Connery, A K; Peterson, R L; Baker, D A; Randolph, C; Kirkwood, M W
The Role of Neuropsychological Evaluation in the Clinical Management of Concussion Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 475–486, 2016.
Links | BibTeX | Tags: brain concussion, childhood injury, CONVALESCENCE, health care access, health care delivery, human, medical history, mild TBI, Neuropsychological assessment, neuropsychological test, postconcussion syndrome, priority journal, return to sport, Review, risk factor, traumatic brain injury, validity
@article{Connery2016a,
title = {The Role of Neuropsychological Evaluation in the Clinical Management of Concussion},
author = {Connery, A K and Peterson, R L and Baker, D A and Randolph, C and Kirkwood, M W},
doi = {10.1016/j.pmr.2015.12.001},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {475--486},
keywords = {brain concussion, childhood injury, CONVALESCENCE, health care access, health care delivery, human, medical history, mild TBI, Neuropsychological assessment, neuropsychological test, postconcussion syndrome, priority journal, return to sport, Review, risk factor, traumatic brain injury, validity},
pubstate = {published},
tppubtype = {article}
}
McDevitt, J; Appiah-Kubi, K O; Tierney, R; Wright, W G
Vestibular and Oculomotor Assessments May Increase Accuracy of Subacute Concussion Assessment Journal Article
In: International Journal of Sports Medicine, vol. 37, no. 9, pp. 738–747, 2016.
Abstract | Links | BibTeX | Tags: BESS, Concussion, gaze stabilization test, mild TBI, near point convergence, optokinetic stimulation, SOT
@article{McDevitt2016,
title = {Vestibular and Oculomotor Assessments May Increase Accuracy of Subacute Concussion Assessment},
author = {McDevitt, J and Appiah-Kubi, K O and Tierney, R and Wright, W G},
doi = {10.1055/s-0042-100470},
year = {2016},
date = {2016-01-01},
journal = {International Journal of Sports Medicine},
volume = {37},
number = {9},
pages = {738--747},
abstract = {In this study, we collected and analyzed preliminary data for the internal consistency of a new condensed model to assess vestibular and oculomotor impairments following a concussion. We also examined this model's ability to discriminate concussed athletes from healthy controls. Each participant was tested in a concussion assessment protocol that consisted of the Neurocom's Sensory Organization Test (SOT), Balance Error Scoring System exam, and a series of 8 vestibular and oculomotor assessments. Of these 10 assessments, only the SOT, near point convergence, and the signs and symptoms (S/S) scores collected following optokinetic stimulation, the horizontal eye saccades test, and the gaze stabilization test were significantly correlated with health status, and were used in further analyses. Multivariate logistic regression for binary outcomes was employed and these beta weights were used to calculate the area under the receiver operating characteristic curve (area under the curve). The best model supported by our findings suggest that an exam consisting of the 4 SOT sensory ratios, near point convergence, and the optokinetic stimulation signs and symptoms score are sensitive in discriminating concussed athletes from healthy controls (accuracy=98.6%},
keywords = {BESS, Concussion, gaze stabilization test, mild TBI, near point convergence, optokinetic stimulation, SOT},
pubstate = {published},
tppubtype = {article}
}
Belanger, H G; Vanderploeg, R D; McAllister, T
Subconcussive blows to the head: A formative review of short-term clinical outcomes Journal Article
In: Journal of Head Trauma Rehabilitation, vol. 31, no. 3, pp. 159–166, 2016.
