Morgan, C D; Zuckerman, S L; King, L E; Beaird, S E; Sills, A K; Solomon, G S
Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging Journal Article
In: Child's Nervous System, vol. 31, no. 12, pp. 2305–2309, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, arachnoid cyst, Article, brain, Brain Injury, Child, Computed tomography (CT) neuroimaging, computer assisted tomography, Computer-Assisted, Concussion, cost effectiveness analysis, cost utility analysis, DECISION making, diagnostic value, DSM-IV, Female, human, Humans, image processing, Magnetic Resonance Imaging, Magnetic resonance imaging (MRI), major clinical study, Male, mild traumatic brain injury, neuroimaging, neurosurgery, nuclear magnetic resonance, nuclear magnetic resonance imaging, pathology, Post-Concussion Syndrome, postconcussion syndrome, Preschool, preschool child, priority journal, Radiography, Retrospective Studies, retrospective study, Sports, STATISTICS, Tomography, traumatic brain injury, X ray, X-Ray Computed
@article{Morgan2015,
title = {Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging},
author = {Morgan, C D and Zuckerman, S L and King, L E and Beaird, S E and Sills, A K and Solomon, G S},
doi = {10.1007/s00381-015-2916-y},
year = {2015},
date = {2015-01-01},
journal = {Child's Nervous System},
volume = {31},
number = {12},
pages = {2305--2309},
abstract = {Purpose: Approximately 90% of concussions are transient, with symptoms resolving within 10\textendash14 days. However, a minority of patients remain symptomatic several months post-injury, a condition known as post-concussion syndrome (PCS). The treatment of these patients can be challenging. The goal of our study was to assess the utility and cost-effectiveness of neurologic imaging two or more weeks post-injury in a cohort of youth with PCS. Methods: We conducted a retrospective study of 52 pediatric patients with persistent post-concussion symptoms after 3 months. We collected demographics and neuroimaging results obtained greater than 2 weeks post-concussion. Neuroimaging ordered in the first 2 weeks post-concussion was excluded, except to determine the rate of re-imaging. Descriptive statistics and corresponding cost data were collected. Results: Of 52 patients with PCS, 23/52 (44 %) had neuroimaging at least 2 weeks after the initial injury, for a total of 32 diagnostic studies. In summary, 1/19 MRIs (5.3 %), 1/8 CTs (13 %), and 0/5 x-rays (0 %) yielded significant positive findings, none of which altered clinical management. Chronic phase neuroimaging estimated costs from these 52 pediatric patients totaled $129,025. We estimate the cost to identify a single positive finding was $21,000 for head CT and $104,500 for brain MRI. Conclusions: In this cohort of pediatric PCS patients, brain imaging in the chronic phase (defined as more than 2 weeks after concussion) was pursued in almost half the study sample, had low diagnostic yield, and had poor cost-effectiveness. Based on these results, outpatient management of pediatric patients with long-term post-concussive symptoms should rarely include repeat neuroimaging beyond the acute phase. © 2015, Springer-Verlag Berlin Heidelberg.},
keywords = {Adolescent, arachnoid cyst, Article, brain, Brain Injury, Child, Computed tomography (CT) neuroimaging, computer assisted tomography, Computer-Assisted, Concussion, cost effectiveness analysis, cost utility analysis, DECISION making, diagnostic value, DSM-IV, Female, human, Humans, image processing, Magnetic Resonance Imaging, Magnetic resonance imaging (MRI), major clinical study, Male, mild traumatic brain injury, neuroimaging, neurosurgery, nuclear magnetic resonance, nuclear magnetic resonance imaging, pathology, Post-Concussion Syndrome, postconcussion syndrome, Preschool, preschool child, priority journal, Radiography, Retrospective Studies, retrospective study, Sports, STATISTICS, Tomography, traumatic brain injury, X ray, X-Ray Computed},
pubstate = {published},
tppubtype = {article}
}
Dang, H; Stayman, J W; Sisniega, A; Xu, J; Zbijewski, W; Wang, X; Foos, D H; Aygun, N; Koliatsos, V E; Siewerdsen, J H
Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: Application to high-quality head imaging Journal Article
In: Physics in Medicine and Biology, vol. 60, no. 16, pp. 6153–6175, 2015.
