Vestberg, Torbjörn; Reinebo, Gustaf; Maurex, Liselotte; Ingvar, Martin; Petrovic, Predrag
Core executive functions are associated with success in young elite soccer players Journal Article
In: PLoS ONE, vol. 12, no. 2, pp. 1–13, 2017, ISBN: 19326203.
Abstract | Links | BibTeX | Tags: adolescents, Age groups, attention, behavior, Biology and life sciences, cognition, Cognitive neuroscience, Cognitive psychology, Cognitive science, Creativity, Inhibitions, Learning and memory, Memory, Neuroscience, People and places, Population groupings, psychology, recreation, Research Article, Social sciences, Sports, Sports science, working memory
@article{Vestberg2017,
title = {Core executive functions are associated with success in young elite soccer players},
author = {Vestberg, Torbj\"{o}rn and Reinebo, Gustaf and Maurex, Liselotte and Ingvar, Martin and Petrovic, Predrag},
doi = {10.1371/journal.pone.0170845},
isbn = {19326203},
year = {2017},
date = {2017-01-01},
journal = {PLoS ONE},
volume = {12},
number = {2},
pages = {1--13},
publisher = {Public Library of Science},
abstract = {Physical capacity and coordination cannot alone predict success in team sports such as soccer. Instead, more focus has been directed towards the importance of cognitive abilities, and it has been suggested that executive functions (EF) are fundamentally important for success in soccer. However, executive functions are going through a steep development from adolescence to adulthood. Moreover, more complex EF involving manipulation of information (higher level EF) develop later than simple executive functions such as those linked to simple working memory capacity (Core EF). The link between EF and success in young soccer players is therefore not obvious. In the present study we investigated whether EF are associated with success in soccer in young elite soccer players. We performed tests measuring core EF (a demanding working memory task involving a variable n-back task; dWM) and higher level EF (Design Fluency test; DF). Color-Word Interference Test and Trail Making Test were performed on an exploratory level as they contain a linguistic element. The lower level EF test (dWM) was taken from CogStateSport computerized concussion testing and the higher level EF test (DF) was from Delis-Kaplan Executive Function System test battery (D-KEFS). In a group of young elite soccer players (n = 30; aged 12\textendash19 years) we show that they perform better than the norm in both the dWM (+0.49 SD) and DF (+0.86 SD). Moreover, we could show that both dWM and DF correlate with the number of goals the players perform during the season. The effect was more prominent for dWM (r = 0.437) than for DF (r = 0.349), but strongest for a combined measurement (r = 0.550). The effect was still present when we controlled for intelligence, length and age in a partial correlation analysis. Thus, our study suggests that both core and higher level EF may predict success in soccer also in young players. [ABSTRACT FROM AUTHOR]},
keywords = {adolescents, Age groups, attention, behavior, Biology and life sciences, cognition, Cognitive neuroscience, Cognitive psychology, Cognitive science, Creativity, Inhibitions, Learning and memory, Memory, Neuroscience, People and places, Population groupings, psychology, recreation, Research Article, Social sciences, Sports, Sports science, working memory},
pubstate = {published},
tppubtype = {article}
}
Gerrard, Paul B; Iverson, Grant L; Atkins, Joseph E; Maxwell, Bruce A; Zafonte, Ross; Schatz, Philip; Berkner, Paul D
Factor Structure of ImPACT® in Adolescent Student Athletes Journal Article
In: Archives of Clinical Neuropsychology, vol. 32, no. 1, pp. 117–122, 2017, ISBN: 08876177.
Abstract | Links | BibTeX | Tags: Athletes -- Psychology, ATTENTION-deficit hyperactivity disorder, Cognitive, COGNITIVE testing, Concussion, FACTOR analysis, Headache -- Treatment, Memory, Neuropsychological Tests, Sports
@article{Gerrard2017,
title = {Factor Structure of ImPACT® in Adolescent Student Athletes},
author = {Gerrard, Paul B and Iverson, Grant L and Atkins, Joseph E and Maxwell, Bruce A and Zafonte, Ross and Schatz, Philip and Berkner, Paul D},
doi = {10.1093/arclin/acw097},
isbn = {08876177},
year = {2017},
date = {2017-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {32},
number = {1},
pages = {117--122},
abstract = {Objective: ImPACT® (Immediate Post-Concussion Assessment and Cognitive Testing) is a computerized neuropsychological screening battery, which is widely used to measure the acute effects of sport-related concussion and to monitor recovery from injury. This study examined the factor structure of ImPACT® in several samples of high school student athletes. We hypothesized that a 2-factor structure would be present in all samples. Method: A sample of 4,809 adolescent student athletes was included, and subgroups with a history of treatment for headaches or a self-reported history of learning problems or attention-deficit hyperactivity disorder were analyzed separately. Exploratory principal axis factor analyses with Promax rotations were used. Results: As hypothesized, both the combination of Verbal Memory and Visual Memory Composite scores loaded on one (Memory) factor, while Visual Motor Speed and Reaction Time loaded on a different (Speed) factor, in the total sample and in all subgroups. Conclusion: These results provide reasonably compelling evidence, across multiple samples, which ImPACT® measures 2 distinct factors: memory and speed. [ABSTRACT FROM AUTHOR]},
keywords = {Athletes -- Psychology, ATTENTION-deficit hyperactivity disorder, Cognitive, COGNITIVE testing, Concussion, FACTOR analysis, Headache -- Treatment, Memory, Neuropsychological Tests, Sports},
pubstate = {published},
tppubtype = {article}
}
Le Berre, A P; Sullivan, E V
Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory Journal Article
In: Neuropsychology Review, vol. 26, no. 4, pp. 420–431, 2016.
Abstract | Links | BibTeX | Tags: Alcoholism, Anosognosia, brain, Memory, Metamemory
@article{LeBerre2016,
title = {Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory},
author = {{Le Berre}, A P and Sullivan, E V},
doi = {10.1007/s11065-016-9323-3},
year = {2016},
date = {2016-01-01},
journal = {Neuropsychology Review},
volume = {26},
number = {4},
pages = {420--431},
abstract = {In addiction, notably Alcohol Use Disorder (AUD), patients often have a tendency to fail to acknowledge the reality of the disease and to minimize the physical, psychological, and social difficulties attendant to chronic alcohol consumption. This lack of awareness can reduce the chances of initiating and maintaining sobriety. Presented here is a model focusing on compromised awareness in individuals with AUD of mild to moderate cognitive deficits, in particular, for episodic memory impairment\textemdashthe ability to learn new information, such as recent personal experiences. Early in abstinence, alcoholics can be unaware of their memory deficits and overestimate their mnemonic capacities, which can be investigated with metamemory paradigms. Relevant neuropsychological and neuroimaging results considered suggest that the alcoholics’ impairment of awareness of their attenuated memory function can be a clinical manifestation explained mechanistically by neurobiological factors, including compromise of brain systems that result in a mild form of mnemonic anosognosia. Specifically, unawareness of memory impairment in AUD may result from a lack of personal knowledge updating attributable to damage in brain regions or connections supporting conscious recollection in episodic memory. Likely candidates are posterior parietal and medial frontal regions known to be integral part of the Default Mode Network (DMN) and the insula leading to an impaired switching mechanism between the DMN and the Central-Executive Control (i.e., Lateral Prefronto-Parietal) Network. The cognitive concepts and neural substrates noted for addictive disorders may also be relevant for problems in self-identification of functional impairment resulting from injury following war-related blast, sport-related concussion, and insidiously occurring dementia. © 2016, Springer Science+Business Media New York.},
keywords = {Alcoholism, Anosognosia, brain, Memory, Metamemory},
pubstate = {published},
tppubtype = {article}
}
Raikes, A C; Schaefer, S Y
Phasic electrodermal activity during the standardized assessment of concussion (SAC) Journal Article
In: Journal of Athletic Training, vol. 51, no. 7, pp. 533–539, 2016.
Abstract | Links | BibTeX | Tags: Memory, Traumatic Brain Injuries, Wireless technology
@article{Raikes2016,
title = {Phasic electrodermal activity during the standardized assessment of concussion (SAC)},
author = {Raikes, A C and Schaefer, S Y},
doi = {10.4085/1062-6050-51.8.09},
year = {2016},
date = {2016-01-01},
journal = {Journal of Athletic Training},
volume = {51},
number = {7},
pages = {533--539},
abstract = {Context: The long-term effects of concussion on brain function during cognitive tasks are not fully understood and neuroimaging findings are equivocal. Some images show hyperactivation of prefrontal brain regions in previously concussed individuals relative to controls, suggesting increased cognitive resource allocation. Others show prefrontal hypoactivation and hyperactivation in other regions as a presumed compensatory mechanism. Given the relationship between sympathetic arousal and neural activation, physiologic measures of arousal, such as electrodermal activity, may provide additional insight into the brain's functional changes in those with a history of concussion. Objective: To quantify differences in electrodermal activity during a commonly used standardized neurocognitive assessment between individuals with or without a history of concussion. Design: Descriptive laboratory study. Setting: Research laboratory. Patients or Other Participants: Seven asymptomatic individuals with a self-reported history of physician-diagnosed, sport-related concussion (number of previous concussions = 1.43 ± 0.53; time since most recent concussion = 0.75 to ± years},
keywords = {Memory, Traumatic Brain Injuries, Wireless technology},
pubstate = {published},
tppubtype = {article}
}
Carter-Allison, S N; Potter, S; Rimes, K
Diagnosis Threat and Injury Beliefs after Mild Traumatic Brain Injury Journal Article
In: Archives of Clinical Neuropsychology, vol. 31, no. 7, pp. 727–737, 2016.
