Steiger, B
Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion Journal Article
In: Physician Leadership Journal, vol. 3, no. 2, pp. 8–10, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Football, Athletic Injuries/co [Complications], Brain Injury, Chronic, Chronic/et [Etiology], Humans, Motion Pictures as Topic
@article{Steiger2016,
title = {Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion},
author = {Steiger, B},
year = {2016},
date = {2016-01-01},
journal = {Physician Leadership Journal},
volume = {3},
number = {2},
pages = {8--10},
abstract = {The pathologist who discovered chronic traumatic encephalopathy in professional football players didn't set out to attack America's favorite sport. He didn't even know much about the game.},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Football, Athletic Injuries/co [Complications], Brain Injury, Chronic, Chronic/et [Etiology], Humans, Motion Pictures as Topic},
pubstate = {published},
tppubtype = {article}
}
McCarthy, M
Chronic traumatic encephalopathy is reported in 25 year old former American football player Journal Article
In: BMJ, vol. 352, pp. h7027, 2016.
BibTeX | Tags: *Brain Injury, *Football, Chronic, Humans, Play and Playthings
@article{McCarthy2016,
title = {Chronic traumatic encephalopathy is reported in 25 year old former American football player},
author = {McCarthy, M},
year = {2016},
date = {2016-01-01},
journal = {BMJ},
volume = {352},
pages = {h7027},
keywords = {*Brain Injury, *Football, Chronic, Humans, Play and Playthings},
pubstate = {published},
tppubtype = {article}
}
Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
Abstract | Links | BibTeX | Tags: amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Noble, J M
The Long Drive Ahead to Better Understanding Chronic Traumatic Encephalopathy: First (Case) and 10 (Years Later) Journal Article
In: JAMA Neurology, vol. 73, no. 3, pp. 263–265, 2016.
BibTeX | Tags: *Brain Injuries, *Brain Injury, Chronic, football, Humans
@article{Noble2016,
title = {The Long Drive Ahead to Better Understanding Chronic Traumatic Encephalopathy: First (Case) and 10 (Years Later)},
author = {Noble, J M},
year = {2016},
date = {2016-01-01},
journal = {JAMA Neurology},
volume = {73},
number = {3},
pages = {263--265},
keywords = {*Brain Injuries, *Brain Injury, Chronic, football, Humans},
pubstate = {published},
tppubtype = {article}
}
Martini, D N; Goulet, G C; Gates, D H; Broglio, S P
Long-term effects of adolescent concussion history on gait, across age Journal Article
In: Gait & Posture, vol. 49, pp. 264–270, 2016.
Abstract | Links | BibTeX | Tags: Chronic, dual task, high school, sport concussion
@article{Martini2016,
title = {Long-term effects of adolescent concussion history on gait, across age},
author = {Martini, D N and Goulet, G C and Gates, D H and Broglio, S P},
doi = {10.1016/j.gaitpost.2016.06.028},
year = {2016},
date = {2016-01-01},
journal = {Gait \& Posture},
volume = {49},
pages = {264--270},
abstract = {The aim of this study was to examine the possible long-term effects of high school concussion history on gait performance across the lifespan. Individuals with and without a concussion history were grouped into 20-year-old (yo) (n = 40), 40yo (n = 19), and 60yo (n = 18) age groups. Participants completed five trials of four walking conditions: a normal walk, a dual task walk, an obstructed walk, and an obstructed, dual task walk. Spatiotemporal gait parameters for gait analyses during single and dual task conditions. Gait velocity, step width, stride length, percent of time in double support, and obstacle toe clearance were the gait variables assessed along with number correct from dual task. Gait was analyzed via optical motion capture. Data were analyzed by two-factor, multivariate ANOVAs and significant interactions were explored using post hoc contrasts. A significant (F = 2.62},
keywords = {Chronic, dual task, high school, sport concussion},
pubstate = {published},
tppubtype = {article}
}
McGinley, A D; Master, C L; Zonfrillo, M R
Sports-Related Head Injuries in Adolescents: A Comprehensive Update Journal Article
In: Adolescent Medicine, vol. 26, no. 3, pp. 491–506, 2015.
BibTeX | Tags: Adolescent, Athletic Injuries, brain concussion, Brain Injuries, Brain Injury, Chronic, CONVALESCENCE, human, Humans, injury scale, Recovery of Function, sport injury, Trauma Severity Indices
@article{McGinley2015,
title = {Sports-Related Head Injuries in Adolescents: A Comprehensive Update},
author = {McGinley, A D and Master, C L and Zonfrillo, M R},
year = {2015},
date = {2015-01-01},
journal = {Adolescent Medicine},
volume = {26},
number = {3},
pages = {491--506},
keywords = {Adolescent, Athletic Injuries, brain concussion, Brain Injuries, Brain Injury, Chronic, CONVALESCENCE, human, Humans, injury scale, Recovery of Function, sport injury, Trauma Severity Indices},
pubstate = {published},
tppubtype = {article}
}
Andrikopoulos, J
In: Journal of Neuropathology and Experimental Neurology, vol. 73, no. 4, pp. 375, 2014.
