Laksari, K; Wu, L C; Kurt, M; Kuo, C; Camarillo, D C
Resonance of human brain under head acceleration Journal Article
In: Journal of the Royal Society Interface, vol. 12, no. 108, pp. 20150331, 2015.
Abstract | BibTeX | Tags: *Acceleration/ae [Adverse Effects], *BRAIN, *Brain Injuries, *Craniocerebral Trauma, *MAGNETIC resonance imaging, *Skull, adult, Brain Injuries/dg [Diagnostic Imaging], Brain Injuries/pp [Physiopathology], Brain/dg [Diagnostic Imaging], Brain/pp [Physiopathology], Craniocerebral Trauma/dg [Diagnostic Imaging], Craniocerebral Trauma/pp [Physiopathology], Humans, Male, Radiography, Skull/dg [Diagnostic Imaging], Skull/pp [Physiopathology]
@article{Laksari2015,
title = {Resonance of human brain under head acceleration},
author = {Laksari, K and Wu, L C and Kurt, M and Kuo, C and Camarillo, D C},
year = {2015},
date = {2015-01-01},
journal = {Journal of the Royal Society Interface},
volume = {12},
number = {108},
pages = {20150331},
abstract = {Although safety standards have reduced fatal head trauma due to single severe head impacts, mild trauma from repeated head exposures may carry risks of long-term chronic changes in the brain's function and structure. To study the physical sensitivities of the brain to mild head impacts, we developed the first dynamic model of the skull-brain based on in vivo MRI data. We showed that the motion of the brain can be described by a rigid-body with constrained kinematics. We further demonstrated that skull-brain dynamics can be approximated by an under-damped system with a low-frequency resonance at around 15 Hz. Furthermore, from our previous field measurements, we found that head motions in a variety of activities, including contact sports, show a primary frequency of less than 20 Hz. This implies that typical head exposures may drive the brain dangerously close to its mechanical resonance and lead to amplified brain-skull relative motions. Our results suggest a possible cause for mild brain trauma, which could occur due to repetitive low-acceleration head oscillations in a variety of recreational and occupational activities. Copyright © 2015 The Author(s) Published by the Royal Society. All rights reserved.},
keywords = {*Acceleration/ae [Adverse Effects], *BRAIN, *Brain Injuries, *Craniocerebral Trauma, *MAGNETIC resonance imaging, *Skull, adult, Brain Injuries/dg [Diagnostic Imaging], Brain Injuries/pp [Physiopathology], Brain/dg [Diagnostic Imaging], Brain/pp [Physiopathology], Craniocerebral Trauma/dg [Diagnostic Imaging], Craniocerebral Trauma/pp [Physiopathology], Humans, Male, Radiography, Skull/dg [Diagnostic Imaging], Skull/pp [Physiopathology]},
pubstate = {published},
tppubtype = {article}
}
Baker, J G; Leddy, J J; Darling, S R; Rieger, B P; Mashtare, T L; Sharma, T; Willer, B S
Factors Associated with Problems for Adolescents Returning to the Classroom after Sport-Related Concussion Journal Article
In: Clinical Pediatrics, vol. 54, no. 10, pp. 961–968, 2015.
