Chang, C Y; Torriani, M; Huang, A J
Rock Climbing Injuries: Acute and Chronic Repetitive Trauma Journal Article
In: Current Problems in Diagnostic Radiology, vol. 45, no. 3, pp. 205–214, 2016.
Abstract | BibTeX | Tags: *Cumulative Trauma Disorders/dg [Diagnostic Imagin, *Diagnostic Imaging/mt [Methods], *Mountaineering/in [Injuries], acute disease, chronic disease, Extremities/dg [Diagnostic Imaging], Humans
@article{Chang2016,
title = {Rock Climbing Injuries: Acute and Chronic Repetitive Trauma},
author = {Chang, C Y and Torriani, M and Huang, A J},
year = {2016},
date = {2016-01-01},
journal = {Current Problems in Diagnostic Radiology},
volume = {45},
number = {3},
pages = {205--214},
abstract = {Rock climbing has increased in popularity as a sport, and specific injuries related to its practice are becoming more common. Chronic repetitive injuries are more common than acute injuries, although acute injuries tend to be more severe. We review both acute and chronic upper and lower extremity injuries. Understanding the injury pattern in rock climbers is important for accurate diagnosis. Copyright © 2015 Mosby, Inc. All rights reserved.},
keywords = {*Cumulative Trauma Disorders/dg [Diagnostic Imagin, *Diagnostic Imaging/mt [Methods], *Mountaineering/in [Injuries], acute disease, chronic disease, Extremities/dg [Diagnostic Imaging], Humans},
pubstate = {published},
tppubtype = {article}
}
Astafiev, S V; Zinn, K L; Shulman, G L; Corbetta, M
Exploring the physiological correlates of chronic mild traumatic brain injury symptoms Journal Article
In: NeuroImage Clinical, vol. 11, pp. 10–19, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Brain Concussion/pp [Physiopathology], *Post-Concussion Syndrome/pp [Physiopathology], *White Matter/pp [Physiopathology], anisotropy, chronic disease, Diffusion Tensor Imaging/mt [Methods], Female, Humans, Magnetic Resonance Imaging/mt [Methods], Male, Neuropsychological Tests
@article{Astafiev2016,
title = {Exploring the physiological correlates of chronic mild traumatic brain injury symptoms},
author = {Astafiev, S V and Zinn, K L and Shulman, G L and Corbetta, M},
year = {2016},
date = {2016-01-01},
journal = {NeuroImage Clinical},
volume = {11},
pages = {10--19},
abstract = {We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.},
keywords = {*Brain Concussion/di [Diagnosis], *Brain Concussion/pp [Physiopathology], *Post-Concussion Syndrome/pp [Physiopathology], *White Matter/pp [Physiopathology], anisotropy, chronic disease, Diffusion Tensor Imaging/mt [Methods], Female, Humans, Magnetic Resonance Imaging/mt [Methods], Male, Neuropsychological Tests},
pubstate = {published},
tppubtype = {article}
}
Moon, K; Theodore, N
Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists? Journal Article
In: World Neurosurgery, vol. 89, pp. 720–721, 2016.
Links | BibTeX | Tags: Alzheimer disease, amyloid beta protein, amyloid plaque, anxiety disorder, apolipoprotein E, Article, behavior disorder, Boxing, brain atrophy, brain concussion, brain degeneration, chronic disease, Chronic traumatic encephalopathy, cognitive defect, degenerative disease, depression, environmental factor, football, frontotemporal dementia, genetic predisposition, genetic risk, genetic susceptibility, human, motor control, Neuroanatomy, opiate addiction, Parkinson disease, protein phosphorylation, scar formation, septum pellucidum, sport injury, substantia nigra, suicide, TAR DNA binding protein, tau protein, tauopathy, traumatic brain injury
@article{Moon2016,
title = {Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists?},
author = {Moon, K and Theodore, N},
doi = {10.1016/j.wneu.2016.03.073},
year = {2016},
date = {2016-01-01},
journal = {World Neurosurgery},
volume = {89},
pages = {720--721},
keywords = {Alzheimer disease, amyloid beta protein, amyloid plaque, anxiety disorder, apolipoprotein E, Article, behavior disorder, Boxing, brain atrophy, brain concussion, brain degeneration, chronic disease, Chronic traumatic encephalopathy, cognitive defect, degenerative disease, depression, environmental factor, football, frontotemporal dementia, genetic predisposition, genetic risk, genetic susceptibility, human, motor control, Neuroanatomy, opiate addiction, Parkinson disease, protein phosphorylation, scar formation, septum pellucidum, sport injury, substantia nigra, suicide, TAR DNA binding protein, tau protein, tauopathy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Corboy, J R
Cannabis to concussion Journal Article
In: Neurology: Clinical Practice, vol. 5, no. 4, pp. 273, 2015.
