Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
Abstract | Links | BibTeX | Tags: amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Choe, M C
The Pathophysiology of Concussion Journal Article
In: Current Pain & Headache Reports, vol. 20, no. 6, 2016.
Abstract | Links | BibTeX | Tags: Chronic traumatic encephalopathy, Concussion, diffuse axonal injury, Pathophysiology
@article{Choe2016b,
title = {The Pathophysiology of Concussion},
author = {Choe, M C},
doi = {10.1007/s11916-016-0573-9},
year = {2016},
date = {2016-01-01},
journal = {Current Pain \& Headache Reports},
volume = {20},
number = {6},
abstract = {Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what happens in the brain after traumatic brain injury, particularly with milder injuries where no damage can be seen at the structural level on standard neuroimaging. Understanding the chain of events from a cellular level using studies investigating more severe injuries can help to drive research efforts in understanding the symptomatology that is seen in the acute phase after concussion, as well as point to mechanisms that may underlie persistent post-concussive symptoms. This review discusses the basic neuropathology that occurs after traumatic brain injury at the cellular level. We also present the pathology of chronic traumatic encephalopathy and its similarities to other neurodegenerative diseases. We conclude with recent imaging and biomarker findings looking at changes that may occur after repeated subconcussive blows, which may help to guide efforts in understanding if cumulative subconcussive mechanical forces upon the brain are detrimental in the long term or if concussive symptoms mark the threshold for brain injury. © 2016, Springer Science+Business Media New York.},
keywords = {Chronic traumatic encephalopathy, Concussion, diffuse axonal injury, Pathophysiology},
pubstate = {published},
tppubtype = {article}
}
Seidman, Daniel H; Burlingame, Jennifer; Yousif, Lina R; Donahue, Xinh P; Krier, Joshua; Rayes, Lydia J; Young, Rachel; Lilla, Muareen; Mazurek, Rochelle; Hittle, Kristie; McCloskey, Charles; Misra, Saroj; Shaw, Michael K
'Evaluation of the King–Devick Test as a concussion screening tool in high school football players' Corrigendum Journal Article
In: Journal of the Neurological Sciences, vol. 358, no. 1-2, pp. 540, 2015, ISBN: 0022-510X.
Abstract | Links | BibTeX | Tags: 2015, Athletes, diffuse axonal injury, football, High Schools, Neuropsychological assessment, Neuropsychological Tests, Post-Concussion Syndrome, screening, traumatic brain injury, Visual motor coordination
@article{Seidman2015a,
title = {'Evaluation of the King\textendashDevick Test as a concussion screening tool in high school football players' Corrigendum},
author = {Seidman, Daniel H and Burlingame, Jennifer and Yousif, Lina R and Donahue, Xinh P and Krier, Joshua and Rayes, Lydia J and Young, Rachel and Lilla, Muareen and Mazurek, Rochelle and Hittle, Kristie and McCloskey, Charles and Misra, Saroj and Shaw, Michael K},
doi = {10.1016/j.jns.2015.09.348},
isbn = {0022-510X},
year = {2015},
date = {2015-01-01},
journal = {Journal of the Neurological Sciences},
volume = {358},
number = {1-2},
pages = {540},
publisher = {Elsevier Science},
address = {Netherlands},
abstract = {Reports an error in 'Evaluation of the King\textendashDevick test as a concussion screening tool in high school football players' by Daniel H. Seidman, Jennifer Burlingame, Lina R. Yousif, Xinh P. Donahue, Joshua Krier, Lydia J. Rayes, Rachel Young, Muareen Lilla, Rochelle Mazurek, Kristie Hittle, Charles McCloskey, Saroj Misra and Michael K. Shaw (Journal of the Neurological Sciences, 2015[Sep][15], Vol 356[1-2], 97-101). In the original article, there was an error in the third paragraph. The sentence originally read 'The test subject reads a series of numbers in right-to-left and up-to-down order on three test cards.' This should read: 'The test subject reads a series of numbers in left-to-right and up-to-down order on three test cards.' The correction is present in the erratum. (The following abstract of the original article appeared in record [rid]2015-27894-001[/rid]). Objective: Concussion is the most common type of traumatic brain injury, and results from impact or impulsive forces to the head, neck or face. Due to the variability and subtlety of symptoms, concussions may go unrecognized or be ignored, especially with the pressure placed on athletes to return to competition. The King\textendashDevick (KD) test, an oculomotor test originally designed for reading evaluation, was recently validated as a concussion screening tool in collegiate athletes. A prospective study was performed using high school football players in an attempt to study the KD as a concussion screening tool in this younger population. Methods: 343 athletes from four local high school football teams were recruited to participate. These athletes were given baseline KD tests prior to competition. Individual demographic information was collected on the subjects. Standard team protocol was employed to determine if a concussion had occurred during competition. Immediately after diagnosis, the KD test was re-administered to the concussed athlete for comparison to baseline. Post-season testing was also performed in non-concussed individuals. Results: Of the 343 athletes, nine were diagnosed with concussions. In all concussed players, cumulative read times for the KD test were significantly increased (p \< 0.001). Post-season testing of non-concussed athletes revealed minimal change in read times relative to baseline. Univariate analysis revealed that history of concussion was the only demographic factor predictive of concussion in this cohort. Conclusion: The KD test is an accurate and easily administered sideline screening tool for concussion in adolescent football players. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2015, Athletes, diffuse axonal injury, football, High Schools, Neuropsychological assessment, Neuropsychological Tests, Post-Concussion Syndrome, screening, traumatic brain injury, Visual motor coordination},
pubstate = {published},
tppubtype = {article}
}
Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Choe, M C
The Pathophysiology of Concussion Journal Article
In: Current Pain & Headache Reports, vol. 20, no. 6, 2016.
