Leung, A; Shukla, S; Fallah, A; Song, D; Lin, L; Golshan, S; Tsai, A; Jak, A; Polston, G; Lee, R
Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches Journal Article
In: Neuromodulation, vol. 19, no. 2, pp. 133–141, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Headache/et [Etiology], *Headache/th [Therapy], *Transcranial Magnetic Stimulation/mt [Methods], adult, aged, Female, Humans, Male, middle aged, Neuronavigation, Neuropsychological Tests, treatment outcome
@article{Leung2016,
title = {Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches},
author = {Leung, A and Shukla, S and Fallah, A and Song, D and Lin, L and Golshan, S and Tsai, A and Jak, A and Polston, G and Lee, R},
year = {2016},
date = {2016-01-01},
journal = {Neuromodulation},
volume = {19},
number = {2},
pages = {133--141},
abstract = {OBJECTIVE: Headache is one of the most common debilitating chronic pain conditions in either active or retired military personnel with mild traumatic brain injury (MTBI). This study assessed the effect of repetitive transcranial magnetic stimulation (rTMS) in alleviating MTBI-related headache (MTBI-HA). MATERIALS AND METHOD: Veterans with MTBI-HA were randomized to receive either real rTMS (REAL group) at 10 hz for a total of 2000 pulses divided into 20 trains with one-sec inter-train interval or sham rTMS (SHAM group) at the left motor cortex (LMC) with brain magnetic resonance imaging neuronavigation guidance. Pretreatment, posttreatment one-week and four-week headache and neuropsychological assessments were conducted. RESULT: Thirty veterans were screened and twenty four (21 men and 3 women with average year-old +/- SD at 14.3 +/- 12.6) subjects' data were analyzed. A two-factor (visit x treatment) repeated measures analysis of variance (RM-ANOVA) indicated a close to significant (p = 0.06) trend of interaction between pretreatment and posttreatment one-week assessment with the intensity of the persistent daily headache decreasing from 5.7 +/- 1.9 to 2.2 +/- 2.7 and 4.6 +/- 1.3 to 3.5 +/- 2.0 for the REAL and SHAM groups, respectively. Subsequent analyses indicated REAL group demonstrated a significantly (p = 0.041) higher % of reduction in persistent headache intensity than the SHAM group (56.3 +/- 48.2% vs.15.4 +/- 43.6%) at the posttreatment one-week assessment and the trend continued to the four-week assessment. Overall, a significantly (p = 0.035) higher percentage of the subjects in the REAL group (58.3%) demonstrated at least a 50% headache intensity reduction at posttreatment one-week assessment compared with the SHAM group (16.6%). The overall composite score of functionally debilitating headache exacerbation is significantly (p = 0.017) reduced in REAL group at the posttreatment four-week assessment in comparison with the SHAM group. No major sustained change in neuropsychological assessments was noted. CONCLUSION: The studied rTMS protocol appears to be a clinically feasible and effective treatment option in managing MTBI-HA.Copyright © 2015 International Neuromodulation Society.},
keywords = {*Brain Concussion/co [Complications], *Headache/et [Etiology], *Headache/th [Therapy], *Transcranial Magnetic Stimulation/mt [Methods], adult, aged, Female, Humans, Male, middle aged, Neuronavigation, Neuropsychological Tests, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Little, C E; Emery, C; Black, A; Scott, S H; Meeuwisse, W; Nettel-Aguirre, A; Benson, B; Dukelow, S
Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players Journal Article
In: Journal of Neuroengineering & Rehabilitation, vol. 12, pp. 78, 2015.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Brain Concussion/px [Psychology], *COGNITION, *Hockey/in [Injuries], *Robotics, *Sensation, Adolescent, Biomechanical Phenomena, Brain Concussion/pp [Physiopathology], Child, Computer simulation, Humans, learning, Longitudinal studies, Male, Neuropsychological Tests, Practice (Psychology), Prognosis, Prospective Studies, Psychomotor Performance/ph [Physiology], Reproducibility of Results, treatment outcome
@article{Little2015,
title = {Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players},
author = {Little, C E and Emery, C and Black, A and Scott, S H and Meeuwisse, W and Nettel-Aguirre, A and Benson, B and Dukelow, S},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neuroengineering \& Rehabilitation},
volume = {12},
pages = {78},
abstract = {BACKGROUND: Better diagnostic and prognostic tools are needed to address issues related to early diagnosis and management of concussion across the continuum of aging but particularly in children and adolescents. The purpose of the current study was to evaluate the reliability of robotic technology (KINARM robot) assessments of reaching, position sense, bimanual motor function, visuospatial skills, attention and decision making in youth ice hockey players (ages 10-14). METHODS: Thirty-four male children attended two testing days, one week apart. On day one, each subject completed five tasks on the robot with two examiners (alternating examiner sequence); the 2(nd) examiner followed the same procedure as the 1(st) immediately afterwards. One consistent examiner tested subjects one week later. This is a test-retest reliability study. The robotic tasks characterize sensorimotor and/or cognitive performance; 63 parameters from 5 tasks are reported. Session 1 was the 1(st) time the subject performed the 5 tasks, session 2 the 2(nd) time on day 1, and session 3 one week following. RESULTS: Intra-class correlation coefficients ranged from 0.06 to 0.91 and 0.09 to 0.90 for session 1 to 2 and 2 to 3, respectively. Bland-Altman plots showed agreement in a majority of the parameters and a learning effect in 25 % and 24 % of parameters in session 1 vs 2 and 1 vs 3, respectively but none for session 2 vs 3. Of those that showed a learning effect, only 8 % of parameters in session 1 vs 2 and 10 % in session 1 vs 3 had a clinical relevance measure\>0.8. CONCLUSIONS: The relative homogeneity of the sample and the effect of learning seen in some of the task parameters appears to have negatively impacted the intra-class correlation coefficients from session 1 to 2, with less impact for 2 to 3. The Bland-Altman analysis supports good absolute reliability in healthy male children with no neurological impairment ranging in age from 10 to 14. The clinically relevant learning effect seen, in a small number of parameters could be addressed by creating a learning effect adjustment factor and/or implementing a practice session, which would eliminate the learning effect.},
keywords = {*Brain Concussion/di [Diagnosis], *Brain Concussion/px [Psychology], *COGNITION, *Hockey/in [Injuries], *Robotics, *Sensation, Adolescent, Biomechanical Phenomena, Brain Concussion/pp [Physiopathology], Child, Computer simulation, Humans, learning, Longitudinal studies, Male, Neuropsychological Tests, Practice (Psychology), Prognosis, Prospective Studies, Psychomotor Performance/ph [Physiology], Reproducibility of Results, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Alexander, D G; Shuttleworth-Edwards, A B; Kidd, M; Malcolm, C M
Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1113–1125, 2015.
