Daley, M; Dekaban, G; Bartha, R; Brown, A; Stewart, T C; Doherty, T; Fischer, L; Holmes, J; Menon, R S; Rupar, C A; Shoemaker, J K; Fraser, D D
Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method Journal Article
In: Metabolomics, vol. 12, no. 12, 2016.
Abstract | Links | BibTeX | Tags: adolescents, Biomarker, Concussion, DIAGNOSIS, ice hockey, Metabolomics
@article{Daley2016,
title = {Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method},
author = {Daley, M and Dekaban, G and Bartha, R and Brown, A and Stewart, T C and Doherty, T and Fischer, L and Holmes, J and Menon, R S and Rupar, C A and Shoemaker, J K and Fraser, D D},
doi = {10.1007/s11306-016-1131-5},
year = {2016},
date = {2016-01-01},
journal = {Metabolomics},
volume = {12},
number = {12},
abstract = {Introduction: Concussions are a major health concern as they cause significant acute symptoms and in some athletes, long-term neurologic dysfunction. Diagnosis of concussion can be difficult, as are the decisions to stop play. Objective: To determine if concussions in adolescent male hockey players could be diagnosed using plasma metabolomics profiling. Methods: Plasma was obtained from 12 concussed and 17 non-concussed athletes, and assayed for 174 metabolites with proton nuclear magnetic resonance and direct injection liquid chromatography tandem mass spectrometry. Data were analysed with multivariate statistical analysis and machine learning. Results: The estimated time from concussion occurrence to blood draw at the first clinic visit was 2.3 ± 0.7 days. Using principal component analysis, the leading 10 components, each containing 9 metabolites, were shown to account for 82 % of the variance between cohorts, and relied heavily on changes in glycerophospholipids. Cross-validation of the classifier using a leave-one out approach demonstrated a 92 % accuracy rate in diagnosing a concussion (P \< 0.0001). The number of metabolites required to achieve the 92 % diagnostic accuracy was minimized from 174 to as few as 17 metabolites. Receiver operating characteristic analyses generated an area under the curve of 0.91, indicating excellent concussion diagnostic potential. Conclusion: Metabolomics profiling, together with multivariate statistical analysis and machine learning, identified concussed athletes with \>90 % certainty. Metabolomics profiling represents a novel diagnostic method for concussion, and may be amenable to point-of-care testing. © 2016, Springer Science+Business Media New York.},
keywords = {adolescents, Biomarker, Concussion, DIAGNOSIS, ice hockey, Metabolomics},
pubstate = {published},
tppubtype = {article}
}
Rhine, T; Babcock, L; Zhang, N; Leach, J; Wade, S L
Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury? Journal Article
In: Brain Injury, vol. 30, no. 10, pp. 1231–1238, 2016.
Abstract | Links | BibTeX | Tags: Biomarkers, Concussion, DIAGNOSIS, Paediatric
@article{Rhine2016,
title = {Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury?},
author = {Rhine, T and Babcock, L and Zhang, N and Leach, J and Wade, S L},
doi = {10.1080/02699052.2016.1178396},
year = {2016},
date = {2016-01-01},
journal = {Brain Injury},
volume = {30},
number = {10},
pages = {1231--1238},
abstract = {Objectives: To compare serum biomarker levels between children with mild traumatic brain injury (mTBI) and orthopaedic injury (OI), acutely following injury. Secondarily, to explore the association between biomarker levels and symptom burden over 1 month post-injury. Methods: This was a prospective cohort study of children aged 11\textendash16 years who presented to the emergency department within 6 hours of sustaining mTBI or isolated extremity OI. Serum was drawn at the time of study enrollment and levels of ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) and glial fibrillary acid protein (GFAP) were analysed. Symptom burden was assessed by the Post-Concussion Symptom Scale (PCSS) acutely following injury and at three subsequent time points over 1 month. Results: Twenty-five children with mTBI and 20 children with OI were enrolled. The average age for the overall cohort was 13 (± 1.6) years and the majority were male and injured playing sports. GFAP levels and PCSS scores were significantly higher acutely following mTBI vs OI (p \< 0.01). There was not a significant group difference in UCH-L1 levels. Neither GFAP nor UCH-L1 were predictive of PCSS scores over the 1month post-injury. Conclusions: GFAP may be a promising diagnostic tool for children with mTBI. Additional approaches are needed to predict symptom severity and persistence. © 2016 Taylor \& Francis Group, LLC.},
keywords = {Biomarkers, Concussion, DIAGNOSIS, Paediatric},
pubstate = {published},
tppubtype = {article}
}
Aomura, S; Zhang, Y; Nakadate, H; Koyama, T; Nishimura, A
Brain injury risk estimation of collegiate football player based on game video of concussion suspected accident Journal Article
In: Journal of Biomechanical Science and Engineering, vol. 11, no. 4, 2016.
Abstract | Links | BibTeX | Tags: Accidents, Brain Injury, Brain injury risk estimation, Collision accidents, DIAGNOSIS, FEM, Finite element method, FOOTBALL players, Game video, Game videos, Health risks, Initial conditions, Mechanical parameters, Motion analysis, Relative positions, RISK assessment, Risk perception, Rotational velocity, Sports, Sports-related concussion
@article{Aomura2016,
title = {Brain injury risk estimation of collegiate football player based on game video of concussion suspected accident},
author = {Aomura, S and Zhang, Y and Nakadate, H and Koyama, T and Nishimura, A},
doi = {10.1299/jbse.16-00393},
year = {2016},
date = {2016-01-01},
journal = {Journal of Biomechanical Science and Engineering},
volume = {11},
number = {4},
abstract = {The collision accident in collegiate football game was simulated based on the game video and the concussive impact on the head was analyzed. First, the collision motion of players was reproduced based on the video by using motion analysis, and the translational and rotational velocities, relative position and contact location of the struck and the striking players' heads just before the collision were calculated. Then the data obtained were input to two helmeted finite element (FE) human head models as the initial condition, and the brain injury risk was evaluated by using the impact analysis. The FE helmet model was validated by a drop test of the helmet in which the head impactor was embedded. In the present study, two concussion suspected accident cases were analyzed; then the concussion was evaluated by ten mechanical parameters generated inside the skull caused by the collision. The injury risk evaluated by multi parameters belonged to the dangerous range that may cause concussion and was consistent with the diagnosis of the medical team doctor. The brain injury risk can be successfully estimated by the reconstructed simulation of the game video and FE analysis. To our knowledge, this study is the first attempt in Japan to estimate the brain injury risk systematically by a combination of game video analysis which is originally introduced for the players' health care and FE analysis by helmeted human head model. In the future, brain injury risk caused by an accident can be evaluated with higher accuracy by analyzing more accident cases. © 2016 The Japan Society of Mechanical Engineers.},
keywords = {Accidents, Brain Injury, Brain injury risk estimation, Collision accidents, DIAGNOSIS, FEM, Finite element method, FOOTBALL players, Game video, Game videos, Health risks, Initial conditions, Mechanical parameters, Motion analysis, Relative positions, RISK assessment, Risk perception, Rotational velocity, Sports, Sports-related concussion},
pubstate = {published},
tppubtype = {article}
}
Odom, M J; Lee, Y M; Zuckerman, S L; Apple, R P; Germanos, T; Solomon, G S; Sills, A K
Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System Journal Article
In: J Surg Orthop Adv, vol. 25, no. 2, pp. 93–98, 2016.
Abstract | BibTeX | Tags: *Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Postural Balance, *Sensation Disorders/di [Diagnosis], adult, Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Computer-Assisted, DIAGNOSIS, Female, Humans, Male, Reproducibility of Results, Sensation Disorders/et [Etiology], Young Adult
@article{Odom2016,
title = {Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System},
author = {Odom, M J and Lee, Y M and Zuckerman, S L and Apple, R P and Germanos, T and Solomon, G S and Sills, A K},
year = {2016},
date = {2016-01-01},
journal = {J Surg Orthop Adv},
volume = {25},
number = {2},
pages = {93--98},
abstract = {This study evaluated the test-retest reliability of a novel computer-based, portable balance assessment tool, the Equilibrate System (ES), used to diagnose sports-related concussion. Twenty-seven students participated in ES testing consisting of three sessions over 4 weeks. The modified Balance Error Scoring System was performed. For each participant, test-retest reliability was established using the intraclass correlation coefficient (ICC). The ES test-retest reliability from baseline to week 2 produced an ICC value of 0.495 (95% CI, 0.123-0.745). Week 2 testing produced ICC values of 0.602 (95% CI, 0.279-0.803) and 0.610 (95% CI, 0.299-0.804), respectively. All other single measures test-retest reliability values produced poor ICC values. Same-day ES testing showed fair to good test-retest reliability while interweek measures displayed poor to fair test-retest reliability. Testing conditions should be controlled when using computerized balance assessment methods. ES testing should only be used as a part of a comprehensive assessment.},
keywords = {*Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Postural Balance, *Sensation Disorders/di [Diagnosis], adult, Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Computer-Assisted, DIAGNOSIS, Female, Humans, Male, Reproducibility of Results, Sensation Disorders/et [Etiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Asplund, C A; Kutcher, J S
Syncope in athletes of neurological origin: 2B. From personal history and physical examination sections Journal Article
In: Current Sports Medicine Reports, vol. 14, no. 3, pp. 256–257, 2015.