Abstract | Links | BibTeX | Tags: attention, Concussion, Illness perceptions, Memory, Stereotype threat, Suggestibility
@article{Carter-Allison2016,
title = {Diagnosis Threat and Injury Beliefs after Mild Traumatic Brain Injury},
author = {Carter-Allison, S N and Potter, S and Rimes, K},
doi = {10.1093/arclin/acw062},
year = {2016},
date = {2016-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {31},
number = {7},
pages = {727--737},
abstract = {Background Diagnosis threat is a psychosocial factor proposed to contribute to poor cognitive outcomes following mild traumatic brain injury (mTBI). The current research explored diagnosis threat impact on objective and subjective cognitive performance in a "high risk" population of athletes. Two possible moderators of diagnosis threat - injury beliefs and suggestibility - were also investigated. Method Seventy-six participants with a history of mTBI were recruited through sports clubs and randomized to a months threat group (instructions drew attention to mTBI history) or a control group (no mention of mTBI). They completed a battery of neuropsychological tests and questionnaires regarding day-to-day cognitive abilities. Measures of depression, anxiety, illness beliefs and suggestibility were also collected. Results No significant group differences were found on any neuropsychological tasks, nor on self-report of cognitive difficulties. Illness beliefs were not found to play a moderating role in general, although the majority of the study sample did not report negative mTBI beliefs and expectations: concern about the consequences of injury was associated with weaker performance on one test, WAIS-III Digit Span performance. Suggestibility was also found to have a significant affect on this test. Conclusions Diagnosis threat did not appear to have a marked affect on objective or subjective cognitive performance after mTBI in athletes. Differing injury beliefs between the study's athlete population and the general population is a possible explanation for different findings in the area. This and other sources of potential variation in the affect of diagnosis threat are discussed. © 2016 Crown copyright 2016.},
keywords = {attention, Concussion, Illness perceptions, Memory, Stereotype threat, Suggestibility},
pubstate = {published},
tppubtype = {article}
}
Custer, A; Sufrinko, A; Elbin, R J; Covassin, T; Collins, M; Kontos, A
High Baseline Postconcussion Symptom Scores and Concussion Outcomes in Athletes Journal Article
In: Journal of Athletic Training, vol. 51, no. 2, pp. 136–141, 2016.
Abstract | BibTeX | Tags: *Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Post-Concussion Syndrome/di [Diagnosis], Adolescent, Athletes, Cohort Studies, Female, Humans, Male, Memory, Neuropsychological Tests, Prognosis, reaction time, Risk Factors, Students
@article{Custer2016,
title = {High Baseline Postconcussion Symptom Scores and Concussion Outcomes in Athletes},
author = {Custer, A and Sufrinko, A and Elbin, R J and Covassin, T and Collins, M and Kontos, A},
year = {2016},
date = {2016-01-01},
journal = {Journal of Athletic Training},
volume = {51},
number = {2},
pages = {136--141},
abstract = {CONTEXT: Some healthy athletes report high levels of baseline concussion symptoms, which may be attributable to several factors (eg, illness, personality, somaticizing). However, the role of baseline symptoms in outcomes after sport-related concussion (SRC) has not been empirically examined. OBJECTIVE: To determine if athletes with high symptom scores at baseline performed worse than athletes without baseline symptoms on neurocognitive testing after SRC. DESIGN: Cohort study. SETTING: High school and collegiate athletic programs. PATIENTS OR OTHER PARTICIPANTS: A total of 670 high school and collegiate athletes participated in the study. Participants were divided into groups with either no baseline symptoms (Postconcussion Symptom Scale [PCSS] score = 0},
keywords = {*Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Post-Concussion Syndrome/di [Diagnosis], Adolescent, Athletes, Cohort Studies, Female, Humans, Male, Memory, Neuropsychological Tests, Prognosis, reaction time, Risk Factors, Students},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
Abstract | Links | BibTeX | Tags: 80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale},
pubstate = {published},
tppubtype = {article}
}
Register-Mihalik, J K; De Maio, V J; Tibbo-Valeriote, H L; Wooten, J D
Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia Journal Article
In: Clinical Journal of Sport Medicine, vol. 25, no. 6, pp. 502–508, 2015.
Abstract | BibTeX | Tags: Adolescent, adult, amnesia, anamnesis, Article, brain concussion, Child, complication, Concussion, Concussive injury, Cross-Sectional Studies, cross-sectional study, Demography, disease severity, emergency ward, ethnology, Female, head injury, human, Humans, major clinical study, Male, MEDICAL history taking, Memory, ODDS ratio, outcome assessment, postconcussion symptoms, priority journal, race, Retrospective Studies, retrospective study, Risk, risk factor, Risk Factors, unconsciousness
@article{Register-Mihalik2015,
title = {Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia},
author = {Register-Mihalik, J K and {De Maio}, V J and Tibbo-Valeriote, H L and Wooten, J D},
year = {2015},
date = {2015-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {25},
number = {6},
pages = {502--508},
abstract = {Objective: The current study examines the demographics, injury characteristics, and outcomes associated with the presence of postconcussion amnesia in young concussion clinic patients. Design: Cross-sectional, retrospective clinical cohort. Setting: Concussion services clinic. Patients: Pediatric and adolescent concussion services program patients, presenting within 10 days postinjury, aged 10-18 years, with the goal of returning to sport (n = 245). Assessment of Risk Factors: Age, gender, race, head trauma history, injury mechanism, loss of consciousness (LOC), injuryrelated visit to an emergency department, cognitive and balance scores, symptoms, and management recommendations. Main Outcome Measures: Univariate and multivariate analyses determined adjusted odds ratios for reported presence of any postconcussion amnesia (anterograde or retrograde). Results: Factors associated with amnesia (univariate, P \< 0.10) and included in the multivariate model were race, head trauma history, mechanism of injury, LOC, injury-related visit to an emergency department, management recommendations and time of injury and initial visit symptom severity. Age and gender were also included in the model due to biological significance. Of the 245 patients, 181 had data for all model variables. Of the 181 patients, 58 reported amnesia. History of head trauma [odds ratio (OR), 2.7; 95% confidence interval (CI), 1.3-5.7]; time of injury (TOI) symptom severity \>75th percentile (OR, 2.6; 95% CI, 1.2-5.3) and LOC (OR, 2.2; 95% CI, 1.1-4.6) were found to have significant and independent relationships with amnesia in the multivariate model. Conclusions: This study illustrates that patients presenting with postconcussion amnesia are more likely to have a history of head trauma, LOC, and greater symptom severity. Future research is needed to better understand amnesia following concussion. Clinical Relevance: Amnesia presence, previous head trauma, LOC, and increased symptom severity may aid in identifying patients with a greater initial injury burden who warrant closer observation and more conservative management. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {Adolescent, adult, amnesia, anamnesis, Article, brain concussion, Child, complication, Concussion, Concussive injury, Cross-Sectional Studies, cross-sectional study, Demography, disease severity, emergency ward, ethnology, Female, head injury, human, Humans, major clinical study, Male, MEDICAL history taking, Memory, ODDS ratio, outcome assessment, postconcussion symptoms, priority journal, race, Retrospective Studies, retrospective study, Risk, risk factor, Risk Factors, unconsciousness},
pubstate = {published},
tppubtype = {article}
}
Mayer, A R; Ling, J M; Dodd, A B; Gasparovic, C; Klimaj, S D; Meier, T B
A Longitudinal Assessment of Structural and Chemical Alterations in Mixed Martial Arts Fighters Journal Article
In: Journal of Neurotrauma, vol. 32, no. 22, pp. 1759–1767, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, adult, Article, biological marker, Biomarkers, BRAIN chemistry, brain concussion, brain cortex, brain size, Cerebral Cortex, CHOLINE, clinical article, cognition, Concussion, controlled study, cortical thickness (brain), creatine, executive function, Female, follow up, Follow-Up Studies, frontal gyrus, glutamic acid, glutamine, human, Humans, Injuries, inositol, Longitudinal, Longitudinal studies, longitudinal study, Magnetic Resonance Imaging, Male, martial art, Martial Arts, Memory, middle aged, mixed martial art, n acetylaspartic acid, neuropsychological test, Neuropsychological Tests, nuclear magnetic resonance imaging, NUCLEAR magnetic resonance spectroscopy, occipital cortex, pathology, posterior cingulate, psychology, repetitive injury, Spectroscopy, volumetrics, white matter, Young Adult
@article{Mayer2015b,
title = {A Longitudinal Assessment of Structural and Chemical Alterations in Mixed Martial Arts Fighters},
author = {Mayer, A R and Ling, J M and Dodd, A B and Gasparovic, C and Klimaj, S D and Meier, T B},
doi = {10.1089/neu.2014.3833},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurotrauma},
volume = {32},
number = {22},
pages = {1759--1767},
abstract = {Growing evidence suggests that temporally proximal acute concussions and repetitive subconcussive head injuries may lead to long-term neurological deficits. However, the underlying mechanisms of injury and their relative time-scales are not well documented in human injury models. The current study therefore investigated whether biomarkers of brain chemistry (magnetic resonance [MR] spectroscopy: N-acetylaspartate [NAA], combined glutamate and glutamine [Glx], total creatine [Cre], choline compounds [Cho], and myo-inositol [mI]) and structure (cortical thickness, white matter [WM]/subcortical volume) differed between mixed martial artists (MMA; n = 13) and matched healthy controls (HC) without a history of contact sport participation (HC; n = 14). A subset of participants (MMA = 9; HC = 10) returned for follow-up visits, with MMA (n = 3) with clinician-documented acute concussions also scanned serially. As expected, MMA self-reported a higher incidence of previous concussions and significantly more cognitive symptoms during prior concussion recovery. Fighters also exhibited reduced memory and processing speed relative to controls on neuropsychological testing coupled with cortical thinning in the left posterior cingulate gyrus and right occipital cortex at baseline assessment. Over a 1-year follow-up period, MMA experienced a significant decrease in both WM volume and NAA concentration, as well as relative thinning in the left middle and superior frontal gyri. These longitudinal changes did not correlate with self-reported metrics of injury (i.e., fight diary). In contrast, HC did not exhibit significant longitudinal changes over a 4-month follow-up period (p \> 0.05). Collectively, current results provide preliminary evidence of progressive changes in brain chemistry and structure over a relatively short time period in individuals with high exposure to repetitive head hits. These findings require replication in independent samples. © Mary Ann Liebert, Inc. 2015.},
keywords = {Adolescent, adult, Article, biological marker, Biomarkers, BRAIN chemistry, brain concussion, brain cortex, brain size, Cerebral Cortex, CHOLINE, clinical article, cognition, Concussion, controlled study, cortical thickness (brain), creatine, executive function, Female, follow up, Follow-Up Studies, frontal gyrus, glutamic acid, glutamine, human, Humans, Injuries, inositol, Longitudinal, Longitudinal studies, longitudinal study, Magnetic Resonance Imaging, Male, martial art, Martial Arts, Memory, middle aged, mixed martial art, n acetylaspartic acid, neuropsychological test, Neuropsychological Tests, nuclear magnetic resonance imaging, NUCLEAR magnetic resonance spectroscopy, occipital cortex, pathology, posterior cingulate, psychology, repetitive injury, Spectroscopy, volumetrics, white matter, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Bondi, C O; Semple, B D; Noble-Haeusslein, L J; Osier, N D; Carlson, S W; Dixon, C E; Giza, C C; Kline, A E
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury Journal Article
In: Neuroscience and Biobehavioral Reviews, vol. 58, pp. 123–146, 2015.