Abstract | Links | BibTeX | Tags: Acquired brain injury, act, athlete, brain disease, cerebrovascular accident, chronic disease, clinical practice, Concussion, football, human, medical cannabis, medically uninsured, migraine, neurologist, nurse practitioner, physician assistant, policy, priority journal, Review
@article{Corboy2015,
title = {Cannabis to concussion},
author = {Corboy, J R},
doi = {10.1212/CPJ.0000000000000167},
year = {2015},
date = {2015-01-01},
journal = {Neurology: Clinical Practice},
volume = {5},
number = {4},
pages = {273},
abstract = {This issue of Neurology® Clinical Practice features thought-provoking articles on disparate topics. Gardner et al. (p. 285) tackle chronic traumatic encephalopathy, describing clinical and pathologic features in 14 self-referred symptomatic former professional football players. Harold Adams (p. 296) details the controversy surrounding treatment of patients who awaken with stroke symptoms whose time of onset cannot be established. Borsook and Dodick (p. 317) make a passionate plea to recognize the disabling nature of migraine. While it is not clear whether challenges to the Affordable Care Act will result in large numbers of Americans returning to the rolls of the uninsured, Taylor et al. (p. 302) chronicle the creation of a free neurology clinic that might serve as a model for others. © 2015 American Academy of Neurology.},
keywords = {Acquired brain injury, act, athlete, brain disease, cerebrovascular accident, chronic disease, clinical practice, Concussion, football, human, medical cannabis, medically uninsured, migraine, neurologist, nurse practitioner, physician assistant, policy, priority journal, Review},
pubstate = {published},
tppubtype = {article}
}
Stein, T D; Alvarez, V E; McKee, A C
Chronic traumatic encephalopathy: A spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel Journal Article
In: Alzheimer's Research and Therapy, vol. 6, no. 1, 2014.
Abstract | Links | BibTeX | Tags: Aggression, Alzheimer disease, amnesia, army, astrocyte, athlete, behavior change, brain atrophy, brain stem, brain weight, central sulcus, chronic disease, Chronic Traumatic Encephalopathy TAR DNA binding p, cognitive defect, comorbidity, Dementia, depression, diencephalon, diffuse Lewy body disease, exposure, frontotemporal dementia, human, impulsiveness, irritability, Motor neuron disease, nerve fiber, neurite, neurofibrillary tangle, neuropathology, nonhuman, personality disorder, priority journal, Review, short term memory, soldier, staging, suicidal ideation, tau protein, tauopathy, temporal lobe, traumatic brain injury, veteran
@article{Stein2014,
title = {Chronic traumatic encephalopathy: A spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel},
author = {Stein, T D and Alvarez, V E and McKee, A C},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84892718392\&partnerID=40\&md5=c39a0e58ad33cee7a570b4681131d6ea},
doi = {10.1186/alzrt234},
year = {2014},
date = {2014-01-01},
journal = {Alzheimer's Research and Therapy},
volume = {6},
number = {1},
abstract = {Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that occurs in association with repetitive traumatic brain injury experienced in sport and military service. In most instances, the clinical symptoms of the disease begin after a long period of latency ranging from several years to several decades. The initial symptoms are typically insidious, consisting of irritability, impulsivity, aggression, depression, short-term memory loss and heightened suicidality. The symptoms progress slowly over decades to include cognitive deficits and dementia. The pathology of CTE is characterized by the accumulation of phosphorylated tau protein in neurons and astrocytes in a pattern that is unique from other tauopathies, including Alzheimer's disease. The hyperphosphorylated tau abnormalities begin focally, as perivascular neurofibrillary tangles and neurites at the depths of the cerebral sulci, and then spread to involve superficial layers of adjacent cortex before becoming a widespread degeneration affecting medial temporal lobe structures, diencephalon and brainstem. Most instances of CTE (\>85% of cases) show abnormal accumulations of phosphorylated 43 kDa TAR DNA binding protein that are partially colocalized with phosphorylated tau protein. As CTE is characterized pathologically by frontal and temporal lobe atrophy, by abnormal deposits of phosphorylated tau and by 43 kDa TAR DNA binding protein and is associated clinically with behavioral and personality changes, as well as cognitive impairments, CTE is increasingly categorized as an acquired frontotemporal lobar degeneration. Currently, some of the greatest challenges are that CTE cannot be diagnosed during life and the incidence and prevalence of the disorder remain uncertain. Furthermore, the contribution of age, gender, genetics, stress, alcohol and substance abuse to the development of CTE remains to be determined. © 2014 BioMed Central Ltd.},
keywords = {Aggression, Alzheimer disease, amnesia, army, astrocyte, athlete, behavior change, brain atrophy, brain stem, brain weight, central sulcus, chronic disease, Chronic Traumatic Encephalopathy TAR DNA binding p, cognitive defect, comorbidity, Dementia, depression, diencephalon, diffuse Lewy body disease, exposure, frontotemporal dementia, human, impulsiveness, irritability, Motor neuron disease, nerve fiber, neurite, neurofibrillary tangle, neuropathology, nonhuman, personality disorder, priority journal, Review, short term memory, soldier, staging, suicidal ideation, tau protein, tauopathy, temporal lobe, traumatic brain injury, veteran},
pubstate = {published},
tppubtype = {article}
}
Gandy, S; Ikonomovic, M D; Mitsis, E; Elder, G; Ahlers, S T; Barth, J; Stone, J R; Dekosky, S T
Chronic traumatic encephalopathy: Clinical-biomarker correlations and current concepts in pathogenesis Journal Article
In: Molecular Neurodegeneration, vol. 9, no. 1, 2014.
