from the Numerical Rating Scale, a postconcussive symptoms questionnaire, and the Brief Pain Inventory were included in the review. Results: All 3 patients experienced satisfactory symptomatic reduction following acupuncture treatment. Conclusions: Acupuncture with conventional medication appeared to reduce the postconcussive symptoms in the 3 patients. © Copyright 2016, Mary Ann Liebert, Inc.},
keywords = {Acupuncture, Pediatric Pain, pediatrics, postconcussive symptoms, Sport-related, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Haran, F J; Slaboda, J C; King, L A; Wright, W G; Houlihan, D; Norris, J N
Sensitivity of the Balance Error Scoring System and the Sensory Organization Test in the Combat Environment Journal Article
In: Journal of Neurotrauma, vol. 33, no. 7, pp. 705–711, 2016.
Abstract | Links | BibTeX | Tags: adult, Afghanistan, Article, Balance Error Scoring System, BESS, body posture, brain injury assessment, controlled study, CONVALESCENCE, human, integration, major clinical study, Male, Military, military deployment, mTBI, scoring system, Sensory Organization Test, SOT, traumatic brain injury, visual disorder, War
@article{Haran2016,
title = {Sensitivity of the Balance Error Scoring System and the Sensory Organization Test in the Combat Environment},
author = {Haran, F J and Slaboda, J C and King, L A and Wright, W G and Houlihan, D and Norris, J N},
doi = {10.1089/neu.2015.4060},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurotrauma},
volume = {33},
number = {7},
pages = {705--711},
abstract = {This study evaluated the utility of the Balance Error Scoring System (BESS) and the Sensory Organization Test (SOT) as tools for the screening and monitoring of Service members (SMs) with mild traumatic brain injury (mTBI) in a deployed setting during the acute and subacute phases of recovery. Patient records (N = 699) were reviewed for a cohort of SMs who sustained a blast-related mTBI while deployed to Afghanistan and were treated at the Concussion Restoration Care Center (CRCC) at Camp Leatherneck. On initial intake into the CRCC, participants completed two assessments of postural control, the BESS, and SOT. SMs with mTBI performed significantly worse on the BESS and SOT when compared with comparative samples. When the SOT data were further examined using sensory ratios, the results indicated that postural instability was primarily a result of vestibular and visual integration dysfunction (r \> 0.62). The main finding of this study was that the sensitivity of the SOT composite score (50-58%) during the acute phase was higher than previous sensitivities found in the sports medicine literature for impact-related trauma. Copyright © 2016 Mary Ann Liebert, Inc.},
keywords = {adult, Afghanistan, Article, Balance Error Scoring System, BESS, body posture, brain injury assessment, controlled study, CONVALESCENCE, human, integration, major clinical study, Male, Military, military deployment, mTBI, scoring system, Sensory Organization Test, SOT, traumatic brain injury, visual disorder, War},
pubstate = {published},
tppubtype = {article}
}
Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
Abstract | Links | BibTeX | Tags: amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Leddy, J J; Baker, J G; Willer, B
Active Rehabilitation of Concussion and Post-concussion Syndrome Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 437–454, 2016.
Links | BibTeX | Tags: Active, aerobic exercise, athlete, autonomic dysfunction, brain blood flow, Buffalo Concussion Treadmill Test, cognition, cognitive behavioral therapy, Cognitive rehabilitation, Concussion, DISEASE exacerbation, disease severity, exercise tolerance, functional assessment, functional magnetic resonance imaging, head injury, human, motor dysfunction, nerve cell plasticity, nonhuman, ocular motor dysfunction, ocular therapy, oculomotor training therapy, Pathophysiology, PHYSICAL ACTIVITY, Physical Examination, PHYSIOLOGY, physiotherapy, post concussion syndrome, Post-Concussion Syndrome, priority journal, Psychoeducation, psychologic assessment, Rehabilitation, rehabilitation care, rest, Review, Social behavior, social psychology, sport related concussion, traumatic brain injury, Treatment, treatment contraindication, vestibular disorder, Vestibular therapy
@article{Leddy2016a,
title = {Active Rehabilitation of Concussion and Post-concussion Syndrome},
author = {Leddy, J J and Baker, J G and Willer, B},
doi = {10.1016/j.pmr.2015.12.003},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {437--454},
keywords = {Active, aerobic exercise, athlete, autonomic dysfunction, brain blood flow, Buffalo Concussion Treadmill Test, cognition, cognitive behavioral therapy, Cognitive rehabilitation, Concussion, DISEASE exacerbation, disease severity, exercise tolerance, functional assessment, functional magnetic resonance imaging, head injury, human, motor dysfunction, nerve cell plasticity, nonhuman, ocular motor dysfunction, ocular therapy, oculomotor training therapy, Pathophysiology, PHYSICAL ACTIVITY, Physical Examination, PHYSIOLOGY, physiotherapy, post concussion syndrome, Post-Concussion Syndrome, priority journal, Psychoeducation, psychologic assessment, Rehabilitation, rehabilitation care, rest, Review, Social behavior, social psychology, sport related concussion, traumatic brain injury, Treatment, treatment contraindication, vestibular disorder, Vestibular therapy},
pubstate = {published},
tppubtype = {article}
}
Keener, A B
Tackling the brain: Clues emerge about the pathology of sports-related brain trauma Journal Article
In: Nature Medicine, vol. 22, no. 4, pp. 326–329, 2016.
Links | BibTeX | Tags: amnesia, Article, astrocyte, athlete, Athletic Injuries, behavior change, blood vessel injury, brain, Brain Injuries, Brain Injury, cognitive defect, Concussion, confusion, degenerative disease, Epilepsy, head injury, headache, hearing impairment, human, Humans, Neck pain, nerve cell, nervous system inflammation, neurofibrillary tangle, nonhuman, Pathophysiology, postconcussion syndrome, priority journal, sport injury, traumatic brain injury, unsteadiness, Vision, wrestling
@article{Keener2016,
title = {Tackling the brain: Clues emerge about the pathology of sports-related brain trauma},
author = {Keener, A B},
doi = {10.1038/nm0416-326},
year = {2016},
date = {2016-01-01},
journal = {Nature Medicine},
volume = {22},
number = {4},
pages = {326--329},
keywords = {amnesia, Article, astrocyte, athlete, Athletic Injuries, behavior change, blood vessel injury, brain, Brain Injuries, Brain Injury, cognitive defect, Concussion, confusion, degenerative disease, Epilepsy, head injury, headache, hearing impairment, human, Humans, Neck pain, nerve cell, nervous system inflammation, neurofibrillary tangle, nonhuman, Pathophysiology, postconcussion syndrome, priority journal, sport injury, traumatic brain injury, unsteadiness, Vision, wrestling},
pubstate = {published},
tppubtype = {article}
}
Bressan, S; Babl, F E
Diagnosis and management of paediatric concussion Journal Article
In: Journal of Paediatrics & Child Health, vol. 52, no. 2, pp. 151–157, 2016.
Abstract | Links | BibTeX | Tags: Article, brain concussion, brain injury assessment, Child, child care, childhood injury, chronic brain disease, clinical feature, Concussion, conservative treatment, Glasgow Coma Scale, glial fibrillary acidic protein, human, neuroimaging, neuron specific enolase, patient care, Post Concussive Symptom Scale, post-concussive syndrome, priority journal, protein S100B, Second impact syndrome, Sport Concussion Assessment Tool 3, traumatic brain injury
@article{Bressan2016,
title = {Diagnosis and management of paediatric concussion},
author = {Bressan, S and Babl, F E},
doi = {10.1111/jpc.12967},
year = {2016},
date = {2016-01-01},
journal = {Journal of Paediatrics \& Child Health},
volume = {52},
number = {2},
pages = {151--157},
abstract = {Heightened recognition of concussions and concerns about their sequelae in children has become an increasing community and public health concern. Biomarkers and clinical tests are being explored, but the diagnosis of concussion in the emergency department continues to be based on clinical signs and symptoms. While the majority of children go on to recover from post-concussive symptoms within 2 weeks, it is unclear which patients with concussion will go on to develop short- or long-term sequelae. A number of more or less evidence-based guidelines have become available which seek to guide clinicians on how to manage children post-concussion. In general, care after the emergency department is focused on reducing the risk of re-injury and rest until cerebral recovery with a graduated return to school and then play. © 2015 The Authors. Journal of Paediatrics and Child Health © 2015 Paediatrics and Child Health Division (Royal Australasian College of Physicians).},
keywords = {Article, brain concussion, brain injury assessment, Child, child care, childhood injury, chronic brain disease, clinical feature, Concussion, conservative treatment, Glasgow Coma Scale, glial fibrillary acidic protein, human, neuroimaging, neuron specific enolase, patient care, Post Concussive Symptom Scale, post-concussive syndrome, priority journal, protein S100B, Second impact syndrome, Sport Concussion Assessment Tool 3, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Sussman, E S; Ho, A L; Pendharkar, A V; Ghajar, J
Clinical evaluation of concussion: The evolving role of oculomotor assessments Journal Article
In: Neurosurgical Focus, vol. 40, no. 4, 2016.
Abstract | Links | BibTeX | Tags: Concussion diagnosis, Concussion screening, Eye tracking, Oculomotor tracking, traumatic brain injury, Vision tracking
@article{Sussman2016,
title = {Clinical evaluation of concussion: The evolving role of oculomotor assessments},
author = {Sussman, E S and Ho, A L and Pendharkar, A V and Ghajar, J},
doi = {10.3171/2016.1.FOCUS15610},
year = {2016},
date = {2016-01-01},
journal = {Neurosurgical Focus},
volume = {40},
number = {4},
abstract = {Sports-related concussion is a change in brain function following a direct or an indirect force to the head, identified in awake individuals and accounting for a considerable proportion of mild traumatic brain injury. Although the neurological signs and symptoms of concussion can be subtle and transient, there can be persistent sequelae, such as impaired attention and balance, that make affected patients particularly vulnerable to further injury. Currently, there is no accepted definition or diagnostic criteria for concussion, and there is no single assessment that is accepted as capable of identifying all patients with concussion. In this paper, the authors review the available screening tools for concussion, with particular emphasis on the role of visual function testing. In particular, they discuss the oculomotor assessment tools that are being investigated in the setting of concussion screening. © AANS, 2016.},
keywords = {Concussion diagnosis, Concussion screening, Eye tracking, Oculomotor tracking, traumatic brain injury, Vision tracking},
pubstate = {published},
tppubtype = {article}
}
Kania, K; Shaikh, K A; White, I K; Ackerman, L L
Follow-up issues in children with mild traumatic brain injuries Journal Article
In: Journal of Neurosurgery: Pediatrics, vol. 18, no. 2, pp. 224–230, 2016.
Abstract | Links | BibTeX | Tags: Acute Concussion Evaluation, Concussion, head injury, Patient Outcome Assessment, Trauma, traumatic brain injury
@article{Kania2016,
title = {Follow-up issues in children with mild traumatic brain injuries},
author = {Kania, K and Shaikh, K A and White, I K and Ackerman, L L},
doi = {10.3171/2016.1.PEDS15511},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurosurgery: Pediatrics},
volume = {18},
number = {2},
pages = {224--230},
abstract = {OBJECTIVE: Concerns about mild traumatic brain injury (mTBI) have increased in recent years, and neurosurgical consultation is often requested for patients with radiographic abnormalities or clinical findings suspicious for mTBI. However, to the authors' knowledge, no study has used the Acute Concussion Evaluation (ACE) tool to systematically evaluate the evolution of symptoms in patients with mTBI during neurosurgical follow-up. The goal in this study was to evaluate symptom progression in pediatric patients referred for neurosurgical consultation by using the ACE, as endorsed by the Centers for Disease Control and Prevention. METHODS: The authors performed a retrospective review of records of consecutive pediatric patients who had presented to the emergency department, were diagnosed with possible mTBI, and were referred for neurosurgical consultation. Outpatient follow-up for these patients included serial assessment using the ACE. Data collected included the mechanisms of the patients' injuries, symptoms, follow-up duration, and premorbid conditions that might potentially contribute to protracted recovery. RESULTS: Of 91 patients identified with mTBI, 58 met the inclusion criteria, and 33 of these had sufficient follow-up data to be included in the study. Mechanisms of injury included sports injury (15 patients), isolated falls (10), and motor vehicle collisions (8). Ages ranged from 5 to 17 years (mean age 11.6 years), and 29 of the 33 patients were male. Six patients had preinjury developmental and/or psychiatric diagnoses such as attention deficit hyperactivity disorder. Seventeen had negative findings on head CT scans. The first follow-up evaluation occurred at a mean of 30 days after injury. The mean number of symptoms reported on the ACE inventory at first follow-up were 3.2; 12 patients were symptom free. Patients with positive head CT findings required longer follow-up: these patients needed 14.59 weeks, versus 7.87 weeks of follow-up in patients with negative findings on head CT scans (p \< 0.05). CONCLUSIONS: The data suggest that patients with mTBI, particularly those with developmental and/or psychiatric comorbidities and concurrent cerebral or extracranial injury, often report symptoms for several weeks after their initial injury. Serial ACE assessment permits systematic identification of patients who are experiencing continued symptoms, leading to appropriate patient management and referral. ©AANS, 2016.},
keywords = {Acute Concussion Evaluation, Concussion, head injury, Patient Outcome Assessment, Trauma, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Sanghera, Navjit K; Baas, Eric A; Bakkum, Barclay W; Foreman, Katie; Beckerman, Stephen
Sports vision evaluation findings in an elite athlete population Journal Article
In: Optometry & Visual Performance, vol. 4, no. 3, pp. 137–146, 2016, ISBN: 2325-3479 2325-3487.