Abstract | Links | BibTeX | Tags: Absenteeism, Adolescent, adolescent disease, adult, Article, athlete, Athletic Injuries, brain concussion, computer testing, Concussion, disease association, disease severity, Female, follow up, Follow-Up Studies, health service, human, Humans, interview, Interviews as Topic, Logistic Models, major clinical study, Male, Pathophysiology, receiver operating characteristic, recovery time, Recurrence, recurrent disease, return to learn, ROC Curve, school, school problems, sport injury, Sport-related concussion, statistical model, Symptoms, telephone interview, Young Adult
@article{Baker2015,
title = {Factors Associated with Problems for Adolescents Returning to the Classroom after Sport-Related Concussion},
author = {Baker, J G and Leddy, J J and Darling, S R and Rieger, B P and Mashtare, T L and Sharma, T and Willer, B S},
doi = {10.1177/0009922815588820},
year = {2015},
date = {2015-01-01},
journal = {Clinical Pediatrics},
volume = {54},
number = {10},
pages = {961--968},
abstract = {The primary objective of this study was to determine factors in the clinic setting associated with concussion-related problems in the school setting. A total of 91 student athletes, 13 to 19 years old, completed the SCAT2 and computerized testing during their initial visit to the clinic. During a follow-up telephone interview, one-third reported problems with return to school. The presence of problems reported in school was associated with severity of concussion as represented by recovery time and the overall number of symptoms at the first clinic visit. Gender, age, and previous concussions were not associated with school problems. Athletes with computerized test scores below the ninth percentile were more likely to report school problems. The current study offers some descriptive information for clinicians and ideas for future research related to adolescent athletes with concussion and problems with return to the classroom. © SAGE Publications.},
keywords = {Absenteeism, Adolescent, adolescent disease, adult, Article, athlete, Athletic Injuries, brain concussion, computer testing, Concussion, disease association, disease severity, Female, follow up, Follow-Up Studies, health service, human, Humans, interview, Interviews as Topic, Logistic Models, major clinical study, Male, Pathophysiology, receiver operating characteristic, recovery time, Recurrence, recurrent disease, return to learn, ROC Curve, school, school problems, sport injury, Sport-related concussion, statistical model, Symptoms, telephone interview, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Fitch, T; Villanueva, G; Quadir, M M; Sagiraju, H K; Alamgir, H
The prevalence and risk factors of Post-Traumatic Stress Disorder among workers injured in Rana Plaza building collapse in Bangladesh Journal Article
In: American Journal of Industrial Medicine, vol. 58, no. 7, pp. 756–763, 2015.
Abstract | BibTeX | Tags: *Occupational Diseases/ep [Epidemiology], *Stress Disorders, *Structure Collapse, *Survivors/px [Psychology], *Textile Industry, adult, Bangladesh/ep [Epidemiology], Employment/px [Psychology], Female, Humans, Logistic Models, Male, Marital Status, Occupational Diseases/et [Etiology], ODDS ratio, Post-Traumatic/ep [Epidemiology, Post-Traumatic/et [Etiology], Prevalence, Risk Factors, Stress Disorders, Work/px [Psychology], Young Adult
@article{Fitch2015,
title = {The prevalence and risk factors of Post-Traumatic Stress Disorder among workers injured in Rana Plaza building collapse in Bangladesh},
author = {Fitch, T and Villanueva, G and Quadir, M M and Sagiraju, H K and Alamgir, H},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Industrial Medicine},
volume = {58},
number = {7},
pages = {756--763},
abstract = {OBJECTIVES: Prevalence and risk factors of PTSD among injured garment workers who survived a major factory collapse. METHODS: Survivors receiving treatment or rehabilitation care at one year post event were surveyed, which included Post Traumatic Stress Disorder Checklist Specific version. RESULTS: The respondents consisted of 181 people with a mean age of 27.8 years and a majority had less than high school education (91.2%). Multivariable logistic regression found that the odds of having PTSD was higher among married (OR: 3.2 [95% CI: 1.3-8.0]), those who used to work more than 70hr/week (OR: 2.4 [1.1-5.3]), workers who used to hold higher job positions (OR: 2.6 [1.2-5.6]) or who had a concussion injury (OR: 3.7 [1.4-9.8]). Among the respondents, 83.4% remained unemployed, and only 57.3% (63 people) reported receiving a quarter or less of what they were promised as compensation. CONCLUSIONS: Probable PTSD was prevalent among surviving workers of the Rana Plaza building collapse in Bangladesh.Copyright © 2015 Wiley Periodicals, Inc.},