Abstract | Links | BibTeX | Tags: animal model, army, Article, blast injury, body fluid, Boxing, chronic disease, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy biological marker, Dementia, dementia pugilistica, Diffusion Tensor Imaging, executive function, experimental animal, fluorine 18, football, functional magnetic resonance imaging, functional neuroimaging, human, molecular pathology, neuropathology, neuropsychology, nonhuman, nuclear magnetic resonance imaging, Occupational Exposure, positron emission tomography, punch drunk syndrome, systematic review (topic), traumatic brain injury, white matter, working memory
@article{Gandy2014a,
title = {Chronic traumatic encephalopathy: Clinical-biomarker correlations and current concepts in pathogenesis},
author = {Gandy, S and Ikonomovic, M D and Mitsis, E and Elder, G and Ahlers, S T and Barth, J and Stone, J R and Dekosky, S T},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84907464163\&partnerID=40\&md5=109c916e926417c11bab99fd7b44065c},
doi = {10.1186/1750-1326-9-37},
year = {2014},
date = {2014-01-01},
journal = {Molecular Neurodegeneration},
volume = {9},
number = {1},
abstract = {Background: Chronic traumatic encephalopathy (CTE) is a recently revived term used to describe a neurodegenerative process that occurs as a long term complication of repetitive mild traumatic brain injury (TBI). Corsellis provided one of the classic descriptions of CTE in boxers under the name "dementia pugilistica" (DP). Much recent attention has been drawn to the apparent association of CTE with contact sports (football, soccer, hockey) and with frequent battlefield exposure to blast waves generated by improvised explosive devices (IEDs). Recently, a promising serum biomarker has been identified by measurement of serum levels of the neuronal microtubule associated protein tau. New positron emission tomography (PET) ligands (e.g., [18F] T807) that identify brain tauopathy have been successfully deployed for the in vitro and in vivo detection of presumptive tauopathy in the brains of subjects with clinically probable CTE. Methods. Major academic and lay publications on DP/CTE were reviewed beginning with the 1928 paper describing the initial use of the term CTE by Martland. Results: The major current concepts in the neurological, psychiatric, neuropsychological, neuroimaging, and body fluid biomarker science of DP/CTE have been summarized. Newer achievements, such as serum tau and [18F] T807 tauopathy imaging, are also introduced and their significance has been explained. Conclusion: Recent advances in the science of DP/CTE hold promise for elucidating a long sought accurate determination of the true prevalence of CTE. This information holds potentially important public health implications for estimating the risk of contact sports in inflicting permanent and/or progressive brain damage on children, adolescents, and adults. © 2014Gandy et al.; licensee BioMed Central Ltd.},
keywords = {animal model, army, Article, blast injury, body fluid, Boxing, chronic disease, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy biological marker, Dementia, dementia pugilistica, Diffusion Tensor Imaging, executive function, experimental animal, fluorine 18, football, functional magnetic resonance imaging, functional neuroimaging, human, molecular pathology, neuropathology, neuropsychology, nonhuman, nuclear magnetic resonance imaging, Occupational Exposure, positron emission tomography, punch drunk syndrome, systematic review (topic), traumatic brain injury, white matter, working memory},
pubstate = {published},
tppubtype = {article}
}
Dubourg, J; Messerer, M
Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction Journal Article
In: Neurosurgical Focus, vol. 31, no. 5, pp. E2, 2011.
Abstract | BibTeX | Tags: *Athletic Injuries/pp [Physiopathology], *Brain Injuries/pp [Physiopathology], *HEAD injuries, *Pituitary Diseases/et [Etiology], *Pituitary Gland/pp [Physiopathology], Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Brain Concussion/di [Diagnosis], Brain Concussion/pp [Physiopathology], Brain Injuries/et [Etiology], chronic disease, Closed/co [Complications], Closed/pp [Physiopathology], Early Diagnosis, Head Injuries, Humans, Pituitary Diseases/pp [Physiopathology], Pituitary Gland/in [Injuries]
@article{Dubourg2011,
title = {Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction},
author = {Dubourg, J and Messerer, M},
year = {2011},
date = {2011-01-01},
journal = {Neurosurgical Focus},
volume = {31},
number = {5},
pages = {E2},
abstract = {Traumatic brain injury (TBI) is recognized as a cause of hypopituitarism even after mild TBI. Although over the past decade, a growing body of research has detailed neuroendocrine changes induced by TBI, the mechanisms and risk factors responsible for this pituitary dysfunction are still unclear. Around the world, sports-especially combative sports-are very popular. However, sports are not generally considered as a cause of TBI in most epidemiological studies, and the link between sports-related head trauma and hypopituitarism has not been investigated until recently. Thus, there is a paucity of data regarding this important concern. Because of the large number of young sports participants with near-normal life expectancy, the implications of undiagnosed or untreated postconcussion pituitary dysfunction can be dramatic. Understanding the pathophysiological mechanisms and risk factors of hypopituitarism caused by sports injuries is thus an important issue that concerns both medical staff and sponsors of sports. The aim of this paper was to summarize the best evidence for understanding the pathophysiological mechanisms and to discuss the current data and recommendations on sports-related head trauma as a cause of hypopituitarism.},
keywords = {*Athletic Injuries/pp [Physiopathology], *Brain Injuries/pp [Physiopathology], *HEAD injuries, *Pituitary Diseases/et [Etiology], *Pituitary Gland/pp [Physiopathology], Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Brain Concussion/di [Diagnosis], Brain Concussion/pp [Physiopathology], Brain Injuries/et [Etiology], chronic disease, Closed/co [Complications], Closed/pp [Physiopathology], Early Diagnosis, Head Injuries, Humans, Pituitary Diseases/pp [Physiopathology], Pituitary Gland/in [Injuries]},
pubstate = {published},
tppubtype = {article}
}
Chang, C Y; Torriani, M; Huang, A J
Rock Climbing Injuries: Acute and Chronic Repetitive Trauma Journal Article
In: Current Problems in Diagnostic Radiology, vol. 45, no. 3, pp. 205–214, 2016.