Abstract | BibTeX | Tags: 2016, Binocular Vision, binocular vision disorder, brain concussion, Concussion, Sports, sports vision, traumatic brain injury, Vision Disorders
@article{Sanghera2016,
title = {Sports vision evaluation findings in an elite athlete population},
author = {Sanghera, Navjit K and Baas, Eric A and Bakkum, Barclay W and Foreman, Katie and Beckerman, Stephen},
isbn = {2325-3479
2325-3487},
year = {2016},
date = {2016-01-01},
journal = {Optometry \& Visual Performance},
volume = {4},
number = {3},
pages = {137--146},
publisher = {Optometric Extension Program Foundation, Inc.},
address = {US},
abstract = {Background: Epidemiological studies suggest that the athletic population has a significant need for vision care. Recently, there has been an increased awareness and discussion of sports-related concussion, which can have a negative impact on athletic performance. The goal of this investigation is to characterize baseline performance of a cohort of elite athletes on a battery of sports vision tests. This information can: 1) serve as a baseline for comparison after an athlete is concussed, 2) help evaluate the effects of concussion on the visual system as it relates to athletic performance, and 3) help establish vision-related criteria for determining if and when an athlete is ready to return to play and perform at pre-concussive levels. Methods: Twenty-one male Major League Soccer athletes ages 18-35 were tested on 20 sports vision-related tests. Results: Eighteen of 21 subjects (86%) demonstrated one or more clinically significant problems with visual acuity, ocular health, binocular vision, and/or exhibited visual symptoms. The screening results indicate that 17% failed visual acuity, 26% displayed abnormal ocular health findings, 6% exhibited binocular vision problems, and 29% complained of at least one visual symptom related to a previous incident involving head trauma or concussion. Conclusion: This visual performance testing characterized baseline findings for this population and may help determine how deficits may interfere with optimum athletic performance at the elite level. The baseline testing could also serve as an indicator of recovery in acute vs. chronic stages and help determine if and when a concussed athlete is ready to return to play. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2016, Binocular Vision, binocular vision disorder, brain concussion, Concussion, Sports, sports vision, traumatic brain injury, Vision Disorders},
pubstate = {published},
tppubtype = {article}
}
Stieg, P E; Perrine, K
Helmet Use and Traumatic Brain Injury in Snowboarding Journal Article
In: World Neurosurgery, vol. 86, pp. 65–68, 2016.
Links | BibTeX | Tags: brain hemorrhage, Concussion, disability, emergency ward, Female, head injury, Head Protective Devices, Helmet, human, Humans, Injuries, Male, Morbidity, MORTALITY, Neuroprotection, Review, skiing, skull fracture, Snowboarding, Traumatic, traumatic brain injury, UNITED States, winter sport
@article{Stieg2016,
title = {Helmet Use and Traumatic Brain Injury in Snowboarding},
author = {Stieg, P E and Perrine, K},
doi = {10.1016/j.wneu.2015.07.044},
year = {2016},
date = {2016-01-01},
journal = {World Neurosurgery},
volume = {86},
pages = {65--68},
keywords = {brain hemorrhage, Concussion, disability, emergency ward, Female, head injury, Head Protective Devices, Helmet, human, Humans, Injuries, Male, Morbidity, MORTALITY, Neuroprotection, Review, skiing, skull fracture, Snowboarding, Traumatic, traumatic brain injury, UNITED States, winter sport},
pubstate = {published},
tppubtype = {article}
}
Sullivan, K A; Edmed, S L
New vignettes for the experimental manipulation of injury cause in prospective mild traumatic brain injury research Journal Article
In: Brain Injury, vol. 30, no. 13-14, pp. 1699–1707, 2016.
Abstract | Links | BibTeX | Tags: Concussion, mild brain, survey, traumatic brain injury, vignette
@article{Sullivan2016a,
title = {New vignettes for the experimental manipulation of injury cause in prospective mild traumatic brain injury research},
author = {Sullivan, K A and Edmed, S L},
doi = {10.1080/02699052.2016.1202448},
year = {2016},
date = {2016-01-01},
journal = {Brain Injury},
volume = {30},
number = {13-14},
pages = {1699--1707},
abstract = {Purpose: This study developed standardized vignettes that depict a mild traumatic brain injury (TBI) from one of several causes and subjected them to formal expert review. Method: A base vignette was developed using the World Health Organization operational criteria for mild TBI. Eight specific causes (e.g. sport vs assault) were examined. A convenience sample of mild TBI experts with a discipline background of Neuropsychology from North America, Australasia and Europe (n = 21) used an online survey to evaluate the vignettes and rated the role of cause on outcome. Results: The vignette suite was rated as fitting the mild TBI WHO operational diagnostic criteria at least moderately well. When compared to other factors, cause was not rated as significantly contributing to outcome. When evaluated in isolation, approximately half of the sample rated cause as important or very important and at least two of three clinical outcomes were associated with a different cause. Discussion: The vignettes may be useful in experimental mild TBI research. They enable the injury parameters to be controlled so that the effects of cause can be isolated and examined empirically. Such studies should advance understanding of the role of this factor in mild TBI outcome. © 2016 Taylor \& Francis Group, LLC.},
keywords = {Concussion, mild brain, survey, traumatic brain injury, vignette},
pubstate = {published},
tppubtype = {article}
}
Kawata, K; Rubin, L H; Lee, J H; Sim, T; Takahagi, M; Szwanki, V; Bellamy, A; Darvish, K; Assari, S; Henderer, J D; Tierney, R; Langford, D
Association of football subconcussive head impacts with ocular near point of convergence Journal Article
In: JAMA Ophthalmology, vol. 134, no. 7, pp. 763–769, 2016.
Abstract | Links | BibTeX | Tags: Acceleration, accelerometer, adult, Article, binocular convergence, Concussion, eye movement, follow up, football, head movement, human, KINEMATICS, major clinical study, Male, mouth protector, observational study, priority journal, prospective study, traumatic brain injury, Young Adult
@article{Kawata2016,
title = {Association of football subconcussive head impacts with ocular near point of convergence},
author = {Kawata, K and Rubin, L H and Lee, J H and Sim, T and Takahagi, M and Szwanki, V and Bellamy, A and Darvish, K and Assari, S and Henderer, J D and Tierney, R and Langford, D},
doi = {10.1001/jamaophthalmol.2016.1085},
year = {2016},
date = {2016-01-01},
journal = {JAMA Ophthalmology},
volume = {134},
number = {7},
pages = {763--769},
abstract = {IMPORTANCE An increased understanding of the relationship between subconcussive head impacts and near point of convergence (NPC) ocular-motor function may be useful in delineating traumatic brain injury. OBJECTIVE To investigate whether repetitive subconcussive head impacts during preseason football practice cause changes in NPC. DESIGN, SETTING, AND PARTICIPANTS This prospective, observational study of 29 National Collegiate Athletic Association Division I football players included baseline and preseason practices (1 noncontact and 4 contact), and postseason follow-up and outcome measures were obtained for each time. An accelerometer-embedded mouthguard measured head impact kinematics. Based on the sum of head impacts from all 5 practices, players were categorized into lower (n = 7) or higher (n = 22) impact groups. EXPOSURES Players participated in regular practices, and all head impacts greater than 10g from the 5 practices were recorded using the i1Biometerics Vector mouthguard (i1 Biometrics Inc). MAIN OUTCOMES AND MEASURES Near point of convergence measures and symptom scores. RESULTS A total of 1193 head impacts were recorded from 5 training camp practices in the 29 collegiate football players; 22 were categorized into the higher-impact group and 7 into the lower-impact group. Therewere significant differences in head impact kinematics between lower- and higher-impact groups (number of impacts, 6 vs 41 [lower impact minus higher impact = 35; 95%CI, 21-51; P \< .001]; linear acceleration, 99g vs 1112g [lower impact minus higher impact= 1013; 95%CI, 621 - 1578; P \< .001]; angular acceleration, 7589 radian/s2 vs 65016 radian/s2 [lower impact minus higher impact= 57 427; 95%CI , 31 123-80 498; P \< .001], respectively). The trajectory and cumulative burden of subconcussive impacts on NPC differed by group (F for group × linear trend1},
keywords = {Acceleration, accelerometer, adult, Article, binocular convergence, Concussion, eye movement, follow up, football, head movement, human, KINEMATICS, major clinical study, Male, mouth protector, observational study, priority journal, prospective study, traumatic brain injury, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Papa, L; Brophy, G M; Welch, R D; Lewis, L M; Braga, C F; Tan, C N; Ameli, N J; Lopez, M A; Haeussler, C A; Mendez Giordano, D I; Silvestri, S; Giordano, P; Weber, K D; Hill-Pryor, C; Hack, D C
In: JAMA Neurology, vol. 73, no. 5, pp. 551–560, 2016.
Abstract | Links | BibTeX | Tags: adult, aged, American Indian, amnesia, area under the curve, Article, Asian, assault, bicycle, Black person, blood sampling, blunt trauma, brain concussion, Caucasian, cohort analysis, computer assisted tomography, controlled study, diagnostic accuracy, diagnostic test accuracy study, disorientation, emergency ward, falling, Female, Glasgow Coma Scale, glial fibrillary acidic protein, Hispanic, human, limit of detection, limit of quantitation, major clinical study, Male, mild to moderate traumatic brain injury, neurosurgery, pedestrian, priority journal, prospective study, sport injury, traffic accident, traumatic brain injury, traumatic intracranial lesion, ubiquitin, ubiquitin carboxy terminal hydrolase L1, unclassified drug, unconsciousness, very elderly
@article{Papa2016a,
title = {Time course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic brain injury},
author = {Papa, L and Brophy, G M and Welch, R D and Lewis, L M and Braga, C F and Tan, C N and Ameli, N J and Lopez, M A and Haeussler, C A and {Mendez Giordano}, D I and Silvestri, S and Giordano, P and Weber, K D and Hill-Pryor, C and Hack, D C},
doi = {10.1001/jamaneurol.2016.0039},
year = {2016},
date = {2016-01-01},
journal = {JAMA Neurology},
volume = {73},
number = {5},
pages = {551--560},
abstract = {Importance: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been widely studied and show promise for clinical usefulness in suspected traumatic brain injury (TBI) and concussion. Understanding their diagnostic accuracy over time will help translate them into clinical practice. Objectives: To evaluate the temporal profiles of GFAP and UCH-L1 in a large cohort of trauma patients seen at the emergency department and to assess their diagnostic accuracy over time, both individually and in combination, for detecting mild to moderate TBI (MMTBI), traumatic intracranial lesions on head computed tomography (CT), and neurosurgical intervention. Design, Setting, and Participants: This prospective cohort study enrolled adult trauma patients seen at a level I trauma center from March 1, 2010, to March 5, 2014. All patients underwent rigorous screening to determine whether they had experienced an MMTBI (blunt head trauma with loss of consciousness, amnesia, or disorientation and a Glasgow Coma Scale score of 9-15). Of 3025 trauma patients assessed, 1030 met eligibility criteria for enrollment, and 446 declined participation. Initial blood samples were obtained in 584 patients enrolled within 4 hours of injury. Repeated blood sampling was conducted at 4, 8, 12, 16, 20, 24, 36, 48, 60, 72, 84, 96, 108, 120, 132, 144, 156, 168, and 180 hours after injury. Main Outcomes and Measures: Diagnosis of MMTBI, presence of traumatic intracranial lesions on head CT scan, and neurosurgical intervention. Results: A total of 1831 blood samples were drawn from 584 patients (mean [SD] age, 40 [16] years; 62.0%[362 of 584] male) over 7 days. Both GFAP and UCH-L1 were detectible within 1 hour of injury. GFAP peaked at 20 hours after injury and slowly declined over 72 hours. UCH-L1 rose rapidly and peaked at 8 hours after injury and declined rapidly over 48 hours. Over the course of 1 week, GFAP demonstrated a diagnostic range of areas under the curve for detecting MMTBI of 0.73 (95%CI, 0.69-0.77) to 0.94 (95%CI, 0.78-1.00), and UCH-L1 demonstrated a diagnostic range of 0.30 (95%CI, 0.02-0.50) to 0.67 (95%CI, 0.53-0.81). For detecting intracranial lesions on CT, the diagnostic ranges of areas under the curve were 0.80 (95%CI, 0.67-0.92) to 0.97 (95%CI, 0.93-1.00)for GFAP and 0.31 (95%CI, 0-0.63) to 0.77 (95%CI, 0.68-0.85) for UCH-L1. For distinguishing patients with and without a neurosurgical intervention, the range for GFAP was 0.91 (95%CI, 0.79-1.00) to 1.00 (95% CI, 1.00-1.00), and the range for UCH-L1 was 0.50 (95%CI, 0-1.00) to 0.92 (95%CI, 0.83-1.00). Conclusions and Relevance: GFAP performed consistently in detecting MMTBI, CT lesions, and neurosurgical intervention across 7 days. UCH-L1 performed best in the early postinjury period. © Copyright 2016 American Medical Association. All rights reserved.},
keywords = {adult, aged, American Indian, amnesia, area under the curve, Article, Asian, assault, bicycle, Black person, blood sampling, blunt trauma, brain concussion, Caucasian, cohort analysis, computer assisted tomography, controlled study, diagnostic accuracy, diagnostic test accuracy study, disorientation, emergency ward, falling, Female, Glasgow Coma Scale, glial fibrillary acidic protein, Hispanic, human, limit of detection, limit of quantitation, major clinical study, Male, mild to moderate traumatic brain injury, neurosurgery, pedestrian, priority journal, prospective study, sport injury, traffic accident, traumatic brain injury, traumatic intracranial lesion, ubiquitin, ubiquitin carboxy terminal hydrolase L1, unclassified drug, unconsciousness, very elderly},
pubstate = {published},
tppubtype = {article}
}
Naeser, M A; Martin, P I; Ho, M D; Krengel, M H; Bogdanova, Y; Knight, J A; Yee, M K; Zafonte, R; Frazier, J; Hamblin, M R; Koo, B B
Transcranial, red/near-infrared light-emitting diode therapy to improve cognition in chronic traumatic brain injury Journal Article
In: Photomedicine and Laser Surgery, vol. 34, no. 12, pp. 610–626, 2016.