@article{Choe2016b,
title = {The Pathophysiology of Concussion},
author = {Choe, M C},
doi = {10.1007/s11916-016-0573-9},
year = {2016},
date = {2016-01-01},
journal = {Current Pain \& Headache Reports},
volume = {20},
number = {6},
abstract = {Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what happens in the brain after traumatic brain injury, particularly with milder injuries where no damage can be seen at the structural level on standard neuroimaging. Understanding the chain of events from a cellular level using studies investigating more severe injuries can help to drive research efforts in understanding the symptomatology that is seen in the acute phase after concussion, as well as point to mechanisms that may underlie persistent post-concussive symptoms. This review discusses the basic neuropathology that occurs after traumatic brain injury at the cellular level. We also present the pathology of chronic traumatic encephalopathy and its similarities to other neurodegenerative diseases. We conclude with recent imaging and biomarker findings looking at changes that may occur after repeated subconcussive blows, which may help to guide efforts in understanding if cumulative subconcussive mechanical forces upon the brain are detrimental in the long term or if concussive symptoms mark the threshold for brain injury. © 2016, Springer Science+Business Media New York.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Seidman, Daniel H; Burlingame, Jennifer; Yousif, Lina R; Donahue, Xinh P; Krier, Joshua; Rayes, Lydia J; Young, Rachel; Lilla, Muareen; Mazurek, Rochelle; Hittle, Kristie; McCloskey, Charles; Misra, Saroj; Shaw, Michael K
'Evaluation of the King–Devick Test as a concussion screening tool in high school football players' Corrigendum Journal Article
In: Journal of the Neurological Sciences, vol. 358, no. 1-2, pp. 540, 2015, ISBN: 0022-510X.
@article{Seidman2015a,
title = {'Evaluation of the King\textendashDevick Test as a concussion screening tool in high school football players' Corrigendum},
author = {Seidman, Daniel H and Burlingame, Jennifer and Yousif, Lina R and Donahue, Xinh P and Krier, Joshua and Rayes, Lydia J and Young, Rachel and Lilla, Muareen and Mazurek, Rochelle and Hittle, Kristie and McCloskey, Charles and Misra, Saroj and Shaw, Michael K},
doi = {10.1016/j.jns.2015.09.348},
isbn = {0022-510X},
year = {2015},
date = {2015-01-01},
journal = {Journal of the Neurological Sciences},
volume = {358},
number = {1-2},
pages = {540},
publisher = {Elsevier Science},
address = {Netherlands},
abstract = {Reports an error in 'Evaluation of the King\textendashDevick test as a concussion screening tool in high school football players' by Daniel H. Seidman, Jennifer Burlingame, Lina R. Yousif, Xinh P. Donahue, Joshua Krier, Lydia J. Rayes, Rachel Young, Muareen Lilla, Rochelle Mazurek, Kristie Hittle, Charles McCloskey, Saroj Misra and Michael K. Shaw (Journal of the Neurological Sciences, 2015[Sep][15], Vol 356[1-2], 97-101). In the original article, there was an error in the third paragraph. The sentence originally read 'The test subject reads a series of numbers in right-to-left and up-to-down order on three test cards.' This should read: 'The test subject reads a series of numbers in left-to-right and up-to-down order on three test cards.' The correction is present in the erratum. (The following abstract of the original article appeared in record [rid]2015-27894-001[/rid]). Objective: Concussion is the most common type of traumatic brain injury, and results from impact or impulsive forces to the head, neck or face. Due to the variability and subtlety of symptoms, concussions may go unrecognized or be ignored, especially with the pressure placed on athletes to return to competition. The King\textendashDevick (KD) test, an oculomotor test originally designed for reading evaluation, was recently validated as a concussion screening tool in collegiate athletes. A prospective study was performed using high school football players in an attempt to study the KD as a concussion screening tool in this younger population. Methods: 343 athletes from four local high school football teams were recruited to participate. These athletes were given baseline KD tests prior to competition. Individual demographic information was collected on the subjects. Standard team protocol was employed to determine if a concussion had occurred during competition. Immediately after diagnosis, the KD test was re-administered to the concussed athlete for comparison to baseline. Post-season testing was also performed in non-concussed individuals. Results: Of the 343 athletes, nine were diagnosed with concussions. In all concussed players, cumulative read times for the KD test were significantly increased (p \< 0.001). Post-season testing of non-concussed athletes revealed minimal change in read times relative to baseline. Univariate analysis revealed that history of concussion was the only demographic factor predictive of concussion in this cohort. Conclusion: The KD test is an accurate and easily administered sideline screening tool for concussion in adolescent football players. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ojo, J O; Mouzon, B C; Crawford, F
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men Journal Article
In: Experimental Neurology, vol. 275, pp. 389–404, 2016.