@article{Chang2016,
title = {Rock Climbing Injuries: Acute and Chronic Repetitive Trauma},
author = {Chang, C Y and Torriani, M and Huang, A J},
year = {2016},
date = {2016-01-01},
journal = {Current Problems in Diagnostic Radiology},
volume = {45},
number = {3},
pages = {205--214},
abstract = {Rock climbing has increased in popularity as a sport, and specific injuries related to its practice are becoming more common. Chronic repetitive injuries are more common than acute injuries, although acute injuries tend to be more severe. We review both acute and chronic upper and lower extremity injuries. Understanding the injury pattern in rock climbers is important for accurate diagnosis. Copyright © 2015 Mosby, Inc. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Astafiev, S V; Zinn, K L; Shulman, G L; Corbetta, M
Exploring the physiological correlates of chronic mild traumatic brain injury symptoms Journal Article
In: NeuroImage Clinical, vol. 11, pp. 10–19, 2016.
@article{Astafiev2016,
title = {Exploring the physiological correlates of chronic mild traumatic brain injury symptoms},
author = {Astafiev, S V and Zinn, K L and Shulman, G L and Corbetta, M},
year = {2016},
date = {2016-01-01},
journal = {NeuroImage Clinical},
volume = {11},
pages = {10--19},
abstract = {We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Moon, K; Theodore, N
Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists? Journal Article
In: World Neurosurgery, vol. 89, pp. 720–721, 2016.
@article{Moon2016,
title = {Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists?},
author = {Moon, K and Theodore, N},
doi = {10.1016/j.wneu.2016.03.073},
year = {2016},
date = {2016-01-01},
journal = {World Neurosurgery},
volume = {89},
pages = {720--721},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Corboy, J R
Cannabis to concussion Journal Article
In: Neurology: Clinical Practice, vol. 5, no. 4, pp. 273, 2015.
@article{Corboy2015,
title = {Cannabis to concussion},
author = {Corboy, J R},
doi = {10.1212/CPJ.0000000000000167},
year = {2015},
date = {2015-01-01},
journal = {Neurology: Clinical Practice},
volume = {5},
number = {4},
pages = {273},
abstract = {This issue of Neurology® Clinical Practice features thought-provoking articles on disparate topics. Gardner et al. (p. 285) tackle chronic traumatic encephalopathy, describing clinical and pathologic features in 14 self-referred symptomatic former professional football players. Harold Adams (p. 296) details the controversy surrounding treatment of patients who awaken with stroke symptoms whose time of onset cannot be established. Borsook and Dodick (p. 317) make a passionate plea to recognize the disabling nature of migraine. While it is not clear whether challenges to the Affordable Care Act will result in large numbers of Americans returning to the rolls of the uninsured, Taylor et al. (p. 302) chronicle the creation of a free neurology clinic that might serve as a model for others. © 2015 American Academy of Neurology.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Stein, T D; Alvarez, V E; McKee, A C
Chronic traumatic encephalopathy: A spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel Journal Article
In: Alzheimer's Research and Therapy, vol. 6, no. 1, 2014.
@article{Stein2014,
title = {Chronic traumatic encephalopathy: A spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel},
author = {Stein, T D and Alvarez, V E and McKee, A C},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84892718392\&partnerID=40\&md5=c39a0e58ad33cee7a570b4681131d6ea},
doi = {10.1186/alzrt234},
year = {2014},
date = {2014-01-01},
journal = {Alzheimer's Research and Therapy},
volume = {6},
number = {1},
abstract = {Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that occurs in association with repetitive traumatic brain injury experienced in sport and military service. In most instances, the clinical symptoms of the disease begin after a long period of latency ranging from several years to several decades. The initial symptoms are typically insidious, consisting of irritability, impulsivity, aggression, depression, short-term memory loss and heightened suicidality. The symptoms progress slowly over decades to include cognitive deficits and dementia. The pathology of CTE is characterized by the accumulation of phosphorylated tau protein in neurons and astrocytes in a pattern that is unique from other tauopathies, including Alzheimer's disease. The hyperphosphorylated tau abnormalities begin focally, as perivascular neurofibrillary tangles and neurites at the depths of the cerebral sulci, and then spread to involve superficial layers of adjacent cortex before becoming a widespread degeneration affecting medial temporal lobe structures, diencephalon and brainstem. Most instances of CTE (\>85% of cases) show abnormal accumulations of phosphorylated 43 kDa TAR DNA binding protein that are partially colocalized with phosphorylated tau protein. As CTE is characterized pathologically by frontal and temporal lobe atrophy, by abnormal deposits of phosphorylated tau and by 43 kDa TAR DNA binding protein and is associated clinically with behavioral and personality changes, as well as cognitive impairments, CTE is increasingly categorized as an acquired frontotemporal lobar degeneration. Currently, some of the greatest challenges are that CTE cannot be diagnosed during life and the incidence and prevalence of the disorder remain uncertain. Furthermore, the contribution of age, gender, genetics, stress, alcohol and substance abuse to the development of CTE remains to be determined. © 2014 BioMed Central Ltd.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gandy, S; Ikonomovic, M D; Mitsis, E; Elder, G; Ahlers, S T; Barth, J; Stone, J R; Dekosky, S T
Chronic traumatic encephalopathy: Clinical-biomarker correlations and current concepts in pathogenesis Journal Article
In: Molecular Neurodegeneration, vol. 9, no. 1, 2014.