Abstract | Links | BibTeX | Tags: Accidents, Adenosinetriphosphate, brain, Cognitive dysfunction, Diodes, Explosives, Head Injuries, Hemodynamics, Infrared devices, LED, Light, Light emitting diodes, Lightemitting diodes, LLLT, Nitric oxide, Patient monitoring, Patient treatment, PBM, Photobiomodulation, postconcussion syndrome, PTSD, Sports, Sports head injury, TBI, TBI treatment, Traumatic Brain Injuries, traumatic brain injury
@article{Naeser2016,
title = {Transcranial, red/near-infrared light-emitting diode therapy to improve cognition in chronic traumatic brain injury},
author = {Naeser, M A and Martin, P I and Ho, M D and Krengel, M H and Bogdanova, Y and Knight, J A and Yee, M K and Zafonte, R and Frazier, J and Hamblin, M R and Koo, B B},
doi = {10.1089/pho.2015.4037},
year = {2016},
date = {2016-01-01},
journal = {Photomedicine and Laser Surgery},
volume = {34},
number = {12},
pages = {610--626},
abstract = {Objective: We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM improves mitochondrial function increasing oxygen consumption, production of adenosine triphosphate (ATP), and improving cellular energy stores. Nitric oxide is released from the cells increasing regional blood flow in the brain. Review of published studies: In our previously published study, 11 chronic TBI patients with closed-head TBI caused by different accidents (motor vehicle accident, sports-related, improvised explosive device blast injury) and exhibiting long-lasting cognitive dysfunction received 18 outpatient treatments (Monday, Wednesday, Friday for 6 weeks) starting at 10 months to 8 years post-TBI. LED therapy is nonthermal, painless, and noninvasive. An LED-based device classified as nonsignificant risk (FDA cleared) was used. Each LED cluster head (5.35 cm diameter, 500mW, 22.2 mW/cm2) was applied for 9 min 45 sec (13 J/cm2) using 11 locations on the scalp: midline from front-to-back hairline and bilaterally on frontal, parietal, and temporal areas. Testing was performed before and after transcranial LED (tLED; at 1 week, 1 month, and at 2 months after the 18th treatment) and showed significant improvements in executive function and verbal memory. There were also fewer post-traumatic stress disorder (PTSD) symptoms reported. Ongoing studies: Ongoing, current studies involve TBI patients who have been treated with tLED using either 26 J/cm2 per LED location on the head or treated with intranasal only (iLED) using red (633 nm) and NIR (810 nm) diodes placed into the nostrils. The NIR iLED is hypothesized to deliver photons to the hippocampus, and the red 633 nm iLED is believed to increase melatonin. Results have been similar to the previously published tLED study. Actigraphy sleep data showed increased time asleep (on average one additional hour per night) after the 18th tLED or iLED treatment. LED treatments may be performed in the home. Sham-controlled studies with veterans who have cognitive dysfunction from Gulf War Illness, blast TBI, and TBI/PTSD are currently ongoing. © Mary Ann Liebert, Inc.},
keywords = {Accidents, Adenosinetriphosphate, brain, Cognitive dysfunction, Diodes, Explosives, Head Injuries, Hemodynamics, Infrared devices, LED, Light, Light emitting diodes, Lightemitting diodes, LLLT, Nitric oxide, Patient monitoring, Patient treatment, PBM, Photobiomodulation, postconcussion syndrome, PTSD, Sports, Sports head injury, TBI, TBI treatment, Traumatic Brain Injuries, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Tierney, Gregory J; Lawler, John; Denvir, Karl; McQuilkin, Kurt; Simms, Ciaran K
Risks associated with significant head impact events in elite rugby union Journal Article
In: Brain Injury, vol. 30, no. 11, pp. 1350–1361, 2016, ISBN: 0269-9052 1362-301X.
Abstract | Links | BibTeX | Tags: 2016, brain concussion, Sport, statistical analysis, traumatic brain injury, Video analysis
@article{Tierney2016,
title = {Risks associated with significant head impact events in elite rugby union},
author = {Tierney, Gregory J and Lawler, John and Denvir, Karl and McQuilkin, Kurt and Simms, Ciaran K},
doi = {10.1080/02699052.2016.1193630},
isbn = {0269-9052
1362-301X},
year = {2016},
date = {2016-01-01},
journal = {Brain Injury},
volume = {30},
number = {11},
pages = {1350--1361},
publisher = {Taylor \& Francis},
address = {United Kingdom},
abstract = {Primary objectives: To conduct video and statistical analysis on Rugby Union play, focusing mainly on the tackle, to establish the player to player configurations for significant direct head impacts and non-direct head impacts. Research design: Quantitative, observational cohort study. Methods and procedures: Video analysis of 52 significant direct head impacts (31 Tackle, 10 Ruck, 7 Dive and 4 Ground) and 40 non-direct head impact tackles from 2014/15 International Rugby Union matches. Relative risk, 95% CI and p-values were calculated for a range of tackle variables. Main outcome and results: Upper body tackles and lower body tackles accounted for 37% (19) and 23% (12) of cases, respectively, with the tackler as the head impacted player for 97% (30) of cases. The majority (81%) of tackle-related significant direct head impacts occurred in the second half of the game, with 63% of upper body tackle significant direct head impacts occurring in the final quarter. Tackler head placement and high speed tackles had statistical significance for causing tackle related significant direct head impacts as well as foot planting and difference in tackler and ball carrier mass for upper body tackles and ball carrier change in direction for lower body tackles. Conclusion: Tackle variables that statistically increased the risk of significant direct head impact were identified, which can aid player protection strategies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2016, brain concussion, Sport, statistical analysis, traumatic brain injury, Video analysis},
pubstate = {published},
tppubtype = {article}
}
Bonfield, C M; Kondziolka, D
Beyond the game: The legacy of Bill Masterton Journal Article
In: Neurosurgical Focus, vol. 41, no. 1, 2016.
Abstract | Links | BibTeX | Tags: Bill Masterton, Hockey, neurosurgery, traumatic brain injury
@article{Bonfield2016,
title = {Beyond the game: The legacy of Bill Masterton},
author = {Bonfield, C M and Kondziolka, D},
doi = {10.3171/2016.2.FOCUS1558},
year = {2016},
date = {2016-01-01},
journal = {Neurosurgical Focus},
volume = {41},
number = {1},
abstract = {Bill Masterton is the only man to die of injuries sustained in a National Hockey League (NHL) game. He remains the last fatality in any professional team sport involving a direct in-game injury in North America. While Masterton was originally thought to have suffered a fatal brain injury while being checked on the ice, later analysis of the case revealed evidence of second-impact syndrome and the effects of prior concussions. Masterton's death sparked both an immediate debate in the NHL on whether helmets should be compulsory and the NHL's first vote on mandatory helmet use. Although the subject of mandated helmet use met with resistance in the 10 years after Masterton's death, especially from hockey owners and coaches, the NHL finally legislated helmet use by all players entering the league beginning in the 1979-1980 season. Several awards, including one recognizing the NHL player who best exemplifies the qualities of perseverance, sportsmanship, and dedication to hockey, have been created in memory of Masterton. However, his legacy extends far beyond the awards that bear his name. His death was the seminal event bringing head safety to the forefront of a game that was both unready and unwilling to accept change. An increase in mainstream media attention in recent years has led to unprecedented public awareness of brain injury and concussion in hockey and other sports. Advances in the diagnosis and treatment of head injury in sports have occurred recently, the impetus for which started over 45 years ago, when Bill Masterton died.},
keywords = {Bill Masterton, Hockey, neurosurgery, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Talavage, T M; Nauman, E A; Leverenz, L J
The role of medical imaging in the recharacterization of mild traumatic brain injury using youth sports as a laboratory Journal Article
In: Frontiers in Neurology, vol. 6, no. JAN, 2016.
Abstract | Links | BibTeX | Tags: Article, cognition assessment, Concussion, DIAGNOSTIC imaging, functional magnetic resonance imaging, Functional MRI, human, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Neuroanatomy, neuroimaging, neuromonitoring, nonhuman, NUCLEAR magnetic resonance spectroscopy, Patient monitoring, population risk, prediction, protective equipment, sport injury, Subconcussive, traumatic brain injury, validation process
@article{Talavage2016,
title = {The role of medical imaging in the recharacterization of mild traumatic brain injury using youth sports as a laboratory},
author = {Talavage, T M and Nauman, E A and Leverenz, L J},
doi = {10.3389/fneur.2015.00273},
year = {2016},
date = {2016-01-01},
journal = {Frontiers in Neurology},
volume = {6},
number = {JAN},
abstract = {The short- and long-term impact of mild traumatic brain injury (TBI) is an increasingly vital concern for both military and civilian personnel. Such injuries produce significant social and financial burdens and necessitate improved diagnostic and treatment methods. Recent integration of neuroimaging and biomechanical studies in youth collision-sport athletes has revealed that significant alterations in brain structure and function occur even in the absence of traditional clinical markers of "concussion." While task performance is maintained, athletes exposed to repetitive head accelerations exhibit structural changes to the underlying white matter, altered glial cell metabolism, aberrant vascular response, and marked changes in functional network behavior. Moreover, these changes accumulate with accrued years of exposure, suggesting a cumulative trauma mechanism that may culminate in categorization as "concussion" and long-term neurological deficits. The goal of this review is to elucidate the role of medical imaging in recharacterizing TBI, as a whole, to better identify at-risk individuals and improve the development of preventative and interventional approaches. © 2016 Talavage, Nauman and Leverenz.},
keywords = {Article, cognition assessment, Concussion, DIAGNOSTIC imaging, functional magnetic resonance imaging, Functional MRI, human, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Neuroanatomy, neuroimaging, neuromonitoring, nonhuman, NUCLEAR magnetic resonance spectroscopy, Patient monitoring, population risk, prediction, protective equipment, sport injury, Subconcussive, traumatic brain injury, validation process},
pubstate = {published},
tppubtype = {article}
}
Holtkamp, M D; Grimes, J; Ling, G
Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache Journal Article
In: Current Pain & Headache Reports, vol. 20, no. 6, 2016.
Abstract | Links | BibTeX | Tags: apolipoprotein E4, assessment, biological marker, botulinum toxin, brain concussion, calcitonin gene related peptide receptor antagonis, comorbidity, Concussion, depression, DIAGNOSTIC imaging, disease course, genetic polymorphism, genetic predisposition, glial fibrillary acidic protein, headache, Headache disorder, human, MANAGEMENT, migraine, Military personnel, mTBI, neuroimaging, Pathophysiology, postconcussion syndrome, posttraumatic headache, posttraumatic stress disorder, Prognosis, Review, serotonin 1 agonist, serotonin 1F agonist, soldier, traumatic brain injury, Treatment, tricyclic antidepressant agent, triptan derivative, unclassified drug, UNITED States
@article{Holtkamp2016,
title = {Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache},
author = {Holtkamp, M D and Grimes, J and Ling, G},
doi = {10.1007/s11916-016-0572-x},
year = {2016},
date = {2016-01-01},
journal = {Current Pain \& Headache Reports},
volume = {20},
number = {6},
abstract = {Traumatic brain injury (TBI) is defined as an alteration in brain function caused by an external force. Mild TBI or concussion is now well recognized to be a risk of military service as well as participation in athletic sports such as football. Posttraumatic headache (PTH) is the most common symptom after mTBI in US service members. PTH most commonly presents with migraine-like headache features. The following is an overview of the epidemiology, pathophysiology, clinical course, prognosis, complications, and treatment of mTBI and associated comorbidities with a focus on PTH. There is a particular emphasis on emerging evidence-based clinical practice. One important medical consequence of the recognition that mTBI is a highly prevalent among military service members is that the Department of Defense (DoD) is dedicating significant financial and intellectual resources to better understanding and developing treatments for TBI. The identification of the importance of TBI among the US military population has had the added benefit of increasing awareness of this condition among civilian populations, particularly those engaged in both professional and youth sports. The NIH and NSF are also supporting important TBI research. President Obama’s Brain Initiative is also providing additional impetus for these efforts. Unfortunately, the understanding of the acute and chronic effects of mTBI on the brain remains limited. Gratefully, there is hope that through innovative research, there will be advances in elucidating the underlying pathophysiology, which will lead to clinical and prognostic indicators, ultimately resulting in new treatment options for this very complicated set of disorders. © 2016, Springer Science+Business Media New York (outside the USA).},
keywords = {apolipoprotein E4, assessment, biological marker, botulinum toxin, brain concussion, calcitonin gene related peptide receptor antagonis, comorbidity, Concussion, depression, DIAGNOSTIC imaging, disease course, genetic polymorphism, genetic predisposition, glial fibrillary acidic protein, headache, Headache disorder, human, MANAGEMENT, migraine, Military personnel, mTBI, neuroimaging, Pathophysiology, postconcussion syndrome, posttraumatic headache, posttraumatic stress disorder, Prognosis, Review, serotonin 1 agonist, serotonin 1F agonist, soldier, traumatic brain injury, Treatment, tricyclic antidepressant agent, triptan derivative, unclassified drug, UNITED States},
pubstate = {published},
tppubtype = {article}
}
Schulte, S; Rasmussen, N N; McBeth, J W; Richards, P Q; Yochem, E; Petron, D J; Strathmann, F G
In: EPMA Journal, vol. 7, no. 1, 2016.
Abstract | Links | BibTeX | Tags: adult, Article, athlete-derived reference interval, biological marker, Biomarker panel, Blood test, clinical decision making, clinical laboratory, college, collegiate athletes, Concussion, controlled study, diagnostic test accuracy study, follow up, football, health program, human, Male, neuron specific enolase, NSE, prediction, Predictive diagnostics, priority journal, protein blood level, protein S100B, rating scale, reference value, S100B, Sport-related concussion, Sports-related concussion, traumatic brain injury, validation study
@article{Schulte2016b,
title = {Utilization of the clinical laboratory for the implementation of concussion biomarkers in collegiate football and the necessity of personalized and predictive athlete specific reference intervals},
author = {Schulte, S and Rasmussen, N N and McBeth, J W and Richards, P Q and Yochem, E and Petron, D J and Strathmann, F G},
doi = {10.1186/s13167-016-0050-x},
year = {2016},
date = {2016-01-01},
journal = {EPMA Journal},
volume = {7},
number = {1},
abstract = {Background: A continued interest in concussion biomarkers makes the eventual implementation of identified biomarkers into routine concussion assessment an eventual reality. We sought to develop and test an interdisciplinary approach that could be used to integrate blood-based biomarkers into the established concussion management program for a collegiate football team. Methods: We used a CLIA-certified laboratory for all testing and chose biomarkers where clinically validated testing was available as would be required for results used in clinical decision making. We summarized the existing methods and results for concussion assessment across an entire season to identify and demonstrate the challenges with the eventual integration of a parallel process using blood-based tests for concussion management. We analyzed the results of the biomarkers chosen for trends consistent with the outcome assessments provided from the current concussion management protocols. Results: Baseline samples were collected with three additional post-concussion samples collected at three separate time points from players with a diagnosed concussion (n = 12). A summary of results from currently used concussion assessment tools were compared to the representative biomarkers S100B and NSE results. Nine sport-related concussions occurred during practice and three during play. For S100B, 50% had follow-up testing results lower than the post-injury result. In contrast, 92% of NSE follow-up results were lower than post-injury. One hundred percent of the results for S100B and NSE were within the athlete-derived reference intervals upon return-to-play and season end. Conclusions: The reported workflow provides a framework for the eventual implementation of biomarkers for concussion assessment into existing assessment protocols and strengthens the need for reliance on clinical laboratory testing. Athlete-specific reference intervals will be required to adequately interpret results. © 2016 Schulte et al.},
keywords = {adult, Article, athlete-derived reference interval, biological marker, Biomarker panel, Blood test, clinical decision making, clinical laboratory, college, collegiate athletes, Concussion, controlled study, diagnostic test accuracy study, follow up, football, health program, human, Male, neuron specific enolase, NSE, prediction, Predictive diagnostics, priority journal, protein blood level, protein S100B, rating scale, reference value, S100B, Sport-related concussion, Sports-related concussion, traumatic brain injury, validation study},
pubstate = {published},
tppubtype = {article}
}
Moon, K; Theodore, N
Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists? Journal Article
In: World Neurosurgery, vol. 89, pp. 720–721, 2016.