Abstract | Links | BibTeX | Tags: Balance, cognition, Concussion, mild TBI, neuropsychological, Outcomes, subconcussion
@article{Belanger2016b,
title = {Subconcussive blows to the head: A formative review of short-term clinical outcomes},
author = {Belanger, H G and Vanderploeg, R D and McAllister, T},
doi = {10.1097/HTR.0000000000000138},
year = {2016},
date = {2016-01-01},
journal = {Journal of Head Trauma Rehabilitation},
volume = {31},
number = {3},
pages = {159--166},
abstract = {Background: Given questions about "lower thresholds" for concussion, as well as possible effects of repetitive concussion and chronic traumatic encephalopathy (CTE), and associated controversy, there is increasing interest in "subconcussive" blows and their potential significance. Objective: A formative review with critical examination of the developing literature on subconcussive blows in athletes with an emphasis on clinical outcomes. Methods: Studies of biomechanical, performance and/or symptom-based, and neuroimaging data were identified via PubMed search and critically reviewed. Five studies of symptom reporting/performance and 4 studies of neuroimaging were included. Results: The relation between biomechanical parameters and diagnosed concussion is not straightforward (ie, it is not the case that greater and more force leads to more severe injury or cognitive/behavioral sequelae). Neuropsychological studies of subconcussive blows within a single athletic season have failed to demonstrate any strong and consistent relations between number and severity of subconcussive events and cognitive change. Recent studies using neuroimaging have demonstrated a potential cumulative effect of subconcussive blows, at least in a subset of individuals. Conclusion: Human studies of the neurological/neuropsychological impact of subconcussive blows are currently quite limited. Subconcussive blows, in the short-term, have not been shown to cause significant clinical effects. To date, findings suggest that any effect of subconcussive blows is likely to be small or nonexistent, perhaps evident in a subset of individuals on select measures, and maybe even beneficial in some cases. Longerterm prospective studies are needed to determine if there is a cumulative dose effect. © 2016 Wolters Kluwer Health, Inc.},
keywords = {Balance, cognition, Concussion, mild TBI, neuropsychological, Outcomes, subconcussion},
pubstate = {published},
tppubtype = {article}
}
Dambinova, S A; Maroon, J C; Sufrinko, A M; Mullins, J D; Alexandrova, E V; Potapov, A A
Functional, structural, and neurotoxicity biomarkers in integrative assessment of concussions Journal Article
In: Frontiers in Neurology, vol. 7, no. OCT, 2016.
Abstract | Links | BibTeX | Tags: Advanced MRI sequences, Concussion, mild TBI, Neuropsychological evaluations, Neurotoxicity and neuroplasticity biomarkers
@article{Dambinova2016,
title = {Functional, structural, and neurotoxicity biomarkers in integrative assessment of concussions},
author = {Dambinova, S A and Maroon, J C and Sufrinko, A M and Mullins, J D and Alexandrova, E V and Potapov, A A},
doi = {10.3389/fneur.2016.00172},
year = {2016},
date = {2016-01-01},
journal = {Frontiers in Neurology},
volume = {7},
number = {OCT},
abstract = {Concussion is a complex, heterogeneous process affecting the brain. Accurate assessment and diagnosis and appropriate management of concussion are essential to ensure that athletes do not prematurely return to play or others to work or active military duty, risking re-injury. To date, clinical diagnosis relies primarily on evaluating subjects for functional impairment using instruments that include neurocognitive testing, subjective symptom report, and neurobehavioral assessments, such as balance and vestibular-ocular reflex testing. Structural biomarkers, defined as advanced neuroimaging techniques and biomarkers assessing neurotoxicity and immunoexcitotoxicity, may complement the use of functional biomarkers. We hypothesize that neurotoxicity AMPA, NMDA, and kainite receptor biomarkers might be utilized as a part of comprehensive approach to concussion evaluations, with the goal of increasing diagnostic accuracy and facilitating treatment planning and prognostic assessment. © 2016 Dambinova, Maroon, Sufrinko, Mullins, Alexandrova and Potapov.},
keywords = {Advanced MRI sequences, Concussion, mild TBI, Neuropsychological evaluations, Neurotoxicity and neuroplasticity biomarkers},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
Abstract | Links | BibTeX | Tags: 2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory},
pubstate = {published},
tppubtype = {article}
}
Connery, A K; Peterson, R L; Baker, D A; Randolph, C; Kirkwood, M W
The Role of Neuropsychological Evaluation in the Clinical Management of Concussion Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 475–486, 2016.