@article{Gandy2014a,
title = {Chronic traumatic encephalopathy: Clinical-biomarker correlations and current concepts in pathogenesis},
author = {Gandy, S and Ikonomovic, M D and Mitsis, E and Elder, G and Ahlers, S T and Barth, J and Stone, J R and Dekosky, S T},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84907464163\&partnerID=40\&md5=109c916e926417c11bab99fd7b44065c},
doi = {10.1186/1750-1326-9-37},
year = {2014},
date = {2014-01-01},
journal = {Molecular Neurodegeneration},
volume = {9},
number = {1},
abstract = {Background: Chronic traumatic encephalopathy (CTE) is a recently revived term used to describe a neurodegenerative process that occurs as a long term complication of repetitive mild traumatic brain injury (TBI). Corsellis provided one of the classic descriptions of CTE in boxers under the name "dementia pugilistica" (DP). Much recent attention has been drawn to the apparent association of CTE with contact sports (football, soccer, hockey) and with frequent battlefield exposure to blast waves generated by improvised explosive devices (IEDs). Recently, a promising serum biomarker has been identified by measurement of serum levels of the neuronal microtubule associated protein tau. New positron emission tomography (PET) ligands (e.g., [18F] T807) that identify brain tauopathy have been successfully deployed for the in vitro and in vivo detection of presumptive tauopathy in the brains of subjects with clinically probable CTE. Methods. Major academic and lay publications on DP/CTE were reviewed beginning with the 1928 paper describing the initial use of the term CTE by Martland. Results: The major current concepts in the neurological, psychiatric, neuropsychological, neuroimaging, and body fluid biomarker science of DP/CTE have been summarized. Newer achievements, such as serum tau and [18F] T807 tauopathy imaging, are also introduced and their significance has been explained. Conclusion: Recent advances in the science of DP/CTE hold promise for elucidating a long sought accurate determination of the true prevalence of CTE. This information holds potentially important public health implications for estimating the risk of contact sports in inflicting permanent and/or progressive brain damage on children, adolescents, and adults. © 2014Gandy et al.; licensee BioMed Central Ltd.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dubourg, J; Messerer, M
Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction Journal Article
In: Neurosurgical Focus, vol. 31, no. 5, pp. E2, 2011.
@article{Dubourg2011,
title = {Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction},
author = {Dubourg, J and Messerer, M},
year = {2011},
date = {2011-01-01},
journal = {Neurosurgical Focus},
volume = {31},
number = {5},
pages = {E2},
abstract = {Traumatic brain injury (TBI) is recognized as a cause of hypopituitarism even after mild TBI. Although over the past decade, a growing body of research has detailed neuroendocrine changes induced by TBI, the mechanisms and risk factors responsible for this pituitary dysfunction are still unclear. Around the world, sports-especially combative sports-are very popular. However, sports are not generally considered as a cause of TBI in most epidemiological studies, and the link between sports-related head trauma and hypopituitarism has not been investigated until recently. Thus, there is a paucity of data regarding this important concern. Because of the large number of young sports participants with near-normal life expectancy, the implications of undiagnosed or untreated postconcussion pituitary dysfunction can be dramatic. Understanding the pathophysiological mechanisms and risk factors of hypopituitarism caused by sports injuries is thus an important issue that concerns both medical staff and sponsors of sports. The aim of this paper was to summarize the best evidence for understanding the pathophysiological mechanisms and to discuss the current data and recommendations on sports-related head trauma as a cause of hypopituitarism.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chang, C Y; Torriani, M; Huang, A J
Rock Climbing Injuries: Acute and Chronic Repetitive Trauma Journal Article
In: Current Problems in Diagnostic Radiology, vol. 45, no. 3, pp. 205–214, 2016.