Abstract | Links | BibTeX | Tags: academic achievement, Academic performance, ADOLESCENCE, Adolescent, adolescent disease, adult, Article, Athletic Injuries, brain concussion, Brain Injuries, Child, cognition, Concussion, controlled study, Educational Status, football, human, Humans, Injuries, intelligence test, Intelligence Tests, Longitudinal studies, longitudinal study, major clinical study, Male, mild traumatic brain injury, mTBI, neurocognitive, neuropsychological test, Neuropsychological Tests, Pathophysiology, Prospective Studies, prospective study, psychologic test, psychology, rugby, SOUTH Africa, sport injury, TASK performance, traumatic brain injury, treatment outcome
@article{Alexander2015,
title = {Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes},
author = {Alexander, D G and Shuttleworth-Edwards, A B and Kidd, M and Malcolm, C M},
doi = {10.3109/02699052.2015.1031699},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1113--1125},
abstract = {Background: Information is scant concerning enduring brain injury effects of participation in the contact sport of Rugby Union (hereafter rugby) on early adolescents.Objective: The objective was prospectively to investigate differences between young adolescent male rugby players and non-contact sports controls on neurocognitive test performance over 3 years and academic achievement over 6 years.Method: A sample of boys from the same school and grade was divided into three groups: rugby with seasonal concussions (n = 45), rugby no seasonal concussions (n = 21) and non-contact sports controls (n = 30). Baseline neurocognitive testing was conducted pre-season in Grade 7 and post-season in Grades 8 and 9. Year-end academic grades were documented for Grades 6-9 and 12 (pre-high school to year of school leaving). A mixed model repeated measures ANOVA was conducted to investigate comparative neurocognitive and academic outcomes between the three sub-groups.Results: Compared with controls, both rugby groups were significantly lower on the WISC-III Coding Immediate Recall sub-test. There was a significant interaction effect on the academic measure, with improved scores over time for controls, that was not in evidence for either rugby group.Conclusions: Tentatively, the outcome suggests cognitive vulnerability in association with school level participation in rugby. © 2015 Taylor \& Francis Group, LLC.},
keywords = {academic achievement, Academic performance, ADOLESCENCE, Adolescent, adolescent disease, adult, Article, Athletic Injuries, brain concussion, Brain Injuries, Child, cognition, Concussion, controlled study, Educational Status, football, human, Humans, Injuries, intelligence test, Intelligence Tests, Longitudinal studies, longitudinal study, major clinical study, Male, mild traumatic brain injury, mTBI, neurocognitive, neuropsychological test, Neuropsychological Tests, Pathophysiology, Prospective Studies, prospective study, psychologic test, psychology, rugby, SOUTH Africa, sport injury, TASK performance, traumatic brain injury, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
Abstract | Links | BibTeX | Tags: 80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale},
pubstate = {published},
tppubtype = {article}
}
Maerlender, A; Rieman, W; Lichtenstein, J; Condiracci, C
Programmed physical exertion in recovery from sports-related concussion: A randomized pilot study Journal Article
In: Developmental Neuropsychology, vol. 40, no. 5, pp. 273–278, 2015.
Abstract | Links | BibTeX | Tags: adult, brain concussion, controlled study, CONVALESCENCE, exercise, Female, human, Humans, Male, motor activity, Physical Exertion, Pilot Projects, pilot study, randomized controlled trial, Recovery of Function, Sport, Sports, time, Time Factors, treatment outcome
@article{Maerlender2015a,
title = {Programmed physical exertion in recovery from sports-related concussion: A randomized pilot study},
author = {Maerlender, A and Rieman, W and Lichtenstein, J and Condiracci, C},
doi = {10.1080/87565641.2015.1067706},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {5},
pages = {273--278},
abstract = {Although no data exist, general practice recommends only rest following concussion. This randomized clinical trial found that programmed physical exertion during recovery produced no significant differences in recovery time between groups of participants. However, high levels of exertion were deleterious. This study provides initial evidence that moderate physical activity is a safe replacement behavior during recovery. © 2015 Copyright © 2015 Taylor \& Francis Group, LLC.},
keywords = {adult, brain concussion, controlled study, CONVALESCENCE, exercise, Female, human, Humans, Male, motor activity, Physical Exertion, Pilot Projects, pilot study, randomized controlled trial, Recovery of Function, Sport, Sports, time, Time Factors, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
DiFazio, M; Silverberg, N D; Kirkwood, M W; Bernier, R; Iverson, G L
Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes? Journal Article
In: Clinical Pediatrics, vol. 55, no. 5, pp. 443–451, 2015.