Abstract | Links | BibTeX | Tags: amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends
@article{Ojo2016,
title = {Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men},
author = {Ojo, J O and Mouzon, B C and Crawford, F},
doi = {10.1016/j.expneurol.2015.06.003},
year = {2016},
date = {2016-01-01},
journal = {Experimental Neurology},
volume = {275},
pages = {389--404},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. Recent retrospective case series published over the last decade on athletes and military personnel have added considerably to our clinical and histopathological knowledge of CTE. This has marked a vital turning point in the traumatic brain injury (TBI) field, raising public awareness of the potential long-term effects of mild and moderate repetitive TBI, which has been recognized as one of the major risk factors associated with CTE. Although these human studies have been informative, their retrospective design carries certain inherent limitations that should be cautiously interpreted. In particular, the current overriding issue in the CTE literature remains confusing in regard to appropriate definitions of terminology, variability in individual pathologies and the potential case selection bias in autopsy based studies. There are currently no epidemiological or prospective studies on CTE. Controlled preclinical studies in animals therefore provide an alternative means for specifically interrogating aspects of CTE pathogenesis. In this article, we review the current literature and discuss difficulties and challenges of developing in-vivo TBI experimental paradigms to explore the link between repetitive head trauma and tau-dependent changes. We provide our current opinion list of recommended features to consider for successfully modeling CTE in animals to better understand the pathobiology and develop therapeutics and diagnostics, and critical factors, which might influence outcome. We finally discuss the possible directions of future experimental research in the repetitive TBI/CTE field. © 2015 Elsevier Inc..},
keywords = {amyloid beta protein, animal, Animal models, Animals, Astroglial tangles, Brain Injury, cell activation, Chronic, complication, Concussion, Craniocerebral Trauma, CTE, diffuse axonal injury, disease duration, disease model, Disease Models, genetic predisposition, gliosis, head injury, hippocampus, human, Humans, lifestyle modification, lithium, metabolism, Mice, microglia, minocycline, mouse, nervous system inflammation, Neurobehaviour, Neurofibrillary tangles, neuropathology, nonhuman, pathogenesis, pathology, priority journal, procedures, protein aggregation, protein analysis, protein blood level, protein cleavage, Repetitive TBI, Review, sex difference, stress activated protein kinase inhibitor, Systematic Review, Tau, tau protein, tau Proteins, Transgenic mice, Translational Medical Research, translational research, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Choe, M C
The Pathophysiology of Concussion Journal Article
In: Current Pain & Headache Reports, vol. 20, no. 6, 2016.