Abstract | BibTeX | Tags: *Cumulative Trauma Disorders/dg [Diagnostic Imagin, *Diagnostic Imaging/mt [Methods], *Mountaineering/in [Injuries], acute disease, chronic disease, Extremities/dg [Diagnostic Imaging], Humans
@article{Chang2016,
title = {Rock Climbing Injuries: Acute and Chronic Repetitive Trauma},
author = {Chang, C Y and Torriani, M and Huang, A J},
year = {2016},
date = {2016-01-01},
journal = {Current Problems in Diagnostic Radiology},
volume = {45},
number = {3},
pages = {205--214},
abstract = {Rock climbing has increased in popularity as a sport, and specific injuries related to its practice are becoming more common. Chronic repetitive injuries are more common than acute injuries, although acute injuries tend to be more severe. We review both acute and chronic upper and lower extremity injuries. Understanding the injury pattern in rock climbers is important for accurate diagnosis. Copyright © 2015 Mosby, Inc. All rights reserved.},
keywords = {*Cumulative Trauma Disorders/dg [Diagnostic Imagin, *Diagnostic Imaging/mt [Methods], *Mountaineering/in [Injuries], acute disease, chronic disease, Extremities/dg [Diagnostic Imaging], Humans},
pubstate = {published},
tppubtype = {article}
}
Astafiev, S V; Zinn, K L; Shulman, G L; Corbetta, M
Exploring the physiological correlates of chronic mild traumatic brain injury symptoms Journal Article
In: NeuroImage Clinical, vol. 11, pp. 10–19, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Brain Concussion/pp [Physiopathology], *Post-Concussion Syndrome/pp [Physiopathology], *White Matter/pp [Physiopathology], anisotropy, chronic disease, Diffusion Tensor Imaging/mt [Methods], Female, Humans, Magnetic Resonance Imaging/mt [Methods], Male, Neuropsychological Tests
@article{Astafiev2016,
title = {Exploring the physiological correlates of chronic mild traumatic brain injury symptoms},
author = {Astafiev, S V and Zinn, K L and Shulman, G L and Corbetta, M},
year = {2016},
date = {2016-01-01},
journal = {NeuroImage Clinical},
volume = {11},
pages = {10--19},
abstract = {We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.},
keywords = {*Brain Concussion/di [Diagnosis], *Brain Concussion/pp [Physiopathology], *Post-Concussion Syndrome/pp [Physiopathology], *White Matter/pp [Physiopathology], anisotropy, chronic disease, Diffusion Tensor Imaging/mt [Methods], Female, Humans, Magnetic Resonance Imaging/mt [Methods], Male, Neuropsychological Tests},
pubstate = {published},
tppubtype = {article}
}
Moon, K; Theodore, N
Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists? Journal Article
In: World Neurosurgery, vol. 89, pp. 720–721, 2016.
Links | BibTeX | Tags: Alzheimer disease, amyloid beta protein, amyloid plaque, anxiety disorder, apolipoprotein E, Article, behavior disorder, Boxing, brain atrophy, brain concussion, brain degeneration, chronic disease, Chronic traumatic encephalopathy, cognitive defect, degenerative disease, depression, environmental factor, football, frontotemporal dementia, genetic predisposition, genetic risk, genetic susceptibility, human, motor control, Neuroanatomy, opiate addiction, Parkinson disease, protein phosphorylation, scar formation, septum pellucidum, sport injury, substantia nigra, suicide, TAR DNA binding protein, tau protein, tauopathy, traumatic brain injury
@article{Moon2016,
title = {Football and Chronic Traumatic Encephalopathy: How Much Evidence Actually Exists?},
author = {Moon, K and Theodore, N},
doi = {10.1016/j.wneu.2016.03.073},
year = {2016},
date = {2016-01-01},
journal = {World Neurosurgery},
volume = {89},
pages = {720--721},
keywords = {Alzheimer disease, amyloid beta protein, amyloid plaque, anxiety disorder, apolipoprotein E, Article, behavior disorder, Boxing, brain atrophy, brain concussion, brain degeneration, chronic disease, Chronic traumatic encephalopathy, cognitive defect, degenerative disease, depression, environmental factor, football, frontotemporal dementia, genetic predisposition, genetic risk, genetic susceptibility, human, motor control, Neuroanatomy, opiate addiction, Parkinson disease, protein phosphorylation, scar formation, septum pellucidum, sport injury, substantia nigra, suicide, TAR DNA binding protein, tau protein, tauopathy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Corboy, J R
Cannabis to concussion Journal Article
In: Neurology: Clinical Practice, vol. 5, no. 4, pp. 273, 2015.
Abstract | Links | BibTeX | Tags: Acquired brain injury, act, athlete, brain disease, cerebrovascular accident, chronic disease, clinical practice, Concussion, football, human, medical cannabis, medically uninsured, migraine, neurologist, nurse practitioner, physician assistant, policy, priority journal, Review
@article{Corboy2015,
title = {Cannabis to concussion},
author = {Corboy, J R},
doi = {10.1212/CPJ.0000000000000167},
year = {2015},
date = {2015-01-01},
journal = {Neurology: Clinical Practice},
volume = {5},
number = {4},
pages = {273},
abstract = {This issue of Neurology® Clinical Practice features thought-provoking articles on disparate topics. Gardner et al. (p. 285) tackle chronic traumatic encephalopathy, describing clinical and pathologic features in 14 self-referred symptomatic former professional football players. Harold Adams (p. 296) details the controversy surrounding treatment of patients who awaken with stroke symptoms whose time of onset cannot be established. Borsook and Dodick (p. 317) make a passionate plea to recognize the disabling nature of migraine. While it is not clear whether challenges to the Affordable Care Act will result in large numbers of Americans returning to the rolls of the uninsured, Taylor et al. (p. 302) chronicle the creation of a free neurology clinic that might serve as a model for others. © 2015 American Academy of Neurology.},
keywords = {Acquired brain injury, act, athlete, brain disease, cerebrovascular accident, chronic disease, clinical practice, Concussion, football, human, medical cannabis, medically uninsured, migraine, neurologist, nurse practitioner, physician assistant, policy, priority journal, Review},
pubstate = {published},
tppubtype = {article}
}
Stein, T D; Alvarez, V E; McKee, A C
Chronic traumatic encephalopathy: A spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel Journal Article
In: Alzheimer's Research and Therapy, vol. 6, no. 1, 2014.