Abstract | Links | BibTeX | Tags: activity restriction, Anxiety, Article, athletic trainer, brain concussion, case report, Concussion, daily life activity, depression, Dizziness, evolution, exercise, expectation, headache, human, Male, mood disorder, mTBI, nocebo effect, patient harm, PHYSICAL ACTIVITY, practice guideline, prolonged activity restriction, psychological aspect, Rehabilitation, rest, school, traumatic brain injury, Treatment, treatment outcome, wrestling
@article{DiFazio2015,
title = {Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes?},
author = {DiFazio, M and Silverberg, N D and Kirkwood, M W and Bernier, R and Iverson, G L},
doi = {10.1177/0009922815589914},
year = {2015},
date = {2015-01-01},
journal = {Clinical Pediatrics},
volume = {55},
number = {5},
pages = {443--451},
abstract = {The current treatment of concussion or mild traumatic brain injury (mTBI) is primarily based on expert consensus. Most clinical practice guidelines advise cognitive and physical rest after injury including withdrawal from normal life activities such as school attendance, sports participation, and technology use until symptoms resolve. Some individuals who sustain an mTBI experience persistent physical, cognitive, and mental health problems. Activity restriction itself may contribute to protracted recovery and other complications. Williamson's Activity Restriction Model of Depression, formulated more than 20 years ago, is central to this hypothesis. We review research evidence for potential harms of prolonged activity restriction and report an mTBI case as an example of how an "activity restriction cascade" can unfold. According to this model, psychological consequences of removal from validating life activities, combined with physical deconditioning, contribute to the development and persistence of postconcussive symptoms after mTBI in some youth. A modification to mTBI guidelines that emphasizes prompt reengagement in life activities as tolerated is encouraged. © SAGE Publications.},
keywords = {activity restriction, Anxiety, Article, athletic trainer, brain concussion, case report, Concussion, daily life activity, depression, Dizziness, evolution, exercise, expectation, headache, human, Male, mood disorder, mTBI, nocebo effect, patient harm, PHYSICAL ACTIVITY, practice guideline, prolonged activity restriction, psychological aspect, Rehabilitation, rest, school, traumatic brain injury, Treatment, treatment outcome, wrestling},
pubstate = {published},
tppubtype = {article}
}
Wise, E K; Mathews-Dalton, C; Dikmen, S; Temkin, N; Machamer, J; Bell, K; Powell, J M
Impact of traumatic brain injury on participation in leisure activities Journal Article
In: Archives of Physical Medicine & Rehabilitation, vol. 91, no. 9, pp. 1357–1362, 2010.
Abstract | BibTeX | Tags: *Brain Injuries/rh [Rehabilitation], *Recreation, adult, Age Factors, Female, Humans, Male, Prospective Studies, Sex Factors, treatment outcome, Washington
@article{Wise2010,
title = {Impact of traumatic brain injury on participation in leisure activities},
author = {Wise, E K and Mathews-Dalton, C and Dikmen, S and Temkin, N and Machamer, J and Bell, K and Powell, J M},
year = {2010},
date = {2010-01-01},
journal = {Archives of Physical Medicine \& Rehabilitation},
volume = {91},
number = {9},
pages = {1357--1362},
abstract = {OBJECTIVE: To determine how participation in leisure activities for people with traumatic brain injury (TBI) changes from before injury to 1 year after injury. DESIGN: Prospective evaluation of leisure participation at 1 year after TBI. SETTING: Level I trauma center. PARTICIPANTS: Rehabilitation inpatients (mean age, 35.3 years; 77% male; 77% white) with moderate to severe TBI (N=160). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Functional Status Examination. RESULTS: At 1 year after injury, 81% had not returned to preinjury levels of leisure participation. Activities most frequently discontinued included partying, drug and alcohol use, and various sports. The activity most often reported as new after injury was watching television. Of the small fraction who returned to preinjury levels, 70% did so within 4 months of injury. Sixty percent of those who did not return to preinjury levels were moderately to severely bothered by the changes. CONCLUSIONS: At 1 year after injury, many TBI survivors engage in a reduced number of leisure activities, which are more sedentary and less social, with a substantial fraction dissatisfied with these changes. While discontinuing some activities may be viewed as a positive change, there are few new ones to replace them.},
keywords = {*Brain Injuries/rh [Rehabilitation], *Recreation, adult, Age Factors, Female, Humans, Male, Prospective Studies, Sex Factors, treatment outcome, Washington},
pubstate = {published},
tppubtype = {article}
}
Leung, A; Shukla, S; Fallah, A; Song, D; Lin, L; Golshan, S; Tsai, A; Jak, A; Polston, G; Lee, R
Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches Journal Article
In: Neuromodulation, vol. 19, no. 2, pp. 133–141, 2016.