@article{Connery2016a,
title = {The Role of Neuropsychological Evaluation in the Clinical Management of Concussion},
author = {Connery, A K and Peterson, R L and Baker, D A and Randolph, C and Kirkwood, M W},
doi = {10.1016/j.pmr.2015.12.001},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {475--486},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
McDevitt, J; Appiah-Kubi, K O; Tierney, R; Wright, W G
Vestibular and Oculomotor Assessments May Increase Accuracy of Subacute Concussion Assessment Journal Article
In: International Journal of Sports Medicine, vol. 37, no. 9, pp. 738–747, 2016.
@article{McDevitt2016,
title = {Vestibular and Oculomotor Assessments May Increase Accuracy of Subacute Concussion Assessment},
author = {McDevitt, J and Appiah-Kubi, K O and Tierney, R and Wright, W G},
doi = {10.1055/s-0042-100470},
year = {2016},
date = {2016-01-01},
journal = {International Journal of Sports Medicine},
volume = {37},
number = {9},
pages = {738--747},
abstract = {In this study, we collected and analyzed preliminary data for the internal consistency of a new condensed model to assess vestibular and oculomotor impairments following a concussion. We also examined this model's ability to discriminate concussed athletes from healthy controls. Each participant was tested in a concussion assessment protocol that consisted of the Neurocom's Sensory Organization Test (SOT), Balance Error Scoring System exam, and a series of 8 vestibular and oculomotor assessments. Of these 10 assessments, only the SOT, near point convergence, and the signs and symptoms (S/S) scores collected following optokinetic stimulation, the horizontal eye saccades test, and the gaze stabilization test were significantly correlated with health status, and were used in further analyses. Multivariate logistic regression for binary outcomes was employed and these beta weights were used to calculate the area under the receiver operating characteristic curve (area under the curve). The best model supported by our findings suggest that an exam consisting of the 4 SOT sensory ratios, near point convergence, and the optokinetic stimulation signs and symptoms score are sensitive in discriminating concussed athletes from healthy controls (accuracy=98.6%},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Belanger, H G; Vanderploeg, R D; McAllister, T
Subconcussive blows to the head: A formative review of short-term clinical outcomes Journal Article
In: Journal of Head Trauma Rehabilitation, vol. 31, no. 3, pp. 159–166, 2016.
@article{Belanger2016b,
title = {Subconcussive blows to the head: A formative review of short-term clinical outcomes},
author = {Belanger, H G and Vanderploeg, R D and McAllister, T},
doi = {10.1097/HTR.0000000000000138},
year = {2016},
date = {2016-01-01},
journal = {Journal of Head Trauma Rehabilitation},
volume = {31},
number = {3},
pages = {159--166},
abstract = {Background: Given questions about "lower thresholds" for concussion, as well as possible effects of repetitive concussion and chronic traumatic encephalopathy (CTE), and associated controversy, there is increasing interest in "subconcussive" blows and their potential significance. Objective: A formative review with critical examination of the developing literature on subconcussive blows in athletes with an emphasis on clinical outcomes. Methods: Studies of biomechanical, performance and/or symptom-based, and neuroimaging data were identified via PubMed search and critically reviewed. Five studies of symptom reporting/performance and 4 studies of neuroimaging were included. Results: The relation between biomechanical parameters and diagnosed concussion is not straightforward (ie, it is not the case that greater and more force leads to more severe injury or cognitive/behavioral sequelae). Neuropsychological studies of subconcussive blows within a single athletic season have failed to demonstrate any strong and consistent relations between number and severity of subconcussive events and cognitive change. Recent studies using neuroimaging have demonstrated a potential cumulative effect of subconcussive blows, at least in a subset of individuals. Conclusion: Human studies of the neurological/neuropsychological impact of subconcussive blows are currently quite limited. Subconcussive blows, in the short-term, have not been shown to cause significant clinical effects. To date, findings suggest that any effect of subconcussive blows is likely to be small or nonexistent, perhaps evident in a subset of individuals on select measures, and maybe even beneficial in some cases. Longerterm prospective studies are needed to determine if there is a cumulative dose effect. © 2016 Wolters Kluwer Health, Inc.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dambinova, S A; Maroon, J C; Sufrinko, A M; Mullins, J D; Alexandrova, E V; Potapov, A A
Functional, structural, and neurotoxicity biomarkers in integrative assessment of concussions Journal Article
In: Frontiers in Neurology, vol. 7, no. OCT, 2016.