Abstract | Links | BibTeX | Tags: Aggression, Alzheimer disease, amnesia, army, astrocyte, athlete, behavior change, brain atrophy, brain stem, brain weight, central sulcus, chronic disease, Chronic Traumatic Encephalopathy TAR DNA binding p, cognitive defect, comorbidity, Dementia, depression, diencephalon, diffuse Lewy body disease, exposure, frontotemporal dementia, human, impulsiveness, irritability, Motor neuron disease, nerve fiber, neurite, neurofibrillary tangle, neuropathology, nonhuman, personality disorder, priority journal, Review, short term memory, soldier, staging, suicidal ideation, tau protein, tauopathy, temporal lobe, traumatic brain injury, veteran
@article{Stein2014,
title = {Chronic traumatic encephalopathy: A spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel},
author = {Stein, T D and Alvarez, V E and McKee, A C},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84892718392\&partnerID=40\&md5=c39a0e58ad33cee7a570b4681131d6ea},
doi = {10.1186/alzrt234},
year = {2014},
date = {2014-01-01},
journal = {Alzheimer's Research and Therapy},
volume = {6},
number = {1},
abstract = {Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that occurs in association with repetitive traumatic brain injury experienced in sport and military service. In most instances, the clinical symptoms of the disease begin after a long period of latency ranging from several years to several decades. The initial symptoms are typically insidious, consisting of irritability, impulsivity, aggression, depression, short-term memory loss and heightened suicidality. The symptoms progress slowly over decades to include cognitive deficits and dementia. The pathology of CTE is characterized by the accumulation of phosphorylated tau protein in neurons and astrocytes in a pattern that is unique from other tauopathies, including Alzheimer's disease. The hyperphosphorylated tau abnormalities begin focally, as perivascular neurofibrillary tangles and neurites at the depths of the cerebral sulci, and then spread to involve superficial layers of adjacent cortex before becoming a widespread degeneration affecting medial temporal lobe structures, diencephalon and brainstem. Most instances of CTE (\>85% of cases) show abnormal accumulations of phosphorylated 43 kDa TAR DNA binding protein that are partially colocalized with phosphorylated tau protein. As CTE is characterized pathologically by frontal and temporal lobe atrophy, by abnormal deposits of phosphorylated tau and by 43 kDa TAR DNA binding protein and is associated clinically with behavioral and personality changes, as well as cognitive impairments, CTE is increasingly categorized as an acquired frontotemporal lobar degeneration. Currently, some of the greatest challenges are that CTE cannot be diagnosed during life and the incidence and prevalence of the disorder remain uncertain. Furthermore, the contribution of age, gender, genetics, stress, alcohol and substance abuse to the development of CTE remains to be determined. © 2014 BioMed Central Ltd.},
keywords = {Aggression, Alzheimer disease, amnesia, army, astrocyte, athlete, behavior change, brain atrophy, brain stem, brain weight, central sulcus, chronic disease, Chronic Traumatic Encephalopathy TAR DNA binding p, cognitive defect, comorbidity, Dementia, depression, diencephalon, diffuse Lewy body disease, exposure, frontotemporal dementia, human, impulsiveness, irritability, Motor neuron disease, nerve fiber, neurite, neurofibrillary tangle, neuropathology, nonhuman, personality disorder, priority journal, Review, short term memory, soldier, staging, suicidal ideation, tau protein, tauopathy, temporal lobe, traumatic brain injury, veteran},
pubstate = {published},
tppubtype = {article}
}
Gandy, S; Ikonomovic, M D; Mitsis, E; Elder, G; Ahlers, S T; Barth, J; Stone, J R; Dekosky, S T
Chronic traumatic encephalopathy: Clinical-biomarker correlations and current concepts in pathogenesis Journal Article
In: Molecular Neurodegeneration, vol. 9, no. 1, 2014.