@article{Leung2016,
title = {Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches},
author = {Leung, A and Shukla, S and Fallah, A and Song, D and Lin, L and Golshan, S and Tsai, A and Jak, A and Polston, G and Lee, R},
year = {2016},
date = {2016-01-01},
journal = {Neuromodulation},
volume = {19},
number = {2},
pages = {133--141},
abstract = {OBJECTIVE: Headache is one of the most common debilitating chronic pain conditions in either active or retired military personnel with mild traumatic brain injury (MTBI). This study assessed the effect of repetitive transcranial magnetic stimulation (rTMS) in alleviating MTBI-related headache (MTBI-HA). MATERIALS AND METHOD: Veterans with MTBI-HA were randomized to receive either real rTMS (REAL group) at 10 hz for a total of 2000 pulses divided into 20 trains with one-sec inter-train interval or sham rTMS (SHAM group) at the left motor cortex (LMC) with brain magnetic resonance imaging neuronavigation guidance. Pretreatment, posttreatment one-week and four-week headache and neuropsychological assessments were conducted. RESULT: Thirty veterans were screened and twenty four (21 men and 3 women with average year-old +/- SD at 14.3 +/- 12.6) subjects' data were analyzed. A two-factor (visit x treatment) repeated measures analysis of variance (RM-ANOVA) indicated a close to significant (p = 0.06) trend of interaction between pretreatment and posttreatment one-week assessment with the intensity of the persistent daily headache decreasing from 5.7 +/- 1.9 to 2.2 +/- 2.7 and 4.6 +/- 1.3 to 3.5 +/- 2.0 for the REAL and SHAM groups, respectively. Subsequent analyses indicated REAL group demonstrated a significantly (p = 0.041) higher % of reduction in persistent headache intensity than the SHAM group (56.3 +/- 48.2% vs.15.4 +/- 43.6%) at the posttreatment one-week assessment and the trend continued to the four-week assessment. Overall, a significantly (p = 0.035) higher percentage of the subjects in the REAL group (58.3%) demonstrated at least a 50% headache intensity reduction at posttreatment one-week assessment compared with the SHAM group (16.6%). The overall composite score of functionally debilitating headache exacerbation is significantly (p = 0.017) reduced in REAL group at the posttreatment four-week assessment in comparison with the SHAM group. No major sustained change in neuropsychological assessments was noted. CONCLUSION: The studied rTMS protocol appears to be a clinically feasible and effective treatment option in managing MTBI-HA.Copyright © 2015 International Neuromodulation Society.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Little, C E; Emery, C; Black, A; Scott, S H; Meeuwisse, W; Nettel-Aguirre, A; Benson, B; Dukelow, S
Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players Journal Article
In: Journal of Neuroengineering & Rehabilitation, vol. 12, pp. 78, 2015.
@article{Little2015,
title = {Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players},
author = {Little, C E and Emery, C and Black, A and Scott, S H and Meeuwisse, W and Nettel-Aguirre, A and Benson, B and Dukelow, S},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neuroengineering \& Rehabilitation},
volume = {12},
pages = {78},
abstract = {BACKGROUND: Better diagnostic and prognostic tools are needed to address issues related to early diagnosis and management of concussion across the continuum of aging but particularly in children and adolescents. The purpose of the current study was to evaluate the reliability of robotic technology (KINARM robot) assessments of reaching, position sense, bimanual motor function, visuospatial skills, attention and decision making in youth ice hockey players (ages 10-14). METHODS: Thirty-four male children attended two testing days, one week apart. On day one, each subject completed five tasks on the robot with two examiners (alternating examiner sequence); the 2(nd) examiner followed the same procedure as the 1(st) immediately afterwards. One consistent examiner tested subjects one week later. This is a test-retest reliability study. The robotic tasks characterize sensorimotor and/or cognitive performance; 63 parameters from 5 tasks are reported. Session 1 was the 1(st) time the subject performed the 5 tasks, session 2 the 2(nd) time on day 1, and session 3 one week following. RESULTS: Intra-class correlation coefficients ranged from 0.06 to 0.91 and 0.09 to 0.90 for session 1 to 2 and 2 to 3, respectively. Bland-Altman plots showed agreement in a majority of the parameters and a learning effect in 25 % and 24 % of parameters in session 1 vs 2 and 1 vs 3, respectively but none for session 2 vs 3. Of those that showed a learning effect, only 8 % of parameters in session 1 vs 2 and 10 % in session 1 vs 3 had a clinical relevance measure\>0.8. CONCLUSIONS: The relative homogeneity of the sample and the effect of learning seen in some of the task parameters appears to have negatively impacted the intra-class correlation coefficients from session 1 to 2, with less impact for 2 to 3. The Bland-Altman analysis supports good absolute reliability in healthy male children with no neurological impairment ranging in age from 10 to 14. The clinically relevant learning effect seen, in a small number of parameters could be addressed by creating a learning effect adjustment factor and/or implementing a practice session, which would eliminate the learning effect.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Alexander, D G; Shuttleworth-Edwards, A B; Kidd, M; Malcolm, C M
Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1113–1125, 2015.
@article{Alexander2015,
title = {Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes},
author = {Alexander, D G and Shuttleworth-Edwards, A B and Kidd, M and Malcolm, C M},
doi = {10.3109/02699052.2015.1031699},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1113--1125},
abstract = {Background: Information is scant concerning enduring brain injury effects of participation in the contact sport of Rugby Union (hereafter rugby) on early adolescents.Objective: The objective was prospectively to investigate differences between young adolescent male rugby players and non-contact sports controls on neurocognitive test performance over 3 years and academic achievement over 6 years.Method: A sample of boys from the same school and grade was divided into three groups: rugby with seasonal concussions (n = 45), rugby no seasonal concussions (n = 21) and non-contact sports controls (n = 30). Baseline neurocognitive testing was conducted pre-season in Grade 7 and post-season in Grades 8 and 9. Year-end academic grades were documented for Grades 6-9 and 12 (pre-high school to year of school leaving). A mixed model repeated measures ANOVA was conducted to investigate comparative neurocognitive and academic outcomes between the three sub-groups.Results: Compared with controls, both rugby groups were significantly lower on the WISC-III Coding Immediate Recall sub-test. There was a significant interaction effect on the academic measure, with improved scores over time for controls, that was not in evidence for either rugby group.Conclusions: Tentatively, the outcome suggests cognitive vulnerability in association with school level participation in rugby. © 2015 Taylor \& Francis Group, LLC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Maerlender, A; Rieman, W; Lichtenstein, J; Condiracci, C
Programmed physical exertion in recovery from sports-related concussion: A randomized pilot study Journal Article
In: Developmental Neuropsychology, vol. 40, no. 5, pp. 273–278, 2015.