@article{Dambinova2016,
title = {Functional, structural, and neurotoxicity biomarkers in integrative assessment of concussions},
author = {Dambinova, S A and Maroon, J C and Sufrinko, A M and Mullins, J D and Alexandrova, E V and Potapov, A A},
doi = {10.3389/fneur.2016.00172},
year = {2016},
date = {2016-01-01},
journal = {Frontiers in Neurology},
volume = {7},
number = {OCT},
abstract = {Concussion is a complex, heterogeneous process affecting the brain. Accurate assessment and diagnosis and appropriate management of concussion are essential to ensure that athletes do not prematurely return to play or others to work or active military duty, risking re-injury. To date, clinical diagnosis relies primarily on evaluating subjects for functional impairment using instruments that include neurocognitive testing, subjective symptom report, and neurobehavioral assessments, such as balance and vestibular-ocular reflex testing. Structural biomarkers, defined as advanced neuroimaging techniques and biomarkers assessing neurotoxicity and immunoexcitotoxicity, may complement the use of functional biomarkers. We hypothesize that neurotoxicity AMPA, NMDA, and kainite receptor biomarkers might be utilized as a part of comprehensive approach to concussion evaluations, with the goal of increasing diagnostic accuracy and facilitating treatment planning and prognostic assessment. © 2016 Dambinova, Maroon, Sufrinko, Mullins, Alexandrova and Potapov.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Connery, A K; Peterson, R L; Baker, D A; Randolph, C; Kirkwood, M W
The Role of Neuropsychological Evaluation in the Clinical Management of Concussion Journal Article
In: Physical Medicine & Rehabilitation Clinics of North America, vol. 27, no. 2, pp. 475–486, 2016.
Links | BibTeX | Tags: brain concussion, childhood injury, CONVALESCENCE, health care access, health care delivery, human, medical history, mild TBI, Neuropsychological assessment, neuropsychological test, postconcussion syndrome, priority journal, return to sport, Review, risk factor, traumatic brain injury, validity
@article{Connery2016a,
title = {The Role of Neuropsychological Evaluation in the Clinical Management of Concussion},
author = {Connery, A K and Peterson, R L and Baker, D A and Randolph, C and Kirkwood, M W},
doi = {10.1016/j.pmr.2015.12.001},
year = {2016},
date = {2016-01-01},
journal = {Physical Medicine \& Rehabilitation Clinics of North America},
volume = {27},
number = {2},
pages = {475--486},
keywords = {brain concussion, childhood injury, CONVALESCENCE, health care access, health care delivery, human, medical history, mild TBI, Neuropsychological assessment, neuropsychological test, postconcussion syndrome, priority journal, return to sport, Review, risk factor, traumatic brain injury, validity},
pubstate = {published},
tppubtype = {article}
}
McDevitt, J; Appiah-Kubi, K O; Tierney, R; Wright, W G
Vestibular and Oculomotor Assessments May Increase Accuracy of Subacute Concussion Assessment Journal Article
In: International Journal of Sports Medicine, vol. 37, no. 9, pp. 738–747, 2016.