keywords = {*Occupational Diseases/ep [Epidemiology], *Stress Disorders, *Structure Collapse, *Survivors/px [Psychology], *Textile Industry, adult, Bangladesh/ep [Epidemiology], Employment/px [Psychology], Female, Humans, Logistic Models, Male, Marital Status, Occupational Diseases/et [Etiology], ODDS ratio, Post-Traumatic/ep [Epidemiology, Post-Traumatic/et [Etiology], Prevalence, Risk Factors, Stress Disorders, Work/px [Psychology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Dretsch, M N; Silverberg, N D; Iverson, G L
Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers Journal Article
In: Journal of Neurotrauma, vol. 32, no. 17, pp. 1301–1306, 2015.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Cognition Disorders/di [Diagnosis], *Military Personnel/sn [Statistics & Numerical Dat, *Post-Concussion Syndrome/di [Diagnosis], adult, Brain Concussion/ep [Epidemiology], Cognition Disorders/ep [Epidemiology], Cognition Disorders/et [Etiology], Female, Humans, Male, Post-Concussion Syndrome/ep [Epidemiology], Post-Concussion Syndrome/et [Etiology], United States/ep [Epidemiology], Young Adult
@article{Dretsch2015,
title = {Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers},
author = {Dretsch, M N and Silverberg, N D and Iverson, G L},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurotrauma},
volume = {32},
number = {17},
pages = {1301--1306},
abstract = {The extent to which multiple past concussions are associated with lingering symptoms or mental health problems in military service members is not well understood. The purpose of this study was to examine the association between lifetime concussion history, cognitive functioning, general health, and psychological health in a large sample of fit-for-duty U.S. Army soldiers preparing for deployment. Data on 458 active-duty soldiers were collected and analyzed. A computerized cognitive screening battery (CNS-Vital Signs()) was used to assess complex attention (CA), reaction time (RT), processing speed (PS), cognitive flexibility (CF), and memory. Health questionnaires included the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Military Version (PCL-M), Zung Depression and Anxiety Scales (ZDS; ZAS), Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and the Alcohol Use and Dependency Identification Test (AUDIT). Soldiers with a history of multiple concussions (i.e., three or more concussions) had significantly greater post-concussive symptom scores compared with those with zero (d=1.83, large effect), one (d=0.64, medium effect), and two (d=0.64, medium effect) prior concussions. Although the group with three or more concussions also reported more traumatic stress symptoms, the results revealed that traumatic stress was a mediator between concussions and post-concussive symptom severity. There were no significant differences on neurocognitive testing between the number of concussions. These results add to the accumulating evidence suggesting that most individuals recover from one or two prior concussions, but there is a greater risk for ongoing symptoms if one exceeds this number of injuries.},
keywords = {*Brain Concussion/co [Complications], *Cognition Disorders/di [Diagnosis], *Military Personnel/sn [Statistics \& Numerical Dat, *Post-Concussion Syndrome/di [Diagnosis], adult, Brain Concussion/ep [Epidemiology], Cognition Disorders/ep [Epidemiology], Cognition Disorders/et [Etiology], Female, Humans, Male, Post-Concussion Syndrome/ep [Epidemiology], Post-Concussion Syndrome/et [Etiology], United States/ep [Epidemiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Alexander, D G; Shuttleworth-Edwards, A B; Kidd, M; Malcolm, C M
Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1113–1125, 2015.
Abstract | Links | BibTeX | Tags: academic achievement, Academic performance, ADOLESCENCE, Adolescent, adolescent disease, adult, Article, Athletic Injuries, brain concussion, Brain Injuries, Child, cognition, Concussion, controlled study, Educational Status, football, human, Humans, Injuries, intelligence test, Intelligence Tests, Longitudinal studies, longitudinal study, major clinical study, Male, mild traumatic brain injury, mTBI, neurocognitive, neuropsychological test, Neuropsychological Tests, Pathophysiology, Prospective Studies, prospective study, psychologic test, psychology, rugby, SOUTH Africa, sport injury, TASK performance, traumatic brain injury, treatment outcome
@article{Alexander2015,
title = {Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes},
author = {Alexander, D G and Shuttleworth-Edwards, A B and Kidd, M and Malcolm, C M},
doi = {10.3109/02699052.2015.1031699},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1113--1125},