Links | BibTeX | Tags: Athletic Injuries, Brain Injury, Chronic, Chronic Traumatic Encephalopathy athlete, clinical feature, Closed, dysarthria, Female, Head Injuries, human, Humans, letter, Male, Parkinson disease, priority journal, pyramidal tract, Tauopathies, tauopathy, traumatic brain injury
@article{Andrikopoulos2014,
title = {Correspondence regarding chronic traumatic encephalopathy in athletes: Progressive tauopathy following repetitive concussion. J Neuropathol Exp Neurol 2009;68: 709-35},
author = {Andrikopoulos, J},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84897451593\&partnerID=40\&md5=f463487f44a2ebf124b57a70320560a8},
doi = {10.1097/NEN.0000000000000057},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neuropathology and Experimental Neurology},
volume = {73},
number = {4},
pages = {375},
keywords = {Athletic Injuries, Brain Injury, Chronic, Chronic Traumatic Encephalopathy athlete, clinical feature, Closed, dysarthria, Female, Head Injuries, human, Humans, letter, Male, Parkinson disease, priority journal, pyramidal tract, Tauopathies, tauopathy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Ling, H; Kara, E; Revesz, T; Lees, A J; Plant, G T; Martino, D; Houlden, H; Hardy, J; Holton, J L
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer Journal Article
In: Acta neuropathologica communications, vol. 2, pp. 24, 2014.
Abstract | Links | BibTeX | Tags: aged, Brain Injury, case report, Chronic, Chronic Traumatic Encephalopathy GRN protein, complication, genetics, huma, human, Humans, Intercellular Signaling Peptides and Proteins, LRRK2 protein, Male, MAPT protein, pathology, Progressive, progressive supranuclear palsy, protein serine threonine kinase, Protein-Serine-Threonine Kinases, signal peptide, Supranuclear Palsy, tau protein, tau Proteins
@article{Ling2014,
title = {Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer},
author = {Ling, H and Kara, E and Revesz, T and Lees, A J and Plant, G T and Martino, D and Houlden, H and Hardy, J and Holton, J L},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84921282712\&partnerID=40\&md5=ff0c2f58ec97372861b423eb0aa0d6c0},
doi = {10.1186/2051-5960-2-24},
year = {2014},
date = {2014-01-01},
journal = {Acta neuropathologica communications},
volume = {2},
pages = {24},
abstract = {We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.},
keywords = {aged, Brain Injury, case report, Chronic, Chronic Traumatic Encephalopathy GRN protein, complication, genetics, huma, human, Humans, Intercellular Signaling Peptides and Proteins, LRRK2 protein, Male, MAPT protein, pathology, Progressive, progressive supranuclear palsy, protein serine threonine kinase, Protein-Serine-Threonine Kinases, signal peptide, Supranuclear Palsy, tau protein, tau Proteins},
pubstate = {published},
tppubtype = {article}
}
Solomon, G S; Sills, A
Chronic traumatic encephalopathy and the availability cascade Journal Article
In: The Physician and sportsmedicine, vol. 42, no. 3, pp. 26–31, 2014.
Abstract | Links | BibTeX | Tags: 20th Century, Athletic Injuries, Bias (Epidemiology), brain, Brain Injury, Chronic, Chronic Traumatic Encephalopathy autopsy, HISTORY, human, Humans, pathology, public opinion, sport injury, statistical bias
@article{Solomon2014,
title = {Chronic traumatic encephalopathy and the availability cascade},
author = {Solomon, G S and Sills, A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84922393457\&partnerID=40\&md5=d0415bdf57d1e5162b2dec50aadd55fc},
doi = {10.3810/psm.2014.09.2072},
year = {2014},
date = {2014-01-01},
journal = {The Physician and sportsmedicine},
volume = {42},
number = {3},
pages = {26--31},
abstract = {Chronic traumatic encephalopathy (CTE) in sports has been known for \> 85 years, and has experienced a resurgence of interest over the past decade, both in the media and in the scientific community. However, there appears to be a disconnection between the public's perception of CTE and the currently available scientific data. The cognitive bias known as the "availability cascade" has been suggested as a reason to explain this rift in knowledge. This review summarizes and updates the history of CTE in sports, discusses recent epidemiological and autopsy studies, summarizes the evidence base related to CTE in sports, and offers recommendations for future directions.},
keywords = {20th Century, Athletic Injuries, Bias (Epidemiology), brain, Brain Injury, Chronic, Chronic Traumatic Encephalopathy autopsy, HISTORY, human, Humans, pathology, public opinion, sport injury, statistical bias},
pubstate = {published},
tppubtype = {article}
}
Andrikopoulos, J; Moines, D; Montenigro, P H; Stern, R A
Clinical presentation of chronic traumatic encephalopathy Journal Article
In: Neurology, vol. 83, no. 21, pp. 1991–1993, 2014.
Links | BibTeX | Tags: behavior, Behavioral Symptoms, Brain Injury, Chronic, Chronic Traumatic Encephalopathy alcohol abuse, clinical feature, Cognition Disorders, cognitive defect, etiology, human, Humans, Male, mood, Note, priority journal, prisoner of war, psychosis, traumatic brain injury
@article{Andrikopoulos2014a,
title = {Clinical presentation of chronic traumatic encephalopathy},
author = {Andrikopoulos, J and Moines, D and Montenigro, P H and Stern, R A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84922482119\&partnerID=40\&md5=57625e87083b405a16dda4c0a62ac42e},
year = {2014},
date = {2014-01-01},
journal = {Neurology},
volume = {83},
number = {21},
pages = {1991--1993},
keywords = {behavior, Behavioral Symptoms, Brain Injury, Chronic, Chronic Traumatic Encephalopathy alcohol abuse, clinical feature, Cognition Disorders, cognitive defect, etiology, human, Humans, Male, mood, Note, priority journal, prisoner of war, psychosis, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Levin, B; Bhardwaj, A
Chronic traumatic encephalopathy: A critical appraisal Journal Article
In: Neurocritical Care, vol. 20, no. 2, pp. 334–344, 2014.