Links | BibTeX | Tags: Alzheimer disease, amyloid beta protein, amyloid plaque, anxiety disorder, apolipoprotein E, Article, behavior disorder, Boxing, brain atrophy, brain concussion, brain degeneration, chronic disease, Chronic traumatic encephalopathy, cognitive defect, degenerative disease, depression, environmental factor, football, frontotemporal dementia, genetic predisposition, genetic risk, genetic susceptibility, human, motor control, Neuroanatomy, opiate addiction, Parkinson disease, protein phosphorylation, scar formation, septum pellucidum, sport injury, substantia nigra, suicide, TAR DNA binding protein, tau protein, tauopathy, traumatic brain injury
@article{Moon2016,
title = {Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists?},
author = {Moon, K and Theodore, N},
doi = {10.1016/j.wneu.2016.03.073},
year = {2016},
date = {2016-01-01},
journal = {World Neurosurgery},
volume = {89},
pages = {720--721},
keywords = {Alzheimer disease, amyloid beta protein, amyloid plaque, anxiety disorder, apolipoprotein E, Article, behavior disorder, Boxing, brain atrophy, brain concussion, brain degeneration, chronic disease, Chronic traumatic encephalopathy, cognitive defect, degenerative disease, depression, environmental factor, football, frontotemporal dementia, genetic predisposition, genetic risk, genetic susceptibility, human, motor control, Neuroanatomy, opiate addiction, Parkinson disease, protein phosphorylation, scar formation, septum pellucidum, sport injury, substantia nigra, suicide, TAR DNA binding protein, tau protein, tauopathy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Johnson, K L; Chowdhury, S; Lawrimore, W B; Mao, Y; Mehmani, A; Prabhu, R; Rush, G A; Horstemeyer, M F
Constrained topological optimization of a football helmet facemask based on brain response Journal Article
In: Materials and Design, vol. 111, pp. 108–118, 2016.
Abstract | Links | BibTeX | Tags: Accident prevention, ALGORITHMS, brain, Concussion, Constrained optimization, Design, Design optimization, finite element analysis, Finite element method, football helmet, Fuel additives, Genetic algorithms, Multiobjective optimization, Optimization, Safety devices, Shear strain, Sports, Surrogate model, Surrogate modeling, Topology, Traumatic Brain Injuries, traumatic brain injury
@article{Johnson2016a,
title = {Constrained topological optimization of a football helmet facemask based on brain response},
author = {Johnson, K L and Chowdhury, S and Lawrimore, W B and Mao, Y and Mehmani, A and Prabhu, R and Rush, G A and Horstemeyer, M F},
doi = {10.1016/j.matdes.2016.08.064},
year = {2016},
date = {2016-01-01},
journal = {Materials and Design},
volume = {111},
pages = {108--118},
abstract = {Surrogate model-based multi-objective design optimization was performed to reduce concussion risk during frontal football helmet impacts. In particular, a topological decomposition of the football helmet facemask was performed to formulate the design problem, and brain injury metrics were exploited as objective functions. A validated finite element model of a helmeted human head was used to recreate facemask impacts. Due to the prohibitive computational expense of the full scale simulations, a surrogate modeling approach was employed. An optimal surrogate model selection framework, called Concurrent Surrogate Model Selection, or COSMOS, was utilized to identify the surrogate models best suited to approximate each objective function. The resulting surrogate models were implemented in the Non-dominated Sorting Genetic Algorithm II (NSGA-II) optimization algorithm. Constraints were implemented to control the solid material fraction in the facemask design space, and binary variables were used to control the placement of the facemask bars. The optimized facemask designs reduced the maximum tensile pressure in the brain by 7.5% and the maximum shear strain by a remarkable 39.5%. This research represents a first-of-its-kind approach to multi-objective design optimization on a football helmet, and demonstrates the possibilities that are achievable in improving human safety by using such a simulation-based design optimization. © 2016 Elsevier Ltd},
keywords = {Accident prevention, ALGORITHMS, brain, Concussion, Constrained optimization, Design, Design optimization, finite element analysis, Finite element method, football helmet, Fuel additives, Genetic algorithms, Multiobjective optimization, Optimization, Safety devices, Shear strain, Sports, Surrogate model, Surrogate modeling, Topology, Traumatic Brain Injuries, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Laker, S R; Meron, A; Greher, M R; Wilson, J
Retirement and Activity Restrictions Following Concussion Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 487–501, 2016.
Links | BibTeX | Tags: Activity restrictions, athlete, attention deficit disorder, brain concussion, Concussion, CONVALESCENCE, depression, human, learning disorder, migraine, neuropsychological test, nonhuman, PHYSICAL ACTIVITY, postconcussion syndrome, practice guideline, priority journal, Retirement, return to sport, Review, risk factor, sleep disorder, sport injury, Sport-related concussion, subarachnoid hemorrhage, symptom, traumatic brain injury, unconsciousness
@article{Laker2016,
title = {Retirement and Activity Restrictions Following Concussion},
author = {Laker, S R and Meron, A and Greher, M R and Wilson, J},
doi = {10.1016/j.pmr.2016.01.001},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {487--501},
keywords = {Activity restrictions, athlete, attention deficit disorder, brain concussion, Concussion, CONVALESCENCE, depression, human, learning disorder, migraine, neuropsychological test, nonhuman, PHYSICAL ACTIVITY, postconcussion syndrome, practice guideline, priority journal, Retirement, return to sport, Review, risk factor, sleep disorder, sport injury, Sport-related concussion, subarachnoid hemorrhage, symptom, traumatic brain injury, unconsciousness},
pubstate = {published},
tppubtype = {article}
}
Blennow, K; Brody, D L; Kochanek, P M; Levin, H; McKee, A; Ribbers, G M; Yaffe, K; Zetterberg, H
Traumatic brain injuries Journal Article
In: Nature Reviews Disease Primers, vol. 2, 2016.
Abstract | Links | BibTeX | Tags: amyloid beta protein, Article, axonal injury, biological marker, BIOPHYSICS, blood, brain, BRAIN damage, cerebrospinal fluid, Chronic traumatic encephalopathy, computer assisted tomography, disease severity, endocrine disease, heredity, human, molecular pathology, neuropathology, nonhuman, nuclear magnetic resonance imaging, Pathophysiology, positron emission tomography, postconcussion syndrome, priority journal, protein aggregation, quality of life, screening, tau protein, traumatic brain injury
@article{Blennow2016,
title = {Traumatic brain injuries},
author = {Blennow, K and Brody, D L and Kochanek, P M and Levin, H and McKee, A and Ribbers, G M and Yaffe, K and Zetterberg, H},
doi = {10.1038/nrdp.2016.84},
year = {2016},
date = {2016-01-01},
journal = {Nature Reviews Disease Primers},
volume = {2},
abstract = {Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe. Mild TBI (the least severe form) is synonymous with concussion and is typically caused by blunt non-penetrating head trauma. The trauma causes stretching and tearing of axons, which leads to diffuse axonal injury-the best-studied pathogenetic mechanism of this disorder. However, mild TBI is defined on clinical grounds and no well-validated imaging or fluid biomarkers to determine the presence of neuronal damage in patients with mild TBI is available. Most patients with mild TBI will recover quickly, but others report persistent symptoms, called post-concussive syndrome, the underlying pathophysiology of which is largely unknown. Repeated concussive and subconcussive head injuries have been linked to the neurodegenerative condition chronic traumatic encephalopathy (CTE), which has been reported post-mortem in contact sports athletes and soldiers exposed to blasts. Insights from severe injuries and CTE plausibly shed light on the underlying cellular and molecular processes involved in mild TBI. MRI techniques and blood tests for axonal proteins to identify and grade axonal injury, in addition to PET for tau pathology, show promise as tools to explore CTE pathophysiology in longitudinal clinical studies, and might be developed into diagnostic tools for CTE. Given that CTE is attributed to repeated head trauma, prevention might be possible through rule changes by sports organizations and legislators. © 2016 Macmillan Publishers Limited, part of Springer Nature.},
keywords = {amyloid beta protein, Article, axonal injury, biological marker, BIOPHYSICS, blood, brain, BRAIN damage, cerebrospinal fluid, Chronic traumatic encephalopathy, computer assisted tomography, disease severity, endocrine disease, heredity, human, molecular pathology, neuropathology, nonhuman, nuclear magnetic resonance imaging, Pathophysiology, positron emission tomography, postconcussion syndrome, priority journal, protein aggregation, quality of life, screening, tau protein, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Keays, G; Friedman, D; Gagnon, I
A 20-Year Comparison of Football-Related Injuries in American and Canadian Youth Aged 6 to 17 Years: A replication study Journal Article
In: Clinical Pediatrics, vol. 55, no. 7, pp. 603–613, 2016.
Abstract | Links | BibTeX | Tags: Adolescent, American, Article, CANADA, Canadian, Child, children, Concussion, dislocation, emergency care, Female, football, head injury, human, Injuries, major clinical study, Male, replication study, retrospective study, skull fracture, spine fracture, sport injury, Sports, sprain, traumatic brain injury, UNITED States
@article{Keays2016,
title = {A 20-Year Comparison of Football-Related Injuries in American and Canadian Youth Aged 6 to 17 Years: A replication study},
author = {Keays, G and Friedman, D and Gagnon, I},
doi = {10.1177/0009922815602631},
year = {2016},
date = {2016-01-01},
journal = {Clinical Pediatrics},
volume = {55},
number = {7},
pages = {603--613},
abstract = {Introduction. Little is known about Canadian youth football injuries. The objectives of this study were (a) to contrast the injuries in Canadian and American football players aged 6 to 17 years and (b) compare the injuries sustained during organized football with those in nonorganized football. Methods. Using a retrospective cohort design based on data from the Canadian Hospitals Injury Reporting and Prevention Program and the National Electronic Injury Surveillance System a comparison of injuries was made. Results. Trends in injuries were comparable. Proportions and odds of injuries were similar, except for a few exceptions. In Canada, more girls were injured and fractures were more prevalent. Compared with nonorganized football, organized football players were older, involved more males, and suffered more traumatic brain injuries and injuries to their lower extremities. Conclusion. Canadian and American youth football injuries were similar. The type of football, be it organized or nonorganized, has an impact on injuries. © 2016 The Author(s).},
keywords = {Adolescent, American, Article, CANADA, Canadian, Child, children, Concussion, dislocation, emergency care, Female, football, head injury, human, Injuries, major clinical study, Male, replication study, retrospective study, skull fracture, spine fracture, sport injury, Sports, sprain, traumatic brain injury, UNITED States},
pubstate = {published},
tppubtype = {article}
}
Baldwin, G; Breiding, M; Sleet, D
Using the public health model to address unintentional injuries and TBI: A perspective from the Centers for Disease Control and Prevention (CDC) Journal Article
In: NeuroRehabilitation, vol. 39, no. 3, pp. 345–349, 2016.
Abstract | Links | BibTeX | Tags: injury causes, Injury prevention, traumatic brain injury, unintentional injury
@article{Baldwin2016,
title = {Using the public health model to address unintentional injuries and TBI: A perspective from the Centers for Disease Control and Prevention (CDC)},
author = {Baldwin, G and Breiding, M and Sleet, D},
doi = {10.3233/NRE-161366},
year = {2016},
date = {2016-01-01},
journal = {NeuroRehabilitation},
volume = {39},
number = {3},
pages = {345--349},
abstract = {Traumatic brain injury (TBI) can have long term effects on mental and physical health, and can disrupt vocational, educational, and social functioning. TBIs can range from mild to severe and their effects can last many years after the initial injury. CDC seeks to reduce the burden of TBI from unintentional injuries through a focus on primary prevention, improved recognition and management, and intervening to improve health outcomes after TBI. CDC uses a 4-stage public health model to guide TBI prevention, moving from 1) surveillance of TBI, 2) identification of risk and protective factors for TBI, 3) development and testing of evidence-based interventions, to 4) bringing effective intervention to scale through widespread adoption. CDC's unintentional injury prevention activities focus on the prevention of sports-related concussions, motor vehicle crashes, and older adult falls. For concussion prevention, CDC developed Heads Up - an awareness initiative focusing on ways to prevent a concussion in sports, and identifying how to recognize and manage potential concussions. In motor vehicle injury prevention, CDC has developed a tool (MV PICCS) to calculate the expected number of injuries prevented and lives saved using various evidence-based motor vehicle crash prevention strategies. To help prevent TBI related to older adult falls, CDC has developed STEADI, an initiative to help primary care providers identify their patients' falls risk and provide effective interventions. In the future, CDC is focused on advancing our understanding of the public health burden of TBI through improved surveillance in order to produce more comprehensive estimates of the public health burden of TBI. © 2016 - IOS Press and the authors. All rights reserved.},
keywords = {injury causes, Injury prevention, traumatic brain injury, unintentional injury},
pubstate = {published},
tppubtype = {article}
}
Wallace, B; Lifshitz, J
Traumatic brain injury and vestibulo-ocular function: Current challenges and future prospects Journal Article
In: Eye and Brain, vol. 8, pp. 153–164, 2016.