BibTeX | Tags: *Athletes, *Brain Concussion/di [Diagnosis], *Heat Stroke/di [Diagnosis], *Psychophysiologic Disorders/di [Diagnosis], *Seizures/di [Diagnosis], *Syncope, Accidental Falls, Adolescent, Brain Concussion/co [Complications], DIAGNOSIS, Differential, Female, football, Heat Stroke/co [Complications], Humans, Male, MEDICAL history taking, Psychophysiologic Disorders/co [Complications], Running, Seizures/co [Complications], Vasovagal/et [Etiology], Young Adult
@article{Asplund2015,
title = {Syncope in athletes of neurological origin: 2B. From personal history and physical examination sections},
author = {Asplund, C A and Kutcher, J S},
year = {2015},
date = {2015-01-01},
journal = {Current Sports Medicine Reports},
volume = {14},
number = {3},
pages = {256--257},
keywords = {*Athletes, *Brain Concussion/di [Diagnosis], *Heat Stroke/di [Diagnosis], *Psychophysiologic Disorders/di [Diagnosis], *Seizures/di [Diagnosis], *Syncope, Accidental Falls, Adolescent, Brain Concussion/co [Complications], DIAGNOSIS, Differential, Female, football, Heat Stroke/co [Complications], Humans, Male, MEDICAL history taking, Psychophysiologic Disorders/co [Complications], Running, Seizures/co [Complications], Vasovagal/et [Etiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Daneshvar, Daniel H; Goldstein, Lee E; Kiernan, Patrick T; Stein, Thor D; McKee, Ann C
Post-traumatic neurodegeneration and chronic traumatic encephalopathy Journal Article
In: MCN: Molecular & Cellular Neuroscience, vol. 66, no. Part B, pp. 81–90, 2015, ISBN: 10447431.
Abstract | Links | BibTeX | Tags: A$beta$ beta-amyloid, AD Alzheimer's disease, APOE $epsilon$4 apolipoprotein $epsilon$4, axonal injury, Blast and impact neurotrauma, BRAIN -- Wounds & injuries, Brain trauma, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy NEURODEGENERATION, Concussion, CSF cerebrospinal fluid, CTE chronic traumatic encephalopathy, DIAGNOSIS, DISEASES -- Risk factors, DNA-binding proteins, MORTALITY, Motor neuron disease, mTBI mild traumatic brain injury, NERVOUS system -- Wounds & injuries, NFTs neurofibrillary tangles, p-tau hyperphosphorylated tau, PCS post-concussion syndrome, PET positron emission tomography, PHF-tau paired helical filament-tau, Posttraumatic neurodegeneration, tau protein, TBI traumatic brain injury, TDP-43 43 kDa TAR DNA-binding protein, traumatic brain injury
@article{Daneshvar2015,
title = {Post-traumatic neurodegeneration and chronic traumatic encephalopathy},
author = {Daneshvar, Daniel H and Goldstein, Lee E and Kiernan, Patrick T and Stein, Thor D and McKee, Ann C},
url = {http://search.ebscohost.com/login.aspx?direct=true\&db=aph\&AN=103136351\&site=ehost-live},
doi = {10.1016/j.mcn.2015.03.007},
isbn = {10447431},
year = {2015},
date = {2015-01-01},
journal = {MCN: Molecular \& Cellular Neuroscience},
volume = {66},
number = {Part B},
pages = {81--90},
abstract = {Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world. Concussive and subconcussive forms of closed-head injury due to impact or blast neurotrauma represent the most common types of TBI in civilian and military settings. It is becoming increasingly evident that TBI can lead to persistent, long-term debilitating effects, and in some cases, progressive neurodegeneration and chronic traumatic encephalopathy (CTE). The epidemiological literature suggests that a single moderate-to-severe TBI may be associated with accelerated neurodegeneration and increased risk of Alzheimer's disease, Parkinson's disease, or motor neuron disease. However, the pathologic phenotype of these post-traumatic neurodegenerations is largely unknown and there may be pathobiological differences between post-traumatic disease and the corresponding sporadic disorder. By contrast, the pathology of CTE is increasingly well known and is characterized by a distinctive pattern of progressive brain atrophy and accumulation of hyperphosphorylated tau neurofibrillary and glial tangles, dystrophic neurites, 43 kDa TAR DNA-binding protein (TDP-43) neuronal and glial aggregates, microvasculopathy, myelinated axonopathy, neuroinflammation, and white matter degeneration. Clinically, CTE is associated with behavioral changes, executive dysfunction, memory deficits, and cognitive impairments that begin insidiously and most often progress slowly over decades. Although research on the long-term effects of TBI is advancing quickly, the incidence and prevalence of post-traumatic neurodegeneration and CTE are unknown. Critical knowledge gaps include elucidation of pathogenic mechanisms, identification of genetic risk factors, and clarification of relevant variables\textemdashincluding age at exposure to trauma, history of prior and subsequent head trauma, substance use, gender, stress, and comorbidities\textemdashall of which may contribute to risk profiles and the development of post-traumatic neurodegeneration and CTE. This article is part of a Special Issue entitled 'Traumatic Brain Injury'. [ABSTRACT FROM AUTHOR] Copyright of MCN: Molecular \& Cellular Neuroscience is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)},
keywords = {A$beta$ beta-amyloid, AD Alzheimer's disease, APOE $epsilon$4 apolipoprotein $epsilon$4, axonal injury, Blast and impact neurotrauma, BRAIN -- Wounds \& injuries, Brain trauma, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy NEURODEGENERATION, Concussion, CSF cerebrospinal fluid, CTE chronic traumatic encephalopathy, DIAGNOSIS, DISEASES -- Risk factors, DNA-binding proteins, MORTALITY, Motor neuron disease, mTBI mild traumatic brain injury, NERVOUS system -- Wounds \& injuries, NFTs neurofibrillary tangles, p-tau hyperphosphorylated tau, PCS post-concussion syndrome, PET positron emission tomography, PHF-tau paired helical filament-tau, Posttraumatic neurodegeneration, tau protein, TBI traumatic brain injury, TDP-43 43 kDa TAR DNA-binding protein, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Resch, Jacob; Driscoll, Aoife; McCaffrey, Noel; Brown, Cathleen; Ferrara, Michael S; Macciocchi, Stephen; Baumgartner, Ted; Walpert, Kimberly
ImPact Test-Retest Reliability: Reliably Unreliable? Journal Article
In: Journal of Athletic Training, vol. 48, no. 4, pp. 506–511, 2013, ISBN: 1062-6050.