Abstract | Links | BibTeX | Tags: 8 hydroxy 2 propylaminotetralin, Aggression, Attentional set-shifting test (AST), buspirone, Closed head injury, cognition, cognitive defect, cognitive function test, Concussion, conditioning, Controlled cortical impact (CCI), environmental enrichment, Environmental enrichment (EE), executive function, experimental disease, fear, Fluid percussion (FP), human, interpersonal communication, Memory, motor function test, nerve degeneration, neuropsychological test, Neurorehabilitation, nonhuman, outcome assessment, Pathophysiology, pediatrics, priority journal, rehabilitation care, Review, rodent, rotarod test, sensorimotor function, Social behavior, social disability, social interaction, spatial learning, TASK performance, traumatic brain injury
@article{Bondi2015,
title = {Found in translation: Understanding the biology and behavior of experimental traumatic brain injury},
author = {Bondi, C O and Semple, B D and Noble-Haeusslein, L J and Osier, N D and Carlson, S W and Dixon, C E and Giza, C C and Kline, A E},
doi = {10.1016/j.neubiorev.2014.12.004},
year = {2015},
date = {2015-01-01},
journal = {Neuroscience and Biobehavioral Reviews},
volume = {58},
pages = {123--146},
abstract = {The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided. © 2014 Elsevier Ltd.},
keywords = {8 hydroxy 2 propylaminotetralin, Aggression, Attentional set-shifting test (AST), buspirone, Closed head injury, cognition, cognitive defect, cognitive function test, Concussion, conditioning, Controlled cortical impact (CCI), environmental enrichment, Environmental enrichment (EE), executive function, experimental disease, fear, Fluid percussion (FP), human, interpersonal communication, Memory, motor function test, nerve degeneration, neuropsychological test, Neurorehabilitation, nonhuman, outcome assessment, Pathophysiology, pediatrics, priority journal, rehabilitation care, Review, rodent, rotarod test, sensorimotor function, Social behavior, social disability, social interaction, spatial learning, TASK performance, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Zuckerman, Scott L; Lee, Young M; Odom, Mitchell J; Solomon, Gary S; Sills, Allen K
Baseline neurocognitive scores in athletes with attention deficit-spectrum disorders and/or learning disability Journal Article
In: Journal of Neurosurgery: Pediatrics, vol. 12, no. 2, pp. 103–109, 2013, ISBN: 1933-0707.
Links | BibTeX | Tags: ADOLESCENCE, Athletes, Athletic Injuries -- Complications, attention, Attention Deficit Hyperactivity Disorder -- Compli, Brain Concussion -- Complications, Brain Concussion -- Diagnosis, Brain Concussion -- Psychosocial Factors, Child, cognition, Cognition Disorders -- Diagnosis, Cognition Disorders -- Etiology, Female, human, Learning Disorders -- Complications, Male, Memory, Neuropsychological Tests, reaction time, Severity of Illness Indices, Sports
@article{Zuckerman2013,
title = {Baseline neurocognitive scores in athletes with attention deficit-spectrum disorders and/or learning disability},
author = {Zuckerman, Scott L and Lee, Young M and Odom, Mitchell J and Solomon, Gary S and Sills, Allen K},
doi = {10.3171/2013.5.PEDS12524},
isbn = {1933-0707},
year = {2013},
date = {2013-01-01},
journal = {Journal of Neurosurgery: Pediatrics},
volume = {12},
number = {2},
pages = {103--109},
publisher = {American Association of Neurological Surgeons \& the Journal of Neurosurgical Publishing Group},
address = {Rolling Meadows, Illinois},
keywords = {ADOLESCENCE, Athletes, Athletic Injuries -- Complications, attention, Attention Deficit Hyperactivity Disorder -- Compli, Brain Concussion -- Complications, Brain Concussion -- Diagnosis, Brain Concussion -- Psychosocial Factors, Child, cognition, Cognition Disorders -- Diagnosis, Cognition Disorders -- Etiology, Female, human, Learning Disorders -- Complications, Male, Memory, Neuropsychological Tests, reaction time, Severity of Illness Indices, Sports},
pubstate = {published},
tppubtype = {article}
}
Gay, Robin K
Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury Journal Article
In: NeuroRehabilitation, vol. 32, no. 3, pp. 473–482, 2013, ISBN: 10538135.
Abstract | Links | BibTeX | Tags: ACOUSTIC stimulation (Neurophysiology), Balance, BRAIN -- Wounds & injuries -- Complications, brain injury rehabilitation, cognition, Concussion, DIAGNOSIS, DISEASES, Dizziness, Dizziness -- Risk factors, EQUILIBRIUM (Physiology), falls prevention, GAIT in humans, Memory, mild traumatic brain injury, neurocognitive assessment, sports injury, VESTIBULAR apparatus
@article{Gay2013,
title = {Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury},
author = {Gay, Robin K},
doi = {10.3233/NRE-130870},
isbn = {10538135},
year = {2013},
date = {2013-01-01},
journal = {NeuroRehabilitation},
volume = {32},
number = {3},
pages = {473--482},
publisher = {IOS Press},
abstract = {INTRODUCTION: Problems with balance and dizziness are one of the most common complaints of individuals who have experienced a brain injury and are reported in up to 90% of cases. Despite the ubiquity of vestibular disturbance in this population, there remains a dearth of research on the interaction between physiological and cognitive systems responsible for maintaining balance. PURPOSE: The purpose of this article is to review studies on the interaction of physiological and cognitive processes required to maintain balance that may aide assessment and recovery of balance disturbance in patients with brain injury. SUMMARY: This article provides a review of research on the role of higher order cognitive processes in maintaining balance and rational for further inclusion of neurocognitive measures in the assessment of vestibular disturbance. CONCLUSION: Greater inclusion of neurocognitive measures in assessment of vestibular disturbance provides a method of assessment containing increased ecological validity compared to traditional assessments, better prepares patients for discharge, and may reduce the incidence of future injury.},
keywords = {ACOUSTIC stimulation (Neurophysiology), Balance, BRAIN -- Wounds \& injuries -- Complications, brain injury rehabilitation, cognition, Concussion, DIAGNOSIS, DISEASES, Dizziness, Dizziness -- Risk factors, EQUILIBRIUM (Physiology), falls prevention, GAIT in humans, Memory, mild traumatic brain injury, neurocognitive assessment, sports injury, VESTIBULAR apparatus},
pubstate = {published},
tppubtype = {article}
}
Vestberg, Torbjörn; Reinebo, Gustaf; Maurex, Liselotte; Ingvar, Martin; Petrovic, Predrag
Core executive functions are associated with success in young elite soccer players Journal Article
In: PLoS ONE, vol. 12, no. 2, pp. 1–13, 2017, ISBN: 19326203.