Abstract | Links | BibTeX | Tags: Concussion, Ocular motor, Symptoms, traumatic brain injury, vestibular
@article{Wallace2016,
title = {Traumatic brain injury and vestibulo-ocular function: Current challenges and future prospects},
author = {Wallace, B and Lifshitz, J},
doi = {10.2147/EB.S82670},
year = {2016},
date = {2016-01-01},
journal = {Eye and Brain},
volume = {8},
pages = {153--164},
abstract = {Normal function of the vestibulo-ocular reflex (VOR) coordinates eye movement with head movement, in order to provide clear vision during motion and maintain balance. VOR is generated within the semicircular canals of the inner ear to elicit compensatory eye movements, which maintain stability of images on the fovea during brief, rapid head motion, otherwise known as gaze stability. Normal VOR function is necessary in carrying out activities of daily living (eg, walking and riding in a car) and is of particular importance in higher demand activities (eg, sports-related activities). Disruption or damage in the VOR can result in symptoms such as movement-related dizziness, blurry vision, difficulty maintaining balance with head movements, and even nausea. Dizziness is one of the most common symptoms following traumatic brain injury (TBI) and is considered a risk factor for a prolonged recovery. Assessment of the vestibular system is of particular importance following TBI, in conjunction with oculomotor control, due to the intrinsic neural circuitry that exists between the ocular and vestibular systems. The purpose of this article is to review the physiology of the VOR and the visual-vestibular symptoms associated with TBI and to discuss assessment and treatment guidelines for TBI. Current challenges and future prospects will also be addressed. © 2016 Wallace and Lifshitz.},
keywords = {Concussion, Ocular motor, Symptoms, traumatic brain injury, vestibular},
pubstate = {published},
tppubtype = {article}
}
Ikram, M Q; Sajjad, F H; Salardini, A
The head that wears the crown: Henry VIII and traumatic brain injury Journal Article
In: Journal of Clinical Neuroscience, vol. 28, pp. 16–19, 2016.
Abstract | Links | BibTeX | Tags: Henry VIII, HISTORY, sport concussion, traumatic brain injury
@article{Ikram2016,
title = {The head that wears the crown: Henry VIII and traumatic brain injury},
author = {Ikram, M Q and Sajjad, F H and Salardini, A},
doi = {10.1016/j.jocn.2015.10.035},
year = {2016},
date = {2016-01-01},
journal = {Journal of Clinical Neuroscience},
volume = {28},
pages = {16--19},
abstract = {Henry VIII of England is one of the most controversial figures in European history. He was born on 28 June 1491 as the second son of Henry VII and Elizabeth of York and became the heir to the English throne after his elder brother died prematurely. A contradictory picture of Henry's character emerges from history: the young Henry was a vigorous, generous and intelligent king who saw early military and naval successes. In contrast, in his later years he became cruel, petty and tyrannical. His political paranoia and military misjudgements are in direct contrast to his earlier successes and promise. Several hypotheses have been put forward regarding his transformation from a renaissance king to a later medieval tyrant, including endocrinopathies, psychiatric illnesses and traumatic brain injury. In this paper we examine the historical evidence linking the change in Henry's personality and health problems to traumatic brain injury. To our knowledge this is the first systematic neurological study of traumatic brain injury in Henry VIII. © 2016 Elsevier Ltd. All rights reserved.},
keywords = {Henry VIII, HISTORY, sport concussion, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Oliver, J M; Jones, M T; Kirk, K M; Gable, D A; Repshas, J T; Johnson, T A; Andréasson, U; Norgren, N; Blennow, K; Zetterberg, H
Serum Neurofilament Light in American Football Athletes over the Course of a Season Journal Article
In: Journal of Neurotrauma, vol. 33, no. 19, pp. 1784–1789, 2016.
Abstract | Links | BibTeX | Tags: adult brain injury, axonal injury, Biomarkers, Head trauma, traumatic brain injury
@article{Oliver2016,
title = {Serum Neurofilament Light in American Football Athletes over the Course of a Season},
author = {Oliver, J M and Jones, M T and Kirk, K M and Gable, D A and Repshas, J T and Johnson, T A and Andr\'{e}asson, U and Norgren, N and Blennow, K and Zetterberg, H},
doi = {10.1089/neu.2015.4295},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurotrauma},
volume = {33},
number = {19},
pages = {1784--1789},
abstract = {Despite being underreported, American football boasts the highest incidence of concussion among all team sports, likely due to exposure to head impacts that vary in number and magnitude over the season. This study compared a biological marker of head trauma in American football athletes with non-contact sport athletes and examined changes over the course of a season. Baseline serum neurofilament light polypeptide (NFL) was measured after 9 weeks of no contact and compared with a non-contact sport. Serum NFL was then measured over the course of the entire season at eight time-points coincident with expected changes in likelihood of increased head impacts. Data were compared between starters (n = 11) and non-starters (n = 9). Compared with non-starters (mean ± standard deviation) (7.30 ± 3.57 pg•mL-1) and controls (6.75 ± 1.68 pg•mL-1), serum NFL in starters (8.45 ± 5.90 pg•mL-1) was higher at baseline (mean difference; ±90% confidence interval) (1.69; ± 1.96 pg•mL-1 and 1.15; ± 1.4 pg•mL-1, respectively). Over the course of the season, an increase (effect size [ES] = 1.8; p \< 0.001) was observed post-camp relative to baseline (1.52 ± 1.18 pg•mL-1), which remained elevated until conference play, when a second increase was observed (ES = 2.6; p = 0.008) over baseline (4.82 ± 2.64 pg•mL-1). A lack of change in non-starters resulted in substantial differences between starters and non-starters over the course of the season. These data suggest that a season of collegiate American football is associated with elevations in serum NFL, which is indicative of axonal injury, as a result of head impacts. Copyright © 2016, Mary Ann Liebert, Inc.},
keywords = {adult brain injury, axonal injury, Biomarkers, Head trauma, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Vassilyadi, M; Macartney, G; Barrowman, N; Anderson, P; Dube, K
Symptom experience and quality of life in children after sport-related head injuries: A cross-sectional study Journal Article
In: Pediatric Neurosurgery, vol. 50, no. 4, pp. 196–203, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, adult, affect, Article, Athletic Injuries, behavior disorder, brain concussion, Child, clinical article, clinical assessment, cognitive defect, Cognitive Efficiency Index, complication, Concussion, Concussion Symptom Scale, controlled study, Craniocerebral Trauma, Cross-Sectional Studies, cross-sectional study, fatigue, Female, head injury, headache, human, Humans, Immediate Postconcussion Assessment and Cognitive, Likert scale, Male, memory disorder, mild traumatic brain injury, neuropsychological test, noise, Paediatric patients, Pediatric Quality of Life Inventory, postconcussion syndrome, priority journal, psychology, quality of life, rating scale, scoring system, Sport, sport injury, Sports, symptom, time factor, Time Factors, traumatic brain injury, trends
@article{Vassilyadi2015,
title = {Symptom experience and quality of life in children after sport-related head injuries: A cross-sectional study},
author = {Vassilyadi, M and Macartney, G and Barrowman, N and Anderson, P and Dube, K},
doi = {10.1159/000431232},
year = {2015},
date = {2015-01-01},
journal = {Pediatric Neurosurgery},
volume = {50},
number = {4},
pages = {196--203},
abstract = {Background: Sports are a major cause of concussions, and little is known about the symptom experience and health-related quality of life (HRQL) in children who remain symptomatic for over 3 months following such head injuries. Methods: A cross-sectional study of children aged 10-18 years was performed who were referred to the Neurosurgery Clinic at our centre following a head injury. Symptom experience was measured using the modified Concussion Symptom Scale, and HRQL was measured using the Pediatric Quality of Life Inventory (PedsQL). The Immediate Postconcussion Assessment and Cognitive Test (ImPACT) was administered to assess neurocognitive and neurobehavioural sequelae. Results: Symptoms with the highest mean symptom scores on a Likert scale of 0-6 in 35 children at the time of assessment included headaches (3.1), poor concentration (2.7), memory problems (2.1), fatigue (2.1) and sensitivity to noise (2.0). Compared with normative data, children in this study had ImPACT summary scores between the 28th and 38th percentiles and a comparably low Cognitive Efficiency Index score. Mean scores for females were consistently statistically significantly lower (p \< 0.05) than for males across all of the HRQL domains. Trouble falling asleep and memory problems explained 62% of the variance in the PedsQL total scores. Conclusions: Children continue to experience many symptoms at least 3 months following sport-related head injuries that significantly impact their HRQL and neurocognitive abilities. © 2015 S. Karger AG, Basel.},
keywords = {Adolescent, adult, affect, Article, Athletic Injuries, behavior disorder, brain concussion, Child, clinical article, clinical assessment, cognitive defect, Cognitive Efficiency Index, complication, Concussion, Concussion Symptom Scale, controlled study, Craniocerebral Trauma, Cross-Sectional Studies, cross-sectional study, fatigue, Female, head injury, headache, human, Humans, Immediate Postconcussion Assessment and Cognitive, Likert scale, Male, memory disorder, mild traumatic brain injury, neuropsychological test, noise, Paediatric patients, Pediatric Quality of Life Inventory, postconcussion syndrome, priority journal, psychology, quality of life, rating scale, scoring system, Sport, sport injury, Sports, symptom, time factor, Time Factors, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Daneshvar, Daniel H; Goldstein, Lee E; Kiernan, Patrick T; Stein, Thor D; McKee, Ann C
Post-traumatic neurodegeneration and chronic traumatic encephalopathy Journal Article
In: MCN: Molecular & Cellular Neuroscience, vol. 66, no. Part B, pp. 81–90, 2015, ISBN: 10447431.
Abstract | Links | BibTeX | Tags: A$beta$ beta-amyloid, AD Alzheimer's disease, APOE $epsilon$4 apolipoprotein $epsilon$4, axonal injury, Blast and impact neurotrauma, BRAIN -- Wounds & injuries, Brain trauma, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy NEURODEGENERATION, Concussion, CSF cerebrospinal fluid, CTE chronic traumatic encephalopathy, DIAGNOSIS, DISEASES -- Risk factors, DNA-binding proteins, MORTALITY, Motor neuron disease, mTBI mild traumatic brain injury, NERVOUS system -- Wounds & injuries, NFTs neurofibrillary tangles, p-tau hyperphosphorylated tau, PCS post-concussion syndrome, PET positron emission tomography, PHF-tau paired helical filament-tau, Posttraumatic neurodegeneration, tau protein, TBI traumatic brain injury, TDP-43 43 kDa TAR DNA-binding protein, traumatic brain injury
@article{Daneshvar2015,
title = {Post-traumatic neurodegeneration and chronic traumatic encephalopathy},
author = {Daneshvar, Daniel H and Goldstein, Lee E and Kiernan, Patrick T and Stein, Thor D and McKee, Ann C},
url = {http://search.ebscohost.com/login.aspx?direct=true\&db=aph\&AN=103136351\&site=ehost-live},
doi = {10.1016/j.mcn.2015.03.007},
isbn = {10447431},
year = {2015},
date = {2015-01-01},
journal = {MCN: Molecular \& Cellular Neuroscience},
volume = {66},
number = {Part B},
pages = {81--90},
abstract = {Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world. Concussive and subconcussive forms of closed-head injury due to impact or blast neurotrauma represent the most common types of TBI in civilian and military settings. It is becoming increasingly evident that TBI can lead to persistent, long-term debilitating effects, and in some cases, progressive neurodegeneration and chronic traumatic encephalopathy (CTE). The epidemiological literature suggests that a single moderate-to-severe TBI may be associated with accelerated neurodegeneration and increased risk of Alzheimer's disease, Parkinson's disease, or motor neuron disease. However, the pathologic phenotype of these post-traumatic neurodegenerations is largely unknown and there may be pathobiological differences between post-traumatic disease and the corresponding sporadic disorder. By contrast, the pathology of CTE is increasingly well known and is characterized by a distinctive pattern of progressive brain atrophy and accumulation of hyperphosphorylated tau neurofibrillary and glial tangles, dystrophic neurites, 43 kDa TAR DNA-binding protein (TDP-43) neuronal and glial aggregates, microvasculopathy, myelinated axonopathy, neuroinflammation, and white matter degeneration. Clinically, CTE is associated with behavioral changes, executive dysfunction, memory deficits, and cognitive impairments that begin insidiously and most often progress slowly over decades. Although research on the long-term effects of TBI is advancing quickly, the incidence and prevalence of post-traumatic neurodegeneration and CTE are unknown. Critical knowledge gaps include elucidation of pathogenic mechanisms, identification of genetic risk factors, and clarification of relevant variables\textemdashincluding age at exposure to trauma, history of prior and subsequent head trauma, substance use, gender, stress, and comorbidities\textemdashall of which may contribute to risk profiles and the development of post-traumatic neurodegeneration and CTE. This article is part of a Special Issue entitled 'Traumatic Brain Injury'. [ABSTRACT FROM AUTHOR] Copyright of MCN: Molecular \& Cellular Neuroscience is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)},
keywords = {A$beta$ beta-amyloid, AD Alzheimer's disease, APOE $epsilon$4 apolipoprotein $epsilon$4, axonal injury, Blast and impact neurotrauma, BRAIN -- Wounds \& injuries, Brain trauma, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy NEURODEGENERATION, Concussion, CSF cerebrospinal fluid, CTE chronic traumatic encephalopathy, DIAGNOSIS, DISEASES -- Risk factors, DNA-binding proteins, MORTALITY, Motor neuron disease, mTBI mild traumatic brain injury, NERVOUS system -- Wounds \& injuries, NFTs neurofibrillary tangles, p-tau hyperphosphorylated tau, PCS post-concussion syndrome, PET positron emission tomography, PHF-tau paired helical filament-tau, Posttraumatic neurodegeneration, tau protein, TBI traumatic brain injury, TDP-43 43 kDa TAR DNA-binding protein, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Dessy, A M; Rasouli, J; Choudhri, T F
Second Impact Syndrome: A Rare, Devastating Consequence of Repetitive Head Injuries Journal Article
In: Neurosurgery Quarterly, vol. 25, no. 3, pp. 423–426, 2015.