Abstract | Links | BibTeX | Tags: ANALYSIS of variance, Body Weights and Measures, Cognition -- Evaluation, college, Computer Assisted, Continuing (Credit), Cross Sectional Studies, Data Analysis Software, DESCRIPTIVE statistics, DIAGNOSIS, Education, Effect Size, Female, human, Instrument Validation, Intraclass Correlation Coefficient, Ireland, Male, Multicenter Studies, Neuropsychological Tests, ONE-way analysis of variance, Post Hoc Analysis, Repeated Measures, Scales, Students, test-retest reliability, UNITED States, Validation Studies, Young Adult
@article{Resch2013b,
title = {ImPact Test-Retest Reliability: Reliably Unreliable?},
author = {Resch, Jacob and Driscoll, Aoife and McCaffrey, Noel and Brown, Cathleen and Ferrara, Michael S and Macciocchi, Stephen and Baumgartner, Ted and Walpert, Kimberly},
doi = {10.4085/1062-6050-48.3.09},
isbn = {1062-6050},
year = {2013},
date = {2013-01-01},
journal = {Journal of Athletic Training},
volume = {48},
number = {4},
pages = {506--511},
abstract = {Context: Computerized neuropsychological testing is commonly used in the assessment and management of sport-related concussion. Even though computerized testing is widespread, psychometric evidence for test-retest reliability is somewhat limited. Additional evidence for test-retest reliability is needed to optimize clinical decision making after concussion. Objective: To document test-retest reliability for a commercially available computerized neuropsychological test battery (ImPACT) using 2 different clinically relevant time intervals. Design: Cross-sectional study. Setting: Two research laboratories. Patients or Other Participants: Group 1 (n=46) consisted of 25 men and 21 women (age=22.4 ± 1.89 years). Group 2 (n = 45) consisted of 17 men and 28 women (age = 20.9 ± 1.72 years). Intervention(s): Both groups completed ImPACT forms 1, 2, and 3, which were delivered sequentially either at 1-week intervals (group 1) or at baseline, day 45, and day 50 (group 2). Group 2 also completed the Green Word Memory Test (WMT) as a measure of effort. Main Outcome Measures: Intraclass correlation coefficients (ICCs) were calculated for the composite scores of ImPACT between time points. Repeated-measures analysis of variance was used to evaluate changes in ImPACT and WMT results over time. Results: The ICC values for group 1 ranged from 0.26 to 0.88 for the 4 ImPACT composite scores. The ICC values for group 2 ranged from 0.37 to 0.76. In group 1, ImPACT classified 37.0% and 46.0% of healthy participants as impaired at time points 2 and 3, respectively. In group 2, ImPACT classified 22.2% and 28.9% of healthy participants as impaired at time points 2 and 3, respectively. Conclusions: We found variable test-retest reliability for ImPACT metrics. Visual motor speed and reaction time demonstrated greater reliability than verbal and visual memory. Our current data support a multifaceted approach to concussion assessment using clinical examinations, symptom reports, cognitive testing, and balance assessment.},
keywords = {ANALYSIS of variance, Body Weights and Measures, Cognition -- Evaluation, college, Computer Assisted, Continuing (Credit), Cross Sectional Studies, Data Analysis Software, DESCRIPTIVE statistics, DIAGNOSIS, Education, Effect Size, Female, human, Instrument Validation, Intraclass Correlation Coefficient, Ireland, Male, Multicenter Studies, Neuropsychological Tests, ONE-way analysis of variance, Post Hoc Analysis, Repeated Measures, Scales, Students, test-retest reliability, UNITED States, Validation Studies, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Gay, Robin K
Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury Journal Article
In: NeuroRehabilitation, vol. 32, no. 3, pp. 473–482, 2013, ISBN: 10538135.
Abstract | Links | BibTeX | Tags: ACOUSTIC stimulation (Neurophysiology), Balance, BRAIN -- Wounds & injuries -- Complications, brain injury rehabilitation, cognition, Concussion, DIAGNOSIS, DISEASES, Dizziness, Dizziness -- Risk factors, EQUILIBRIUM (Physiology), falls prevention, GAIT in humans, Memory, mild traumatic brain injury, neurocognitive assessment, sports injury, VESTIBULAR apparatus
@article{Gay2013,
title = {Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury},
author = {Gay, Robin K},
doi = {10.3233/NRE-130870},
isbn = {10538135},
year = {2013},
date = {2013-01-01},
journal = {NeuroRehabilitation},
volume = {32},
number = {3},
pages = {473--482},
publisher = {IOS Press},
abstract = {INTRODUCTION: Problems with balance and dizziness are one of the most common complaints of individuals who have experienced a brain injury and are reported in up to 90% of cases. Despite the ubiquity of vestibular disturbance in this population, there remains a dearth of research on the interaction between physiological and cognitive systems responsible for maintaining balance. PURPOSE: The purpose of this article is to review studies on the interaction of physiological and cognitive processes required to maintain balance that may aide assessment and recovery of balance disturbance in patients with brain injury. SUMMARY: This article provides a review of research on the role of higher order cognitive processes in maintaining balance and rational for further inclusion of neurocognitive measures in the assessment of vestibular disturbance. CONCLUSION: Greater inclusion of neurocognitive measures in assessment of vestibular disturbance provides a method of assessment containing increased ecological validity compared to traditional assessments, better prepares patients for discharge, and may reduce the incidence of future injury.},
keywords = {ACOUSTIC stimulation (Neurophysiology), Balance, BRAIN -- Wounds \& injuries -- Complications, brain injury rehabilitation, cognition, Concussion, DIAGNOSIS, DISEASES, Dizziness, Dizziness -- Risk factors, EQUILIBRIUM (Physiology), falls prevention, GAIT in humans, Memory, mild traumatic brain injury, neurocognitive assessment, sports injury, VESTIBULAR apparatus},
pubstate = {published},
tppubtype = {article}
}
Samuels, Christina A
Efforts to Prevent Concussions Target Schools Journal Article
In: Education Week, vol. 30, no. 5, pp. 1–11, 2010, ISBN: 02774232.
Abstract | BibTeX | Tags: ATHLETIC trainers, BRAIN -- Concussion, DIAGNOSIS, Health, HIGH school athletes, School sports, Sports injuries in children
@article{Samuels2010,
title = {Efforts to Prevent Concussions Target Schools},
author = {Samuels, Christina A},
isbn = {02774232},
year = {2010},
date = {2010-01-01},
journal = {Education Week},
volume = {30},
number = {5},
pages = {1--11},
publisher = {Editorial Projects in Education Inc.},
abstract = {The article discusses the issue of concussions in high school sports. The article profiles efforts in the U.S. from the National Athletic Trainers' Association, the National Academy of Neuropsychology, and the House Education and Labor Committee to develop treatment and recovery plans for concussed student athletes across the country. Other topics include the risks associated with concussions, the role of athletic trainers in diagnosing concussions, and sports with high risks for concussions.},
keywords = {ATHLETIC trainers, BRAIN -- Concussion, DIAGNOSIS, Health, HIGH school athletes, School sports, Sports injuries in children},
pubstate = {published},
tppubtype = {article}
}
Gladstone, Jonathan
From psychoneurosis to ICHD-2: an overview of the state of the art in post-traumatic headache Journal Article
In: Headache, vol. 49, pp. 1097–1111, 2009.
Abstract | BibTeX | Tags: DIAGNOSIS, Differential Health Status Humans Neuro
@article{Gladstone2009,
title = {From psychoneurosis to ICHD-2: an overview of the state of the art in post-traumatic headache},
author = {Gladstone, Jonathan},
year = {2009},
date = {2009-01-01},
journal = {Headache},
volume = {49},
pages = {1097--1111},
address = {Gladstone Headache Clinic, Cleveland Clinic Canada, 1333 Sheppard Ave. E, Suite 122, Toronto, Ontario M2J 1V1, Canada.},
abstract = {Post-traumatic headache (PTH) is an important public health issue - head injuries are common, headache is the most common sequelae of head injuries, and PTH can be particularly disabling. Fortunately, for most individuals with PTH, the headache gradually dissipates over a period of several days, weeks, or months either spontaneously or aided by non-pharmacologic and/or pharmacologic management. Regrettably, for a minority of head-injured individuals, the PTH is intractable and disabling despite aggressive and comprehensive treatment. Unfortunately, there are many prejudices against individuals with PTH. Frequently, the presence or absence of litigation and/or the mechanism of head injury (sports-related trauma, slip-and-fall injury, motor vehicle accident, or military service-related injury) biases physicians' views on the legitimacy of the patient's PTH. Accordingly, this review attempts to summarize the state of the art of our understanding of PTH. This clinical review highlights: (a) views on PTH throughout the last few centuries, (b) the ICHD-2 classification of PTH, (c) the epidemiology of head injuries and PTH, (d) the clinical characteristics of PTH, (e) PTH related postconcussive symptoms, (f) pathophysiology of PTH, (g) evaluation of PTH, and (h) management of PTH. [References: 121]},
keywords = {DIAGNOSIS, Differential Health Status Humans Neuro},
pubstate = {published},
tppubtype = {article}
}
Moss, R I
Prevention. Preventing postconcussion sequelae Journal Article
In: Athletic Therapy Today, vol. 6, no. 2, pp. 28–29, 2001, ISBN: 1078-7895.
BibTeX | Tags: Athletic Injuries -- Diagnosis, Brain Concussion -- Diagnosis, Clinical Assessment Tools, DIAGNOSIS, football, Memory Disorders -- Diagnosis, Neurologic -- Methods
@article{Moss2001,
title = {Prevention. Preventing postconcussion sequelae},
author = {Moss, R I},
isbn = {1078-7895},
year = {2001},
date = {2001-01-01},
journal = {Athletic Therapy Today},
volume = {6},
number = {2},
pages = {28--29},
publisher = {Human Kinetics Publishers, Inc.},
address = {Champaign, Illinois},
keywords = {Athletic Injuries -- Diagnosis, Brain Concussion -- Diagnosis, Clinical Assessment Tools, DIAGNOSIS, football, Memory Disorders -- Diagnosis, Neurologic -- Methods},
pubstate = {published},
tppubtype = {article}
}
Daley, M; Dekaban, G; Bartha, R; Brown, A; Stewart, T C; Doherty, T; Fischer, L; Holmes, J; Menon, R S; Rupar, C A; Shoemaker, J K; Fraser, D D
Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method Journal Article
In: Metabolomics, vol. 12, no. 12, 2016.