@article{Maerlender2015a,
title = {Programmed physical exertion in recovery from sports-related concussion: A randomized pilot study},
author = {Maerlender, A and Rieman, W and Lichtenstein, J and Condiracci, C},
doi = {10.1080/87565641.2015.1067706},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {5},
pages = {273--278},
abstract = {Although no data exist, general practice recommends only rest following concussion. This randomized clinical trial found that programmed physical exertion during recovery produced no significant differences in recovery time between groups of participants. However, high levels of exertion were deleterious. This study provides initial evidence that moderate physical activity is a safe replacement behavior during recovery. © 2015 Copyright © 2015 Taylor \& Francis Group, LLC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
DiFazio, M; Silverberg, N D; Kirkwood, M W; Bernier, R; Iverson, G L
Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes? Journal Article
In: Clinical Pediatrics, vol. 55, no. 5, pp. 443–451, 2015.
@article{DiFazio2015,
title = {Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes?},
author = {DiFazio, M and Silverberg, N D and Kirkwood, M W and Bernier, R and Iverson, G L},
doi = {10.1177/0009922815589914},
year = {2015},
date = {2015-01-01},
journal = {Clinical Pediatrics},
volume = {55},
number = {5},
pages = {443--451},
abstract = {The current treatment of concussion or mild traumatic brain injury (mTBI) is primarily based on expert consensus. Most clinical practice guidelines advise cognitive and physical rest after injury including withdrawal from normal life activities such as school attendance, sports participation, and technology use until symptoms resolve. Some individuals who sustain an mTBI experience persistent physical, cognitive, and mental health problems. Activity restriction itself may contribute to protracted recovery and other complications. Williamson's Activity Restriction Model of Depression, formulated more than 20 years ago, is central to this hypothesis. We review research evidence for potential harms of prolonged activity restriction and report an mTBI case as an example of how an "activity restriction cascade" can unfold. According to this model, psychological consequences of removal from validating life activities, combined with physical deconditioning, contribute to the development and persistence of postconcussive symptoms after mTBI in some youth. A modification to mTBI guidelines that emphasizes prompt reengagement in life activities as tolerated is encouraged. © SAGE Publications.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wise, E K; Mathews-Dalton, C; Dikmen, S; Temkin, N; Machamer, J; Bell, K; Powell, J M
Impact of traumatic brain injury on participation in leisure activities Journal Article
In: Archives of Physical Medicine & Rehabilitation, vol. 91, no. 9, pp. 1357–1362, 2010.
@article{Wise2010,
title = {Impact of traumatic brain injury on participation in leisure activities},
author = {Wise, E K and Mathews-Dalton, C and Dikmen, S and Temkin, N and Machamer, J and Bell, K and Powell, J M},
year = {2010},
date = {2010-01-01},
journal = {Archives of Physical Medicine \& Rehabilitation},
volume = {91},
number = {9},
pages = {1357--1362},
abstract = {OBJECTIVE: To determine how participation in leisure activities for people with traumatic brain injury (TBI) changes from before injury to 1 year after injury. DESIGN: Prospective evaluation of leisure participation at 1 year after TBI. SETTING: Level I trauma center. PARTICIPANTS: Rehabilitation inpatients (mean age, 35.3 years; 77% male; 77% white) with moderate to severe TBI (N=160). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Functional Status Examination. RESULTS: At 1 year after injury, 81% had not returned to preinjury levels of leisure participation. Activities most frequently discontinued included partying, drug and alcohol use, and various sports. The activity most often reported as new after injury was watching television. Of the small fraction who returned to preinjury levels, 70% did so within 4 months of injury. Sixty percent of those who did not return to preinjury levels were moderately to severely bothered by the changes. CONCLUSIONS: At 1 year after injury, many TBI survivors engage in a reduced number of leisure activities, which are more sedentary and less social, with a substantial fraction dissatisfied with these changes. While discontinuing some activities may be viewed as a positive change, there are few new ones to replace them.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Leung, A; Shukla, S; Fallah, A; Song, D; Lin, L; Golshan, S; Tsai, A; Jak, A; Polston, G; Lee, R
Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches Journal Article
In: Neuromodulation, vol. 19, no. 2, pp. 133–141, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Headache/et [Etiology], *Headache/th [Therapy], *Transcranial Magnetic Stimulation/mt [Methods], adult, aged, Female, Humans, Male, middle aged, Neuronavigation, Neuropsychological Tests, treatment outcome
@article{Leung2016,
title = {Repetitive Transcranial Magnetic Stimulation in Managing Mild Traumatic Brain Injury-Related Headaches},
author = {Leung, A and Shukla, S and Fallah, A and Song, D and Lin, L and Golshan, S and Tsai, A and Jak, A and Polston, G and Lee, R},
year = {2016},
date = {2016-01-01},
journal = {Neuromodulation},
volume = {19},
number = {2},
pages = {133--141},