@article{Vestberg2017,
title = {Core executive functions are associated with success in young elite soccer players},
author = {Vestberg, Torbj\"{o}rn and Reinebo, Gustaf and Maurex, Liselotte and Ingvar, Martin and Petrovic, Predrag},
doi = {10.1371/journal.pone.0170845},
isbn = {19326203},
year = {2017},
date = {2017-01-01},
journal = {PLoS ONE},
volume = {12},
number = {2},
pages = {1--13},
publisher = {Public Library of Science},
abstract = {Physical capacity and coordination cannot alone predict success in team sports such as soccer. Instead, more focus has been directed towards the importance of cognitive abilities, and it has been suggested that executive functions (EF) are fundamentally important for success in soccer. However, executive functions are going through a steep development from adolescence to adulthood. Moreover, more complex EF involving manipulation of information (higher level EF) develop later than simple executive functions such as those linked to simple working memory capacity (Core EF). The link between EF and success in young soccer players is therefore not obvious. In the present study we investigated whether EF are associated with success in soccer in young elite soccer players. We performed tests measuring core EF (a demanding working memory task involving a variable n-back task; dWM) and higher level EF (Design Fluency test; DF). Color-Word Interference Test and Trail Making Test were performed on an exploratory level as they contain a linguistic element. The lower level EF test (dWM) was taken from CogStateSport computerized concussion testing and the higher level EF test (DF) was from Delis-Kaplan Executive Function System test battery (D-KEFS). In a group of young elite soccer players (n = 30; aged 12\textendash19 years) we show that they perform better than the norm in both the dWM (+0.49 SD) and DF (+0.86 SD). Moreover, we could show that both dWM and DF correlate with the number of goals the players perform during the season. The effect was more prominent for dWM (r = 0.437) than for DF (r = 0.349), but strongest for a combined measurement (r = 0.550). The effect was still present when we controlled for intelligence, length and age in a partial correlation analysis. Thus, our study suggests that both core and higher level EF may predict success in soccer also in young players. [ABSTRACT FROM AUTHOR]},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gerrard, Paul B; Iverson, Grant L; Atkins, Joseph E; Maxwell, Bruce A; Zafonte, Ross; Schatz, Philip; Berkner, Paul D
Factor Structure of ImPACT® in Adolescent Student Athletes Journal Article
In: Archives of Clinical Neuropsychology, vol. 32, no. 1, pp. 117–122, 2017, ISBN: 08876177.
@article{Gerrard2017,
title = {Factor Structure of ImPACT® in Adolescent Student Athletes},
author = {Gerrard, Paul B and Iverson, Grant L and Atkins, Joseph E and Maxwell, Bruce A and Zafonte, Ross and Schatz, Philip and Berkner, Paul D},
doi = {10.1093/arclin/acw097},
isbn = {08876177},
year = {2017},
date = {2017-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {32},
number = {1},
pages = {117--122},
abstract = {Objective: ImPACT® (Immediate Post-Concussion Assessment and Cognitive Testing) is a computerized neuropsychological screening battery, which is widely used to measure the acute effects of sport-related concussion and to monitor recovery from injury. This study examined the factor structure of ImPACT® in several samples of high school student athletes. We hypothesized that a 2-factor structure would be present in all samples. Method: A sample of 4,809 adolescent student athletes was included, and subgroups with a history of treatment for headaches or a self-reported history of learning problems or attention-deficit hyperactivity disorder were analyzed separately. Exploratory principal axis factor analyses with Promax rotations were used. Results: As hypothesized, both the combination of Verbal Memory and Visual Memory Composite scores loaded on one (Memory) factor, while Visual Motor Speed and Reaction Time loaded on a different (Speed) factor, in the total sample and in all subgroups. Conclusion: These results provide reasonably compelling evidence, across multiple samples, which ImPACT® measures 2 distinct factors: memory and speed. [ABSTRACT FROM AUTHOR]},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Le Berre, A P; Sullivan, E V
Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory Journal Article
In: Neuropsychology Review, vol. 26, no. 4, pp. 420–431, 2016.
@article{LeBerre2016,
title = {Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory},
author = {{Le Berre}, A P and Sullivan, E V},
doi = {10.1007/s11065-016-9323-3},
year = {2016},
date = {2016-01-01},
journal = {Neuropsychology Review},
volume = {26},
number = {4},
pages = {420--431},
abstract = {In addiction, notably Alcohol Use Disorder (AUD), patients often have a tendency to fail to acknowledge the reality of the disease and to minimize the physical, psychological, and social difficulties attendant to chronic alcohol consumption. This lack of awareness can reduce the chances of initiating and maintaining sobriety. Presented here is a model focusing on compromised awareness in individuals with AUD of mild to moderate cognitive deficits, in particular, for episodic memory impairment\textemdashthe ability to learn new information, such as recent personal experiences. Early in abstinence, alcoholics can be unaware of their memory deficits and overestimate their mnemonic capacities, which can be investigated with metamemory paradigms. Relevant neuropsychological and neuroimaging results considered suggest that the alcoholics’ impairment of awareness of their attenuated memory function can be a clinical manifestation explained mechanistically by neurobiological factors, including compromise of brain systems that result in a mild form of mnemonic anosognosia. Specifically, unawareness of memory impairment in AUD may result from a lack of personal knowledge updating attributable to damage in brain regions or connections supporting conscious recollection in episodic memory. Likely candidates are posterior parietal and medial frontal regions known to be integral part of the Default Mode Network (DMN) and the insula leading to an impaired switching mechanism between the DMN and the Central-Executive Control (i.e., Lateral Prefronto-Parietal) Network. The cognitive concepts and neural substrates noted for addictive disorders may also be relevant for problems in self-identification of functional impairment resulting from injury following war-related blast, sport-related concussion, and insidiously occurring dementia. © 2016, Springer Science+Business Media New York.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Raikes, A C; Schaefer, S Y
Phasic electrodermal activity during the standardized assessment of concussion (SAC) Journal Article
In: Journal of Athletic Training, vol. 51, no. 7, pp. 533–539, 2016.
@article{Raikes2016,
title = {Phasic electrodermal activity during the standardized assessment of concussion (SAC)},
author = {Raikes, A C and Schaefer, S Y},
doi = {10.4085/1062-6050-51.8.09},
year = {2016},
date = {2016-01-01},
journal = {Journal of Athletic Training},
volume = {51},
number = {7},
pages = {533--539},
abstract = {Context: The long-term effects of concussion on brain function during cognitive tasks are not fully understood and neuroimaging findings are equivocal. Some images show hyperactivation of prefrontal brain regions in previously concussed individuals relative to controls, suggesting increased cognitive resource allocation. Others show prefrontal hypoactivation and hyperactivation in other regions as a presumed compensatory mechanism. Given the relationship between sympathetic arousal and neural activation, physiologic measures of arousal, such as electrodermal activity, may provide additional insight into the brain's functional changes in those with a history of concussion. Objective: To quantify differences in electrodermal activity during a commonly used standardized neurocognitive assessment between individuals with or without a history of concussion. Design: Descriptive laboratory study. Setting: Research laboratory. Patients or Other Participants: Seven asymptomatic individuals with a self-reported history of physician-diagnosed, sport-related concussion (number of previous concussions = 1.43 ± 0.53; time since most recent concussion = 0.75 to ± years},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Carter-Allison, S N; Potter, S; Rimes, K
Diagnosis Threat and Injury Beliefs after Mild Traumatic Brain Injury Journal Article
In: Archives of Clinical Neuropsychology, vol. 31, no. 7, pp. 727–737, 2016.
@article{Carter-Allison2016,
title = {Diagnosis Threat and Injury Beliefs after Mild Traumatic Brain Injury},
author = {Carter-Allison, S N and Potter, S and Rimes, K},
doi = {10.1093/arclin/acw062},
year = {2016},
date = {2016-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {31},
number = {7},
pages = {727--737},
abstract = {Background Diagnosis threat is a psychosocial factor proposed to contribute to poor cognitive outcomes following mild traumatic brain injury (mTBI). The current research explored diagnosis threat impact on objective and subjective cognitive performance in a "high risk" population of athletes. Two possible moderators of diagnosis threat - injury beliefs and suggestibility - were also investigated. Method Seventy-six participants with a history of mTBI were recruited through sports clubs and randomized to a months threat group (instructions drew attention to mTBI history) or a control group (no mention of mTBI). They completed a battery of neuropsychological tests and questionnaires regarding day-to-day cognitive abilities. Measures of depression, anxiety, illness beliefs and suggestibility were also collected. Results No significant group differences were found on any neuropsychological tasks, nor on self-report of cognitive difficulties. Illness beliefs were not found to play a moderating role in general, although the majority of the study sample did not report negative mTBI beliefs and expectations: concern about the consequences of injury was associated with weaker performance on one test, WAIS-III Digit Span performance. Suggestibility was also found to have a significant affect on this test. Conclusions Diagnosis threat did not appear to have a marked affect on objective or subjective cognitive performance after mTBI in athletes. Differing injury beliefs between the study's athlete population and the general population is a possible explanation for different findings in the area. This and other sources of potential variation in the affect of diagnosis threat are discussed. © 2016 Crown copyright 2016.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Custer, A; Sufrinko, A; Elbin, R J; Covassin, T; Collins, M; Kontos, A
High Baseline Postconcussion Symptom Scores and Concussion Outcomes in Athletes Journal Article
In: Journal of Athletic Training, vol. 51, no. 2, pp. 136–141, 2016.