Abstract | Links | BibTeX | Tags: Article, brain concussion, clinical feature, Concussion, Dizziness, fatigue, headache, human, hyperemia, intracranial hypertension, memory disorder, Neck pain, neuropathology, neurosurgeon, neurosurgery, Pathophysiology, postconcussion syndrome, priority journal, respiratory failure, Second impact syndrome, sport injury, traumatic brain injury
@article{Dessy2015,
title = {Second Impact Syndrome: A Rare, Devastating Consequence of Repetitive Head Injuries},
author = {Dessy, A M and Rasouli, J and Choudhri, T F},
doi = {10.1097/WNQ.0000000000000085},
year = {2015},
date = {2015-01-01},
journal = {Neurosurgery Quarterly},
volume = {25},
number = {3},
pages = {423--426},
abstract = {Sports-related concussion has been viewed as a developing public health crisis in recent years. Underrecognition of concussions can lead to premature clearance for athletic participation. Second impact syndrome (SIS) represents a rare, yet devastating, potential outcome of premature return to play. SIS is a condition in which rapid brain swelling occurs as a result of a repeat head injury sustained before symptoms of a previous head injury have resolved. Within minutes of the second impact, diffuse cerebral swelling, brain herniation, and death can occur. There are \<20 documented cases of SIS in the world literature to date, and the general understanding of the syndrome is based largely on interpretation of anecdotal cases. This article reviews current understanding of the epidemiology and pathology of SIS. Given neurosurgeons' role in management of head trauma, it is essential that neurosurgeons acquire and maintain thorough knowledge of concussion diagnosis, treatment, and management. © 2014 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {Article, brain concussion, clinical feature, Concussion, Dizziness, fatigue, headache, human, hyperemia, intracranial hypertension, memory disorder, Neck pain, neuropathology, neurosurgeon, neurosurgery, Pathophysiology, postconcussion syndrome, priority journal, respiratory failure, Second impact syndrome, sport injury, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Russo, C R; Lathan, C E
An Evaluation of the Consistency and Reliability of the Defense Automated Neurocognitive Assessment Tool Journal Article
In: Applied Psychological Measurement, vol. 39, no. 7, pp. 566–572, 2015.
Abstract | Links | BibTeX | Tags: CNT, Cognitive Assessment, Concussion, reliability, screening, sports concussion, traumatic brain injury
@article{Russo2015,
title = {An Evaluation of the Consistency and Reliability of the Defense Automated Neurocognitive Assessment Tool},
author = {Russo, C R and Lathan, C E},
doi = {10.1177/0146621615577361},
year = {2015},
date = {2015-01-01},
journal = {Applied Psychological Measurement},
volume = {39},
number = {7},
pages = {566--572},
abstract = {A durable, portable, and field-hardened computerized neurocognitive test (CNT) called the Defense Automated Neurobehavioral Assessment (DANA) tool was recently developed to provide a practical means to conduct neurological and psychological assessment in situ. The psychometric properties of the DANA have been previously described. This present work discusses the test\textendashretest reliability of the DANA Rapid test battery, as administered to a homogeneous population of U.S. Air Force Academy football team players (N = 162) across the duration of the season. The intraclass correlation coefficient (ICC) metric of the DANA is compared with that from two different CNTs recently reported in Cole et al., and the implications of using the metric to interpret comparative test reliability among different CNTs are discussed. © 2015, © The Author(s) 2015.},
keywords = {CNT, Cognitive Assessment, Concussion, reliability, screening, sports concussion, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Kerr, Z Y; Mihalik, J P; Guskiewicz, K M; Rosamond, W D; Evenson, K R; Marshall, S W
Agreement between athlete-recalled and clinically documented concussion histories in former collegiate athletes Journal Article
In: American Journal of Sports Medicine, vol. 43, no. 3, pp. 606–613, 2015.
Abstract | Links | BibTeX | Tags: adult, athlete, Athletes, Athletic Injuries, brain concussion, cohort analysis, Cohort Studies, comparative study, concurrent validity, Concussion, EPIDEMIOLOGY, Female, human, Humans, injury, interpersonal communication, medical record, MEDICAL records, Mental Recall, psychology, recall, self report, sex difference, Sex Factors, traumatic brain injury, Truth Disclosure, Universities, university
@article{Kerr2015,
title = {Agreement between athlete-recalled and clinically documented concussion histories in former collegiate athletes},
author = {Kerr, Z Y and Mihalik, J P and Guskiewicz, K M and Rosamond, W D and Evenson, K R and Marshall, S W},
doi = {10.1177/0363546514562180},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Sports Medicine},
volume = {43},
number = {3},
pages = {606--613},
abstract = {Background: Athlete-recalled and clinically documented concussion histories have been used in research on former athletes, but both have limitations. Comparisons of these 2 types of concussion histories are needed to improve the accuracy of estimates of concussion history for future research and clinical care. Purpose: To estimate the agreement between athlete-recalled and clinically documented concussion histories during college and to explore reasons for differences. Study: Cohort study (diagnosis); Level of evidence, 3. Methods: Athlete-recalled concussion histories were provided by a convenience sample of 130 former collegiate athletes using an online questionnaire, and they were individually linked to previously collected clinical data that tracked medically diagnosed concussions at the host institution from 1996 to 2012. The intraclass correlation coefficient (ICC2,1) was used to assess agreement between athlete-recalled and clinically documented concussion histories. Descriptive analyses were performed to assess reasons for disagreement. Results: Agreement between athlete-recalled and clinically documented concussion histories was low (ICC2},
keywords = {adult, athlete, Athletes, Athletic Injuries, brain concussion, cohort analysis, Cohort Studies, comparative study, concurrent validity, Concussion, EPIDEMIOLOGY, Female, human, Humans, injury, interpersonal communication, medical record, MEDICAL records, Mental Recall, psychology, recall, self report, sex difference, Sex Factors, traumatic brain injury, Truth Disclosure, Universities, university},
pubstate = {published},
tppubtype = {article}
}
Phillips, S; Woessner, D
Sports-Related Traumatic Brain Injury Journal Article
In: Primary Care - Clinics in Office Practice, vol. 42, no. 2, pp. 243–248, 2015.
Abstract | Links | BibTeX | Tags: Anxiety, Athletic Injuries, attention deficit disorder, balance disorder, Balance Error Scoring System, benzodiazepine derivative, beta adrenergic receptor blocking agent, body equilibrium, brain concussion, Brain Injuries, clinical assessment tool, computer assisted tomography, Concussion, coordination disorder, depression, Dizziness, drowsiness, evaluation and follow up, headache, human, Humans, irritability, meclozine, memory disorder, mental concentration, Mild TBI guidelines, mild traumatic brain injury, mood change, mTBI, nausea, NFL Sideline Concussion Assessment Tool, nuclear magnetic resonance imaging, paracetamol, personal hygiene, postconcussion syndrome, Postconcussive syndrome, Primary Health Care, priority journal, procedures, recurrent disease, rest, Review, scoring system, Sideline Concussion Assessment Tool 3, Sideline concussion assessment tool 3 (SCAT3), sleep disorder, Sport, sport injury, Sports, Sports-related, Tomography, traumatic brain injury, tricyclic antidepressant agent, VERTIGO, visual disorder, vomiting, X-Ray Computed
@article{Phillips2015b,
title = {Sports-Related Traumatic Brain Injury},
author = {Phillips, S and Woessner, D},
doi = {10.1016/j.pop.2015.01.010},
year = {2015},
date = {2015-01-01},
journal = {Primary Care - Clinics in Office Practice},
volume = {42},
number = {2},
pages = {243--248},
abstract = {Concussions have garnered more attention in the medical literature, media, and social media. As such, in the nomenclature according to the Centers for Disease Control and Prevention, the term concussion has been supplanted by the term mild traumatic brain injury. Current numbers indicate that 1.7 million TBIs are documented annually, with estimates around 3 million annually (173,285 sports- and recreation-related TBIs among children and adolescents). The Sideline Concussion Assessment Tool 3 and the NFL Sideline Concussion Assessment Tool are commonly used sideline tools. © 2015 Elsevier Inc.},
keywords = {Anxiety, Athletic Injuries, attention deficit disorder, balance disorder, Balance Error Scoring System, benzodiazepine derivative, beta adrenergic receptor blocking agent, body equilibrium, brain concussion, Brain Injuries, clinical assessment tool, computer assisted tomography, Concussion, coordination disorder, depression, Dizziness, drowsiness, evaluation and follow up, headache, human, Humans, irritability, meclozine, memory disorder, mental concentration, Mild TBI guidelines, mild traumatic brain injury, mood change, mTBI, nausea, NFL Sideline Concussion Assessment Tool, nuclear magnetic resonance imaging, paracetamol, personal hygiene, postconcussion syndrome, Postconcussive syndrome, Primary Health Care, priority journal, procedures, recurrent disease, rest, Review, scoring system, Sideline Concussion Assessment Tool 3, Sideline concussion assessment tool 3 (SCAT3), sleep disorder, Sport, sport injury, Sports, Sports-related, Tomography, traumatic brain injury, tricyclic antidepressant agent, VERTIGO, visual disorder, vomiting, X-Ray Computed},
pubstate = {published},
tppubtype = {article}
}
Seidman, Daniel H; Burlingame, Jennifer; Yousif, Lina R; Donahue, Xinh P; Krier, Joshua; Rayes, Lydia J; Young, Rachel; Lilla, Muareen; Mazurek, Rochelle; Hittle, Kristie; McCloskey, Charles; Misra, Saroj; Shaw, Michael K
'Evaluation of the King–Devick Test as a concussion screening tool in high school football players' Corrigendum Journal Article
In: Journal of the Neurological Sciences, vol. 358, no. 1-2, pp. 540, 2015, ISBN: 0022-510X.
Abstract | Links | BibTeX | Tags: 2015, Athletes, diffuse axonal injury, football, High Schools, Neuropsychological assessment, Neuropsychological Tests, Post-Concussion Syndrome, screening, traumatic brain injury, Visual motor coordination
@article{Seidman2015a,
title = {'Evaluation of the King\textendashDevick Test as a concussion screening tool in high school football players' Corrigendum},
author = {Seidman, Daniel H and Burlingame, Jennifer and Yousif, Lina R and Donahue, Xinh P and Krier, Joshua and Rayes, Lydia J and Young, Rachel and Lilla, Muareen and Mazurek, Rochelle and Hittle, Kristie and McCloskey, Charles and Misra, Saroj and Shaw, Michael K},
doi = {10.1016/j.jns.2015.09.348},
isbn = {0022-510X},
year = {2015},
date = {2015-01-01},
journal = {Journal of the Neurological Sciences},
volume = {358},
number = {1-2},
pages = {540},
publisher = {Elsevier Science},
address = {Netherlands},
abstract = {Reports an error in 'Evaluation of the King\textendashDevick test as a concussion screening tool in high school football players' by Daniel H. Seidman, Jennifer Burlingame, Lina R. Yousif, Xinh P. Donahue, Joshua Krier, Lydia J. Rayes, Rachel Young, Muareen Lilla, Rochelle Mazurek, Kristie Hittle, Charles McCloskey, Saroj Misra and Michael K. Shaw (Journal of the Neurological Sciences, 2015[Sep][15], Vol 356[1-2], 97-101). In the original article, there was an error in the third paragraph. The sentence originally read 'The test subject reads a series of numbers in right-to-left and up-to-down order on three test cards.' This should read: 'The test subject reads a series of numbers in left-to-right and up-to-down order on three test cards.' The correction is present in the erratum. (The following abstract of the original article appeared in record [rid]2015-27894-001[/rid]). Objective: Concussion is the most common type of traumatic brain injury, and results from impact or impulsive forces to the head, neck or face. Due to the variability and subtlety of symptoms, concussions may go unrecognized or be ignored, especially with the pressure placed on athletes to return to competition. The King\textendashDevick (KD) test, an oculomotor test originally designed for reading evaluation, was recently validated as a concussion screening tool in collegiate athletes. A prospective study was performed using high school football players in an attempt to study the KD as a concussion screening tool in this younger population. Methods: 343 athletes from four local high school football teams were recruited to participate. These athletes were given baseline KD tests prior to competition. Individual demographic information was collected on the subjects. Standard team protocol was employed to determine if a concussion had occurred during competition. Immediately after diagnosis, the KD test was re-administered to the concussed athlete for comparison to baseline. Post-season testing was also performed in non-concussed individuals. Results: Of the 343 athletes, nine were diagnosed with concussions. In all concussed players, cumulative read times for the KD test were significantly increased (p \< 0.001). Post-season testing of non-concussed athletes revealed minimal change in read times relative to baseline. Univariate analysis revealed that history of concussion was the only demographic factor predictive of concussion in this cohort. Conclusion: The KD test is an accurate and easily administered sideline screening tool for concussion in adolescent football players. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2015, Athletes, diffuse axonal injury, football, High Schools, Neuropsychological assessment, Neuropsychological Tests, Post-Concussion Syndrome, screening, traumatic brain injury, Visual motor coordination},
pubstate = {published},
tppubtype = {article}
}
Morgan, C D; Zuckerman, S L; King, L E; Beaird, S E; Sills, A K; Solomon, G S
Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging Journal Article
In: Child's Nervous System, vol. 31, no. 12, pp. 2305–2309, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, arachnoid cyst, Article, brain, Brain Injury, Child, Computed tomography (CT) neuroimaging, computer assisted tomography, Computer-Assisted, Concussion, cost effectiveness analysis, cost utility analysis, DECISION making, diagnostic value, DSM-IV, Female, human, Humans, image processing, Magnetic Resonance Imaging, Magnetic resonance imaging (MRI), major clinical study, Male, mild traumatic brain injury, neuroimaging, neurosurgery, nuclear magnetic resonance, nuclear magnetic resonance imaging, pathology, Post-Concussion Syndrome, postconcussion syndrome, Preschool, preschool child, priority journal, Radiography, Retrospective Studies, retrospective study, Sports, STATISTICS, Tomography, traumatic brain injury, X ray, X-Ray Computed
@article{Morgan2015,
title = {Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging},
author = {Morgan, C D and Zuckerman, S L and King, L E and Beaird, S E and Sills, A K and Solomon, G S},
doi = {10.1007/s00381-015-2916-y},
year = {2015},
date = {2015-01-01},
journal = {Child's Nervous System},
volume = {31},
number = {12},
pages = {2305--2309},
abstract = {Purpose: Approximately 90% of concussions are transient, with symptoms resolving within 10\textendash14 days. However, a minority of patients remain symptomatic several months post-injury, a condition known as post-concussion syndrome (PCS). The treatment of these patients can be challenging. The goal of our study was to assess the utility and cost-effectiveness of neurologic imaging two or more weeks post-injury in a cohort of youth with PCS. Methods: We conducted a retrospective study of 52 pediatric patients with persistent post-concussion symptoms after 3 months. We collected demographics and neuroimaging results obtained greater than 2 weeks post-concussion. Neuroimaging ordered in the first 2 weeks post-concussion was excluded, except to determine the rate of re-imaging. Descriptive statistics and corresponding cost data were collected. Results: Of 52 patients with PCS, 23/52 (44 %) had neuroimaging at least 2 weeks after the initial injury, for a total of 32 diagnostic studies. In summary, 1/19 MRIs (5.3 %), 1/8 CTs (13 %), and 0/5 x-rays (0 %) yielded significant positive findings, none of which altered clinical management. Chronic phase neuroimaging estimated costs from these 52 pediatric patients totaled $129,025. We estimate the cost to identify a single positive finding was $21,000 for head CT and $104,500 for brain MRI. Conclusions: In this cohort of pediatric PCS patients, brain imaging in the chronic phase (defined as more than 2 weeks after concussion) was pursued in almost half the study sample, had low diagnostic yield, and had poor cost-effectiveness. Based on these results, outpatient management of pediatric patients with long-term post-concussive symptoms should rarely include repeat neuroimaging beyond the acute phase. © 2015, Springer-Verlag Berlin Heidelberg.},
keywords = {Adolescent, arachnoid cyst, Article, brain, Brain Injury, Child, Computed tomography (CT) neuroimaging, computer assisted tomography, Computer-Assisted, Concussion, cost effectiveness analysis, cost utility analysis, DECISION making, diagnostic value, DSM-IV, Female, human, Humans, image processing, Magnetic Resonance Imaging, Magnetic resonance imaging (MRI), major clinical study, Male, mild traumatic brain injury, neuroimaging, neurosurgery, nuclear magnetic resonance, nuclear magnetic resonance imaging, pathology, Post-Concussion Syndrome, postconcussion syndrome, Preschool, preschool child, priority journal, Radiography, Retrospective Studies, retrospective study, Sports, STATISTICS, Tomography, traumatic brain injury, X ray, X-Ray Computed},
pubstate = {published},
tppubtype = {article}
}
Wang, H; Wang, B; Jackson, K; Miller, C M; Hasadsri, L; Llano, D; Rubin, R; Zimmerman, J; Johnson, C; Sutton, B
A novel head-neck cooling device for concussion injury in contact sports Journal Article
In: Translational Neuroscience, vol. 6, pp. 20–31, 2015.