Abstract | Links | BibTeX | Tags: BESS, Concussion, gaze stabilization test, mild TBI, near point convergence, optokinetic stimulation, SOT
@article{McDevitt2016,
title = {Vestibular and Oculomotor Assessments May Increase Accuracy of Subacute Concussion Assessment},
author = {McDevitt, J and Appiah-Kubi, K O and Tierney, R and Wright, W G},
doi = {10.1055/s-0042-100470},
year = {2016},
date = {2016-01-01},
journal = {International Journal of Sports Medicine},
volume = {37},
number = {9},
pages = {738--747},
abstract = {In this study, we collected and analyzed preliminary data for the internal consistency of a new condensed model to assess vestibular and oculomotor impairments following a concussion. We also examined this model's ability to discriminate concussed athletes from healthy controls. Each participant was tested in a concussion assessment protocol that consisted of the Neurocom's Sensory Organization Test (SOT), Balance Error Scoring System exam, and a series of 8 vestibular and oculomotor assessments. Of these 10 assessments, only the SOT, near point convergence, and the signs and symptoms (S/S) scores collected following optokinetic stimulation, the horizontal eye saccades test, and the gaze stabilization test were significantly correlated with health status, and were used in further analyses. Multivariate logistic regression for binary outcomes was employed and these beta weights were used to calculate the area under the receiver operating characteristic curve (area under the curve). The best model supported by our findings suggest that an exam consisting of the 4 SOT sensory ratios, near point convergence, and the optokinetic stimulation signs and symptoms score are sensitive in discriminating concussed athletes from healthy controls (accuracy=98.6%},
keywords = {BESS, Concussion, gaze stabilization test, mild TBI, near point convergence, optokinetic stimulation, SOT},
pubstate = {published},
tppubtype = {article}
}
Belanger, H G; Vanderploeg, R D; McAllister, T
Subconcussive blows to the head: A formative review of short-term clinical outcomes Journal Article
In: Journal of Head Trauma Rehabilitation, vol. 31, no. 3, pp. 159–166, 2016.
Abstract | Links | BibTeX | Tags: Balance, cognition, Concussion, mild TBI, neuropsychological, Outcomes, subconcussion
@article{Belanger2016b,
title = {Subconcussive blows to the head: A formative review of short-term clinical outcomes},
author = {Belanger, H G and Vanderploeg, R D and McAllister, T},
doi = {10.1097/HTR.0000000000000138},
year = {2016},
date = {2016-01-01},
journal = {Journal of Head Trauma Rehabilitation},
volume = {31},
number = {3},
pages = {159--166},
abstract = {Background: Given questions about "lower thresholds" for concussion, as well as possible effects of repetitive concussion and chronic traumatic encephalopathy (CTE), and associated controversy, there is increasing interest in "subconcussive" blows and their potential significance. Objective: A formative review with critical examination of the developing literature on subconcussive blows in athletes with an emphasis on clinical outcomes. Methods: Studies of biomechanical, performance and/or symptom-based, and neuroimaging data were identified via PubMed search and critically reviewed. Five studies of symptom reporting/performance and 4 studies of neuroimaging were included. Results: The relation between biomechanical parameters and diagnosed concussion is not straightforward (ie, it is not the case that greater and more force leads to more severe injury or cognitive/behavioral sequelae). Neuropsychological studies of subconcussive blows within a single athletic season have failed to demonstrate any strong and consistent relations between number and severity of subconcussive events and cognitive change. Recent studies using neuroimaging have demonstrated a potential cumulative effect of subconcussive blows, at least in a subset of individuals. Conclusion: Human studies of the neurological/neuropsychological impact of subconcussive blows are currently quite limited. Subconcussive blows, in the short-term, have not been shown to cause significant clinical effects. To date, findings suggest that any effect of subconcussive blows is likely to be small or nonexistent, perhaps evident in a subset of individuals on select measures, and maybe even beneficial in some cases. Longerterm prospective studies are needed to determine if there is a cumulative dose effect. © 2016 Wolters Kluwer Health, Inc.},
keywords = {Balance, cognition, Concussion, mild TBI, neuropsychological, Outcomes, subconcussion},
pubstate = {published},
tppubtype = {article}
}
Dambinova, S A; Maroon, J C; Sufrinko, A M; Mullins, J D; Alexandrova, E V; Potapov, A A
Functional, structural, and neurotoxicity biomarkers in integrative assessment of concussions Journal Article
In: Frontiers in Neurology, vol. 7, no. OCT, 2016.