Abstract | Links | BibTeX | Tags: artifact correction, brain, Computerized tomography, cone-beam CT, Flat panel displays, image processing, Image quality, Image reconstruction, Intensive care units, intracranial hemorrhage, Intracranial hemorrhages, Iterative methods, Least squares approximations, Measurement Noise, measurement noise model, Model based iterative reconstruction, model-based iterative reconstruction, Soft tissue, soft-tissue image quality, Tissue, Traumatic Brain Injuries, traumatic brain injury
@article{Dang2015,
title = {Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: Application to high-quality head imaging},
author = {Dang, H and Stayman, J W and Sisniega, A and Xu, J and Zbijewski, W and Wang, X and Foos, D H and Aygun, N and Koliatsos, V E and Siewerdsen, J H},
doi = {10.1088/0031-9155/60/16/6153},
year = {2015},
date = {2015-01-01},
journal = {Physics in Medicine and Biology},
volume = {60},
number = {16},
pages = {6153--6175},
abstract = {Non-contrast CT reliably detects fresh blood in the brain and is the current front-line imaging modality for intracranial hemorrhage such as that occurring in acute traumatic brain injury (contrast ∼40-80 HU, size \> 1 mm). We are developing flat-panel detector (FPD) cone-beam CT (CBCT) to facilitate such diagnosis in a low-cost, mobile platform suitable for point-of-care deployment. Such a system may offer benefits in the ICU, urgent care/concussion clinic, ambulance, and sports and military theatres. However, current FPD-CBCT systems face significant challenges that confound low-contrast, soft-tissue imaging. Artifact correction can overcome major sources of bias in FPD-CBCT but imparts noise amplification in filtered backprojection (FBP). Model-based reconstruction improves soft-tissue image quality compared to FBP by leveraging a high-fidelity forward model and image regularization. In this work, we develop a novel penalized weighted least-squares (PWLS) image reconstruction method with a noise model that includes accurate modeling of the noise characteristics associated with the two dominant artifact corrections (scatter and beam-hardening) in CBCT and utilizes modified weights to compensate for noise amplification imparted by each correction. Experiments included real data acquired on a FPD-CBCT test-bench and an anthropomorphic head phantom emulating intra-parenchymal hemorrhage. The proposed PWLS method demonstrated superior noise-resolution tradeoffs in comparison to FBP and PWLS with conventional weights (viz. at matched 0.50 mm spatial resolution},
keywords = {artifact correction, brain, Computerized tomography, cone-beam CT, Flat panel displays, image processing, Image quality, Image reconstruction, Intensive care units, intracranial hemorrhage, Intracranial hemorrhages, Iterative methods, Least squares approximations, Measurement Noise, measurement noise model, Model based iterative reconstruction, model-based iterative reconstruction, Soft tissue, soft-tissue image quality, Tissue, Traumatic Brain Injuries, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Matthews, S; Simmons, A; Strigo, I
The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131] Journal Article
In: Psychiatry Research, vol. 191, no. 1, pp. 76–79, 2011.
Abstract | BibTeX | Tags: *Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs & Derivatives], Urea/bl [Blood], Young Adult
@article{Matthews2011a,
title = {The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131]},
author = {Matthews, S and Simmons, A and Strigo, I},
year = {2011},
date = {2011-01-01},
journal = {Psychiatry Research},
volume = {191},
number = {1},
pages = {76--79},
abstract = {In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC. Copyright Published by Elsevier Ireland Ltd.},
keywords = {*Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs \& Derivatives], Urea/bl [Blood], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Morgan, C D; Zuckerman, S L; King, L E; Beaird, S E; Sills, A K; Solomon, G S
Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging Journal Article
In: Child's Nervous System, vol. 31, no. 12, pp. 2305–2309, 2015.