Abstract | Links | BibTeX | Tags: accident, alcohol consumption, amnesia, amyloid plaque, animal, Animals, Athletic Injuries, autopsy, behavior change, Brain Injury, Chronic, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy Dementia, complication, Diffusion Tensor Imaging, disease course, Encephalopathy, functional magnetic resonance imaging, histopathology, human, Humans, longitudinal study, Male, Neurodegenerative, Neurodegenerative Diseases, nonhuman, NUCLEAR magnetic resonance spectroscopy, Parkinsonism, pathogenesis, pathology, Pathophysiology, Prevalence, priority journal, Pugilistic, Review, risk factor, Risk Factors, sport injury, suicide, Systematic Review, traumatic brain injury, violence
@article{Levin2014,
title = {Chronic traumatic encephalopathy: A critical appraisal},
author = {Levin, B and Bhardwaj, A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84896549537\&partnerID=40\&md5=138104db42f7ca99527a78bb9c821f59},
doi = {10.1007/s12028-013-9931-1},
year = {2014},
date = {2014-01-01},
journal = {Neurocritical Care},
volume = {20},
number = {2},
pages = {334--344},
abstract = {Chronic traumatic encephalopathy (CTE) formerly known as dementia pugilistica is a long-term neurodegenerative disorder associated with repeated subconcussive head injuries in high-contact sports. We reviewed the existing literature on CTE and examined epidemiological trends, risk factors, and its temporal progression, and proposed the underlying pathophysiological mechanisms that may provide unique insights to clinicians with an in-depth understanding of the disease to aid in the diagnosis and prevention, and provide future perspectives for research via search of Medline and Cochrane databases as well as manual review of bibliographies from selected articles and monographs. The prevalence of CTE in recent years is on the rise and almost exclusively affects men, with pathologic signs characterized by progressive memory loss, behavioral changes, and violent tendencies with some patients demonstrating Parkinsonian-like symptoms and signs. Many patients with CTE die following suicide, accident, or complications of drug or alcohol use. Postmortem pathologic analysis is characterized by neurofibrillary tangles and A$beta$ plaques in 50 % of cases. Currently, there are no ante-mortem diagnostic criteria, but modern imaging techniques such as functional magnetic resonance (MR) imaging, MR spectroscopy, and diffusion tension imaging hold promise for delineating the future diagnostic criteria. Further long-term longitudinal studies are warranted to investigate risk factors that will enhance understanding of the disease progression and its pathogenesis. © 2013 Springer Science+Business Media.},
keywords = {accident, alcohol consumption, amnesia, amyloid plaque, animal, Animals, Athletic Injuries, autopsy, behavior change, Brain Injury, Chronic, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy Dementia, complication, Diffusion Tensor Imaging, disease course, Encephalopathy, functional magnetic resonance imaging, histopathology, human, Humans, longitudinal study, Male, Neurodegenerative, Neurodegenerative Diseases, nonhuman, NUCLEAR magnetic resonance spectroscopy, Parkinsonism, pathogenesis, pathology, Pathophysiology, Prevalence, priority journal, Pugilistic, Review, risk factor, Risk Factors, sport injury, suicide, Systematic Review, traumatic brain injury, violence},
pubstate = {published},
tppubtype = {article}
}
Haglund, Y; Edman, G; Murelius, O; Oreland, L; Sachs, C
Does Swedish amateur boxing lead to chronic brain damage? 1. A retrospective medical, neurological and personality trait study Journal Article
In: Acta Neurologica Scandinavica, vol. 82, pp. 245–252, 1990.
Abstract | BibTeX | Tags: Adult *Boxing/in [Injuries] *Brain Damage, Chronic
@article{Haglund1990,
title = {Does Swedish amateur boxing lead to chronic brain damage? 1. A retrospective medical, neurological and personality trait study},
author = {Haglund, Y and Edman, G and Murelius, O and Oreland, L and Sachs, C},
year = {1990},
date = {1990-01-01},
journal = {Acta Neurologica Scandinavica},
volume = {82},
pages = {245--252},
address = {Dept of Orthopaedic Surgery, Karolinska Hospital, Stockholm, Sweden.},
abstract = {Sweden banned professional boxing in 1969 and has also considered banning amateur boxing. We therefore analysed possible chronic brain damage in 47 former amateur boxers who started their careers after the introduction of stricter Swedish amateur boxing rules. The boxers were compared with three control groups--25 soccer players, 25 track and field athletes and 19 conscripts. All athletes were interviewed about their sports career, medical history and social variables. They then underwent a physical and a neurological examination, including a mini-mental state examination. Personality traits were investigated and related to their platelet MAO activity in the athletes as well as in the conscripts. No significant differences were found between the groups in any of the physical or neurological examinations. All had a normal mini-mental state examination. Thus, results from these test methods did not reveal any signs of chronic brain damage from Swedish amateur boxing. Neither were any significant differences found with regard to platelet MAO activity, while significant differences were found in some of the social and personality traits variables.},
keywords = {Adult *Boxing/in [Injuries] *Brain Damage, Chronic},
pubstate = {published},
tppubtype = {article}
}
Steiger, B
Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion Journal Article
In: Physician Leadership Journal, vol. 3, no. 2, pp. 8–10, 2016.