abstract = {OBJECTIVE: Headache is one of the most common debilitating chronic pain conditions in either active or retired military personnel with mild traumatic brain injury (MTBI). This study assessed the effect of repetitive transcranial magnetic stimulation (rTMS) in alleviating MTBI-related headache (MTBI-HA). MATERIALS AND METHOD: Veterans with MTBI-HA were randomized to receive either real rTMS (REAL group) at 10 hz for a total of 2000 pulses divided into 20 trains with one-sec inter-train interval or sham rTMS (SHAM group) at the left motor cortex (LMC) with brain magnetic resonance imaging neuronavigation guidance. Pretreatment, posttreatment one-week and four-week headache and neuropsychological assessments were conducted. RESULT: Thirty veterans were screened and twenty four (21 men and 3 women with average year-old +/- SD at 14.3 +/- 12.6) subjects' data were analyzed. A two-factor (visit x treatment) repeated measures analysis of variance (RM-ANOVA) indicated a close to significant (p = 0.06) trend of interaction between pretreatment and posttreatment one-week assessment with the intensity of the persistent daily headache decreasing from 5.7 +/- 1.9 to 2.2 +/- 2.7 and 4.6 +/- 1.3 to 3.5 +/- 2.0 for the REAL and SHAM groups, respectively. Subsequent analyses indicated REAL group demonstrated a significantly (p = 0.041) higher % of reduction in persistent headache intensity than the SHAM group (56.3 +/- 48.2% vs.15.4 +/- 43.6%) at the posttreatment one-week assessment and the trend continued to the four-week assessment. Overall, a significantly (p = 0.035) higher percentage of the subjects in the REAL group (58.3%) demonstrated at least a 50% headache intensity reduction at posttreatment one-week assessment compared with the SHAM group (16.6%). The overall composite score of functionally debilitating headache exacerbation is significantly (p = 0.017) reduced in REAL group at the posttreatment four-week assessment in comparison with the SHAM group. No major sustained change in neuropsychological assessments was noted. CONCLUSION: The studied rTMS protocol appears to be a clinically feasible and effective treatment option in managing MTBI-HA.Copyright © 2015 International Neuromodulation Society.},
keywords = {*Brain Concussion/co [Complications], *Headache/et [Etiology], *Headache/th [Therapy], *Transcranial Magnetic Stimulation/mt [Methods], adult, aged, Female, Humans, Male, middle aged, Neuronavigation, Neuropsychological Tests, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Little, C E; Emery, C; Black, A; Scott, S H; Meeuwisse, W; Nettel-Aguirre, A; Benson, B; Dukelow, S
Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players Journal Article
In: Journal of Neuroengineering & Rehabilitation, vol. 12, pp. 78, 2015.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Brain Concussion/px [Psychology], *COGNITION, *Hockey/in [Injuries], *Robotics, *Sensation, Adolescent, Biomechanical Phenomena, Brain Concussion/pp [Physiopathology], Child, Computer simulation, Humans, learning, Longitudinal studies, Male, Neuropsychological Tests, Practice (Psychology), Prognosis, Prospective Studies, Psychomotor Performance/ph [Physiology], Reproducibility of Results, treatment outcome
@article{Little2015,
title = {Test-retest reliability of KINARM robot sensorimotor and cognitive assessment: in pediatric ice hockey players},
author = {Little, C E and Emery, C and Black, A and Scott, S H and Meeuwisse, W and Nettel-Aguirre, A and Benson, B and Dukelow, S},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neuroengineering \& Rehabilitation},
volume = {12},
pages = {78},
abstract = {BACKGROUND: Better diagnostic and prognostic tools are needed to address issues related to early diagnosis and management of concussion across the continuum of aging but particularly in children and adolescents. The purpose of the current study was to evaluate the reliability of robotic technology (KINARM robot) assessments of reaching, position sense, bimanual motor function, visuospatial skills, attention and decision making in youth ice hockey players (ages 10-14). METHODS: Thirty-four male children attended two testing days, one week apart. On day one, each subject completed five tasks on the robot with two examiners (alternating examiner sequence); the 2(nd) examiner followed the same procedure as the 1(st) immediately afterwards. One consistent examiner tested subjects one week later. This is a test-retest reliability study. The robotic tasks characterize sensorimotor and/or cognitive performance; 63 parameters from 5 tasks are reported. Session 1 was the 1(st) time the subject performed the 5 tasks, session 2 the 2(nd) time on day 1, and session 3 one week following. RESULTS: Intra-class correlation coefficients ranged from 0.06 to 0.91 and 0.09 to 0.90 for session 1 to 2 and 2 to 3, respectively. Bland-Altman plots showed agreement in a majority of the parameters and a learning effect in 25 % and 24 % of parameters in session 1 vs 2 and 1 vs 3, respectively but none for session 2 vs 3. Of those that showed a learning effect, only 8 % of parameters in session 1 vs 2 and 10 % in session 1 vs 3 had a clinical relevance measure\>0.8. CONCLUSIONS: The relative homogeneity of the sample and the effect of learning seen in some of the task parameters appears to have negatively impacted the intra-class correlation coefficients from session 1 to 2, with less impact for 2 to 3. The Bland-Altman analysis supports good absolute reliability in healthy male children with no neurological impairment ranging in age from 10 to 14. The clinically relevant learning effect seen, in a small number of parameters could be addressed by creating a learning effect adjustment factor and/or implementing a practice session, which would eliminate the learning effect.},
keywords = {*Brain Concussion/di [Diagnosis], *Brain Concussion/px [Psychology], *COGNITION, *Hockey/in [Injuries], *Robotics, *Sensation, Adolescent, Biomechanical Phenomena, Brain Concussion/pp [Physiopathology], Child, Computer simulation, Humans, learning, Longitudinal studies, Male, Neuropsychological Tests, Practice (Psychology), Prognosis, Prospective Studies, Psychomotor Performance/ph [Physiology], Reproducibility of Results, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Alexander, D G; Shuttleworth-Edwards, A B; Kidd, M; Malcolm, C M
Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1113–1125, 2015.