@article{Daley2016,
title = {Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method},
author = {Daley, M and Dekaban, G and Bartha, R and Brown, A and Stewart, T C and Doherty, T and Fischer, L and Holmes, J and Menon, R S and Rupar, C A and Shoemaker, J K and Fraser, D D},
doi = {10.1007/s11306-016-1131-5},
year = {2016},
date = {2016-01-01},
journal = {Metabolomics},
volume = {12},
number = {12},
abstract = {Introduction: Concussions are a major health concern as they cause significant acute symptoms and in some athletes, long-term neurologic dysfunction. Diagnosis of concussion can be difficult, as are the decisions to stop play. Objective: To determine if concussions in adolescent male hockey players could be diagnosed using plasma metabolomics profiling. Methods: Plasma was obtained from 12 concussed and 17 non-concussed athletes, and assayed for 174 metabolites with proton nuclear magnetic resonance and direct injection liquid chromatography tandem mass spectrometry. Data were analysed with multivariate statistical analysis and machine learning. Results: The estimated time from concussion occurrence to blood draw at the first clinic visit was 2.3 ± 0.7 days. Using principal component analysis, the leading 10 components, each containing 9 metabolites, were shown to account for 82 % of the variance between cohorts, and relied heavily on changes in glycerophospholipids. Cross-validation of the classifier using a leave-one out approach demonstrated a 92 % accuracy rate in diagnosing a concussion (P \< 0.0001). The number of metabolites required to achieve the 92 % diagnostic accuracy was minimized from 174 to as few as 17 metabolites. Receiver operating characteristic analyses generated an area under the curve of 0.91, indicating excellent concussion diagnostic potential. Conclusion: Metabolomics profiling, together with multivariate statistical analysis and machine learning, identified concussed athletes with \>90 % certainty. Metabolomics profiling represents a novel diagnostic method for concussion, and may be amenable to point-of-care testing. © 2016, Springer Science+Business Media New York.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Rhine, T; Babcock, L; Zhang, N; Leach, J; Wade, S L
Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury? Journal Article
In: Brain Injury, vol. 30, no. 10, pp. 1231–1238, 2016.
@article{Rhine2016,
title = {Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury?},
author = {Rhine, T and Babcock, L and Zhang, N and Leach, J and Wade, S L},
doi = {10.1080/02699052.2016.1178396},
year = {2016},
date = {2016-01-01},
journal = {Brain Injury},
volume = {30},
number = {10},
pages = {1231--1238},
abstract = {Objectives: To compare serum biomarker levels between children with mild traumatic brain injury (mTBI) and orthopaedic injury (OI), acutely following injury. Secondarily, to explore the association between biomarker levels and symptom burden over 1 month post-injury. Methods: This was a prospective cohort study of children aged 11\textendash16 years who presented to the emergency department within 6 hours of sustaining mTBI or isolated extremity OI. Serum was drawn at the time of study enrollment and levels of ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) and glial fibrillary acid protein (GFAP) were analysed. Symptom burden was assessed by the Post-Concussion Symptom Scale (PCSS) acutely following injury and at three subsequent time points over 1 month. Results: Twenty-five children with mTBI and 20 children with OI were enrolled. The average age for the overall cohort was 13 (± 1.6) years and the majority were male and injured playing sports. GFAP levels and PCSS scores were significantly higher acutely following mTBI vs OI (p \< 0.01). There was not a significant group difference in UCH-L1 levels. Neither GFAP nor UCH-L1 were predictive of PCSS scores over the 1month post-injury. Conclusions: GFAP may be a promising diagnostic tool for children with mTBI. Additional approaches are needed to predict symptom severity and persistence. © 2016 Taylor \& Francis Group, LLC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Aomura, S; Zhang, Y; Nakadate, H; Koyama, T; Nishimura, A
Brain injury risk estimation of collegiate football player based on game video of concussion suspected accident Journal Article
In: Journal of Biomechanical Science and Engineering, vol. 11, no. 4, 2016.
@article{Aomura2016,
title = {Brain injury risk estimation of collegiate football player based on game video of concussion suspected accident},
author = {Aomura, S and Zhang, Y and Nakadate, H and Koyama, T and Nishimura, A},
doi = {10.1299/jbse.16-00393},
year = {2016},
date = {2016-01-01},
journal = {Journal of Biomechanical Science and Engineering},
volume = {11},
number = {4},
abstract = {The collision accident in collegiate football game was simulated based on the game video and the concussive impact on the head was analyzed. First, the collision motion of players was reproduced based on the video by using motion analysis, and the translational and rotational velocities, relative position and contact location of the struck and the striking players' heads just before the collision were calculated. Then the data obtained were input to two helmeted finite element (FE) human head models as the initial condition, and the brain injury risk was evaluated by using the impact analysis. The FE helmet model was validated by a drop test of the helmet in which the head impactor was embedded. In the present study, two concussion suspected accident cases were analyzed; then the concussion was evaluated by ten mechanical parameters generated inside the skull caused by the collision. The injury risk evaluated by multi parameters belonged to the dangerous range that may cause concussion and was consistent with the diagnosis of the medical team doctor. The brain injury risk can be successfully estimated by the reconstructed simulation of the game video and FE analysis. To our knowledge, this study is the first attempt in Japan to estimate the brain injury risk systematically by a combination of game video analysis which is originally introduced for the players' health care and FE analysis by helmeted human head model. In the future, brain injury risk caused by an accident can be evaluated with higher accuracy by analyzing more accident cases. © 2016 The Japan Society of Mechanical Engineers.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Odom, M J; Lee, Y M; Zuckerman, S L; Apple, R P; Germanos, T; Solomon, G S; Sills, A K
Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System Journal Article
In: J Surg Orthop Adv, vol. 25, no. 2, pp. 93–98, 2016.
@article{Odom2016,
title = {Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System},
author = {Odom, M J and Lee, Y M and Zuckerman, S L and Apple, R P and Germanos, T and Solomon, G S and Sills, A K},
year = {2016},
date = {2016-01-01},
journal = {J Surg Orthop Adv},
volume = {25},
number = {2},
pages = {93--98},
abstract = {This study evaluated the test-retest reliability of a novel computer-based, portable balance assessment tool, the Equilibrate System (ES), used to diagnose sports-related concussion. Twenty-seven students participated in ES testing consisting of three sessions over 4 weeks. The modified Balance Error Scoring System was performed. For each participant, test-retest reliability was established using the intraclass correlation coefficient (ICC). The ES test-retest reliability from baseline to week 2 produced an ICC value of 0.495 (95% CI, 0.123-0.745). Week 2 testing produced ICC values of 0.602 (95% CI, 0.279-0.803) and 0.610 (95% CI, 0.299-0.804), respectively. All other single measures test-retest reliability values produced poor ICC values. Same-day ES testing showed fair to good test-retest reliability while interweek measures displayed poor to fair test-retest reliability. Testing conditions should be controlled when using computerized balance assessment methods. ES testing should only be used as a part of a comprehensive assessment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Asplund, C A; Kutcher, J S
Syncope in athletes of neurological origin: 2B. From personal history and physical examination sections Journal Article
In: Current Sports Medicine Reports, vol. 14, no. 3, pp. 256–257, 2015.
@article{Asplund2015,
title = {Syncope in athletes of neurological origin: 2B. From personal history and physical examination sections},
author = {Asplund, C A and Kutcher, J S},
year = {2015},
date = {2015-01-01},
journal = {Current Sports Medicine Reports},
volume = {14},
number = {3},
pages = {256--257},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Daneshvar, Daniel H; Goldstein, Lee E; Kiernan, Patrick T; Stein, Thor D; McKee, Ann C
Post-traumatic neurodegeneration and chronic traumatic encephalopathy Journal Article
In: MCN: Molecular & Cellular Neuroscience, vol. 66, no. Part B, pp. 81–90, 2015, ISBN: 10447431.