@article{Steiger2016,
title = {Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion},
author = {Steiger, B},
year = {2016},
date = {2016-01-01},
journal = {Physician Leadership Journal},
volume = {3},
number = {2},
pages = {8--10},
abstract = {The pathologist who discovered chronic traumatic encephalopathy in professional football players didn't set out to attack America's favorite sport. He didn't even know much about the game.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
McCarthy, M
Chronic traumatic encephalopathy is reported in 25 year old former American football player Journal Article
In: BMJ, vol. 352, pp. h7027, 2016.
@article{McCarthy2016,
title = {Chronic traumatic encephalopathy is reported in 25 year old former American football player},
author = {McCarthy, M},
year = {2016},
date = {2016-01-01},
journal = {BMJ},
volume = {352},
pages = {h7027},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Noble, J M
The Long Drive Ahead to Better Understanding Chronic Traumatic Encephalopathy: First (Case) and 10 (Years Later) Journal Article
In: JAMA Neurology, vol. 73, no. 3, pp. 263–265, 2016.
@article{Noble2016,
title = {The Long Drive Ahead to Better Understanding Chronic Traumatic Encephalopathy: First (Case) and 10 (Years Later)},
author = {Noble, J M},
year = {2016},
date = {2016-01-01},
journal = {JAMA Neurology},
volume = {73},
number = {3},
pages = {263--265},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Martini, D N; Goulet, G C; Gates, D H; Broglio, S P
Long-term effects of adolescent concussion history on gait, across age Journal Article
In: Gait & Posture, vol. 49, pp. 264–270, 2016.
@article{Martini2016,
title = {Long-term effects of adolescent concussion history on gait, across age},
author = {Martini, D N and Goulet, G C and Gates, D H and Broglio, S P},
doi = {10.1016/j.gaitpost.2016.06.028},
year = {2016},
date = {2016-01-01},
journal = {Gait \& Posture},
volume = {49},
pages = {264--270},
abstract = {The aim of this study was to examine the possible long-term effects of high school concussion history on gait performance across the lifespan. Individuals with and without a concussion history were grouped into 20-year-old (yo) (n = 40), 40yo (n = 19), and 60yo (n = 18) age groups. Participants completed five trials of four walking conditions: a normal walk, a dual task walk, an obstructed walk, and an obstructed, dual task walk. Spatiotemporal gait parameters for gait analyses during single and dual task conditions. Gait velocity, step width, stride length, percent of time in double support, and obstacle toe clearance were the gait variables assessed along with number correct from dual task. Gait was analyzed via optical motion capture. Data were analyzed by two-factor, multivariate ANOVAs and significant interactions were explored using post hoc contrasts. A significant (F = 2.62},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
McGinley, A D; Master, C L; Zonfrillo, M R
Sports-Related Head Injuries in Adolescents: A Comprehensive Update Journal Article
In: Adolescent Medicine, vol. 26, no. 3, pp. 491–506, 2015.
@article{McGinley2015,
title = {Sports-Related Head Injuries in Adolescents: A Comprehensive Update},
author = {McGinley, A D and Master, C L and Zonfrillo, M R},
year = {2015},
date = {2015-01-01},
journal = {Adolescent Medicine},
volume = {26},
number = {3},
pages = {491--506},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Andrikopoulos, J
In: Journal of Neuropathology and Experimental Neurology, vol. 73, no. 4, pp. 375, 2014.
@article{Andrikopoulos2014,
title = {Correspondence regarding chronic traumatic encephalopathy in athletes: Progressive tauopathy following repetitive concussion. J Neuropathol Exp Neurol 2009;68: 709-35},
author = {Andrikopoulos, J},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84897451593\&partnerID=40\&md5=f463487f44a2ebf124b57a70320560a8},
doi = {10.1097/NEN.0000000000000057},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neuropathology and Experimental Neurology},
volume = {73},
number = {4},
pages = {375},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ling, H; Kara, E; Revesz, T; Lees, A J; Plant, G T; Martino, D; Houlden, H; Hardy, J; Holton, J L
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer Journal Article
In: Acta neuropathologica communications, vol. 2, pp. 24, 2014.
@article{Ling2014,
title = {Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer},
author = {Ling, H and Kara, E and Revesz, T and Lees, A J and Plant, G T and Martino, D and Houlden, H and Hardy, J and Holton, J L},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84921282712\&partnerID=40\&md5=ff0c2f58ec97372861b423eb0aa0d6c0},
doi = {10.1186/2051-5960-2-24},
year = {2014},
date = {2014-01-01},
journal = {Acta neuropathologica communications},
volume = {2},
pages = {24},
abstract = {We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Solomon, G S; Sills, A
Chronic traumatic encephalopathy and the availability cascade Journal Article
In: The Physician and sportsmedicine, vol. 42, no. 3, pp. 26–31, 2014.