Abstract | Links | BibTeX | Tags: Acceleration, Article, brain concussion, Brain hypothermia, brain perfusion, brain temperature, brain tissue, clinical study, cognition, contact sport, cooling, diving, exercise, exercise induced hyperthermia, experimental study, government, head neck cooling device, Head-neck cooling, human, hyperthermia, induced hypothermia, mild traumatic brain injury, nonhuman, priority journal, randomized controlled trial (topic), sport injury, Sports, surface property, thermal regulating system, thermal stimulation, thermoregulation, traumatic brain injury
@article{Wang2015a,
title = {A novel head-neck cooling device for concussion injury in contact sports},
author = {Wang, H and Wang, B and Jackson, K and Miller, C M and Hasadsri, L and Llano, D and Rubin, R and Zimmerman, J and Johnson, C and Sutton, B},
doi = {10.1515/tnsci-2015-0004},
year = {2015},
date = {2015-01-01},
journal = {Translational Neuroscience},
volume = {6},
pages = {20--31},
abstract = {Emerging research on the long-term impact of concussions on athletes has allowed public recognition of the potentially devastating effects of these and other mild head injuries. Mild traumatic brain injury (mTBI) is a multifaceted disease for which management remains a clinical challenge. Recent pre-clinical and clinical data strongly suggest a destructive synergism between brain temperature elevation and mTBI; conversely, brain hypothermia, with its broader, pleiotropic effects, represents the most potent neuro-protectant in laboratory studies to date. Although well-established in selected clinical conditions, a systemic approach to accomplish regional hypothermia has failed to yield an effective treatment strategy in traumatic brain injury (TBI). Furthermore, although systemic hypothermia remains a potentially valid treatment strategy for moderate to severe TBIs, it is neither practical nor safe for mTBIs. Therefore, selective head-neck cooling may represent an ideal strategy to provide therapeutic benefits to the brain. Optimizing brain temperature management using a National Aeronautics and Space Administration (NASA) spacesuit spinoff head-neck cooling technology before and/or after mTBI in contact sports may represent a sensible, practical, and effective method to potentially enhance recover and minimize post-injury deficits. In this paper, we discuss and summarize the anatomical, physiological, preclinical, and clinical data concerning NASA spinoff head-neck cooling technology as a potential treatment for mTBIs, particularly in the context of contact sports. © 2015 Huan Wang et al., licensee De Gruyter Open.},
keywords = {Acceleration, Article, brain concussion, Brain hypothermia, brain perfusion, brain temperature, brain tissue, clinical study, cognition, contact sport, cooling, diving, exercise, exercise induced hyperthermia, experimental study, government, head neck cooling device, Head-neck cooling, human, hyperthermia, induced hypothermia, mild traumatic brain injury, nonhuman, priority journal, randomized controlled trial (topic), sport injury, Sports, surface property, thermal regulating system, thermal stimulation, thermoregulation, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Bondi, C O; Semple, B D; Noble-Haeusslein, L J; Osier, N D; Carlson, S W; Dixon, C E; Giza, C C; Kline, A E
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury Journal Article
In: Neuroscience and Biobehavioral Reviews, vol. 58, pp. 123–146, 2015.
Abstract | Links | BibTeX | Tags: 8 hydroxy 2 propylaminotetralin, Aggression, Attentional set-shifting test (AST), buspirone, Closed head injury, cognition, cognitive defect, cognitive function test, Concussion, conditioning, Controlled cortical impact (CCI), environmental enrichment, Environmental enrichment (EE), executive function, experimental disease, fear, Fluid percussion (FP), human, interpersonal communication, Memory, motor function test, nerve degeneration, neuropsychological test, Neurorehabilitation, nonhuman, outcome assessment, Pathophysiology, pediatrics, priority journal, rehabilitation care, Review, rodent, rotarod test, sensorimotor function, Social behavior, social disability, social interaction, spatial learning, TASK performance, traumatic brain injury
@article{Bondi2015,
title = {Found in translation: Understanding the biology and behavior of experimental traumatic brain injury},
author = {Bondi, C O and Semple, B D and Noble-Haeusslein, L J and Osier, N D and Carlson, S W and Dixon, C E and Giza, C C and Kline, A E},
doi = {10.1016/j.neubiorev.2014.12.004},
year = {2015},
date = {2015-01-01},
journal = {Neuroscience and Biobehavioral Reviews},
volume = {58},
pages = {123--146},
abstract = {The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided. © 2014 Elsevier Ltd.},
keywords = {8 hydroxy 2 propylaminotetralin, Aggression, Attentional set-shifting test (AST), buspirone, Closed head injury, cognition, cognitive defect, cognitive function test, Concussion, conditioning, Controlled cortical impact (CCI), environmental enrichment, Environmental enrichment (EE), executive function, experimental disease, fear, Fluid percussion (FP), human, interpersonal communication, Memory, motor function test, nerve degeneration, neuropsychological test, Neurorehabilitation, nonhuman, outcome assessment, Pathophysiology, pediatrics, priority journal, rehabilitation care, Review, rodent, rotarod test, sensorimotor function, Social behavior, social disability, social interaction, spatial learning, TASK performance, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Stone Jr., M E; Safadjou, S; Farber, B; Velazco, N; Man, J; Reddy, S H; Todor, R; Teperman, S
Utility of the Military Acute Concussion Evaluation as a screening tool for mild traumatic brain injury in a civilian trauma population Journal Article
In: Journal of Trauma and Acute Care Surgery, vol. 79, no. 1, pp. 147–151, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, adult, aged, Alcoholic Intoxication, amnesia, Article, assessment of humans, brain concussion, Brain Injuries, clinical assessment tool, computer assisted tomography, Concussion screening, Confounding Factors (Epidemiology), controlled study, DATA analysis, Demography, diagnostic test accuracy study, Dizziness, emergency health service, Female, Head, headache, hospital admission, human, Humans, injury severity, irritability, major clinical study, Male, middle aged, mild traumatic brain injury, Military Acute Concussion Evaluation, military medicine, nausea and vomiting, predictive value, priority journal, quality control, receiver operating characteristic, ROC Curve, screening test, Sensitivity and Specificity, traumatic brain injury, unconsciousness, Urban Population, visual disorder, Young Adult
@article{StoneJr.2015,
title = {Utility of the Military Acute Concussion Evaluation as a screening tool for mild traumatic brain injury in a civilian trauma population},
author = {{Stone Jr.}, M E and Safadjou, S and Farber, B and Velazco, N and Man, J and Reddy, S H and Todor, R and Teperman, S},
doi = {10.1097/TA.0000000000000679},
year = {2015},
date = {2015-01-01},
journal = {Journal of Trauma and Acute Care Surgery},
volume = {79},
number = {1},
pages = {147--151},
abstract = {BACKGROUND: Mild traumatic brain injury (mTBI) constitutes 75% of more than 1.5 million traumatic brain injuries annually. There exists no consensus on point-of-care screening for mTBI. The Military Acute Concussion Evaluation (MACE) is a quick and easy test used by the US Army to screen for mTBI; however, its utility in civilian trauma is unclear. It has two parts: a history section and the Standardized Assessment of Concussion (SAC) score (0-30) previously validated in sports injury. As a performance improvement project, our institution sought to evaluate the MACE as a concussion screening tool that could be used by housestaff in a general civilian trauma population. METHODS: From June 2013 to May 2014, patients 18 years to 65 years old with suspected concussion were given the MACE within 72 hours of admission to our urban Level I trauma center. Patients with a positive head computed tomography were excluded. Demographic data and MACE scores were recorded in prospect. Concussion was defined as loss of consciousness and/or posttraumatic amnesia; concussed patients were compared with those nonconcussed. Sensitivity and specificity for each respective MACE score were used to plot a receiver operating characteristic (ROC) curve. An ROC curve area of 0.8 was set as the benchmark for a good screening test to distinguish concussion from nonconcussion. RESULTS: There were 84 concussions and 30 nonconcussed patients. Both groups were similar; however, the concussion group had a lower mean MACE score than the nonconcussed patients. Data analysis demonstrated the sensitivity and specificity of a range of MACE scores used to generate an ROC curve area of only 0.65. CONCLUSION: The MACE showed a lower mean score for individuals with concussion, defined by loss of consciousness and/or posttraumatic amnesia. However, the ROC curve area of 0.65 highly suggests that MACE alone would be a poor screening test for mTBI in a general civilian trauma population. LEVEL OF EVIDENCE: Diagnostic study, level II. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {Adolescent, adult, aged, Alcoholic Intoxication, amnesia, Article, assessment of humans, brain concussion, Brain Injuries, clinical assessment tool, computer assisted tomography, Concussion screening, Confounding Factors (Epidemiology), controlled study, DATA analysis, Demography, diagnostic test accuracy study, Dizziness, emergency health service, Female, Head, headache, hospital admission, human, Humans, injury severity, irritability, major clinical study, Male, middle aged, mild traumatic brain injury, Military Acute Concussion Evaluation, military medicine, nausea and vomiting, predictive value, priority journal, quality control, receiver operating characteristic, ROC Curve, screening test, Sensitivity and Specificity, traumatic brain injury, unconsciousness, Urban Population, visual disorder, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Liu, C Y; Law, M; Romano, R
Rational approach to understanding and preventing sports-related traumatic brain injuries Journal Article
In: World Neurosurgery, vol. 84, no. 6, pp. 1556–1557, 2015.
Links | BibTeX | Tags: accelerometer, ACCELEROMETRY, biological marker, brain, brain concussion, brain hemorrhage, cognitive defect, Diffusion Tensor Imaging, Electroencephalography, emergency health service, Female, Head Protective Devices, Helmet, high risk patient, human, Humans, Injuries, Male, neuroimaging, neuromodulation, neuroprotective agent, nuclear magnetic resonance imaging, Occupational Exposure, protective equipment, Review, risk factor, risk reduction, SAFETY, skiing, Snowboarding, sport injury, Traumatic, traumatic brain injury, viscoelastic substance
@article{Liu2015,
title = {Rational approach to understanding and preventing sports-related traumatic brain injuries},
author = {Liu, C Y and Law, M and Romano, R},
doi = {10.1016/j.wneu.2015.07.076},
year = {2015},
date = {2015-01-01},
journal = {World Neurosurgery},
volume = {84},
number = {6},
pages = {1556--1557},
keywords = {accelerometer, ACCELEROMETRY, biological marker, brain, brain concussion, brain hemorrhage, cognitive defect, Diffusion Tensor Imaging, Electroencephalography, emergency health service, Female, Head Protective Devices, Helmet, high risk patient, human, Humans, Injuries, Male, neuroimaging, neuromodulation, neuroprotective agent, nuclear magnetic resonance imaging, Occupational Exposure, protective equipment, Review, risk factor, risk reduction, SAFETY, skiing, Snowboarding, sport injury, Traumatic, traumatic brain injury, viscoelastic substance},
pubstate = {published},
tppubtype = {article}
}
Caron, A M; Stephenson, R
Sleep deprivation does not affect neuronal susceptibility to mild traumatic brain injury in the rat Journal Article
In: Nature and Science of Sleep, vol. 7, pp. 63–72, 2015.