@article{Custer2016,
title = {High Baseline Postconcussion Symptom Scores and Concussion Outcomes in Athletes},
author = {Custer, A and Sufrinko, A and Elbin, R J and Covassin, T and Collins, M and Kontos, A},
year = {2016},
date = {2016-01-01},
journal = {Journal of Athletic Training},
volume = {51},
number = {2},
pages = {136--141},
abstract = {CONTEXT: Some healthy athletes report high levels of baseline concussion symptoms, which may be attributable to several factors (eg, illness, personality, somaticizing). However, the role of baseline symptoms in outcomes after sport-related concussion (SRC) has not been empirically examined. OBJECTIVE: To determine if athletes with high symptom scores at baseline performed worse than athletes without baseline symptoms on neurocognitive testing after SRC. DESIGN: Cohort study. SETTING: High school and collegiate athletic programs. PATIENTS OR OTHER PARTICIPANTS: A total of 670 high school and collegiate athletes participated in the study. Participants were divided into groups with either no baseline symptoms (Postconcussion Symptom Scale [PCSS] score = 0},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Register-Mihalik, J K; De Maio, V J; Tibbo-Valeriote, H L; Wooten, J D
Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia Journal Article
In: Clinical Journal of Sport Medicine, vol. 25, no. 6, pp. 502–508, 2015.
@article{Register-Mihalik2015,
title = {Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia},
author = {Register-Mihalik, J K and {De Maio}, V J and Tibbo-Valeriote, H L and Wooten, J D},
year = {2015},
date = {2015-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {25},
number = {6},
pages = {502--508},
abstract = {Objective: The current study examines the demographics, injury characteristics, and outcomes associated with the presence of postconcussion amnesia in young concussion clinic patients. Design: Cross-sectional, retrospective clinical cohort. Setting: Concussion services clinic. Patients: Pediatric and adolescent concussion services program patients, presenting within 10 days postinjury, aged 10-18 years, with the goal of returning to sport (n = 245). Assessment of Risk Factors: Age, gender, race, head trauma history, injury mechanism, loss of consciousness (LOC), injuryrelated visit to an emergency department, cognitive and balance scores, symptoms, and management recommendations. Main Outcome Measures: Univariate and multivariate analyses determined adjusted odds ratios for reported presence of any postconcussion amnesia (anterograde or retrograde). Results: Factors associated with amnesia (univariate, P \< 0.10) and included in the multivariate model were race, head trauma history, mechanism of injury, LOC, injury-related visit to an emergency department, management recommendations and time of injury and initial visit symptom severity. Age and gender were also included in the model due to biological significance. Of the 245 patients, 181 had data for all model variables. Of the 181 patients, 58 reported amnesia. History of head trauma [odds ratio (OR), 2.7; 95% confidence interval (CI), 1.3-5.7]; time of injury (TOI) symptom severity \>75th percentile (OR, 2.6; 95% CI, 1.2-5.3) and LOC (OR, 2.2; 95% CI, 1.1-4.6) were found to have significant and independent relationships with amnesia in the multivariate model. Conclusions: This study illustrates that patients presenting with postconcussion amnesia are more likely to have a history of head trauma, LOC, and greater symptom severity. Future research is needed to better understand amnesia following concussion. Clinical Relevance: Amnesia presence, previous head trauma, LOC, and increased symptom severity may aid in identifying patients with a greater initial injury burden who warrant closer observation and more conservative management. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Mayer, A R; Ling, J M; Dodd, A B; Gasparovic, C; Klimaj, S D; Meier, T B
A Longitudinal Assessment of Structural and Chemical Alterations in Mixed Martial Arts Fighters Journal Article
In: Journal of Neurotrauma, vol. 32, no. 22, pp. 1759–1767, 2015.
@article{Mayer2015b,
title = {A Longitudinal Assessment of Structural and Chemical Alterations in Mixed Martial Arts Fighters},
author = {Mayer, A R and Ling, J M and Dodd, A B and Gasparovic, C and Klimaj, S D and Meier, T B},
doi = {10.1089/neu.2014.3833},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurotrauma},
volume = {32},
number = {22},
pages = {1759--1767},
abstract = {Growing evidence suggests that temporally proximal acute concussions and repetitive subconcussive head injuries may lead to long-term neurological deficits. However, the underlying mechanisms of injury and their relative time-scales are not well documented in human injury models. The current study therefore investigated whether biomarkers of brain chemistry (magnetic resonance [MR] spectroscopy: N-acetylaspartate [NAA], combined glutamate and glutamine [Glx], total creatine [Cre], choline compounds [Cho], and myo-inositol [mI]) and structure (cortical thickness, white matter [WM]/subcortical volume) differed between mixed martial artists (MMA; n = 13) and matched healthy controls (HC) without a history of contact sport participation (HC; n = 14). A subset of participants (MMA = 9; HC = 10) returned for follow-up visits, with MMA (n = 3) with clinician-documented acute concussions also scanned serially. As expected, MMA self-reported a higher incidence of previous concussions and significantly more cognitive symptoms during prior concussion recovery. Fighters also exhibited reduced memory and processing speed relative to controls on neuropsychological testing coupled with cortical thinning in the left posterior cingulate gyrus and right occipital cortex at baseline assessment. Over a 1-year follow-up period, MMA experienced a significant decrease in both WM volume and NAA concentration, as well as relative thinning in the left middle and superior frontal gyri. These longitudinal changes did not correlate with self-reported metrics of injury (i.e., fight diary). In contrast, HC did not exhibit significant longitudinal changes over a 4-month follow-up period (p \> 0.05). Collectively, current results provide preliminary evidence of progressive changes in brain chemistry and structure over a relatively short time period in individuals with high exposure to repetitive head hits. These findings require replication in independent samples. © Mary Ann Liebert, Inc. 2015.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bondi, C O; Semple, B D; Noble-Haeusslein, L J; Osier, N D; Carlson, S W; Dixon, C E; Giza, C C; Kline, A E
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury Journal Article
In: Neuroscience and Biobehavioral Reviews, vol. 58, pp. 123–146, 2015.
@article{Bondi2015,
title = {Found in translation: Understanding the biology and behavior of experimental traumatic brain injury},
author = {Bondi, C O and Semple, B D and Noble-Haeusslein, L J and Osier, N D and Carlson, S W and Dixon, C E and Giza, C C and Kline, A E},
doi = {10.1016/j.neubiorev.2014.12.004},
year = {2015},
date = {2015-01-01},
journal = {Neuroscience and Biobehavioral Reviews},
volume = {58},
pages = {123--146},
abstract = {The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided. © 2014 Elsevier Ltd.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Zuckerman, Scott L; Lee, Young M; Odom, Mitchell J; Solomon, Gary S; Sills, Allen K
Baseline neurocognitive scores in athletes with attention deficit-spectrum disorders and/or learning disability Journal Article
In: Journal of Neurosurgery: Pediatrics, vol. 12, no. 2, pp. 103–109, 2013, ISBN: 1933-0707.
@article{Zuckerman2013,
title = {Baseline neurocognitive scores in athletes with attention deficit-spectrum disorders and/or learning disability},
author = {Zuckerman, Scott L and Lee, Young M and Odom, Mitchell J and Solomon, Gary S and Sills, Allen K},
doi = {10.3171/2013.5.PEDS12524},
isbn = {1933-0707},
year = {2013},
date = {2013-01-01},
journal = {Journal of Neurosurgery: Pediatrics},
volume = {12},
number = {2},
pages = {103--109},
publisher = {American Association of Neurological Surgeons \& the Journal of Neurosurgical Publishing Group},
address = {Rolling Meadows, Illinois},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gay, Robin K
Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury Journal Article
In: NeuroRehabilitation, vol. 32, no. 3, pp. 473–482, 2013, ISBN: 10538135.
@article{Gay2013,
title = {Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury},
author = {Gay, Robin K},
doi = {10.3233/NRE-130870},
isbn = {10538135},
year = {2013},
date = {2013-01-01},
journal = {NeuroRehabilitation},
volume = {32},
number = {3},
pages = {473--482},
publisher = {IOS Press},
abstract = {INTRODUCTION: Problems with balance and dizziness are one of the most common complaints of individuals who have experienced a brain injury and are reported in up to 90% of cases. Despite the ubiquity of vestibular disturbance in this population, there remains a dearth of research on the interaction between physiological and cognitive systems responsible for maintaining balance. PURPOSE: The purpose of this article is to review studies on the interaction of physiological and cognitive processes required to maintain balance that may aide assessment and recovery of balance disturbance in patients with brain injury. SUMMARY: This article provides a review of research on the role of higher order cognitive processes in maintaining balance and rational for further inclusion of neurocognitive measures in the assessment of vestibular disturbance. CONCLUSION: Greater inclusion of neurocognitive measures in assessment of vestibular disturbance provides a method of assessment containing increased ecological validity compared to traditional assessments, better prepares patients for discharge, and may reduce the incidence of future injury.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Vestberg, Torbjörn; Reinebo, Gustaf; Maurex, Liselotte; Ingvar, Martin; Petrovic, Predrag
Core executive functions are associated with success in young elite soccer players Journal Article
In: PLoS ONE, vol. 12, no. 2, pp. 1–13, 2017, ISBN: 19326203.