@article{Solomon2014,
title = {Chronic traumatic encephalopathy and the availability cascade},
author = {Solomon, G S and Sills, A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84922393457\&partnerID=40\&md5=d0415bdf57d1e5162b2dec50aadd55fc},
doi = {10.3810/psm.2014.09.2072},
year = {2014},
date = {2014-01-01},
journal = {The Physician and sportsmedicine},
volume = {42},
number = {3},
pages = {26--31},
abstract = {Chronic traumatic encephalopathy (CTE) in sports has been known for \> 85 years, and has experienced a resurgence of interest over the past decade, both in the media and in the scientific community. However, there appears to be a disconnection between the public's perception of CTE and the currently available scientific data. The cognitive bias known as the "availability cascade" has been suggested as a reason to explain this rift in knowledge. This review summarizes and updates the history of CTE in sports, discusses recent epidemiological and autopsy studies, summarizes the evidence base related to CTE in sports, and offers recommendations for future directions.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Andrikopoulos, J; Moines, D; Montenigro, P H; Stern, R A
Clinical presentation of chronic traumatic encephalopathy Journal Article
In: Neurology, vol. 83, no. 21, pp. 1991–1993, 2014.
@article{Andrikopoulos2014a,
title = {Clinical presentation of chronic traumatic encephalopathy},
author = {Andrikopoulos, J and Moines, D and Montenigro, P H and Stern, R A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84922482119\&partnerID=40\&md5=57625e87083b405a16dda4c0a62ac42e},
year = {2014},
date = {2014-01-01},
journal = {Neurology},
volume = {83},
number = {21},
pages = {1991--1993},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Levin, B; Bhardwaj, A
Chronic traumatic encephalopathy: A critical appraisal Journal Article
In: Neurocritical Care, vol. 20, no. 2, pp. 334–344, 2014.
@article{Levin2014,
title = {Chronic traumatic encephalopathy: A critical appraisal},
author = {Levin, B and Bhardwaj, A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84896549537\&partnerID=40\&md5=138104db42f7ca99527a78bb9c821f59},
doi = {10.1007/s12028-013-9931-1},
year = {2014},
date = {2014-01-01},
journal = {Neurocritical Care},
volume = {20},
number = {2},
pages = {334--344},
abstract = {Chronic traumatic encephalopathy (CTE) formerly known as dementia pugilistica is a long-term neurodegenerative disorder associated with repeated subconcussive head injuries in high-contact sports. We reviewed the existing literature on CTE and examined epidemiological trends, risk factors, and its temporal progression, and proposed the underlying pathophysiological mechanisms that may provide unique insights to clinicians with an in-depth understanding of the disease to aid in the diagnosis and prevention, and provide future perspectives for research via search of Medline and Cochrane databases as well as manual review of bibliographies from selected articles and monographs. The prevalence of CTE in recent years is on the rise and almost exclusively affects men, with pathologic signs characterized by progressive memory loss, behavioral changes, and violent tendencies with some patients demonstrating Parkinsonian-like symptoms and signs. Many patients with CTE die following suicide, accident, or complications of drug or alcohol use. Postmortem pathologic analysis is characterized by neurofibrillary tangles and A$beta$ plaques in 50 % of cases. Currently, there are no ante-mortem diagnostic criteria, but modern imaging techniques such as functional magnetic resonance (MR) imaging, MR spectroscopy, and diffusion tension imaging hold promise for delineating the future diagnostic criteria. Further long-term longitudinal studies are warranted to investigate risk factors that will enhance understanding of the disease progression and its pathogenesis. © 2013 Springer Science+Business Media.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Haglund, Y; Edman, G; Murelius, O; Oreland, L; Sachs, C
Does Swedish amateur boxing lead to chronic brain damage? 1. A retrospective medical, neurological and personality trait study Journal Article
In: Acta Neurologica Scandinavica, vol. 82, pp. 245–252, 1990.
@article{Haglund1990,
title = {Does Swedish amateur boxing lead to chronic brain damage? 1. A retrospective medical, neurological and personality trait study},
author = {Haglund, Y and Edman, G and Murelius, O and Oreland, L and Sachs, C},
year = {1990},
date = {1990-01-01},
journal = {Acta Neurologica Scandinavica},
volume = {82},
pages = {245--252},
address = {Dept of Orthopaedic Surgery, Karolinska Hospital, Stockholm, Sweden.},
abstract = {Sweden banned professional boxing in 1969 and has also considered banning amateur boxing. We therefore analysed possible chronic brain damage in 47 former amateur boxers who started their careers after the introduction of stricter Swedish amateur boxing rules. The boxers were compared with three control groups--25 soccer players, 25 track and field athletes and 19 conscripts. All athletes were interviewed about their sports career, medical history and social variables. They then underwent a physical and a neurological examination, including a mini-mental state examination. Personality traits were investigated and related to their platelet MAO activity in the athletes as well as in the conscripts. No significant differences were found between the groups in any of the physical or neurological examinations. All had a normal mini-mental state examination. Thus, results from these test methods did not reveal any signs of chronic brain damage from Swedish amateur boxing. Neither were any significant differences found with regard to platelet MAO activity, while significant differences were found in some of the social and personality traits variables.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Steiger, B
Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion Journal Article
In: Physician Leadership Journal, vol. 3, no. 2, pp. 8–10, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Football, Athletic Injuries/co [Complications], Brain Injury, Chronic, Chronic/et [Etiology], Humans, Motion Pictures as Topic
@article{Steiger2016,
title = {Meet Bennet Omalu, Md: The Physician Leader Whose Research Inspired the Movie Concussion},
author = {Steiger, B},
year = {2016},
date = {2016-01-01},
journal = {Physician Leadership Journal},
volume = {3},
number = {2},
pages = {8--10},
abstract = {The pathologist who discovered chronic traumatic encephalopathy in professional football players didn't set out to attack America's favorite sport. He didn't even know much about the game.},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Football, Athletic Injuries/co [Complications], Brain Injury, Chronic, Chronic/et [Etiology], Humans, Motion Pictures as Topic},
pubstate = {published},
tppubtype = {article}
}
McCarthy, M
Chronic traumatic encephalopathy is reported in 25 year old former American football player Journal Article
In: BMJ, vol. 352, pp. h7027, 2016.