Abstract | Links | BibTeX | Tags: academic achievement, Academic performance, ADOLESCENCE, Adolescent, adolescent disease, adult, Article, Athletic Injuries, brain concussion, Brain Injuries, Child, cognition, Concussion, controlled study, Educational Status, football, human, Humans, Injuries, intelligence test, Intelligence Tests, Longitudinal studies, longitudinal study, major clinical study, Male, mild traumatic brain injury, mTBI, neurocognitive, neuropsychological test, Neuropsychological Tests, Pathophysiology, Prospective Studies, prospective study, psychologic test, psychology, rugby, SOUTH Africa, sport injury, TASK performance, traumatic brain injury, treatment outcome
@article{Alexander2015,
title = {Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes},
author = {Alexander, D G and Shuttleworth-Edwards, A B and Kidd, M and Malcolm, C M},
doi = {10.3109/02699052.2015.1031699},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1113--1125},
abstract = {Background: Information is scant concerning enduring brain injury effects of participation in the contact sport of Rugby Union (hereafter rugby) on early adolescents.Objective: The objective was prospectively to investigate differences between young adolescent male rugby players and non-contact sports controls on neurocognitive test performance over 3 years and academic achievement over 6 years.Method: A sample of boys from the same school and grade was divided into three groups: rugby with seasonal concussions (n = 45), rugby no seasonal concussions (n = 21) and non-contact sports controls (n = 30). Baseline neurocognitive testing was conducted pre-season in Grade 7 and post-season in Grades 8 and 9. Year-end academic grades were documented for Grades 6-9 and 12 (pre-high school to year of school leaving). A mixed model repeated measures ANOVA was conducted to investigate comparative neurocognitive and academic outcomes between the three sub-groups.Results: Compared with controls, both rugby groups were significantly lower on the WISC-III Coding Immediate Recall sub-test. There was a significant interaction effect on the academic measure, with improved scores over time for controls, that was not in evidence for either rugby group.Conclusions: Tentatively, the outcome suggests cognitive vulnerability in association with school level participation in rugby. © 2015 Taylor \& Francis Group, LLC.},
keywords = {academic achievement, Academic performance, ADOLESCENCE, Adolescent, adolescent disease, adult, Article, Athletic Injuries, brain concussion, Brain Injuries, Child, cognition, Concussion, controlled study, Educational Status, football, human, Humans, Injuries, intelligence test, Intelligence Tests, Longitudinal studies, longitudinal study, major clinical study, Male, mild traumatic brain injury, mTBI, neurocognitive, neuropsychological test, Neuropsychological Tests, Pathophysiology, Prospective Studies, prospective study, psychologic test, psychology, rugby, SOUTH Africa, sport injury, TASK performance, traumatic brain injury, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Lawrence, D W; Comper, P; Hutchison, M G; Sharma, B
The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1018–1031, 2015.
Abstract | Links | BibTeX | Tags: 80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale
@article{Lawrence2015,
title = {The role of apolipoprotein E episilon ($epsilon$)-4 allele on outcome following traumatic brain injury: A systematic review},
author = {Lawrence, D W and Comper, P and Hutchison, M G and Sharma, B},
doi = {10.3109/02699052.2015.1005131},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1018--1031},
abstract = {Background: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOE$epsilon$4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI.Methods: A systematic review was conducted, including all primary articles investigating the role of APOE$epsilon$4 on TBI outcome. A total of 65 studies were included, including 24 predominantly investigating mild (mTBI), seven moderate (modTBI) and 33 severe (sTBI); severity was not reported in one study.Results: In mTBI studies, the association between APOE$epsilon$4 and post-TBI outcome was concluded as non-contributory in 14 studies (58.3%), hazardous in nine (37.5%) and protective in one (4.2%). In sTBI studies, the role of APOE$epsilon$4 was hazardous in 21 (63.6%), non-contributory in nine (27.3%) and protective in three (9.1%). Of the seven studies investigating dementia outcomes, four observed a hazardous association with APOE$epsilon$4, while three reported no association. Six studies examined Alzheimers dementia pathology, of which three reported a hazardous influence of APOE$epsilon$4.Conclusions: The influence of APOE$epsilon$4 on neuropsychological testing, functional outcome and in paediatric populations was incongruous. This review supports the majority of research indicating APOE$epsilon$4 adversely influences recovery following TBI, particularly with respect to dementia-related outcomes and outcomes following sTBI. © 2015 Taylor \& Francis Group, LLC.},
keywords = {80 and over, aged, allele, Alleles, Alzheimer disease, amyloid beta protein, APOE, apolipoprotein E, apolipoprotein E4, Article, athlete, brain concussion, Brain Injuries, clinical evaluation, cognition, cognitive defect, disease severity, Female, follow up, genetic association, genetic risk, genetics, GENOTYPE, Glasgow Outcome Scale, heterozygote, histopathology, homozygote, human, Humans, Incidence, injury severity, Male, Memory, nerve cell necrosis, neuropathology, Neuroprotection, outcome assessment, pediatrics, Prevalence, Prognosis, prognostic assessment, protein function, psychologic test, psychology, Recovery, scoring system, Systematic Review, tau protein, traumatic brain injury, treatment outcome, very elderly, Wechsler Intelligence Scale},
pubstate = {published},
tppubtype = {article}
}
Maerlender, A; Rieman, W; Lichtenstein, J; Condiracci, C
Programmed physical exertion in recovery from sports-related concussion: A randomized pilot study Journal Article
In: Developmental Neuropsychology, vol. 40, no. 5, pp. 273–278, 2015.