Abstract | Links | BibTeX | Tags: adolescents, Age groups, attention, behavior, Biology and life sciences, cognition, Cognitive neuroscience, Cognitive psychology, Cognitive science, Creativity, Inhibitions, Learning and memory, Memory, Neuroscience, People and places, Population groupings, psychology, recreation, Research Article, Social sciences, Sports, Sports science, working memory
@article{Vestberg2017,
title = {Core executive functions are associated with success in young elite soccer players},
author = {Vestberg, Torbj\"{o}rn and Reinebo, Gustaf and Maurex, Liselotte and Ingvar, Martin and Petrovic, Predrag},
doi = {10.1371/journal.pone.0170845},
isbn = {19326203},
year = {2017},
date = {2017-01-01},
journal = {PLoS ONE},
volume = {12},
number = {2},
pages = {1--13},
publisher = {Public Library of Science},
abstract = {Physical capacity and coordination cannot alone predict success in team sports such as soccer. Instead, more focus has been directed towards the importance of cognitive abilities, and it has been suggested that executive functions (EF) are fundamentally important for success in soccer. However, executive functions are going through a steep development from adolescence to adulthood. Moreover, more complex EF involving manipulation of information (higher level EF) develop later than simple executive functions such as those linked to simple working memory capacity (Core EF). The link between EF and success in young soccer players is therefore not obvious. In the present study we investigated whether EF are associated with success in soccer in young elite soccer players. We performed tests measuring core EF (a demanding working memory task involving a variable n-back task; dWM) and higher level EF (Design Fluency test; DF). Color-Word Interference Test and Trail Making Test were performed on an exploratory level as they contain a linguistic element. The lower level EF test (dWM) was taken from CogStateSport computerized concussion testing and the higher level EF test (DF) was from Delis-Kaplan Executive Function System test battery (D-KEFS). In a group of young elite soccer players (n = 30; aged 12\textendash19 years) we show that they perform better than the norm in both the dWM (+0.49 SD) and DF (+0.86 SD). Moreover, we could show that both dWM and DF correlate with the number of goals the players perform during the season. The effect was more prominent for dWM (r = 0.437) than for DF (r = 0.349), but strongest for a combined measurement (r = 0.550). The effect was still present when we controlled for intelligence, length and age in a partial correlation analysis. Thus, our study suggests that both core and higher level EF may predict success in soccer also in young players. [ABSTRACT FROM AUTHOR]},
keywords = {adolescents, Age groups, attention, behavior, Biology and life sciences, cognition, Cognitive neuroscience, Cognitive psychology, Cognitive science, Creativity, Inhibitions, Learning and memory, Memory, Neuroscience, People and places, Population groupings, psychology, recreation, Research Article, Social sciences, Sports, Sports science, working memory},
pubstate = {published},
tppubtype = {article}
}
Gerrard, Paul B; Iverson, Grant L; Atkins, Joseph E; Maxwell, Bruce A; Zafonte, Ross; Schatz, Philip; Berkner, Paul D
Factor Structure of ImPACT® in Adolescent Student Athletes Journal Article
In: Archives of Clinical Neuropsychology, vol. 32, no. 1, pp. 117–122, 2017, ISBN: 08876177.
Abstract | Links | BibTeX | Tags: Athletes -- Psychology, ATTENTION-deficit hyperactivity disorder, Cognitive, COGNITIVE testing, Concussion, FACTOR analysis, Headache -- Treatment, Memory, Neuropsychological Tests, Sports
@article{Gerrard2017,
title = {Factor Structure of ImPACT® in Adolescent Student Athletes},
author = {Gerrard, Paul B and Iverson, Grant L and Atkins, Joseph E and Maxwell, Bruce A and Zafonte, Ross and Schatz, Philip and Berkner, Paul D},
doi = {10.1093/arclin/acw097},
isbn = {08876177},
year = {2017},
date = {2017-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {32},
number = {1},
pages = {117--122},
abstract = {Objective: ImPACT® (Immediate Post-Concussion Assessment and Cognitive Testing) is a computerized neuropsychological screening battery, which is widely used to measure the acute effects of sport-related concussion and to monitor recovery from injury. This study examined the factor structure of ImPACT® in several samples of high school student athletes. We hypothesized that a 2-factor structure would be present in all samples. Method: A sample of 4,809 adolescent student athletes was included, and subgroups with a history of treatment for headaches or a self-reported history of learning problems or attention-deficit hyperactivity disorder were analyzed separately. Exploratory principal axis factor analyses with Promax rotations were used. Results: As hypothesized, both the combination of Verbal Memory and Visual Memory Composite scores loaded on one (Memory) factor, while Visual Motor Speed and Reaction Time loaded on a different (Speed) factor, in the total sample and in all subgroups. Conclusion: These results provide reasonably compelling evidence, across multiple samples, which ImPACT® measures 2 distinct factors: memory and speed. [ABSTRACT FROM AUTHOR]},
keywords = {Athletes -- Psychology, ATTENTION-deficit hyperactivity disorder, Cognitive, COGNITIVE testing, Concussion, FACTOR analysis, Headache -- Treatment, Memory, Neuropsychological Tests, Sports},
pubstate = {published},
tppubtype = {article}
}
Le Berre, A P; Sullivan, E V
Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory Journal Article
In: Neuropsychology Review, vol. 26, no. 4, pp. 420–431, 2016.
Abstract | Links | BibTeX | Tags: Alcoholism, Anosognosia, brain, Memory, Metamemory
@article{LeBerre2016,
title = {Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory},
author = {{Le Berre}, A P and Sullivan, E V},
doi = {10.1007/s11065-016-9323-3},
year = {2016},
date = {2016-01-01},
journal = {Neuropsychology Review},
volume = {26},
number = {4},
pages = {420--431},
abstract = {In addiction, notably Alcohol Use Disorder (AUD), patients often have a tendency to fail to acknowledge the reality of the disease and to minimize the physical, psychological, and social difficulties attendant to chronic alcohol consumption. This lack of awareness can reduce the chances of initiating and maintaining sobriety. Presented here is a model focusing on compromised awareness in individuals with AUD of mild to moderate cognitive deficits, in particular, for episodic memory impairment\textemdashthe ability to learn new information, such as recent personal experiences. Early in abstinence, alcoholics can be unaware of their memory deficits and overestimate their mnemonic capacities, which can be investigated with metamemory paradigms. Relevant neuropsychological and neuroimaging results considered suggest that the alcoholics’ impairment of awareness of their attenuated memory function can be a clinical manifestation explained mechanistically by neurobiological factors, including compromise of brain systems that result in a mild form of mnemonic anosognosia. Specifically, unawareness of memory impairment in AUD may result from a lack of personal knowledge updating attributable to damage in brain regions or connections supporting conscious recollection in episodic memory. Likely candidates are posterior parietal and medial frontal regions known to be integral part of the Default Mode Network (DMN) and the insula leading to an impaired switching mechanism between the DMN and the Central-Executive Control (i.e., Lateral Prefronto-Parietal) Network. The cognitive concepts and neural substrates noted for addictive disorders may also be relevant for problems in self-identification of functional impairment resulting from injury following war-related blast, sport-related concussion, and insidiously occurring dementia. © 2016, Springer Science+Business Media New York.},
keywords = {Alcoholism, Anosognosia, brain, Memory, Metamemory},
pubstate = {published},
tppubtype = {article}
}
Raikes, A C; Schaefer, S Y
Phasic electrodermal activity during the standardized assessment of concussion (SAC) Journal Article
In: Journal of Athletic Training, vol. 51, no. 7, pp. 533–539, 2016.
Abstract | Links | BibTeX | Tags: Memory, Traumatic Brain Injuries, Wireless technology
@article{Raikes2016,
title = {Phasic electrodermal activity during the standardized assessment of concussion (SAC)},
author = {Raikes, A C and Schaefer, S Y},
doi = {10.4085/1062-6050-51.8.09},
year = {2016},
date = {2016-01-01},
journal = {Journal of Athletic Training},
volume = {51},
number = {7},
pages = {533--539},
abstract = {Context: The long-term effects of concussion on brain function during cognitive tasks are not fully understood and neuroimaging findings are equivocal. Some images show hyperactivation of prefrontal brain regions in previously concussed individuals relative to controls, suggesting increased cognitive resource allocation. Others show prefrontal hypoactivation and hyperactivation in other regions as a presumed compensatory mechanism. Given the relationship between sympathetic arousal and neural activation, physiologic measures of arousal, such as electrodermal activity, may provide additional insight into the brain's functional changes in those with a history of concussion. Objective: To quantify differences in electrodermal activity during a commonly used standardized neurocognitive assessment between individuals with or without a history of concussion. Design: Descriptive laboratory study. Setting: Research laboratory. Patients or Other Participants: Seven asymptomatic individuals with a self-reported history of physician-diagnosed, sport-related concussion (number of previous concussions = 1.43 ± 0.53; time since most recent concussion = 0.75 to ± years},
keywords = {Memory, Traumatic Brain Injuries, Wireless technology},
pubstate = {published},
tppubtype = {article}
}
Carter-Allison, S N; Potter, S; Rimes, K
Diagnosis Threat and Injury Beliefs after Mild Traumatic Brain Injury Journal Article
In: Archives of Clinical Neuropsychology, vol. 31, no. 7, pp. 727–737, 2016.