BibTeX | Tags: *Brain Injury, *Football, Chronic, Humans, Play and Playthings
@article{McCarthy2016,
title = {Chronic traumatic encephalopathy is reported in 25 year old former American football player},
author = {McCarthy, M},
year = {2016},
date = {2016-01-01},
journal = {BMJ},
volume = {352},
pages = {h7027},
keywords = {*Brain Injury, *Football, Chronic, Humans, Play and Playthings},
pubstate = {published},
tppubtype = {article}
}
Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
Abstract | Links | BibTeX | Tags: amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Noble, J M
The Long Drive Ahead to Better Understanding Chronic Traumatic Encephalopathy: First (Case) and 10 (Years Later) Journal Article
In: JAMA Neurology, vol. 73, no. 3, pp. 263–265, 2016.
BibTeX | Tags: *Brain Injuries, *Brain Injury, Chronic, football, Humans
@article{Noble2016,
title = {The Long Drive Ahead to Better Understanding Chronic Traumatic Encephalopathy: First (Case) and 10 (Years Later)},
author = {Noble, J M},
year = {2016},
date = {2016-01-01},
journal = {JAMA Neurology},
volume = {73},
number = {3},
pages = {263--265},
keywords = {*Brain Injuries, *Brain Injury, Chronic, football, Humans},
pubstate = {published},
tppubtype = {article}
}
Martini, D N; Goulet, G C; Gates, D H; Broglio, S P
Long-term effects of adolescent concussion history on gait, across age Journal Article
In: Gait & Posture, vol. 49, pp. 264–270, 2016.
Abstract | Links | BibTeX | Tags: Chronic, dual task, high school, sport concussion
@article{Martini2016,
title = {Long-term effects of adolescent concussion history on gait, across age},
author = {Martini, D N and Goulet, G C and Gates, D H and Broglio, S P},
doi = {10.1016/j.gaitpost.2016.06.028},
year = {2016},
date = {2016-01-01},
journal = {Gait \& Posture},
volume = {49},
pages = {264--270},
abstract = {The aim of this study was to examine the possible long-term effects of high school concussion history on gait performance across the lifespan. Individuals with and without a concussion history were grouped into 20-year-old (yo) (n = 40), 40yo (n = 19), and 60yo (n = 18) age groups. Participants completed five trials of four walking conditions: a normal walk, a dual task walk, an obstructed walk, and an obstructed, dual task walk. Spatiotemporal gait parameters for gait analyses during single and dual task conditions. Gait velocity, step width, stride length, percent of time in double support, and obstacle toe clearance were the gait variables assessed along with number correct from dual task. Gait was analyzed via optical motion capture. Data were analyzed by two-factor, multivariate ANOVAs and significant interactions were explored using post hoc contrasts. A significant (F = 2.62},
keywords = {Chronic, dual task, high school, sport concussion},
pubstate = {published},
tppubtype = {article}
}
McGinley, A D; Master, C L; Zonfrillo, M R
Sports-Related Head Injuries in Adolescents: A Comprehensive Update Journal Article
In: Adolescent Medicine, vol. 26, no. 3, pp. 491–506, 2015.
BibTeX | Tags: Adolescent, Athletic Injuries, brain concussion, Brain Injuries, Brain Injury, Chronic, CONVALESCENCE, human, Humans, injury scale, Recovery of Function, sport injury, Trauma Severity Indices
@article{McGinley2015,
title = {Sports-Related Head Injuries in Adolescents: A Comprehensive Update},
author = {McGinley, A D and Master, C L and Zonfrillo, M R},
year = {2015},
date = {2015-01-01},
journal = {Adolescent Medicine},
volume = {26},
number = {3},
pages = {491--506},
keywords = {Adolescent, Athletic Injuries, brain concussion, Brain Injuries, Brain Injury, Chronic, CONVALESCENCE, human, Humans, injury scale, Recovery of Function, sport injury, Trauma Severity Indices},
pubstate = {published},
tppubtype = {article}
}
Andrikopoulos, J
In: Journal of Neuropathology and Experimental Neurology, vol. 73, no. 4, pp. 375, 2014.