@article{Morgan2015,
title = {Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging},
author = {Morgan, C D and Zuckerman, S L and King, L E and Beaird, S E and Sills, A K and Solomon, G S},
doi = {10.1007/s00381-015-2916-y},
year = {2015},
date = {2015-01-01},
journal = {Child's Nervous System},
volume = {31},
number = {12},
pages = {2305--2309},
abstract = {Purpose: Approximately 90% of concussions are transient, with symptoms resolving within 10\textendash14 days. However, a minority of patients remain symptomatic several months post-injury, a condition known as post-concussion syndrome (PCS). The treatment of these patients can be challenging. The goal of our study was to assess the utility and cost-effectiveness of neurologic imaging two or more weeks post-injury in a cohort of youth with PCS. Methods: We conducted a retrospective study of 52 pediatric patients with persistent post-concussion symptoms after 3 months. We collected demographics and neuroimaging results obtained greater than 2 weeks post-concussion. Neuroimaging ordered in the first 2 weeks post-concussion was excluded, except to determine the rate of re-imaging. Descriptive statistics and corresponding cost data were collected. Results: Of 52 patients with PCS, 23/52 (44 %) had neuroimaging at least 2 weeks after the initial injury, for a total of 32 diagnostic studies. In summary, 1/19 MRIs (5.3 %), 1/8 CTs (13 %), and 0/5 x-rays (0 %) yielded significant positive findings, none of which altered clinical management. Chronic phase neuroimaging estimated costs from these 52 pediatric patients totaled $129,025. We estimate the cost to identify a single positive finding was $21,000 for head CT and $104,500 for brain MRI. Conclusions: In this cohort of pediatric PCS patients, brain imaging in the chronic phase (defined as more than 2 weeks after concussion) was pursued in almost half the study sample, had low diagnostic yield, and had poor cost-effectiveness. Based on these results, outpatient management of pediatric patients with long-term post-concussive symptoms should rarely include repeat neuroimaging beyond the acute phase. © 2015, Springer-Verlag Berlin Heidelberg.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dang, H; Stayman, J W; Sisniega, A; Xu, J; Zbijewski, W; Wang, X; Foos, D H; Aygun, N; Koliatsos, V E; Siewerdsen, J H
Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: Application to high-quality head imaging Journal Article
In: Physics in Medicine and Biology, vol. 60, no. 16, pp. 6153–6175, 2015.
@article{Dang2015,
title = {Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: Application to high-quality head imaging},
author = {Dang, H and Stayman, J W and Sisniega, A and Xu, J and Zbijewski, W and Wang, X and Foos, D H and Aygun, N and Koliatsos, V E and Siewerdsen, J H},
doi = {10.1088/0031-9155/60/16/6153},
year = {2015},
date = {2015-01-01},
journal = {Physics in Medicine and Biology},
volume = {60},
number = {16},
pages = {6153--6175},
abstract = {Non-contrast CT reliably detects fresh blood in the brain and is the current front-line imaging modality for intracranial hemorrhage such as that occurring in acute traumatic brain injury (contrast ∼40-80 HU, size \> 1 mm). We are developing flat-panel detector (FPD) cone-beam CT (CBCT) to facilitate such diagnosis in a low-cost, mobile platform suitable for point-of-care deployment. Such a system may offer benefits in the ICU, urgent care/concussion clinic, ambulance, and sports and military theatres. However, current FPD-CBCT systems face significant challenges that confound low-contrast, soft-tissue imaging. Artifact correction can overcome major sources of bias in FPD-CBCT but imparts noise amplification in filtered backprojection (FBP). Model-based reconstruction improves soft-tissue image quality compared to FBP by leveraging a high-fidelity forward model and image regularization. In this work, we develop a novel penalized weighted least-squares (PWLS) image reconstruction method with a noise model that includes accurate modeling of the noise characteristics associated with the two dominant artifact corrections (scatter and beam-hardening) in CBCT and utilizes modified weights to compensate for noise amplification imparted by each correction. Experiments included real data acquired on a FPD-CBCT test-bench and an anthropomorphic head phantom emulating intra-parenchymal hemorrhage. The proposed PWLS method demonstrated superior noise-resolution tradeoffs in comparison to FBP and PWLS with conventional weights (viz. at matched 0.50 mm spatial resolution},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Matthews, S; Simmons, A; Strigo, I
The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131] Journal Article
In: Psychiatry Research, vol. 191, no. 1, pp. 76–79, 2011.