@article{Daneshvar2015,
title = {Post-traumatic neurodegeneration and chronic traumatic encephalopathy},
author = {Daneshvar, Daniel H and Goldstein, Lee E and Kiernan, Patrick T and Stein, Thor D and McKee, Ann C},
url = {http://search.ebscohost.com/login.aspx?direct=true\&db=aph\&AN=103136351\&site=ehost-live},
doi = {10.1016/j.mcn.2015.03.007},
isbn = {10447431},
year = {2015},
date = {2015-01-01},
journal = {MCN: Molecular \& Cellular Neuroscience},
volume = {66},
number = {Part B},
pages = {81--90},
abstract = {Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world. Concussive and subconcussive forms of closed-head injury due to impact or blast neurotrauma represent the most common types of TBI in civilian and military settings. It is becoming increasingly evident that TBI can lead to persistent, long-term debilitating effects, and in some cases, progressive neurodegeneration and chronic traumatic encephalopathy (CTE). The epidemiological literature suggests that a single moderate-to-severe TBI may be associated with accelerated neurodegeneration and increased risk of Alzheimer's disease, Parkinson's disease, or motor neuron disease. However, the pathologic phenotype of these post-traumatic neurodegenerations is largely unknown and there may be pathobiological differences between post-traumatic disease and the corresponding sporadic disorder. By contrast, the pathology of CTE is increasingly well known and is characterized by a distinctive pattern of progressive brain atrophy and accumulation of hyperphosphorylated tau neurofibrillary and glial tangles, dystrophic neurites, 43 kDa TAR DNA-binding protein (TDP-43) neuronal and glial aggregates, microvasculopathy, myelinated axonopathy, neuroinflammation, and white matter degeneration. Clinically, CTE is associated with behavioral changes, executive dysfunction, memory deficits, and cognitive impairments that begin insidiously and most often progress slowly over decades. Although research on the long-term effects of TBI is advancing quickly, the incidence and prevalence of post-traumatic neurodegeneration and CTE are unknown. Critical knowledge gaps include elucidation of pathogenic mechanisms, identification of genetic risk factors, and clarification of relevant variables\textemdashincluding age at exposure to trauma, history of prior and subsequent head trauma, substance use, gender, stress, and comorbidities\textemdashall of which may contribute to risk profiles and the development of post-traumatic neurodegeneration and CTE. This article is part of a Special Issue entitled 'Traumatic Brain Injury'. [ABSTRACT FROM AUTHOR] Copyright of MCN: Molecular \& Cellular Neuroscience is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Resch, Jacob; Driscoll, Aoife; McCaffrey, Noel; Brown, Cathleen; Ferrara, Michael S; Macciocchi, Stephen; Baumgartner, Ted; Walpert, Kimberly
ImPact Test-Retest Reliability: Reliably Unreliable? Journal Article
In: Journal of Athletic Training, vol. 48, no. 4, pp. 506–511, 2013, ISBN: 1062-6050.
@article{Resch2013b,
title = {ImPact Test-Retest Reliability: Reliably Unreliable?},
author = {Resch, Jacob and Driscoll, Aoife and McCaffrey, Noel and Brown, Cathleen and Ferrara, Michael S and Macciocchi, Stephen and Baumgartner, Ted and Walpert, Kimberly},
doi = {10.4085/1062-6050-48.3.09},
isbn = {1062-6050},
year = {2013},
date = {2013-01-01},
journal = {Journal of Athletic Training},
volume = {48},
number = {4},
pages = {506--511},
abstract = {Context: Computerized neuropsychological testing is commonly used in the assessment and management of sport-related concussion. Even though computerized testing is widespread, psychometric evidence for test-retest reliability is somewhat limited. Additional evidence for test-retest reliability is needed to optimize clinical decision making after concussion. Objective: To document test-retest reliability for a commercially available computerized neuropsychological test battery (ImPACT) using 2 different clinically relevant time intervals. Design: Cross-sectional study. Setting: Two research laboratories. Patients or Other Participants: Group 1 (n=46) consisted of 25 men and 21 women (age=22.4 ± 1.89 years). Group 2 (n = 45) consisted of 17 men and 28 women (age = 20.9 ± 1.72 years). Intervention(s): Both groups completed ImPACT forms 1, 2, and 3, which were delivered sequentially either at 1-week intervals (group 1) or at baseline, day 45, and day 50 (group 2). Group 2 also completed the Green Word Memory Test (WMT) as a measure of effort. Main Outcome Measures: Intraclass correlation coefficients (ICCs) were calculated for the composite scores of ImPACT between time points. Repeated-measures analysis of variance was used to evaluate changes in ImPACT and WMT results over time. Results: The ICC values for group 1 ranged from 0.26 to 0.88 for the 4 ImPACT composite scores. The ICC values for group 2 ranged from 0.37 to 0.76. In group 1, ImPACT classified 37.0% and 46.0% of healthy participants as impaired at time points 2 and 3, respectively. In group 2, ImPACT classified 22.2% and 28.9% of healthy participants as impaired at time points 2 and 3, respectively. Conclusions: We found variable test-retest reliability for ImPACT metrics. Visual motor speed and reaction time demonstrated greater reliability than verbal and visual memory. Our current data support a multifaceted approach to concussion assessment using clinical examinations, symptom reports, cognitive testing, and balance assessment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gay, Robin K
Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury Journal Article
In: NeuroRehabilitation, vol. 32, no. 3, pp. 473–482, 2013, ISBN: 10538135.
@article{Gay2013,
title = {Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury},
author = {Gay, Robin K},
doi = {10.3233/NRE-130870},
isbn = {10538135},
year = {2013},
date = {2013-01-01},
journal = {NeuroRehabilitation},
volume = {32},
number = {3},
pages = {473--482},
publisher = {IOS Press},
abstract = {INTRODUCTION: Problems with balance and dizziness are one of the most common complaints of individuals who have experienced a brain injury and are reported in up to 90% of cases. Despite the ubiquity of vestibular disturbance in this population, there remains a dearth of research on the interaction between physiological and cognitive systems responsible for maintaining balance. PURPOSE: The purpose of this article is to review studies on the interaction of physiological and cognitive processes required to maintain balance that may aide assessment and recovery of balance disturbance in patients with brain injury. SUMMARY: This article provides a review of research on the role of higher order cognitive processes in maintaining balance and rational for further inclusion of neurocognitive measures in the assessment of vestibular disturbance. CONCLUSION: Greater inclusion of neurocognitive measures in assessment of vestibular disturbance provides a method of assessment containing increased ecological validity compared to traditional assessments, better prepares patients for discharge, and may reduce the incidence of future injury.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Samuels, Christina A
Efforts to Prevent Concussions Target Schools Journal Article
In: Education Week, vol. 30, no. 5, pp. 1–11, 2010, ISBN: 02774232.
@article{Samuels2010,
title = {Efforts to Prevent Concussions Target Schools},
author = {Samuels, Christina A},
isbn = {02774232},
year = {2010},
date = {2010-01-01},
journal = {Education Week},
volume = {30},
number = {5},
pages = {1--11},
publisher = {Editorial Projects in Education Inc.},
abstract = {The article discusses the issue of concussions in high school sports. The article profiles efforts in the U.S. from the National Athletic Trainers' Association, the National Academy of Neuropsychology, and the House Education and Labor Committee to develop treatment and recovery plans for concussed student athletes across the country. Other topics include the risks associated with concussions, the role of athletic trainers in diagnosing concussions, and sports with high risks for concussions.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gladstone, Jonathan
From psychoneurosis to ICHD-2: an overview of the state of the art in post-traumatic headache Journal Article
In: Headache, vol. 49, pp. 1097–1111, 2009.
@article{Gladstone2009,
title = {From psychoneurosis to ICHD-2: an overview of the state of the art in post-traumatic headache},
author = {Gladstone, Jonathan},
year = {2009},
date = {2009-01-01},
journal = {Headache},
volume = {49},
pages = {1097--1111},
address = {Gladstone Headache Clinic, Cleveland Clinic Canada, 1333 Sheppard Ave. E, Suite 122, Toronto, Ontario M2J 1V1, Canada.},
abstract = {Post-traumatic headache (PTH) is an important public health issue - head injuries are common, headache is the most common sequelae of head injuries, and PTH can be particularly disabling. Fortunately, for most individuals with PTH, the headache gradually dissipates over a period of several days, weeks, or months either spontaneously or aided by non-pharmacologic and/or pharmacologic management. Regrettably, for a minority of head-injured individuals, the PTH is intractable and disabling despite aggressive and comprehensive treatment. Unfortunately, there are many prejudices against individuals with PTH. Frequently, the presence or absence of litigation and/or the mechanism of head injury (sports-related trauma, slip-and-fall injury, motor vehicle accident, or military service-related injury) biases physicians' views on the legitimacy of the patient's PTH. Accordingly, this review attempts to summarize the state of the art of our understanding of PTH. This clinical review highlights: (a) views on PTH throughout the last few centuries, (b) the ICHD-2 classification of PTH, (c) the epidemiology of head injuries and PTH, (d) the clinical characteristics of PTH, (e) PTH related postconcussive symptoms, (f) pathophysiology of PTH, (g) evaluation of PTH, and (h) management of PTH. [References: 121]},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Moss, R I
Prevention. Preventing postconcussion sequelae Journal Article
In: Athletic Therapy Today, vol. 6, no. 2, pp. 28–29, 2001, ISBN: 1078-7895.