Links | BibTeX | Tags: Athletic Injuries, Brain Injury, Chronic, Chronic Traumatic Encephalopathy athlete, clinical feature, Closed, dysarthria, Female, Head Injuries, human, Humans, letter, Male, Parkinson disease, priority journal, pyramidal tract, Tauopathies, tauopathy, traumatic brain injury
@article{Andrikopoulos2014,
title = {Correspondence regarding chronic traumatic encephalopathy in athletes: Progressive tauopathy following repetitive concussion. J Neuropathol Exp Neurol 2009;68: 709-35},
author = {Andrikopoulos, J},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84897451593\&partnerID=40\&md5=f463487f44a2ebf124b57a70320560a8},
doi = {10.1097/NEN.0000000000000057},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neuropathology and Experimental Neurology},
volume = {73},
number = {4},
pages = {375},
keywords = {Athletic Injuries, Brain Injury, Chronic, Chronic Traumatic Encephalopathy athlete, clinical feature, Closed, dysarthria, Female, Head Injuries, human, Humans, letter, Male, Parkinson disease, priority journal, pyramidal tract, Tauopathies, tauopathy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Ling, H; Kara, E; Revesz, T; Lees, A J; Plant, G T; Martino, D; Houlden, H; Hardy, J; Holton, J L
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer Journal Article
In: Acta neuropathologica communications, vol. 2, pp. 24, 2014.
Abstract | Links | BibTeX | Tags: aged, Brain Injury, case report, Chronic, Chronic Traumatic Encephalopathy GRN protein, complication, genetics, huma, human, Humans, Intercellular Signaling Peptides and Proteins, LRRK2 protein, Male, MAPT protein, pathology, Progressive, progressive supranuclear palsy, protein serine threonine kinase, Protein-Serine-Threonine Kinases, signal peptide, Supranuclear Palsy, tau protein, tau Proteins
@article{Ling2014,
title = {Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer},
author = {Ling, H and Kara, E and Revesz, T and Lees, A J and Plant, G T and Martino, D and Houlden, H and Hardy, J and Holton, J L},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84921282712\&partnerID=40\&md5=ff0c2f58ec97372861b423eb0aa0d6c0},
doi = {10.1186/2051-5960-2-24},
year = {2014},
date = {2014-01-01},
journal = {Acta neuropathologica communications},
volume = {2},
pages = {24},
abstract = {We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.},
keywords = {aged, Brain Injury, case report, Chronic, Chronic Traumatic Encephalopathy GRN protein, complication, genetics, huma, human, Humans, Intercellular Signaling Peptides and Proteins, LRRK2 protein, Male, MAPT protein, pathology, Progressive, progressive supranuclear palsy, protein serine threonine kinase, Protein-Serine-Threonine Kinases, signal peptide, Supranuclear Palsy, tau protein, tau Proteins},
pubstate = {published},
tppubtype = {article}
}
Solomon, G S; Sills, A
Chronic traumatic encephalopathy and the availability cascade Journal Article
In: The Physician and sportsmedicine, vol. 42, no. 3, pp. 26–31, 2014.
Abstract | Links | BibTeX | Tags: 20th Century, Athletic Injuries, Bias (Epidemiology), brain, Brain Injury, Chronic, Chronic Traumatic Encephalopathy autopsy, HISTORY, human, Humans, pathology, public opinion, sport injury, statistical bias
@article{Solomon2014,
title = {Chronic traumatic encephalopathy and the availability cascade},
author = {Solomon, G S and Sills, A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84922393457\&partnerID=40\&md5=d0415bdf57d1e5162b2dec50aadd55fc},
doi = {10.3810/psm.2014.09.2072},
year = {2014},
date = {2014-01-01},
journal = {The Physician and sportsmedicine},
volume = {42},
number = {3},
pages = {26--31},
abstract = {Chronic traumatic encephalopathy (CTE) in sports has been known for \> 85 years, and has experienced a resurgence of interest over the past decade, both in the media and in the scientific community. However, there appears to be a disconnection between the public's perception of CTE and the currently available scientific data. The cognitive bias known as the "availability cascade" has been suggested as a reason to explain this rift in knowledge. This review summarizes and updates the history of CTE in sports, discusses recent epidemiological and autopsy studies, summarizes the evidence base related to CTE in sports, and offers recommendations for future directions.},
keywords = {20th Century, Athletic Injuries, Bias (Epidemiology), brain, Brain Injury, Chronic, Chronic Traumatic Encephalopathy autopsy, HISTORY, human, Humans, pathology, public opinion, sport injury, statistical bias},
pubstate = {published},
tppubtype = {article}
}
Andrikopoulos, J; Moines, D; Montenigro, P H; Stern, R A
Clinical presentation of chronic traumatic encephalopathy Journal Article
In: Neurology, vol. 83, no. 21, pp. 1991–1993, 2014.
Links | BibTeX | Tags: behavior, Behavioral Symptoms, Brain Injury, Chronic, Chronic Traumatic Encephalopathy alcohol abuse, clinical feature, Cognition Disorders, cognitive defect, etiology, human, Humans, Male, mood, Note, priority journal, prisoner of war, psychosis, traumatic brain injury
@article{Andrikopoulos2014a,
title = {Clinical presentation of chronic traumatic encephalopathy},
author = {Andrikopoulos, J and Moines, D and Montenigro, P H and Stern, R A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84922482119\&partnerID=40\&md5=57625e87083b405a16dda4c0a62ac42e},
year = {2014},
date = {2014-01-01},
journal = {Neurology},
volume = {83},
number = {21},
pages = {1991--1993},
keywords = {behavior, Behavioral Symptoms, Brain Injury, Chronic, Chronic Traumatic Encephalopathy alcohol abuse, clinical feature, Cognition Disorders, cognitive defect, etiology, human, Humans, Male, mood, Note, priority journal, prisoner of war, psychosis, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Levin, B; Bhardwaj, A
Chronic traumatic encephalopathy: A critical appraisal Journal Article
In: Neurocritical Care, vol. 20, no. 2, pp. 334–344, 2014.