@article{Matthews2011a,
title = {The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131]},
author = {Matthews, S and Simmons, A and Strigo, I},
year = {2011},
date = {2011-01-01},
journal = {Psychiatry Research},
volume = {191},
number = {1},
pages = {76--79},
abstract = {In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC. Copyright Published by Elsevier Ireland Ltd.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Morgan, C D; Zuckerman, S L; King, L E; Beaird, S E; Sills, A K; Solomon, G S
Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging Journal Article
In: Child's Nervous System, vol. 31, no. 12, pp. 2305–2309, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, arachnoid cyst, Article, brain, Brain Injury, Child, Computed tomography (CT) neuroimaging, computer assisted tomography, Computer-Assisted, Concussion, cost effectiveness analysis, cost utility analysis, DECISION making, diagnostic value, DSM-IV, Female, human, Humans, image processing, Magnetic Resonance Imaging, Magnetic resonance imaging (MRI), major clinical study, Male, mild traumatic brain injury, neuroimaging, neurosurgery, nuclear magnetic resonance, nuclear magnetic resonance imaging, pathology, Post-Concussion Syndrome, postconcussion syndrome, Preschool, preschool child, priority journal, Radiography, Retrospective Studies, retrospective study, Sports, STATISTICS, Tomography, traumatic brain injury, X ray, X-Ray Computed
@article{Morgan2015,
title = {Post-concussion syndrome (PCS) in a youth population: defining the diagnostic value and cost-utility of brain imaging},
author = {Morgan, C D and Zuckerman, S L and King, L E and Beaird, S E and Sills, A K and Solomon, G S},
doi = {10.1007/s00381-015-2916-y},
year = {2015},
date = {2015-01-01},
journal = {Child's Nervous System},
volume = {31},
number = {12},
pages = {2305--2309},
abstract = {Purpose: Approximately 90% of concussions are transient, with symptoms resolving within 10\textendash14 days. However, a minority of patients remain symptomatic several months post-injury, a condition known as post-concussion syndrome (PCS). The treatment of these patients can be challenging. The goal of our study was to assess the utility and cost-effectiveness of neurologic imaging two or more weeks post-injury in a cohort of youth with PCS. Methods: We conducted a retrospective study of 52 pediatric patients with persistent post-concussion symptoms after 3 months. We collected demographics and neuroimaging results obtained greater than 2 weeks post-concussion. Neuroimaging ordered in the first 2 weeks post-concussion was excluded, except to determine the rate of re-imaging. Descriptive statistics and corresponding cost data were collected. Results: Of 52 patients with PCS, 23/52 (44 %) had neuroimaging at least 2 weeks after the initial injury, for a total of 32 diagnostic studies. In summary, 1/19 MRIs (5.3 %), 1/8 CTs (13 %), and 0/5 x-rays (0 %) yielded significant positive findings, none of which altered clinical management. Chronic phase neuroimaging estimated costs from these 52 pediatric patients totaled $129,025. We estimate the cost to identify a single positive finding was $21,000 for head CT and $104,500 for brain MRI. Conclusions: In this cohort of pediatric PCS patients, brain imaging in the chronic phase (defined as more than 2 weeks after concussion) was pursued in almost half the study sample, had low diagnostic yield, and had poor cost-effectiveness. Based on these results, outpatient management of pediatric patients with long-term post-concussive symptoms should rarely include repeat neuroimaging beyond the acute phase. © 2015, Springer-Verlag Berlin Heidelberg.},
keywords = {Adolescent, arachnoid cyst, Article, brain, Brain Injury, Child, Computed tomography (CT) neuroimaging, computer assisted tomography, Computer-Assisted, Concussion, cost effectiveness analysis, cost utility analysis, DECISION making, diagnostic value, DSM-IV, Female, human, Humans, image processing, Magnetic Resonance Imaging, Magnetic resonance imaging (MRI), major clinical study, Male, mild traumatic brain injury, neuroimaging, neurosurgery, nuclear magnetic resonance, nuclear magnetic resonance imaging, pathology, Post-Concussion Syndrome, postconcussion syndrome, Preschool, preschool child, priority journal, Radiography, Retrospective Studies, retrospective study, Sports, STATISTICS, Tomography, traumatic brain injury, X ray, X-Ray Computed},
pubstate = {published},
tppubtype = {article}
}
Dang, H; Stayman, J W; Sisniega, A; Xu, J; Zbijewski, W; Wang, X; Foos, D H; Aygun, N; Koliatsos, V E; Siewerdsen, J H
Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: Application to high-quality head imaging Journal Article
In: Physics in Medicine and Biology, vol. 60, no. 16, pp. 6153–6175, 2015.