@article{Moss2001,
title = {Prevention. Preventing postconcussion sequelae},
author = {Moss, R I},
isbn = {1078-7895},
year = {2001},
date = {2001-01-01},
journal = {Athletic Therapy Today},
volume = {6},
number = {2},
pages = {28--29},
publisher = {Human Kinetics Publishers, Inc.},
address = {Champaign, Illinois},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Daley, M; Dekaban, G; Bartha, R; Brown, A; Stewart, T C; Doherty, T; Fischer, L; Holmes, J; Menon, R S; Rupar, C A; Shoemaker, J K; Fraser, D D
Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method Journal Article
In: Metabolomics, vol. 12, no. 12, 2016.
Abstract | Links | BibTeX | Tags: adolescents, Biomarker, Concussion, DIAGNOSIS, ice hockey, Metabolomics
@article{Daley2016,
title = {Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method},
author = {Daley, M and Dekaban, G and Bartha, R and Brown, A and Stewart, T C and Doherty, T and Fischer, L and Holmes, J and Menon, R S and Rupar, C A and Shoemaker, J K and Fraser, D D},
doi = {10.1007/s11306-016-1131-5},
year = {2016},
date = {2016-01-01},
journal = {Metabolomics},
volume = {12},
number = {12},
abstract = {Introduction: Concussions are a major health concern as they cause significant acute symptoms and in some athletes, long-term neurologic dysfunction. Diagnosis of concussion can be difficult, as are the decisions to stop play. Objective: To determine if concussions in adolescent male hockey players could be diagnosed using plasma metabolomics profiling. Methods: Plasma was obtained from 12 concussed and 17 non-concussed athletes, and assayed for 174 metabolites with proton nuclear magnetic resonance and direct injection liquid chromatography tandem mass spectrometry. Data were analysed with multivariate statistical analysis and machine learning. Results: The estimated time from concussion occurrence to blood draw at the first clinic visit was 2.3 ± 0.7 days. Using principal component analysis, the leading 10 components, each containing 9 metabolites, were shown to account for 82 % of the variance between cohorts, and relied heavily on changes in glycerophospholipids. Cross-validation of the classifier using a leave-one out approach demonstrated a 92 % accuracy rate in diagnosing a concussion (P \< 0.0001). The number of metabolites required to achieve the 92 % diagnostic accuracy was minimized from 174 to as few as 17 metabolites. Receiver operating characteristic analyses generated an area under the curve of 0.91, indicating excellent concussion diagnostic potential. Conclusion: Metabolomics profiling, together with multivariate statistical analysis and machine learning, identified concussed athletes with \>90 % certainty. Metabolomics profiling represents a novel diagnostic method for concussion, and may be amenable to point-of-care testing. © 2016, Springer Science+Business Media New York.},
keywords = {adolescents, Biomarker, Concussion, DIAGNOSIS, ice hockey, Metabolomics},
pubstate = {published},
tppubtype = {article}
}
Rhine, T; Babcock, L; Zhang, N; Leach, J; Wade, S L
Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury? Journal Article
In: Brain Injury, vol. 30, no. 10, pp. 1231–1238, 2016.
Abstract | Links | BibTeX | Tags: Biomarkers, Concussion, DIAGNOSIS, Paediatric
@article{Rhine2016,
title = {Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury?},
author = {Rhine, T and Babcock, L and Zhang, N and Leach, J and Wade, S L},
doi = {10.1080/02699052.2016.1178396},
year = {2016},
date = {2016-01-01},
journal = {Brain Injury},
volume = {30},
number = {10},
pages = {1231--1238},
abstract = {Objectives: To compare serum biomarker levels between children with mild traumatic brain injury (mTBI) and orthopaedic injury (OI), acutely following injury. Secondarily, to explore the association between biomarker levels and symptom burden over 1 month post-injury. Methods: This was a prospective cohort study of children aged 11\textendash16 years who presented to the emergency department within 6 hours of sustaining mTBI or isolated extremity OI. Serum was drawn at the time of study enrollment and levels of ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) and glial fibrillary acid protein (GFAP) were analysed. Symptom burden was assessed by the Post-Concussion Symptom Scale (PCSS) acutely following injury and at three subsequent time points over 1 month. Results: Twenty-five children with mTBI and 20 children with OI were enrolled. The average age for the overall cohort was 13 (± 1.6) years and the majority were male and injured playing sports. GFAP levels and PCSS scores were significantly higher acutely following mTBI vs OI (p \< 0.01). There was not a significant group difference in UCH-L1 levels. Neither GFAP nor UCH-L1 were predictive of PCSS scores over the 1month post-injury. Conclusions: GFAP may be a promising diagnostic tool for children with mTBI. Additional approaches are needed to predict symptom severity and persistence. © 2016 Taylor \& Francis Group, LLC.},
keywords = {Biomarkers, Concussion, DIAGNOSIS, Paediatric},
pubstate = {published},
tppubtype = {article}
}
Aomura, S; Zhang, Y; Nakadate, H; Koyama, T; Nishimura, A
Brain injury risk estimation of collegiate football player based on game video of concussion suspected accident Journal Article
In: Journal of Biomechanical Science and Engineering, vol. 11, no. 4, 2016.
Abstract | Links | BibTeX | Tags: Accidents, Brain Injury, Brain injury risk estimation, Collision accidents, DIAGNOSIS, FEM, Finite element method, FOOTBALL players, Game video, Game videos, Health risks, Initial conditions, Mechanical parameters, Motion analysis, Relative positions, RISK assessment, Risk perception, Rotational velocity, Sports, Sports-related concussion
@article{Aomura2016,
title = {Brain injury risk estimation of collegiate football player based on game video of concussion suspected accident},
author = {Aomura, S and Zhang, Y and Nakadate, H and Koyama, T and Nishimura, A},
doi = {10.1299/jbse.16-00393},
year = {2016},
date = {2016-01-01},
journal = {Journal of Biomechanical Science and Engineering},
volume = {11},
number = {4},
abstract = {The collision accident in collegiate football game was simulated based on the game video and the concussive impact on the head was analyzed. First, the collision motion of players was reproduced based on the video by using motion analysis, and the translational and rotational velocities, relative position and contact location of the struck and the striking players' heads just before the collision were calculated. Then the data obtained were input to two helmeted finite element (FE) human head models as the initial condition, and the brain injury risk was evaluated by using the impact analysis. The FE helmet model was validated by a drop test of the helmet in which the head impactor was embedded. In the present study, two concussion suspected accident cases were analyzed; then the concussion was evaluated by ten mechanical parameters generated inside the skull caused by the collision. The injury risk evaluated by multi parameters belonged to the dangerous range that may cause concussion and was consistent with the diagnosis of the medical team doctor. The brain injury risk can be successfully estimated by the reconstructed simulation of the game video and FE analysis. To our knowledge, this study is the first attempt in Japan to estimate the brain injury risk systematically by a combination of game video analysis which is originally introduced for the players' health care and FE analysis by helmeted human head model. In the future, brain injury risk caused by an accident can be evaluated with higher accuracy by analyzing more accident cases. © 2016 The Japan Society of Mechanical Engineers.},
keywords = {Accidents, Brain Injury, Brain injury risk estimation, Collision accidents, DIAGNOSIS, FEM, Finite element method, FOOTBALL players, Game video, Game videos, Health risks, Initial conditions, Mechanical parameters, Motion analysis, Relative positions, RISK assessment, Risk perception, Rotational velocity, Sports, Sports-related concussion},
pubstate = {published},
tppubtype = {article}
}
Odom, M J; Lee, Y M; Zuckerman, S L; Apple, R P; Germanos, T; Solomon, G S; Sills, A K
Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System Journal Article
In: J Surg Orthop Adv, vol. 25, no. 2, pp. 93–98, 2016.
Abstract | BibTeX | Tags: *Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Postural Balance, *Sensation Disorders/di [Diagnosis], adult, Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Computer-Assisted, DIAGNOSIS, Female, Humans, Male, Reproducibility of Results, Sensation Disorders/et [Etiology], Young Adult
@article{Odom2016,
title = {Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System},
author = {Odom, M J and Lee, Y M and Zuckerman, S L and Apple, R P and Germanos, T and Solomon, G S and Sills, A K},
year = {2016},
date = {2016-01-01},
journal = {J Surg Orthop Adv},
volume = {25},
number = {2},
pages = {93--98},
abstract = {This study evaluated the test-retest reliability of a novel computer-based, portable balance assessment tool, the Equilibrate System (ES), used to diagnose sports-related concussion. Twenty-seven students participated in ES testing consisting of three sessions over 4 weeks. The modified Balance Error Scoring System was performed. For each participant, test-retest reliability was established using the intraclass correlation coefficient (ICC). The ES test-retest reliability from baseline to week 2 produced an ICC value of 0.495 (95% CI, 0.123-0.745). Week 2 testing produced ICC values of 0.602 (95% CI, 0.279-0.803) and 0.610 (95% CI, 0.299-0.804), respectively. All other single measures test-retest reliability values produced poor ICC values. Same-day ES testing showed fair to good test-retest reliability while interweek measures displayed poor to fair test-retest reliability. Testing conditions should be controlled when using computerized balance assessment methods. ES testing should only be used as a part of a comprehensive assessment.},
keywords = {*Athletic Injuries/di [Diagnosis], *Brain Concussion/di [Diagnosis], *Postural Balance, *Sensation Disorders/di [Diagnosis], adult, Athletic Injuries/co [Complications], Brain Concussion/co [Complications], Computer-Assisted, DIAGNOSIS, Female, Humans, Male, Reproducibility of Results, Sensation Disorders/et [Etiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Asplund, C A; Kutcher, J S
Syncope in athletes of neurological origin: 2B. From personal history and physical examination sections Journal Article
In: Current Sports Medicine Reports, vol. 14, no. 3, pp. 256–257, 2015.