abstract = {Background: Information is scant concerning enduring brain injury effects of participation in the contact sport of Rugby Union (hereafter rugby) on early adolescents.Objective: The objective was prospectively to investigate differences between young adolescent male rugby players and non-contact sports controls on neurocognitive test performance over 3 years and academic achievement over 6 years.Method: A sample of boys from the same school and grade was divided into three groups: rugby with seasonal concussions (n = 45), rugby no seasonal concussions (n = 21) and non-contact sports controls (n = 30). Baseline neurocognitive testing was conducted pre-season in Grade 7 and post-season in Grades 8 and 9. Year-end academic grades were documented for Grades 6-9 and 12 (pre-high school to year of school leaving). A mixed model repeated measures ANOVA was conducted to investigate comparative neurocognitive and academic outcomes between the three sub-groups.Results: Compared with controls, both rugby groups were significantly lower on the WISC-III Coding Immediate Recall sub-test. There was a significant interaction effect on the academic measure, with improved scores over time for controls, that was not in evidence for either rugby group.Conclusions: Tentatively, the outcome suggests cognitive vulnerability in association with school level participation in rugby. © 2015 Taylor \& Francis Group, LLC.},
keywords = {academic achievement, Academic performance, ADOLESCENCE, Adolescent, adolescent disease, adult, Article, Athletic Injuries, brain concussion, Brain Injuries, Child, cognition, Concussion, controlled study, Educational Status, football, human, Humans, Injuries, intelligence test, Intelligence Tests, Longitudinal studies, longitudinal study, major clinical study, Male, mild traumatic brain injury, mTBI, neurocognitive, neuropsychological test, Neuropsychological Tests, Pathophysiology, Prospective Studies, prospective study, psychologic test, psychology, rugby, SOUTH Africa, sport injury, TASK performance, traumatic brain injury, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Biederman, J; Feinberg, L; Chan, J; Adeyemo, B O; Woodworth, K Y; Panis, W; McGrath, N; Bhatnagar, S; Spencer, T J; Uchida, M; Kenworthy, T; Grossman, R; Zafonte, R; Faraone, S V
Mild Traumatic Brain Injury and Attention-Deficit Hyperactivity Disorder in Young Student Athletes Journal Article
In: Journal of Nervous & Mental Disease, vol. 203, no. 11, pp. 813–819, 2015.
Abstract | BibTeX | Tags: *Athletes, *Athletic Injuries/ep [Epidemiology], *Attention Deficit Disorder with Hyperactivity/ep, *Brain Injuries/ep [Epidemiology], *Students, Adolescent, adult, Athletic Injuries/di [Diagnosis], Attention Deficit Disorder with Hyperactivity/di [, Brain Injuries/di [Diagnosis], Child, Female, Humans, Male, Risk Factors, Young Adult
@article{Biederman2015,
title = {Mild Traumatic Brain Injury and Attention-Deficit Hyperactivity Disorder in Young Student Athletes},
author = {Biederman, J and Feinberg, L and Chan, J and Adeyemo, B O and Woodworth, K Y and Panis, W and McGrath, N and Bhatnagar, S and Spencer, T J and Uchida, M and Kenworthy, T and Grossman, R and Zafonte, R and Faraone, S V},
year = {2015},
date = {2015-01-01},
journal = {Journal of Nervous \& Mental Disease},
volume = {203},
number = {11},
pages = {813--819},
abstract = {A recent meta-analysis documented a significant statistical association between mild traumatic brain injury (mTBI) and attention deficit hyperactivity disorder (ADHD) (Adeyemo et al., 2014), but the direction of this effect was unclear. In this study, we hypothesized that ADHD would be an antecedent risk factor for mTBI. Participants were student athletes ages 12 to 25 who had sustained a mTBI and Controls of similar age and sex selected from studies of youth with and without ADHD. Subjects were assessed for symptoms of ADHD, concussion severity, and cognitive function. mTBI subjects had a significantly higher rate of ADHD than Controls, and in all cases the age of onset of ADHD was before mTBI onset. mTBI+ADHD subjects also had more severe concussion symptoms (fatigue and poor concentration) than mTBI-ADHD subjects. These results support ADHD as an antecedent risk factor for mTBI in student athletes and that its presence complicates the course of mTBI.},
keywords = {*Athletes, *Athletic Injuries/ep [Epidemiology], *Attention Deficit Disorder with Hyperactivity/ep, *Brain Injuries/ep [Epidemiology], *Students, Adolescent, adult, Athletic Injuries/di [Diagnosis], Attention Deficit Disorder with Hyperactivity/di [, Brain Injuries/di [Diagnosis], Child, Female, Humans, Male, Risk Factors, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Jackson, K; Rubin, R; Van Hoeck, N; Hauert, T; Lana, V; Wang, H
The effect of selective head-neck cooling on physiological and cognitive functions in healthy volunteers Journal Article
In: Translational Neuroscience, vol. 6, no. 1, pp. 131–138, 2015.