Abstract | Links | BibTeX | Tags: artifact correction, brain, Computerized tomography, cone-beam CT, Flat panel displays, image processing, Image quality, Image reconstruction, Intensive care units, intracranial hemorrhage, Intracranial hemorrhages, Iterative methods, Least squares approximations, Measurement Noise, measurement noise model, Model based iterative reconstruction, model-based iterative reconstruction, Soft tissue, soft-tissue image quality, Tissue, Traumatic Brain Injuries, traumatic brain injury
@article{Dang2015,
title = {Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: Application to high-quality head imaging},
author = {Dang, H and Stayman, J W and Sisniega, A and Xu, J and Zbijewski, W and Wang, X and Foos, D H and Aygun, N and Koliatsos, V E and Siewerdsen, J H},
doi = {10.1088/0031-9155/60/16/6153},
year = {2015},
date = {2015-01-01},
journal = {Physics in Medicine and Biology},
volume = {60},
number = {16},
pages = {6153--6175},
abstract = {Non-contrast CT reliably detects fresh blood in the brain and is the current front-line imaging modality for intracranial hemorrhage such as that occurring in acute traumatic brain injury (contrast ∼40-80 HU, size \> 1 mm). We are developing flat-panel detector (FPD) cone-beam CT (CBCT) to facilitate such diagnosis in a low-cost, mobile platform suitable for point-of-care deployment. Such a system may offer benefits in the ICU, urgent care/concussion clinic, ambulance, and sports and military theatres. However, current FPD-CBCT systems face significant challenges that confound low-contrast, soft-tissue imaging. Artifact correction can overcome major sources of bias in FPD-CBCT but imparts noise amplification in filtered backprojection (FBP). Model-based reconstruction improves soft-tissue image quality compared to FBP by leveraging a high-fidelity forward model and image regularization. In this work, we develop a novel penalized weighted least-squares (PWLS) image reconstruction method with a noise model that includes accurate modeling of the noise characteristics associated with the two dominant artifact corrections (scatter and beam-hardening) in CBCT and utilizes modified weights to compensate for noise amplification imparted by each correction. Experiments included real data acquired on a FPD-CBCT test-bench and an anthropomorphic head phantom emulating intra-parenchymal hemorrhage. The proposed PWLS method demonstrated superior noise-resolution tradeoffs in comparison to FBP and PWLS with conventional weights (viz. at matched 0.50 mm spatial resolution},
keywords = {artifact correction, brain, Computerized tomography, cone-beam CT, Flat panel displays, image processing, Image quality, Image reconstruction, Intensive care units, intracranial hemorrhage, Intracranial hemorrhages, Iterative methods, Least squares approximations, Measurement Noise, measurement noise model, Model based iterative reconstruction, model-based iterative reconstruction, Soft tissue, soft-tissue image quality, Tissue, Traumatic Brain Injuries, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Matthews, S; Simmons, A; Strigo, I
The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131] Journal Article
In: Psychiatry Research, vol. 191, no. 1, pp. 76–79, 2011.
Abstract | BibTeX | Tags: *Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs & Derivatives], Urea/bl [Blood], Young Adult
@article{Matthews2011a,
title = {The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131]},
author = {Matthews, S and Simmons, A and Strigo, I},
year = {2011},
date = {2011-01-01},
journal = {Psychiatry Research},
volume = {191},
number = {1},
pages = {76--79},
abstract = {In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC. Copyright Published by Elsevier Ireland Ltd.},
keywords = {*Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs \& Derivatives], Urea/bl [Blood], Young Adult},
pubstate = {published},
tppubtype = {article}
}