BibTeX | Tags: *Athletes, *Brain Concussion/di [Diagnosis], *Heat Stroke/di [Diagnosis], *Psychophysiologic Disorders/di [Diagnosis], *Seizures/di [Diagnosis], *Syncope, Accidental Falls, Adolescent, Brain Concussion/co [Complications], DIAGNOSIS, Differential, Female, football, Heat Stroke/co [Complications], Humans, Male, MEDICAL history taking, Psychophysiologic Disorders/co [Complications], Running, Seizures/co [Complications], Vasovagal/et [Etiology], Young Adult
@article{Asplund2015,
title = {Syncope in athletes of neurological origin: 2B. From personal history and physical examination sections},
author = {Asplund, C A and Kutcher, J S},
year = {2015},
date = {2015-01-01},
journal = {Current Sports Medicine Reports},
volume = {14},
number = {3},
pages = {256--257},
keywords = {*Athletes, *Brain Concussion/di [Diagnosis], *Heat Stroke/di [Diagnosis], *Psychophysiologic Disorders/di [Diagnosis], *Seizures/di [Diagnosis], *Syncope, Accidental Falls, Adolescent, Brain Concussion/co [Complications], DIAGNOSIS, Differential, Female, football, Heat Stroke/co [Complications], Humans, Male, MEDICAL history taking, Psychophysiologic Disorders/co [Complications], Running, Seizures/co [Complications], Vasovagal/et [Etiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Daneshvar, Daniel H; Goldstein, Lee E; Kiernan, Patrick T; Stein, Thor D; McKee, Ann C
Post-traumatic neurodegeneration and chronic traumatic encephalopathy Journal Article
In: MCN: Molecular & Cellular Neuroscience, vol. 66, no. Part B, pp. 81–90, 2015, ISBN: 10447431.
Abstract | Links | BibTeX | Tags: A$beta$ beta-amyloid, AD Alzheimer's disease, APOE $epsilon$4 apolipoprotein $epsilon$4, axonal injury, Blast and impact neurotrauma, BRAIN -- Wounds & injuries, Brain trauma, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy NEURODEGENERATION, Concussion, CSF cerebrospinal fluid, CTE chronic traumatic encephalopathy, DIAGNOSIS, DISEASES -- Risk factors, DNA-binding proteins, MORTALITY, Motor neuron disease, mTBI mild traumatic brain injury, NERVOUS system -- Wounds & injuries, NFTs neurofibrillary tangles, p-tau hyperphosphorylated tau, PCS post-concussion syndrome, PET positron emission tomography, PHF-tau paired helical filament-tau, Posttraumatic neurodegeneration, tau protein, TBI traumatic brain injury, TDP-43 43 kDa TAR DNA-binding protein, traumatic brain injury
@article{Daneshvar2015,
title = {Post-traumatic neurodegeneration and chronic traumatic encephalopathy},
author = {Daneshvar, Daniel H and Goldstein, Lee E and Kiernan, Patrick T and Stein, Thor D and McKee, Ann C},
url = {http://search.ebscohost.com/login.aspx?direct=true\&db=aph\&AN=103136351\&site=ehost-live},
doi = {10.1016/j.mcn.2015.03.007},
isbn = {10447431},
year = {2015},
date = {2015-01-01},
journal = {MCN: Molecular \& Cellular Neuroscience},
volume = {66},
number = {Part B},
pages = {81--90},
abstract = {Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world. Concussive and subconcussive forms of closed-head injury due to impact or blast neurotrauma represent the most common types of TBI in civilian and military settings. It is becoming increasingly evident that TBI can lead to persistent, long-term debilitating effects, and in some cases, progressive neurodegeneration and chronic traumatic encephalopathy (CTE). The epidemiological literature suggests that a single moderate-to-severe TBI may be associated with accelerated neurodegeneration and increased risk of Alzheimer's disease, Parkinson's disease, or motor neuron disease. However, the pathologic phenotype of these post-traumatic neurodegenerations is largely unknown and there may be pathobiological differences between post-traumatic disease and the corresponding sporadic disorder. By contrast, the pathology of CTE is increasingly well known and is characterized by a distinctive pattern of progressive brain atrophy and accumulation of hyperphosphorylated tau neurofibrillary and glial tangles, dystrophic neurites, 43 kDa TAR DNA-binding protein (TDP-43) neuronal and glial aggregates, microvasculopathy, myelinated axonopathy, neuroinflammation, and white matter degeneration. Clinically, CTE is associated with behavioral changes, executive dysfunction, memory deficits, and cognitive impairments that begin insidiously and most often progress slowly over decades. Although research on the long-term effects of TBI is advancing quickly, the incidence and prevalence of post-traumatic neurodegeneration and CTE are unknown. Critical knowledge gaps include elucidation of pathogenic mechanisms, identification of genetic risk factors, and clarification of relevant variables\textemdashincluding age at exposure to trauma, history of prior and subsequent head trauma, substance use, gender, stress, and comorbidities\textemdashall of which may contribute to risk profiles and the development of post-traumatic neurodegeneration and CTE. This article is part of a Special Issue entitled 'Traumatic Brain Injury'. [ABSTRACT FROM AUTHOR] Copyright of MCN: Molecular \& Cellular Neuroscience is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)},
keywords = {A$beta$ beta-amyloid, AD Alzheimer's disease, APOE $epsilon$4 apolipoprotein $epsilon$4, axonal injury, Blast and impact neurotrauma, BRAIN -- Wounds \& injuries, Brain trauma, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy NEURODEGENERATION, Concussion, CSF cerebrospinal fluid, CTE chronic traumatic encephalopathy, DIAGNOSIS, DISEASES -- Risk factors, DNA-binding proteins, MORTALITY, Motor neuron disease, mTBI mild traumatic brain injury, NERVOUS system -- Wounds \& injuries, NFTs neurofibrillary tangles, p-tau hyperphosphorylated tau, PCS post-concussion syndrome, PET positron emission tomography, PHF-tau paired helical filament-tau, Posttraumatic neurodegeneration, tau protein, TBI traumatic brain injury, TDP-43 43 kDa TAR DNA-binding protein, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Resch, Jacob; Driscoll, Aoife; McCaffrey, Noel; Brown, Cathleen; Ferrara, Michael S; Macciocchi, Stephen; Baumgartner, Ted; Walpert, Kimberly
ImPact Test-Retest Reliability: Reliably Unreliable? Journal Article
In: Journal of Athletic Training, vol. 48, no. 4, pp. 506–511, 2013, ISBN: 1062-6050.