Abstract | Links | BibTeX | Tags: adult, Article, Athletics, body temperature, body temperature measurement, brain, brain temperature, clinical assessment, clinical effectiveness, cognition, cold tolerance, cold treatment, Concussion, diastolic blood pressure, executive function, Feasibility, Female, head neck cooling, Heart Rate, human, human experiment, infrared thermometer, Intervention, Male, mouth temperature, normal human, physiological process, priority journal, pulse oximetry, room temperature, systolic blood pressure, TASK performance, temperature management device, thermoregulation, tympanic temperature, velocity, welkins emt temperature management system, working memory
@article{Jackson2015,
title = {The effect of selective head-neck cooling on physiological and cognitive functions in healthy volunteers},
author = {Jackson, K and Rubin, R and {Van Hoeck}, N and Hauert, T and Lana, V and Wang, H},
doi = {10.1515/tnsci-2015-0012},
year = {2015},
date = {2015-01-01},
journal = {Translational Neuroscience},
volume = {6},
number = {1},
pages = {131--138},
abstract = {In general, brain temperatures are elevated during physical sporting activities; therefore, reducing brain temperature shortly after a sports-related concussion (SRC) could be a promising intervention technique. The main objective of this study was to examine the effects of head and neck cooling on physiological and cognitive function in normal healthy volunteers. Twelve healthy volunteers underwent two different sessions of combined head and neck cooling, one session with a cold pack and one session with a room temperature pack. Physiological measurements included: systolic/diastolic blood pressure, pulse oximetry, heart rate, and sublingual and tympanic temperature. Cognitive assessment included: processing speed, executive function, and working memory tasks. Physiological measurements were taken pre-, mid- and post-cooling, while cognitive assessments were done before and after cooling. The order of the sessions was randomized. There was a significant decrease in tympanic temperature across both sessions; however more cooling occurred when the cold pack was in the device. There was no significant decrease in sublingual temperature across either session. The observed heart rates, pulse oximetry, systolic and diastolic blood pressure during the sessions were all within range of a normal healthy adult. Cognitive assessment remained stable across each session for both pre- and post-cooling. We propose that optimizing brain temperature management after brain injury using head and neck cooling technology may represent a sensible, practical, and effective strategy to potentially enhance recovery and perhaps minimize the subsequent short and long term consequences from SRC. © 2015 Kevin Jackson et al.},
keywords = {adult, Article, Athletics, body temperature, body temperature measurement, brain, brain temperature, clinical assessment, clinical effectiveness, cognition, cold tolerance, cold treatment, Concussion, diastolic blood pressure, executive function, Feasibility, Female, head neck cooling, Heart Rate, human, human experiment, infrared thermometer, Intervention, Male, mouth temperature, normal human, physiological process, priority journal, pulse oximetry, room temperature, systolic blood pressure, TASK performance, temperature management device, thermoregulation, tympanic temperature, velocity, welkins emt temperature management system, working memory},
pubstate = {published},
tppubtype = {article}
}
Billock, R M; Anderegg, J J; Mehan, T J; Chounthirath, T; Smith, G A
Zipline-related injuries treated in US EDs, 1997-2012 Journal Article
In: American Journal of Emergency Medicine, vol. 33, no. 12, pp. 1745–1749, 2015.