Abstract | Links | BibTeX | Tags: adult, brain concussion, controlled study, CONVALESCENCE, exercise, Female, human, Humans, Male, motor activity, Physical Exertion, Pilot Projects, pilot study, randomized controlled trial, Recovery of Function, Sport, Sports, time, Time Factors, treatment outcome
@article{Maerlender2015a,
title = {Programmed physical exertion in recovery from sports-related concussion: A randomized pilot study},
author = {Maerlender, A and Rieman, W and Lichtenstein, J and Condiracci, C},
doi = {10.1080/87565641.2015.1067706},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {5},
pages = {273--278},
abstract = {Although no data exist, general practice recommends only rest following concussion. This randomized clinical trial found that programmed physical exertion during recovery produced no significant differences in recovery time between groups of participants. However, high levels of exertion were deleterious. This study provides initial evidence that moderate physical activity is a safe replacement behavior during recovery. © 2015 Copyright © 2015 Taylor \& Francis Group, LLC.},
keywords = {adult, brain concussion, controlled study, CONVALESCENCE, exercise, Female, human, Humans, Male, motor activity, Physical Exertion, Pilot Projects, pilot study, randomized controlled trial, Recovery of Function, Sport, Sports, time, Time Factors, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
DiFazio, M; Silverberg, N D; Kirkwood, M W; Bernier, R; Iverson, G L
Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes? Journal Article
In: Clinical Pediatrics, vol. 55, no. 5, pp. 443–451, 2015.
Abstract | Links | BibTeX | Tags: activity restriction, Anxiety, Article, athletic trainer, brain concussion, case report, Concussion, daily life activity, depression, Dizziness, evolution, exercise, expectation, headache, human, Male, mood disorder, mTBI, nocebo effect, patient harm, PHYSICAL ACTIVITY, practice guideline, prolonged activity restriction, psychological aspect, Rehabilitation, rest, school, traumatic brain injury, Treatment, treatment outcome, wrestling
@article{DiFazio2015,
title = {Prolonged Activity Restriction after Concussion: Are We Worsening Outcomes?},
author = {DiFazio, M and Silverberg, N D and Kirkwood, M W and Bernier, R and Iverson, G L},
doi = {10.1177/0009922815589914},
year = {2015},
date = {2015-01-01},
journal = {Clinical Pediatrics},
volume = {55},
number = {5},
pages = {443--451},
abstract = {The current treatment of concussion or mild traumatic brain injury (mTBI) is primarily based on expert consensus. Most clinical practice guidelines advise cognitive and physical rest after injury including withdrawal from normal life activities such as school attendance, sports participation, and technology use until symptoms resolve. Some individuals who sustain an mTBI experience persistent physical, cognitive, and mental health problems. Activity restriction itself may contribute to protracted recovery and other complications. Williamson's Activity Restriction Model of Depression, formulated more than 20 years ago, is central to this hypothesis. We review research evidence for potential harms of prolonged activity restriction and report an mTBI case as an example of how an "activity restriction cascade" can unfold. According to this model, psychological consequences of removal from validating life activities, combined with physical deconditioning, contribute to the development and persistence of postconcussive symptoms after mTBI in some youth. A modification to mTBI guidelines that emphasizes prompt reengagement in life activities as tolerated is encouraged. © SAGE Publications.},
keywords = {activity restriction, Anxiety, Article, athletic trainer, brain concussion, case report, Concussion, daily life activity, depression, Dizziness, evolution, exercise, expectation, headache, human, Male, mood disorder, mTBI, nocebo effect, patient harm, PHYSICAL ACTIVITY, practice guideline, prolonged activity restriction, psychological aspect, Rehabilitation, rest, school, traumatic brain injury, Treatment, treatment outcome, wrestling},
pubstate = {published},
tppubtype = {article}
}
Wise, E K; Mathews-Dalton, C; Dikmen, S; Temkin, N; Machamer, J; Bell, K; Powell, J M
Impact of traumatic brain injury on participation in leisure activities Journal Article
In: Archives of Physical Medicine & Rehabilitation, vol. 91, no. 9, pp. 1357–1362, 2010.
Abstract | BibTeX | Tags: *Brain Injuries/rh [Rehabilitation], *Recreation, adult, Age Factors, Female, Humans, Male, Prospective Studies, Sex Factors, treatment outcome, Washington
@article{Wise2010,
title = {Impact of traumatic brain injury on participation in leisure activities},
author = {Wise, E K and Mathews-Dalton, C and Dikmen, S and Temkin, N and Machamer, J and Bell, K and Powell, J M},
year = {2010},
date = {2010-01-01},
journal = {Archives of Physical Medicine \& Rehabilitation},
volume = {91},
number = {9},
pages = {1357--1362},
abstract = {OBJECTIVE: To determine how participation in leisure activities for people with traumatic brain injury (TBI) changes from before injury to 1 year after injury. DESIGN: Prospective evaluation of leisure participation at 1 year after TBI. SETTING: Level I trauma center. PARTICIPANTS: Rehabilitation inpatients (mean age, 35.3 years; 77% male; 77% white) with moderate to severe TBI (N=160). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Functional Status Examination. RESULTS: At 1 year after injury, 81% had not returned to preinjury levels of leisure participation. Activities most frequently discontinued included partying, drug and alcohol use, and various sports. The activity most often reported as new after injury was watching television. Of the small fraction who returned to preinjury levels, 70% did so within 4 months of injury. Sixty percent of those who did not return to preinjury levels were moderately to severely bothered by the changes. CONCLUSIONS: At 1 year after injury, many TBI survivors engage in a reduced number of leisure activities, which are more sedentary and less social, with a substantial fraction dissatisfied with these changes. While discontinuing some activities may be viewed as a positive change, there are few new ones to replace them.},
keywords = {*Brain Injuries/rh [Rehabilitation], *Recreation, adult, Age Factors, Female, Humans, Male, Prospective Studies, Sex Factors, treatment outcome, Washington},
pubstate = {published},
tppubtype = {article}
}