Abstract | Links | BibTeX | Tags: Concussion, Dark neuron, NEURODEGENERATION, Rat cortex, sleep deprivation, traumatic brain injury
@article{Caron2015b,
title = {Sleep deprivation does not affect neuronal susceptibility to mild traumatic brain injury in the rat},
author = {Caron, A M and Stephenson, R},
doi = {10.2147/NSS.S82888},
year = {2015},
date = {2015-01-01},
journal = {Nature and Science of Sleep},
volume = {7},
pages = {63--72},
abstract = {Mild and moderate traumatic brain injuries (TBIs) (and concussion) occur frequently as a result of falls, automobile accidents, and sporting activities, and are a major cause of acute and chronic disability. Fatigue and excessive sleepiness are associated with increased risk of accidents, but it is unknown whether prior sleep debt also affects the pathophysiological outcome of concussive injury. Using the "dark neuron" (DN) as a marker of reversible neuronal damage, we tested the hypothesis that acute (48 hours) total sleep deprivation (TSD) and chronic sleep restriction (CSR; 10 days, 6-hour sleep/day) affect DN formation following mild TBI in the rat. TSD and CSR were administered using a walking wheel apparatus. Mild TBI was administered under anesthesia using a weight-drop impact model, and the acute neuronal response was observed without recovery. DNs were detected using standard bright-field microscopy with toluidine blue stain following appropriate tissue fixation. DN density was low under home cage and sleep deprivation control conditions (respective median DN densities, 0.14% and 0.22% of neurons), and this was unaffected by TSD alone (0.1%). Mild TBI caused significantly higher DN densities (0.76%), and this was unchanged by preexisting acute or chronic sleep debt (TSD, 0.23%; CSR, 0.7%). Thus, although sleep debt may be predicted to increase the incidence of concussive injury, the present data suggest that sleep debt does not exacerbate the resulting neuronal damage. © 2015 Caron and Stephenson.},
keywords = {Concussion, Dark neuron, NEURODEGENERATION, Rat cortex, sleep deprivation, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
DiFazio, M; Silverberg, N D; Kirkwood, M W; Bernier, R; Iverson, G L
Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes? Journal Article
In: Clinical Pediatrics, vol. 55, no. 5, pp. 443–451, 2015.
Abstract | Links | BibTeX | Tags: activity restriction, Anxiety, Article, athletic trainer, brain concussion, case report, Concussion, daily life activity, depression, Dizziness, evolution, exercise, expectation, headache, human, Male, mood disorder, mTBI, nocebo effect, patient harm, PHYSICAL ACTIVITY, practice guideline, prolonged activity restriction, psychological aspect, Rehabilitation, rest, school, traumatic brain injury, Treatment, treatment outcome, wrestling
@article{DiFazio2015,
title = {Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes?},
author = {DiFazio, M and Silverberg, N D and Kirkwood, M W and Bernier, R and Iverson, G L},
doi = {10.1177/0009922815589914},
year = {2015},
date = {2015-01-01},
journal = {Clinical Pediatrics},
volume = {55},
number = {5},
pages = {443--451},
abstract = {The current treatment of concussion or mild traumatic brain injury (mTBI) is primarily based on expert consensus. Most clinical practice guidelines advise cognitive and physical rest after injury including withdrawal from normal life activities such as school attendance, sports participation, and technology use until symptoms resolve. Some individuals who sustain an mTBI experience persistent physical, cognitive, and mental health problems. Activity restriction itself may contribute to protracted recovery and other complications. Williamson's Activity Restriction Model of Depression, formulated more than 20 years ago, is central to this hypothesis. We review research evidence for potential harms of prolonged activity restriction and report an mTBI case as an example of how an "activity restriction cascade" can unfold. According to this model, psychological consequences of removal from validating life activities, combined with physical deconditioning, contribute to the development and persistence of postconcussive symptoms after mTBI in some youth. A modification to mTBI guidelines that emphasizes prompt reengagement in life activities as tolerated is encouraged. © SAGE Publications.},
keywords = {activity restriction, Anxiety, Article, athletic trainer, brain concussion, case report, Concussion, daily life activity, depression, Dizziness, evolution, exercise, expectation, headache, human, Male, mood disorder, mTBI, nocebo effect, patient harm, PHYSICAL ACTIVITY, practice guideline, prolonged activity restriction, psychological aspect, Rehabilitation, rest, school, traumatic brain injury, Treatment, treatment outcome, wrestling},
pubstate = {published},
tppubtype = {article}
}
Oeur, R A; Karton, C; Post, A; Rousseau, P; Hoshizaki, T B; Marshall, S; Brien, S E; Smith, A; Cusimano, M D; Gilchrist, M D
In: Journal of Neurosurgery, vol. 123, no. 2, pp. 415–422, 2015.
Abstract | Links | BibTeX | Tags: accident, Accident reconstruction, accidental injury, Accidents, Adolescent, adult, Article, Biomechanical Phenomena, Biomechanics, brain, brain concussion, brain stem, brain tissue, Cerebellum, clinical article, comparative study, Concussion, controlled study, Female, finite element analysis, Finite element modelling, gray matter, Hematoma, human, Humans, Hybrid iii headform, injury severity, laboratory test, Male, Mechanical, mechanical stress, middle aged, pathology, Pathophysiology, Persistent postconcussive symptoms, PHYSIOLOGY, Post Hoc Analysis, Post-Concussion Syndrome, postconcussion syndrome, priority journal, shear stress, simulation, SPORTS medicine, STATISTICAL significance, Stress, stress strain relationship, Subdural, subdural hematoma, traumatic brain injury, white matter, Young Adult
@article{Oeur2015,
title = {A comparison of head dynamic response and brain tissue stress and strain using accident reconstructions for concussion, concussion with persistent postconcussive symptoms, and subdural hematoma},
author = {Oeur, R A and Karton, C and Post, A and Rousseau, P and Hoshizaki, T B and Marshall, S and Brien, S E and Smith, A and Cusimano, M D and Gilchrist, M D},
doi = {10.3171/2014.10.JNS14440},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurosurgery},
volume = {123},
number = {2},
pages = {415--422},
abstract = {Object Concussions typically resolve within several days, but in a few cases the symptoms last for a month or longer and are termed persistent postconcussive symptoms (PPCS). These persisting symptoms may also be associated with more serious brain trauma similar to subdural hematoma (SDH). The objective of this study was to investigate the head dynamic and brain tissue responses of injury reconstructions resulting in concussion, PPCS, and SDH. Methods Reconstruction cases were obtained from sports medicine clinics and hospitals. All subjects received a direct blow to the head resulting in symptoms. Those symptoms that resolved in 9 days or fewer were defined as concussions (n = 3). Those with symptoms lasting longer than 18 months were defined as PPCS (n = 3), and 3 patients presented with SDHs (n = 3). A Hybrid III headform was used in reconstruction to obtain linear and rotational accelerations of the head. These dynamic response data were then input into the University College Dublin Brain Trauma Model to calculate maximum principal strain and von Mises stress. A Kruskal-Wallis test followed by Tukey post hoc tests were used to compare head dynamic and brain tissue responses between injury groups. Statistical significance was set at p \< 0.05. Results A significant difference was identified for peak resultant linear and rotational acceleration between injury groups. Post hoc analyses revealed the SDH group had higher linear and rotational acceleration responses (316 g and 23,181 rad/sec2, respectively) than the concussion group (149 g and 8111 rad/sec2, respectively; p \< 0.05). No significant differences were found between groups for either brain tissue measures of maximum principal strain or von Mises stress. Conclusions The reconstruction of accidents resulting in a concussion with transient symptoms (low severity) and SDHs revealed a positive relationship between an increase in head dynamic response and the risk for more serious brain injury. This type of relationship was not found for brain tissue stress and strain results derived by finite element analysis. Future research should be undertaken using a larger sample size to confirm these initial findings. Understanding the relationship between the head dynamic and brain tissue response and the nature of the injury provides important information for developing strategies for injury prevention. © AANS, 2015.},
keywords = {accident, Accident reconstruction, accidental injury, Accidents, Adolescent, adult, Article, Biomechanical Phenomena, Biomechanics, brain, brain concussion, brain stem, brain tissue, Cerebellum, clinical article, comparative study, Concussion, controlled study, Female, finite element analysis, Finite element modelling, gray matter, Hematoma, human, Humans, Hybrid iii headform, injury severity, laboratory test, Male, Mechanical, mechanical stress, middle aged, pathology, Pathophysiology, Persistent postconcussive symptoms, PHYSIOLOGY, Post Hoc Analysis, Post-Concussion Syndrome, postconcussion syndrome, priority journal, shear stress, simulation, SPORTS medicine, STATISTICAL significance, Stress, stress strain relationship, Subdural, subdural hematoma, traumatic brain injury, white matter, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Rapp, P E; Keyser, D O; Albano, A; Hernandez, R; Gibson, D B; Zambon, R A; David Hairston, W; Hughes, J D; Krystal, A; Nichols, A S
Traumatic brain injury detection using electrophysiological methods Journal Article
In: Frontiers in Human Neuroscience, vol. 9, no. FEB, 2015.
Abstract | Links | BibTeX | Tags: Article, brain electrophysiology, computer assisted tomography, Concussion, connectome, diagnostic accuracy, EEG, electroencephalogram, Electroencephalography, event related potential, Event-Related Potentials, evidence based medicine, executive function, human, intermethod comparison, latent period, neuroimaging, neuropathology, Non-linear dynamical analysis, nuclear magnetic resonance imaging, QEEG, Signal Processing, traumatic brain injury
@article{Rapp2015,
title = {Traumatic brain injury detection using electrophysiological methods},
author = {Rapp, P E and Keyser, D O and Albano, A and Hernandez, R and Gibson, D B and Zambon, R A and {David Hairston}, W and Hughes, J D and Krystal, A and Nichols, A S},
doi = {10.3389/fnhum.2015.00011},
year = {2015},
date = {2015-01-01},
journal = {Frontiers in Human Neuroscience},
volume = {9},
number = {FEB},
abstract = {Measuring neuronal activity with electrophysiological methods may be useful in detecting neurological dysfunctions, such as mild traumatic brain injury (mTBI).This approach may be particularly valuable for rapid detection in at-risk populations including military service members and athletes. Electrophysiological methods, such as quantitative electroencephalography (qEEG) and recording event-related potentials (ERPs) may be promising; however, the field is nascent and significant controversy exists on the efficacy and accuracy of the approaches as diagnostic tools. For example, the specific measures derived from an electroencephalogram (EEG) that are most suitable as markers of dysfunction have not been clearly established. A study was conducted to summarize and evaluate the statistical rigor of evidence on the overall utility of qEEG as an mTBI detection tool. The analysis evaluated qEEG measures/parameters that may be most suitable as fieldable diagnostic tools, identified other types of EEG measures and analysis methods of promise, recommended specific measures and analysis methods for further development as mTBI detection tools, identified research gaps in the field, and recommended future research and development thrust areas. The qEEG study group formed the following conclusions: (1) Individual qEEG measures provide limited diagnostic utility for mTBI. However, many measures can be important features of qEEG discriminant functions, which do show significant promise as mTBI detection tools. (2) ERPs offer utility in mTBI detection. In fact, evidence indicates that ERPs can identify abnormalities in cases where EEGs alone are non-disclosing. (3)The standard mathematical procedures used in the characterization of mTBI EEGs should be expanded to incorporate newer methods of analysis including non-linear dynamical analysis, complexity measures, analysis of causal interactions, graph theory, and information dynamics. (4) Reports of high specificity in qEEG evaluations of TBI must be interpreted with care. High specificities have been reported in carefully constructed clinical studies in which healthy controls were compared against a carefully selected TBI population. The published literature indicates, however, that similar abnormalities in qEEG measures are observed in other neuropsychiatric disorders. While it may be possible to distinguish a clinical patient from a healthy control participant with this technology, these measures are unlikely to discriminate between, for example, major depressive disorder, bipolar disorder, or TBI. The specificities observed in these clinical studies may well be lost in real world clinical practice. (5)The absence of specificity does not preclude clinical utility. The possibility of use as a longitudinal measure of treatment response remains. However, efficacy as a longitudinal clinical measure does require acceptable test-retest reliability. To date, very few test-retest reliability studies have been published with qEEG data obtained from TBI patients or from healthy controls. This is a particular concern because high variability is a known characteristic of the injured central nervous system. © 2015 Rapp, Keyser , Albano, Hernandez, Gibson, Zambon, Hairston, Hughes, Krystal and Nichols.},
keywords = {Article, brain electrophysiology, computer assisted tomography, Concussion, connectome, diagnostic accuracy, EEG, electroencephalogram, Electroencephalography, event related potential, Event-Related Potentials, evidence based medicine, executive function, human, intermethod comparison, latent period, neuroimaging, neuropathology, Non-linear dynamical analysis, nuclear magnetic resonance imaging, QEEG, Signal Processing, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Boddé, Tamar Roos Annemarie; Scheinberg, Adam; McKinlay, Audrey
A critical examination of mild traumatic brain injury management information distributed to parents Journal Article
In: Developmental Neuropsychology, vol. 40, no. 4, pp. 254–271, 2015, ISBN: 8756-5641 1532-6942.
Abstract | Links | BibTeX | Tags: 2015, MANAGEMENT, mild traumatic brain injury, Parents, pediatrics, traumatic brain injury
@article{Bodde2015,
title = {A critical examination of mild traumatic brain injury management information distributed to parents},
author = {Bodd\'{e}, Tamar Roos Annemarie and Scheinberg, Adam and McKinlay, Audrey},
doi = {10.1080/87565641.2015.1034864},
isbn = {8756-5641
1532-6942},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {4},
pages = {254--271},
publisher = {Taylor \& Francis},
address = {United Kingdom},
abstract = {Considerable confusion surrounds pediatric mild traumatic brain injury (mTBI) and its management. This study provides a comparison between mTBI management pamphlets distributed by Australasian hospitals and the Centers for Disease Control and Prevention (CDC) gold standard. Twenty-seven different pamphlets were collected from 96 hospitals in Australia and New Zealand and were assessed for readability, compliance with nine CDC criteria, and inclusion of confusing or incorrect information. None of the pamphlets completely complied with the CDC criteria and all included incorrect information. Findings demonstrate that mTBI management information in Australasia needs urgent revision, and evaluation in other countries is strongly advised. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2015, MANAGEMENT, mild traumatic brain injury, Parents, pediatrics, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}