Abstract | Links | BibTeX | Tags: Accidental Falls, Adolescent, adult, arm fracture, Article, body regions, Child, Concussion, emergency health service, Emergency Service, emergency ward, EPIDEMIOLOGY, falling, Female, head and neck injury, head injury, Hospital, hospitalization, human, Humans, Infant, leg injury, major clinical study, Male, Newborn, Preschool, preschool child, priority journal, recreation, residential area, SAFETY, soft tissue injury, sport injury, sprain, statistics and numerical data, trunk injury, UNITED States, Wounds and Injuries, Young Adult, zipline related injury
@article{Billock2015,
title = {Zipline-related injuries treated in US EDs, 1997-2012},
author = {Billock, R M and Anderegg, J J and Mehan, T J and Chounthirath, T and Smith, G A},
doi = {10.1016/j.ajem.2015.08.022},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Emergency Medicine},
volume = {33},
number = {12},
pages = {1745--1749},
abstract = {Purpose To investigate the epidemiology of zipline-related injuries in the United States. Basic Procedures The National Electronic Injury Surveillance System database was used to examine non-fatal zipline-related injuries treated in US emergency departments (EDs) from 1997 through 2012. Sample weights were applied to calculate national estimates. Main Findings From 1997 through 2012, an estimated 16 850 (95% CI, 13 188-20 512) zipline-related injuries were treated in US EDs. The annual injury rate per 1 million population increased by 52.3% from 7.64 (95% CI, 4.86-10.42) injuries in 2009 (the first year with a stable annual estimate) to 11.64 (95% CI, 7.83-15.45) injuries in 2012. Patients aged 0-9 years accounted for 45.0% of injuries, females made up 53.1% of injuries, and 11.7% of patients required hospitalization. Fractures accounted for the largest proportion of injuries (46.7%), and the upper extremities were the most commonly injured body region (44.1%). Falls were the most common mechanism of injury, accounting for 77.3% of injuries. Among cases where the location of the injury event was known, 30.8% of injuries occurred in a residential setting and 69.2% occurred in a public place. Principal Conclusions This study is the first to characterize the epidemiology of zipline-related injuries using a nationally representative database. The rapid increase in zipline-related injuries in recent years suggests the need for additional safety guidelines and regulations. Commercial ziplines and publicly accessible non-commercial ziplines should be subject to uniform safety standards in all states and jurisdictions across the US, and homemade ziplines should not be used. © 2015 Elsevier Inc.},
keywords = {Accidental Falls, Adolescent, adult, arm fracture, Article, body regions, Child, Concussion, emergency health service, Emergency Service, emergency ward, EPIDEMIOLOGY, falling, Female, head and neck injury, head injury, Hospital, hospitalization, human, Humans, Infant, leg injury, major clinical study, Male, Newborn, Preschool, preschool child, priority journal, recreation, residential area, SAFETY, soft tissue injury, sport injury, sprain, statistics and numerical data, trunk injury, UNITED States, Wounds and Injuries, Young Adult, zipline related injury},
pubstate = {published},
tppubtype = {article}
}
Kerr, Z Y; Mihalik, J P; Guskiewicz, K M; Rosamond, W D; Evenson, K R; Marshall, S W
Agreement between athlete-recalled and clinically documented concussion histories in former collegiate athletes Journal Article
In: American Journal of Sports Medicine, vol. 43, no. 3, pp. 606–613, 2015.
Abstract | Links | BibTeX | Tags: adult, athlete, Athletes, Athletic Injuries, brain concussion, cohort analysis, Cohort Studies, comparative study, concurrent validity, Concussion, EPIDEMIOLOGY, Female, human, Humans, injury, interpersonal communication, medical record, MEDICAL records, Mental Recall, psychology, recall, self report, sex difference, Sex Factors, traumatic brain injury, Truth Disclosure, Universities, university
@article{Kerr2015,
title = {Agreement between athlete-recalled and clinically documented concussion histories in former collegiate athletes},
author = {Kerr, Z Y and Mihalik, J P and Guskiewicz, K M and Rosamond, W D and Evenson, K R and Marshall, S W},
doi = {10.1177/0363546514562180},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Sports Medicine},
volume = {43},
number = {3},
pages = {606--613},
abstract = {Background: Athlete-recalled and clinically documented concussion histories have been used in research on former athletes, but both have limitations. Comparisons of these 2 types of concussion histories are needed to improve the accuracy of estimates of concussion history for future research and clinical care. Purpose: To estimate the agreement between athlete-recalled and clinically documented concussion histories during college and to explore reasons for differences. Study: Cohort study (diagnosis); Level of evidence, 3. Methods: Athlete-recalled concussion histories were provided by a convenience sample of 130 former collegiate athletes using an online questionnaire, and they were individually linked to previously collected clinical data that tracked medically diagnosed concussions at the host institution from 1996 to 2012. The intraclass correlation coefficient (ICC2,1) was used to assess agreement between athlete-recalled and clinically documented concussion histories. Descriptive analyses were performed to assess reasons for disagreement. Results: Agreement between athlete-recalled and clinically documented concussion histories was low (ICC2},
keywords = {adult, athlete, Athletes, Athletic Injuries, brain concussion, cohort analysis, Cohort Studies, comparative study, concurrent validity, Concussion, EPIDEMIOLOGY, Female, human, Humans, injury, interpersonal communication, medical record, MEDICAL records, Mental Recall, psychology, recall, self report, sex difference, Sex Factors, traumatic brain injury, Truth Disclosure, Universities, university},
pubstate = {published},
tppubtype = {article}
}
Register-Mihalik, J K; De Maio, V J; Tibbo-Valeriote, H L; Wooten, J D
Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia Journal Article
In: Clinical Journal of Sport Medicine, vol. 25, no. 6, pp. 502–508, 2015.