Abstract | Links | BibTeX | Tags: attention, Concussion, Illness perceptions, Memory, Stereotype threat, Suggestibility
@article{Carter-Allison2016,
title = {Diagnosis Threat and Injury Beliefs after Mild Traumatic Brain Injury},
author = {Carter-Allison, S N and Potter, S and Rimes, K},
doi = {10.1093/arclin/acw062},
year = {2016},
date = {2016-01-01},
journal = {Archives of Clinical Neuropsychology},
volume = {31},
number = {7},
pages = {727--737},
abstract = {Background Diagnosis threat is a psychosocial factor proposed to contribute to poor cognitive outcomes following mild traumatic brain injury (mTBI). The current research explored diagnosis threat impact on objective and subjective cognitive performance in a "high risk" population of athletes. Two possible moderators of diagnosis threat - injury beliefs and suggestibility - were also investigated. Method Seventy-six participants with a history of mTBI were recruited through sports clubs and randomized to a months threat group (instructions drew attention to mTBI history) or a control group (no mention of mTBI). They completed a battery of neuropsychological tests and questionnaires regarding day-to-day cognitive abilities. Measures of depression, anxiety, illness beliefs and suggestibility were also collected. Results No significant group differences were found on any neuropsychological tasks, nor on self-report of cognitive difficulties. Illness beliefs were not found to play a moderating role in general, although the majority of the study sample did not report negative mTBI beliefs and expectations: concern about the consequences of injury was associated with weaker performance on one test, WAIS-III Digit Span performance. Suggestibility was also found to have a significant affect on this test. Conclusions Diagnosis threat did not appear to have a marked affect on objective or subjective cognitive performance after mTBI in athletes. Differing injury beliefs between the study's athlete population and the general population is a possible explanation for different findings in the area. This and other sources of potential variation in the affect of diagnosis threat are discussed. © 2016 Crown copyright 2016.},
keywords = {attention, Concussion, Illness perceptions, Memory, Stereotype threat, Suggestibility},
pubstate = {published},
tppubtype = {article}
}
Custer, A; Sufrinko, A; Elbin, R J; Covassin, T; Collins, M; Kontos, A
High Baseline Postconcussion Symptom Scores and Concussion Outcomes in Athletes Journal Article
In: Journal of Athletic Training, vol. 51, no. 2, pp. 136–141, 2016.
Abstract | BibTeX | Tags: *Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Post-Concussion Syndrome/di [Diagnosis], Adolescent, Athletes, Cohort Studies, Female, Humans, Male, Memory, Neuropsychological Tests, Prognosis, reaction time, Risk Factors, Students
@article{Custer2016,
title = {High Baseline Postconcussion Symptom Scores and Concussion Outcomes in Athletes},
author = {Custer, A and Sufrinko, A and Elbin, R J and Covassin, T and Collins, M and Kontos, A},
year = {2016},
date = {2016-01-01},
journal = {Journal of Athletic Training},
volume = {51},
number = {2},
pages = {136--141},
abstract = {CONTEXT: Some healthy athletes report high levels of baseline concussion symptoms, which may be attributable to several factors (eg, illness, personality, somaticizing). However, the role of baseline symptoms in outcomes after sport-related concussion (SRC) has not been empirically examined. OBJECTIVE: To determine if athletes with high symptom scores at baseline performed worse than athletes without baseline symptoms on neurocognitive testing after SRC. DESIGN: Cohort study. SETTING: High school and collegiate athletic programs. PATIENTS OR OTHER PARTICIPANTS: A total of 670 high school and collegiate athletes participated in the study. Participants were divided into groups with either no baseline symptoms (Postconcussion Symptom Scale [PCSS] score = 0},
keywords = {*Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Post-Concussion Syndrome/di [Diagnosis], Adolescent, Athletes, Cohort Studies, Female, Humans, Male, Memory, Neuropsychological Tests, Prognosis, reaction time, Risk Factors, Students},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
Abstract | Links | BibTeX | Tags: 80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale},
pubstate = {published},
tppubtype = {article}
}
Register-Mihalik, J K; De Maio, V J; Tibbo-Valeriote, H L; Wooten, J D
Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia Journal Article
In: Clinical Journal of Sport Medicine, vol. 25, no. 6, pp. 502–508, 2015.
Abstract | BibTeX | Tags: Adolescent, adult, amnesia, anamnesis, Article, brain concussion, Child, complication, Concussion, Concussive injury, Cross-Sectional Studies, cross-sectional study, Demography, disease severity, emergency ward, ethnology, Female, head injury, human, Humans, major clinical study, Male, MEDICAL history taking, Memory, ODDS ratio, outcome assessment, postconcussion symptoms, priority journal, race, Retrospective Studies, retrospective study, Risk, risk factor, Risk Factors, unconsciousness
@article{Register-Mihalik2015,
title = {Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia},
author = {Register-Mihalik, J K and {De Maio}, V J and Tibbo-Valeriote, H L and Wooten, J D},
year = {2015},
date = {2015-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {25},
number = {6},
pages = {502--508},
abstract = {Objective: The current study examines the demographics, injury characteristics, and outcomes associated with the presence of postconcussion amnesia in young concussion clinic patients. Design: Cross-sectional, retrospective clinical cohort. Setting: Concussion services clinic. Patients: Pediatric and adolescent concussion services program patients, presenting within 10 days postinjury, aged 10-18 years, with the goal of returning to sport (n = 245). Assessment of Risk Factors: Age, gender, race, head trauma history, injury mechanism, loss of consciousness (LOC), injuryrelated visit to an emergency department, cognitive and balance scores, symptoms, and management recommendations. Main Outcome Measures: Univariate and multivariate analyses determined adjusted odds ratios for reported presence of any postconcussion amnesia (anterograde or retrograde). Results: Factors associated with amnesia (univariate, P \< 0.10) and included in the multivariate model were race, head trauma history, mechanism of injury, LOC, injury-related visit to an emergency department, management recommendations and time of injury and initial visit symptom severity. Age and gender were also included in the model due to biological significance. Of the 245 patients, 181 had data for all model variables. Of the 181 patients, 58 reported amnesia. History of head trauma [odds ratio (OR), 2.7; 95% confidence interval (CI), 1.3-5.7]; time of injury (TOI) symptom severity \>75th percentile (OR, 2.6; 95% CI, 1.2-5.3) and LOC (OR, 2.2; 95% CI, 1.1-4.6) were found to have significant and independent relationships with amnesia in the multivariate model. Conclusions: This study illustrates that patients presenting with postconcussion amnesia are more likely to have a history of head trauma, LOC, and greater symptom severity. Future research is needed to better understand amnesia following concussion. Clinical Relevance: Amnesia presence, previous head trauma, LOC, and increased symptom severity may aid in identifying patients with a greater initial injury burden who warrant closer observation and more conservative management. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {Adolescent, adult, amnesia, anamnesis, Article, brain concussion, Child, complication, Concussion, Concussive injury, Cross-Sectional Studies, cross-sectional study, Demography, disease severity, emergency ward, ethnology, Female, head injury, human, Humans, major clinical study, Male, MEDICAL history taking, Memory, ODDS ratio, outcome assessment, postconcussion symptoms, priority journal, race, Retrospective Studies, retrospective study, Risk, risk factor, Risk Factors, unconsciousness},
pubstate = {published},
tppubtype = {article}
}
Mayer, A R; Ling, J M; Dodd, A B; Gasparovic, C; Klimaj, S D; Meier, T B
A Longitudinal Assessment of Structural and Chemical Alterations in Mixed Martial Arts Fighters Journal Article
In: Journal of Neurotrauma, vol. 32, no. 22, pp. 1759–1767, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, adult, Article, biological marker, Biomarkers, BRAIN chemistry, brain concussion, brain cortex, brain size, Cerebral Cortex, CHOLINE, clinical article, cognition, Concussion, controlled study, cortical thickness (brain), creatine, executive function, Female, follow up, Follow-Up Studies, frontal gyrus, glutamic acid, glutamine, human, Humans, Injuries, inositol, Longitudinal, Longitudinal studies, longitudinal study, Magnetic Resonance Imaging, Male, martial art, Martial Arts, Memory, middle aged, mixed martial art, n acetylaspartic acid, neuropsychological test, Neuropsychological Tests, nuclear magnetic resonance imaging, NUCLEAR magnetic resonance spectroscopy, occipital cortex, pathology, posterior cingulate, psychology, repetitive injury, Spectroscopy, volumetrics, white matter, Young Adult
@article{Mayer2015b,
title = {A Longitudinal Assessment of Structural and Chemical Alterations in Mixed Martial Arts Fighters},
author = {Mayer, A R and Ling, J M and Dodd, A B and Gasparovic, C and Klimaj, S D and Meier, T B},
doi = {10.1089/neu.2014.3833},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurotrauma},
volume = {32},
number = {22},
pages = {1759--1767},