Abstract | Links | BibTeX | Tags: accident, alcohol consumption, amnesia, amyloid plaque, animal, Animals, Athletic Injuries, autopsy, behavior change, Brain Injury, Chronic, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy Dementia, complication, Diffusion Tensor Imaging, disease course, Encephalopathy, functional magnetic resonance imaging, histopathology, human, Humans, longitudinal study, Male, Neurodegenerative, Neurodegenerative Diseases, nonhuman, NUCLEAR magnetic resonance spectroscopy, Parkinsonism, pathogenesis, pathology, Pathophysiology, Prevalence, priority journal, Pugilistic, Review, risk factor, Risk Factors, sport injury, suicide, Systematic Review, traumatic brain injury, violence
@article{Levin2014,
title = {Chronic traumatic encephalopathy: A critical appraisal},
author = {Levin, B and Bhardwaj, A},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84896549537\&partnerID=40\&md5=138104db42f7ca99527a78bb9c821f59},
doi = {10.1007/s12028-013-9931-1},
year = {2014},
date = {2014-01-01},
journal = {Neurocritical Care},
volume = {20},
number = {2},
pages = {334--344},
abstract = {Chronic traumatic encephalopathy (CTE) formerly known as dementia pugilistica is a long-term neurodegenerative disorder associated with repeated subconcussive head injuries in high-contact sports. We reviewed the existing literature on CTE and examined epidemiological trends, risk factors, and its temporal progression, and proposed the underlying pathophysiological mechanisms that may provide unique insights to clinicians with an in-depth understanding of the disease to aid in the diagnosis and prevention, and provide future perspectives for research via search of Medline and Cochrane databases as well as manual review of bibliographies from selected articles and monographs. The prevalence of CTE in recent years is on the rise and almost exclusively affects men, with pathologic signs characterized by progressive memory loss, behavioral changes, and violent tendencies with some patients demonstrating Parkinsonian-like symptoms and signs. Many patients with CTE die following suicide, accident, or complications of drug or alcohol use. Postmortem pathologic analysis is characterized by neurofibrillary tangles and A$beta$ plaques in 50 % of cases. Currently, there are no ante-mortem diagnostic criteria, but modern imaging techniques such as functional magnetic resonance (MR) imaging, MR spectroscopy, and diffusion tension imaging hold promise for delineating the future diagnostic criteria. Further long-term longitudinal studies are warranted to investigate risk factors that will enhance understanding of the disease progression and its pathogenesis. © 2013 Springer Science+Business Media.},
keywords = {accident, alcohol consumption, amnesia, amyloid plaque, animal, Animals, Athletic Injuries, autopsy, behavior change, Brain Injury, Chronic, Chronic traumatic encephalopathy, Chronic Traumatic Encephalopathy Dementia, complication, Diffusion Tensor Imaging, disease course, Encephalopathy, functional magnetic resonance imaging, histopathology, human, Humans, longitudinal study, Male, Neurodegenerative, Neurodegenerative Diseases, nonhuman, NUCLEAR magnetic resonance spectroscopy, Parkinsonism, pathogenesis, pathology, Pathophysiology, Prevalence, priority journal, Pugilistic, Review, risk factor, Risk Factors, sport injury, suicide, Systematic Review, traumatic brain injury, violence},
pubstate = {published},
tppubtype = {article}
}
Haglund, Y; Edman, G; Murelius, O; Oreland, L; Sachs, C
Does Swedish amateur boxing lead to chronic brain damage? 1. A retrospective medical, neurological and personality trait study Journal Article
In: Acta Neurologica Scandinavica, vol. 82, pp. 245–252, 1990.
Abstract | BibTeX | Tags: Adult *Boxing/in [Injuries] *Brain Damage, Chronic
@article{Haglund1990,
title = {Does Swedish amateur boxing lead to chronic brain damage? 1. A retrospective medical, neurological and personality trait study},
author = {Haglund, Y and Edman, G and Murelius, O and Oreland, L and Sachs, C},
year = {1990},
date = {1990-01-01},
journal = {Acta Neurologica Scandinavica},
volume = {82},
pages = {245--252},
address = {Dept of Orthopaedic Surgery, Karolinska Hospital, Stockholm, Sweden.},
abstract = {Sweden banned professional boxing in 1969 and has also considered banning amateur boxing. We therefore analysed possible chronic brain damage in 47 former amateur boxers who started their careers after the introduction of stricter Swedish amateur boxing rules. The boxers were compared with three control groups--25 soccer players, 25 track and field athletes and 19 conscripts. All athletes were interviewed about their sports career, medical history and social variables. They then underwent a physical and a neurological examination, including a mini-mental state examination. Personality traits were investigated and related to their platelet MAO activity in the athletes as well as in the conscripts. No significant differences were found between the groups in any of the physical or neurological examinations. All had a normal mini-mental state examination. Thus, results from these test methods did not reveal any signs of chronic brain damage from Swedish amateur boxing. Neither were any significant differences found with regard to platelet MAO activity, while significant differences were found in some of the social and personality traits variables.},
keywords = {Adult *Boxing/in [Injuries] *Brain Damage, Chronic},
pubstate = {published},
tppubtype = {article}
}