Abstract | Links | BibTeX | Tags: Chronic traumatic encephalopathy, Concussion, diffuse axonal injury, Pathophysiology
@article{Choe2016b,
title = {The Pathophysiology of Concussion},
author = {Choe, M C},
doi = {10.1007/s11916-016-0573-9},
year = {2016},
date = {2016-01-01},
journal = {Current Pain \& Headache Reports},
volume = {20},
number = {6},
abstract = {Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what happens in the brain after traumatic brain injury, particularly with milder injuries where no damage can be seen at the structural level on standard neuroimaging. Understanding the chain of events from a cellular level using studies investigating more severe injuries can help to drive research efforts in understanding the symptomatology that is seen in the acute phase after concussion, as well as point to mechanisms that may underlie persistent post-concussive symptoms. This review discusses the basic neuropathology that occurs after traumatic brain injury at the cellular level. We also present the pathology of chronic traumatic encephalopathy and its similarities to other neurodegenerative diseases. We conclude with recent imaging and biomarker findings looking at changes that may occur after repeated subconcussive blows, which may help to guide efforts in understanding if cumulative subconcussive mechanical forces upon the brain are detrimental in the long term or if concussive symptoms mark the threshold for brain injury. © 2016, Springer Science+Business Media New York.},
keywords = {Chronic traumatic encephalopathy, Concussion, diffuse axonal injury, Pathophysiology},
pubstate = {published},
tppubtype = {article}
}
Seidman, Daniel H; Burlingame, Jennifer; Yousif, Lina R; Donahue, Xinh P; Krier, Joshua; Rayes, Lydia J; Young, Rachel; Lilla, Muareen; Mazurek, Rochelle; Hittle, Kristie; McCloskey, Charles; Misra, Saroj; Shaw, Michael K
'Evaluation of the King–Devick Test as a concussion screening tool in high school football players' Corrigendum Journal Article
In: Journal of the Neurological Sciences, vol. 358, no. 1-2, pp. 540, 2015, ISBN: 0022-510X.
Abstract | Links | BibTeX | Tags: 2015, Athletes, diffuse axonal injury, football, High Schools, Neuropsychological assessment, Neuropsychological Tests, Post-Concussion Syndrome, screening, traumatic brain injury, Visual motor coordination
@article{Seidman2015a,
title = {'Evaluation of the King\textendashDevick Test as a concussion screening tool in high school football players' Corrigendum},
author = {Seidman, Daniel H and Burlingame, Jennifer and Yousif, Lina R and Donahue, Xinh P and Krier, Joshua and Rayes, Lydia J and Young, Rachel and Lilla, Muareen and Mazurek, Rochelle and Hittle, Kristie and McCloskey, Charles and Misra, Saroj and Shaw, Michael K},
doi = {10.1016/j.jns.2015.09.348},
isbn = {0022-510X},
year = {2015},
date = {2015-01-01},
journal = {Journal of the Neurological Sciences},
volume = {358},
number = {1-2},
pages = {540},
publisher = {Elsevier Science},
address = {Netherlands},
abstract = {Reports an error in 'Evaluation of the King\textendashDevick test as a concussion screening tool in high school football players' by Daniel H. Seidman, Jennifer Burlingame, Lina R. Yousif, Xinh P. Donahue, Joshua Krier, Lydia J. Rayes, Rachel Young, Muareen Lilla, Rochelle Mazurek, Kristie Hittle, Charles McCloskey, Saroj Misra and Michael K. Shaw (Journal of the Neurological Sciences, 2015[Sep][15], Vol 356[1-2], 97-101). In the original article, there was an error in the third paragraph. The sentence originally read 'The test subject reads a series of numbers in right-to-left and up-to-down order on three test cards.' This should read: 'The test subject reads a series of numbers in left-to-right and up-to-down order on three test cards.' The correction is present in the erratum. (The following abstract of the original article appeared in record [rid]2015-27894-001[/rid]). Objective: Concussion is the most common type of traumatic brain injury, and results from impact or impulsive forces to the head, neck or face. Due to the variability and subtlety of symptoms, concussions may go unrecognized or be ignored, especially with the pressure placed on athletes to return to competition. The King\textendashDevick (KD) test, an oculomotor test originally designed for reading evaluation, was recently validated as a concussion screening tool in collegiate athletes. A prospective study was performed using high school football players in an attempt to study the KD as a concussion screening tool in this younger population. Methods: 343 athletes from four local high school football teams were recruited to participate. These athletes were given baseline KD tests prior to competition. Individual demographic information was collected on the subjects. Standard team protocol was employed to determine if a concussion had occurred during competition. Immediately after diagnosis, the KD test was re-administered to the concussed athlete for comparison to baseline. Post-season testing was also performed in non-concussed individuals. Results: Of the 343 athletes, nine were diagnosed with concussions. In all concussed players, cumulative read times for the KD test were significantly increased (p \< 0.001). Post-season testing of non-concussed athletes revealed minimal change in read times relative to baseline. Univariate analysis revealed that history of concussion was the only demographic factor predictive of concussion in this cohort. Conclusion: The KD test is an accurate and easily administered sideline screening tool for concussion in adolescent football players. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2015, Athletes, diffuse axonal injury, football, High Schools, Neuropsychological assessment, Neuropsychological Tests, Post-Concussion Syndrome, screening, traumatic brain injury, Visual motor coordination},
pubstate = {published},
tppubtype = {article}
}