Abstract | Links | BibTeX | Tags: ANALYSIS of variance, Body Weights and Measures, Cognition -- Evaluation, college, Computer Assisted, Continuing (Credit), Cross Sectional Studies, Data Analysis Software, DESCRIPTIVE statistics, DIAGNOSIS, Education, Effect Size, Female, human, Instrument Validation, Intraclass Correlation Coefficient, Ireland, Male, Multicenter Studies, Neuropsychological Tests, ONE-way analysis of variance, Post Hoc Analysis, Repeated Measures, Scales, Students, test-retest reliability, UNITED States, Validation Studies, Young Adult
@article{Resch2013b,
title = {ImPact Test-Retest Reliability: Reliably Unreliable?},
author = {Resch, Jacob and Driscoll, Aoife and McCaffrey, Noel and Brown, Cathleen and Ferrara, Michael S and Macciocchi, Stephen and Baumgartner, Ted and Walpert, Kimberly},
doi = {10.4085/1062-6050-48.3.09},
isbn = {1062-6050},
year = {2013},
date = {2013-01-01},
journal = {Journal of Athletic Training},
volume = {48},
number = {4},
pages = {506--511},
abstract = {Context: Computerized neuropsychological testing is commonly used in the assessment and management of sport-related concussion. Even though computerized testing is widespread, psychometric evidence for test-retest reliability is somewhat limited. Additional evidence for test-retest reliability is needed to optimize clinical decision making after concussion. Objective: To document test-retest reliability for a commercially available computerized neuropsychological test battery (ImPACT) using 2 different clinically relevant time intervals. Design: Cross-sectional study. Setting: Two research laboratories. Patients or Other Participants: Group 1 (n=46) consisted of 25 men and 21 women (age=22.4 ± 1.89 years). Group 2 (n = 45) consisted of 17 men and 28 women (age = 20.9 ± 1.72 years). Intervention(s): Both groups completed ImPACT forms 1, 2, and 3, which were delivered sequentially either at 1-week intervals (group 1) or at baseline, day 45, and day 50 (group 2). Group 2 also completed the Green Word Memory Test (WMT) as a measure of effort. Main Outcome Measures: Intraclass correlation coefficients (ICCs) were calculated for the composite scores of ImPACT between time points. Repeated-measures analysis of variance was used to evaluate changes in ImPACT and WMT results over time. Results: The ICC values for group 1 ranged from 0.26 to 0.88 for the 4 ImPACT composite scores. The ICC values for group 2 ranged from 0.37 to 0.76. In group 1, ImPACT classified 37.0% and 46.0% of healthy participants as impaired at time points 2 and 3, respectively. In group 2, ImPACT classified 22.2% and 28.9% of healthy participants as impaired at time points 2 and 3, respectively. Conclusions: We found variable test-retest reliability for ImPACT metrics. Visual motor speed and reaction time demonstrated greater reliability than verbal and visual memory. Our current data support a multifaceted approach to concussion assessment using clinical examinations, symptom reports, cognitive testing, and balance assessment.},
keywords = {ANALYSIS of variance, Body Weights and Measures, Cognition -- Evaluation, college, Computer Assisted, Continuing (Credit), Cross Sectional Studies, Data Analysis Software, DESCRIPTIVE statistics, DIAGNOSIS, Education, Effect Size, Female, human, Instrument Validation, Intraclass Correlation Coefficient, Ireland, Male, Multicenter Studies, Neuropsychological Tests, ONE-way analysis of variance, Post Hoc Analysis, Repeated Measures, Scales, Students, test-retest reliability, UNITED States, Validation Studies, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Gay, Robin K
Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury Journal Article
In: NeuroRehabilitation, vol. 32, no. 3, pp. 473–482, 2013, ISBN: 10538135.
Abstract | Links | BibTeX | Tags: ACOUSTIC stimulation (Neurophysiology), Balance, BRAIN -- Wounds & injuries -- Complications, brain injury rehabilitation, cognition, Concussion, DIAGNOSIS, DISEASES, Dizziness, Dizziness -- Risk factors, EQUILIBRIUM (Physiology), falls prevention, GAIT in humans, Memory, mild traumatic brain injury, neurocognitive assessment, sports injury, VESTIBULAR apparatus
@article{Gay2013,
title = {Neurocognitive measures in the assessment of vestibular disturbance in patients with brain injury},
author = {Gay, Robin K},
doi = {10.3233/NRE-130870},
isbn = {10538135},
year = {2013},
date = {2013-01-01},
journal = {NeuroRehabilitation},
volume = {32},
number = {3},
pages = {473--482},
publisher = {IOS Press},
abstract = {INTRODUCTION: Problems with balance and dizziness are one of the most common complaints of individuals who have experienced a brain injury and are reported in up to 90% of cases. Despite the ubiquity of vestibular disturbance in this population, there remains a dearth of research on the interaction between physiological and cognitive systems responsible for maintaining balance. PURPOSE: The purpose of this article is to review studies on the interaction of physiological and cognitive processes required to maintain balance that may aide assessment and recovery of balance disturbance in patients with brain injury. SUMMARY: This article provides a review of research on the role of higher order cognitive processes in maintaining balance and rational for further inclusion of neurocognitive measures in the assessment of vestibular disturbance. CONCLUSION: Greater inclusion of neurocognitive measures in assessment of vestibular disturbance provides a method of assessment containing increased ecological validity compared to traditional assessments, better prepares patients for discharge, and may reduce the incidence of future injury.},
keywords = {ACOUSTIC stimulation (Neurophysiology), Balance, BRAIN -- Wounds \& injuries -- Complications, brain injury rehabilitation, cognition, Concussion, DIAGNOSIS, DISEASES, Dizziness, Dizziness -- Risk factors, EQUILIBRIUM (Physiology), falls prevention, GAIT in humans, Memory, mild traumatic brain injury, neurocognitive assessment, sports injury, VESTIBULAR apparatus},
pubstate = {published},
tppubtype = {article}
}
Samuels, Christina A
Efforts to Prevent Concussions Target Schools Journal Article
In: Education Week, vol. 30, no. 5, pp. 1–11, 2010, ISBN: 02774232.
Abstract | BibTeX | Tags: ATHLETIC trainers, BRAIN -- Concussion, DIAGNOSIS, Health, HIGH school athletes, School sports, Sports injuries in children
@article{Samuels2010,
title = {Efforts to Prevent Concussions Target Schools},
author = {Samuels, Christina A},
isbn = {02774232},
year = {2010},
date = {2010-01-01},
journal = {Education Week},
volume = {30},
number = {5},
pages = {1--11},
publisher = {Editorial Projects in Education Inc.},
abstract = {The article discusses the issue of concussions in high school sports. The article profiles efforts in the U.S. from the National Athletic Trainers' Association, the National Academy of Neuropsychology, and the House Education and Labor Committee to develop treatment and recovery plans for concussed student athletes across the country. Other topics include the risks associated with concussions, the role of athletic trainers in diagnosing concussions, and sports with high risks for concussions.},
keywords = {ATHLETIC trainers, BRAIN -- Concussion, DIAGNOSIS, Health, HIGH school athletes, School sports, Sports injuries in children},
pubstate = {published},
tppubtype = {article}
}
Gladstone, Jonathan
From psychoneurosis to ICHD-2: an overview of the state of the art in post-traumatic headache Journal Article
In: Headache, vol. 49, pp. 1097–1111, 2009.
Abstract | BibTeX | Tags: DIAGNOSIS, Differential Health Status Humans Neuro
@article{Gladstone2009,
title = {From psychoneurosis to ICHD-2: an overview of the state of the art in post-traumatic headache},
author = {Gladstone, Jonathan},
year = {2009},
date = {2009-01-01},
journal = {Headache},
volume = {49},
pages = {1097--1111},
address = {Gladstone Headache Clinic, Cleveland Clinic Canada, 1333 Sheppard Ave. E, Suite 122, Toronto, Ontario M2J 1V1, Canada.},
abstract = {Post-traumatic headache (PTH) is an important public health issue - head injuries are common, headache is the most common sequelae of head injuries, and PTH can be particularly disabling. Fortunately, for most individuals with PTH, the headache gradually dissipates over a period of several days, weeks, or months either spontaneously or aided by non-pharmacologic and/or pharmacologic management. Regrettably, for a minority of head-injured individuals, the PTH is intractable and disabling despite aggressive and comprehensive treatment. Unfortunately, there are many prejudices against individuals with PTH. Frequently, the presence or absence of litigation and/or the mechanism of head injury (sports-related trauma, slip-and-fall injury, motor vehicle accident, or military service-related injury) biases physicians' views on the legitimacy of the patient's PTH. Accordingly, this review attempts to summarize the state of the art of our understanding of PTH. This clinical review highlights: (a) views on PTH throughout the last few centuries, (b) the ICHD-2 classification of PTH, (c) the epidemiology of head injuries and PTH, (d) the clinical characteristics of PTH, (e) PTH related postconcussive symptoms, (f) pathophysiology of PTH, (g) evaluation of PTH, and (h) management of PTH. [References: 121]},
keywords = {DIAGNOSIS, Differential Health Status Humans Neuro},
pubstate = {published},
tppubtype = {article}
}
Moss, R I
Prevention. Preventing postconcussion sequelae Journal Article
In: Athletic Therapy Today, vol. 6, no. 2, pp. 28–29, 2001, ISBN: 1078-7895.
BibTeX | Tags: Athletic Injuries -- Diagnosis, Brain Concussion -- Diagnosis, Clinical Assessment Tools, DIAGNOSIS, football, Memory Disorders -- Diagnosis, Neurologic -- Methods
@article{Moss2001,
title = {Prevention. Preventing postconcussion sequelae},
author = {Moss, R I},
isbn = {1078-7895},
year = {2001},
date = {2001-01-01},
journal = {Athletic Therapy Today},
volume = {6},
number = {2},
pages = {28--29},
publisher = {Human Kinetics Publishers, Inc.},
address = {Champaign, Illinois},
keywords = {Athletic Injuries -- Diagnosis, Brain Concussion -- Diagnosis, Clinical Assessment Tools, DIAGNOSIS, football, Memory Disorders -- Diagnosis, Neurologic -- Methods},
pubstate = {published},
tppubtype = {article}
}