Abstract | Links | BibTeX | Tags: animal model, army, Article, blast injury, body fluid, Boxing, chronic disease, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy biological marker, Dementia, dementia pugilistica, Diffusion Tensor Imaging, executive function, experimental animal, fluorine 18, football, functional magnetic resonance imaging, functional neuroimaging, human, molecular pathology, neuropathology, neuropsychology, nonhuman, nuclear magnetic resonance imaging, Occupational Exposure, positron emission tomography, punch drunk syndrome, systematic review (topic), traumatic brain injury, white matter, working memory
@article{Gandy2014a,
title = {Chronic traumatic encephalopathy: Clinical-biomarker correlations and current concepts in pathogenesis},
author = {Gandy, S and Ikonomovic, M D and Mitsis, E and Elder, G and Ahlers, S T and Barth, J and Stone, J R and Dekosky, S T},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84907464163\&partnerID=40\&md5=109c916e926417c11bab99fd7b44065c},
doi = {10.1186/1750-1326-9-37},
year = {2014},
date = {2014-01-01},
journal = {Molecular Neurodegeneration},
volume = {9},
number = {1},
abstract = {Background: Chronic traumatic encephalopathy (CTE) is a recently revived term used to describe a neurodegenerative process that occurs as a long term complication of repetitive mild traumatic brain injury (TBI). Corsellis provided one of the classic descriptions of CTE in boxers under the name "dementia pugilistica" (DP). Much recent attention has been drawn to the apparent association of CTE with contact sports (football, soccer, hockey) and with frequent battlefield exposure to blast waves generated by improvised explosive devices (IEDs). Recently, a promising serum biomarker has been identified by measurement of serum levels of the neuronal microtubule associated protein tau. New positron emission tomography (PET) ligands (e.g., [18F] T807) that identify brain tauopathy have been successfully deployed for the in vitro and in vivo detection of presumptive tauopathy in the brains of subjects with clinically probable CTE. Methods. Major academic and lay publications on DP/CTE were reviewed beginning with the 1928 paper describing the initial use of the term CTE by Martland. Results: The major current concepts in the neurological, psychiatric, neuropsychological, neuroimaging, and body fluid biomarker science of DP/CTE have been summarized. Newer achievements, such as serum tau and [18F] T807 tauopathy imaging, are also introduced and their significance has been explained. Conclusion: Recent advances in the science of DP/CTE hold promise for elucidating a long sought accurate determination of the true prevalence of CTE. This information holds potentially important public health implications for estimating the risk of contact sports in inflicting permanent and/or progressive brain damage on children, adolescents, and adults. © 2014Gandy et al.; licensee BioMed Central Ltd.},
keywords = {animal model, army, Article, blast injury, body fluid, Boxing, chronic disease, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy biological marker, Dementia, dementia pugilistica, Diffusion Tensor Imaging, executive function, experimental animal, fluorine 18, football, functional magnetic resonance imaging, functional neuroimaging, human, molecular pathology, neuropathology, neuropsychology, nonhuman, nuclear magnetic resonance imaging, Occupational Exposure, positron emission tomography, punch drunk syndrome, systematic review (topic), traumatic brain injury, white matter, working memory},
pubstate = {published},
tppubtype = {article}
}
Dubourg, J; Messerer, M
Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction Journal Article
In: Neurosurgical Focus, vol. 31, no. 5, pp. E2, 2011.
Abstract | BibTeX | Tags: *Athletic Injuries/pp [Physiopathology], *Brain Injuries/pp [Physiopathology], *HEAD injuries, *Pituitary Diseases/et [Etiology], *Pituitary Gland/pp [Physiopathology], Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Brain Concussion/di [Diagnosis], Brain Concussion/pp [Physiopathology], Brain Injuries/et [Etiology], chronic disease, Closed/co [Complications], Closed/pp [Physiopathology], Early Diagnosis, Head Injuries, Humans, Pituitary Diseases/pp [Physiopathology], Pituitary Gland/in [Injuries]
@article{Dubourg2011,
title = {Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction},
author = {Dubourg, J and Messerer, M},
year = {2011},
date = {2011-01-01},
journal = {Neurosurgical Focus},
volume = {31},
number = {5},
pages = {E2},
abstract = {Traumatic brain injury (TBI) is recognized as a cause of hypopituitarism even after mild TBI. Although over the past decade, a growing body of research has detailed neuroendocrine changes induced by TBI, the mechanisms and risk factors responsible for this pituitary dysfunction are still unclear. Around the world, sports-especially combative sports-are very popular. However, sports are not generally considered as a cause of TBI in most epidemiological studies, and the link between sports-related head trauma and hypopituitarism has not been investigated until recently. Thus, there is a paucity of data regarding this important concern. Because of the large number of young sports participants with near-normal life expectancy, the implications of undiagnosed or untreated postconcussion pituitary dysfunction can be dramatic. Understanding the pathophysiological mechanisms and risk factors of hypopituitarism caused by sports injuries is thus an important issue that concerns both medical staff and sponsors of sports. The aim of this paper was to summarize the best evidence for understanding the pathophysiological mechanisms and to discuss the current data and recommendations on sports-related head trauma as a cause of hypopituitarism.},
keywords = {*Athletic Injuries/pp [Physiopathology], *Brain Injuries/pp [Physiopathology], *HEAD injuries, *Pituitary Diseases/et [Etiology], *Pituitary Gland/pp [Physiopathology], Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Brain Concussion/di [Diagnosis], Brain Concussion/pp [Physiopathology], Brain Injuries/et [Etiology], chronic disease, Closed/co [Complications], Closed/pp [Physiopathology], Early Diagnosis, Head Injuries, Humans, Pituitary Diseases/pp [Physiopathology], Pituitary Gland/in [Injuries]},
pubstate = {published},
tppubtype = {article}
}