Abstract | Links | BibTeX | Tags: Advanced MRI sequences, Concussion, mild TBI, Neuropsychological evaluations, Neurotoxicity and neuroplasticity biomarkers
@article{Dambinova2016,
title = {Functional, structural, and neurotoxicity biomarkers in integrative assessment of concussions},
author = {Dambinova, S A and Maroon, J C and Sufrinko, A M and Mullins, J D and Alexandrova, E V and Potapov, A A},
doi = {10.3389/fneur.2016.00172},
year = {2016},
date = {2016-01-01},
journal = {Frontiers in Neurology},
volume = {7},
number = {OCT},
abstract = {Concussion is a complex, heterogeneous process affecting the brain. Accurate assessment and diagnosis and appropriate management of concussion are essential to ensure that athletes do not prematurely return to play or others to work or active military duty, risking re-injury. To date, clinical diagnosis relies primarily on evaluating subjects for functional impairment using instruments that include neurocognitive testing, subjective symptom report, and neurobehavioral assessments, such as balance and vestibular-ocular reflex testing. Structural biomarkers, defined as advanced neuroimaging techniques and biomarkers assessing neurotoxicity and immunoexcitotoxicity, may complement the use of functional biomarkers. We hypothesize that neurotoxicity AMPA, NMDA, and kainite receptor biomarkers might be utilized as a part of comprehensive approach to concussion evaluations, with the goal of increasing diagnostic accuracy and facilitating treatment planning and prognostic assessment. © 2016 Dambinova, Maroon, Sufrinko, Mullins, Alexandrova and Potapov.},
keywords = {Advanced MRI sequences, Concussion, mild TBI, Neuropsychological evaluations, Neurotoxicity and neuroplasticity biomarkers},
pubstate = {published},
tppubtype = {article}
}
Sinopoli, Katia J; Chen, Jen-Kai; Wells, Greg; Fait, Philippe; Ptito, Alain; Taha, Tim; Keightley, Michelle
Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance Journal Article
In: Journal of Neurotrauma, vol. 31, no. 22, pp. 1843–1859, 2014, ISBN: 0897-7151 1557-9042.
Abstract | Links | BibTeX | Tags: 2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory
@article{Sinopoli2014,
title = {Imagine 'brain strain' in youth athletes with mild traumatic brain injury during dual-task performance},
author = {Sinopoli, Katia J and Chen, Jen-Kai and Wells, Greg and Fait, Philippe and Ptito, Alain and Taha, Tim and Keightley, Michelle},
doi = {10.1089/neu.2014.3326},
isbn = {0897-7151
1557-9042},
year = {2014},
date = {2014-01-01},
journal = {Journal of Neurotrauma},
volume = {31},
number = {22},
pages = {1843--1859},
publisher = {Mary Ann Liebert, Inc.},
address = {US},
abstract = {Mild traumatic brain injury (mTBI) is a common cause of injury in youth athletes. Much of what is known about the sequelae of mTBI is yielded from the adult literature, and it appears that it is mainly those with persistent post-injury symptoms who have ongoing cognitive and neural abnormalities. However, most studies have employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought to examine the neural correlates of dual-task performance in male athletes aged 9-15 years using a functional neuroimaging protocol. Participants included 13 youths with a history of mTBI three to six months prior to testing and 14 typically-developing controls. All participants completed a working memory task in isolation (single-task) and while completing a concurrent motor task (dual-task); neural activity during performance was then compared between groups. Although working memory performance was similar during the single-task condition, increased working memory load resulted in an altered pattern of neural activation in key working memory areas (i.e., dorsolateral prefrontal and parietal cortices) in youth with mTBI relative to controls. During the dual-task condition, accuracy was similar between groups but injured youth performed slower than typically-developing controls, suggesting a speed-accuracy tradeoff in the mTBI group only. The injured youths also exhibited abnormal recruitment of brain structures involved in both working memory and dual-tasking. These data show that the dual-task paradigm can uncover functional impairments in youth with mTBI who are not highly symptomatic and who do not exhibit neuropsychological dysfunction. Moreover, neural recruitment abnormalities were noted in both task conditions, which we argue suggests mTBI-related disruptions in achieving efficient cognitive control and allocation of processing resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2014, Athletes, dual task, Dual Task Performance, fMRI, functional magnetic resonance imaging, mild TBI, short term memory, traumatic brain injury, working memory},
pubstate = {published},
tppubtype = {article}
}