abstract = {Growing evidence suggests that temporally proximal acute concussions and repetitive subconcussive head injuries may lead to long-term neurological deficits. However, the underlying mechanisms of injury and their relative time-scales are not well documented in human injury models. The current study therefore investigated whether biomarkers of brain chemistry (magnetic resonance [MR] spectroscopy: N-acetylaspartate [NAA], combined glutamate and glutamine [Glx], total creatine [Cre], choline compounds [Cho], and myo-inositol [mI]) and structure (cortical thickness, white matter [WM]/subcortical volume) differed between mixed martial artists (MMA; n = 13) and matched healthy controls (HC) without a history of contact sport participation (HC; n = 14). A subset of participants (MMA = 9; HC = 10) returned for follow-up visits, with MMA (n = 3) with clinician-documented acute concussions also scanned serially. As expected, MMA self-reported a higher incidence of previous concussions and significantly more cognitive symptoms during prior concussion recovery. Fighters also exhibited reduced memory and processing speed relative to controls on neuropsychological testing coupled with cortical thinning in the left posterior cingulate gyrus and right occipital cortex at baseline assessment. Over a 1-year follow-up period, MMA experienced a significant decrease in both WM volume and NAA concentration, as well as relative thinning in the left middle and superior frontal gyri. These longitudinal changes did not correlate with self-reported metrics of injury (i.e., fight diary). In contrast, HC did not exhibit significant longitudinal changes over a 4-month follow-up period (p \> 0.05). Collectively, current results provide preliminary evidence of progressive changes in brain chemistry and structure over a relatively short time period in individuals with high exposure to repetitive head hits. These findings require replication in independent samples. © Mary Ann Liebert, Inc. 2015.},
keywords = {Adolescent, adult, Article, biological marker, Biomarkers, BRAIN chemistry, brain concussion, brain cortex, brain size, Cerebral Cortex, CHOLINE, clinical article, cognition, Concussion, controlled study, cortical thickness (brain), creatine, executive function, Female, follow up, Follow-Up Studies, frontal gyrus, glutamic acid, glutamine, human, Humans, Injuries, inositol, Longitudinal, Longitudinal studies, longitudinal study, Magnetic Resonance Imaging, Male, martial art, Martial Arts, Memory, middle aged, mixed martial art, n acetylaspartic acid, neuropsychological test, Neuropsychological Tests, nuclear magnetic resonance imaging, NUCLEAR magnetic resonance spectroscopy, occipital cortex, pathology, posterior cingulate, psychology, repetitive injury, Spectroscopy, volumetrics, white matter, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Bondi, C O; Semple, B D; Noble-Haeusslein, L J; Osier, N D; Carlson, S W; Dixon, C E; Giza, C C; Kline, A E
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury Journal Article
In: Neuroscience and Biobehavioral Reviews, vol. 58, pp. 123–146, 2015.
Abstract | Links | BibTeX | Tags: 8 hydroxy 2 propylaminotetralin, Aggression, Attentional set-shifting test (AST), buspirone, Closed head injury, cognition, cognitive defect, cognitive function test, Concussion, conditioning, Controlled cortical impact (CCI), environmental enrichment, Environmental enrichment (EE), executive function, experimental disease, fear, Fluid percussion (FP), human, interpersonal communication, Memory, motor function test, nerve degeneration, neuropsychological test, Neurorehabilitation, nonhuman, outcome assessment, Pathophysiology, pediatrics, priority journal, rehabilitation care, Review, rodent, rotarod test, sensorimotor function, Social behavior, social disability, social interaction, spatial learning, TASK performance, traumatic brain injury
@article{Bondi2015,
title = {Found in translation: Understanding the biology and behavior of experimental traumatic brain injury},
author = {Bondi, C O and Semple, B D and Noble-Haeusslein, L J and Osier, N D and Carlson, S W and Dixon, C E and Giza, C C and Kline, A E},
doi = {10.1016/j.neubiorev.2014.12.004},
year = {2015},
date = {2015-01-01},
journal = {Neuroscience and Biobehavioral Reviews},
volume = {58},
pages = {123--146},
abstract = {The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury: laboratory and clinical perspectives," presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein, we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided. © 2014 Elsevier Ltd.},
keywords = {8 hydroxy 2 propylaminotetralin, Aggression, Attentional set-shifting test (AST), buspirone, Closed head injury, cognition, cognitive defect, cognitive function test, Concussion, conditioning, Controlled cortical impact (CCI), environmental enrichment, Environmental enrichment (EE), executive function, experimental disease, fear, Fluid percussion (FP), human, interpersonal communication, Memory, motor function test, nerve degeneration, neuropsychological test, Neurorehabilitation, nonhuman, outcome assessment, Pathophysiology, pediatrics, priority journal, rehabilitation care, Review, rodent, rotarod test, sensorimotor function, Social behavior, social disability, social interaction, spatial learning, TASK performance, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Zuckerman, Scott L; Lee, Young M; Odom, Mitchell J; Solomon, Gary S; Sills, Allen K
Baseline neurocognitive scores in athletes with attention deficit-spectrum disorders and/or learning disability Journal Article
In: Journal of Neurosurgery: Pediatrics, vol. 12, no. 2, pp. 103–109, 2013, ISBN: 1933-0707.
Links | BibTeX | Tags: ADOLESCENCE, Athletes, Athletic Injuries -- Complications, attention, Attention Deficit Hyperactivity Disorder -- Compli, Brain Concussion -- Complications, Brain Concussion -- Diagnosis, Brain Concussion -- Psychosocial Factors, Child, cognition, Cognition Disorders -- Diagnosis, Cognition Disorders -- Etiology, Female, human, Learning Disorders -- Complications, Male, Memory, Neuropsychological Tests, reaction time, Severity of Illness Indices, Sports
@article{Zuckerman2013,
title = {Baseline neurocognitive scores in athletes with attention deficit-spectrum disorders and/or learning disability},
author = {Zuckerman, Scott L and Lee, Young M and Odom, Mitchell J and Solomon, Gary S and Sills, Allen K},
doi = {10.3171/2013.5.PEDS12524},
isbn = {1933-0707},
year = {2013},
date = {2013-01-01},
journal = {Journal of Neurosurgery: Pediatrics},
volume = {12},
number = {2},
pages = {103--109},
publisher = {American Association of Neurological Surgeons \& the Journal of Neurosurgical Publishing Group},
address = {Rolling Meadows, Illinois},
keywords = {ADOLESCENCE, Athletes, Athletic Injuries -- Complications, attention, Attention Deficit Hyperactivity Disorder -- Compli, Brain Concussion -- Complications, Brain Concussion -- Diagnosis, Brain Concussion -- Psychosocial Factors, Child, cognition, Cognition Disorders -- Diagnosis, Cognition Disorders -- Etiology, Female, human, Learning Disorders -- Complications, Male, Memory, Neuropsychological Tests, reaction time, Severity of Illness Indices, Sports},
pubstate = {published},
tppubtype = {article}
}
Gay, Robin K
Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury Journal Article
In: NeuroRehabilitation, vol. 32, no. 3, pp. 473–482, 2013, ISBN: 10538135.
Abstract | Links | BibTeX | Tags: ACOUSTIC stimulation (Neurophysiology), Balance, BRAIN -- Wounds & injuries -- Complications, brain injury rehabilitation, cognition, Concussion, DIAGNOSIS, DISEASES, Dizziness, Dizziness -- Risk factors, EQUILIBRIUM (Physiology), falls prevention, GAIT in humans, Memory, mild traumatic brain injury, neurocognitive assessment, sports injury, VESTIBULAR apparatus
@article{Gay2013,
title = {Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury},
author = {Gay, Robin K},
doi = {10.3233/NRE-130870},
isbn = {10538135},
year = {2013},
date = {2013-01-01},
journal = {NeuroRehabilitation},
volume = {32},
number = {3},
pages = {473--482},
publisher = {IOS Press},
abstract = {INTRODUCTION: Problems with balance and dizziness are one of the most common complaints of individuals who have experienced a brain injury and are reported in up to 90% of cases. Despite the ubiquity of vestibular disturbance in this population, there remains a dearth of research on the interaction between physiological and cognitive systems responsible for maintaining balance. PURPOSE: The purpose of this article is to review studies on the interaction of physiological and cognitive processes required to maintain balance that may aide assessment and recovery of balance disturbance in patients with brain injury. SUMMARY: This article provides a review of research on the role of higher order cognitive processes in maintaining balance and rational for further inclusion of neurocognitive measures in the assessment of vestibular disturbance. CONCLUSION: Greater inclusion of neurocognitive measures in assessment of vestibular disturbance provides a method of assessment containing increased ecological validity compared to traditional assessments, better prepares patients for discharge, and may reduce the incidence of future injury.},
keywords = {ACOUSTIC stimulation (Neurophysiology), Balance, BRAIN -- Wounds \& injuries -- Complications, brain injury rehabilitation, cognition, Concussion, DIAGNOSIS, DISEASES, Dizziness, Dizziness -- Risk factors, EQUILIBRIUM (Physiology), falls prevention, GAIT in humans, Memory, mild traumatic brain injury, neurocognitive assessment, sports injury, VESTIBULAR apparatus},
pubstate = {published},
tppubtype = {article}
}