Abstract | BibTeX | Tags: Adolescent, adult, amnesia, anamnesis, Article, brain concussion, Child, complication, Concussion, Concussive injury, Cross-Sectional Studies, cross-sectional study, Demography, disease severity, emergency ward, ethnology, Female, head injury, human, Humans, major clinical study, Male, MEDICAL history taking, Memory, ODDS ratio, outcome assessment, postconcussion symptoms, priority journal, race, Retrospective Studies, retrospective study, Risk, risk factor, Risk Factors, unconsciousness
@article{Register-Mihalik2015,
title = {Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia},
author = {Register-Mihalik, J K and {De Maio}, V J and Tibbo-Valeriote, H L and Wooten, J D},
year = {2015},
date = {2015-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {25},
number = {6},
pages = {502--508},
abstract = {Objective: The current study examines the demographics, injury characteristics, and outcomes associated with the presence of postconcussion amnesia in young concussion clinic patients. Design: Cross-sectional, retrospective clinical cohort. Setting: Concussion services clinic. Patients: Pediatric and adolescent concussion services program patients, presenting within 10 days postinjury, aged 10-18 years, with the goal of returning to sport (n = 245). Assessment of Risk Factors: Age, gender, race, head trauma history, injury mechanism, loss of consciousness (LOC), injuryrelated visit to an emergency department, cognitive and balance scores, symptoms, and management recommendations. Main Outcome Measures: Univariate and multivariate analyses determined adjusted odds ratios for reported presence of any postconcussion amnesia (anterograde or retrograde). Results: Factors associated with amnesia (univariate, P \< 0.10) and included in the multivariate model were race, head trauma history, mechanism of injury, LOC, injury-related visit to an emergency department, management recommendations and time of injury and initial visit symptom severity. Age and gender were also included in the model due to biological significance. Of the 245 patients, 181 had data for all model variables. Of the 181 patients, 58 reported amnesia. History of head trauma [odds ratio (OR), 2.7; 95% confidence interval (CI), 1.3-5.7]; time of injury (TOI) symptom severity \>75th percentile (OR, 2.6; 95% CI, 1.2-5.3) and LOC (OR, 2.2; 95% CI, 1.1-4.6) were found to have significant and independent relationships with amnesia in the multivariate model. Conclusions: This study illustrates that patients presenting with postconcussion amnesia are more likely to have a history of head trauma, LOC, and greater symptom severity. Future research is needed to better understand amnesia following concussion. Clinical Relevance: Amnesia presence, previous head trauma, LOC, and increased symptom severity may aid in identifying patients with a greater initial injury burden who warrant closer observation and more conservative management. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {Adolescent, adult, amnesia, anamnesis, Article, brain concussion, Child, complication, Concussion, Concussive injury, Cross-Sectional Studies, cross-sectional study, Demography, disease severity, emergency ward, ethnology, Female, head injury, human, Humans, major clinical study, Male, MEDICAL history taking, Memory, ODDS ratio, outcome assessment, postconcussion symptoms, priority journal, race, Retrospective Studies, retrospective study, Risk, risk factor, Risk Factors, unconsciousness},
pubstate = {published},
tppubtype = {article}
}
Brown, J C; Viljoen, W; Lambert, M I; Readhead, C; Fuller, C; Van Mechelen, W; Verhagen, E
The economic burden of time-loss injuries to youth players participating in week-long rugby union tournaments Journal Article
In: Journal of Science & Medicine in Sport, vol. 18, no. 4, pp. 394–399, 2015.
Abstract | Links | BibTeX | Tags: Absenteeism, Adolescent, adult, Article, Athletic Injuries, Back Injuries, biokinetics, bone, Child, competition, Concussion, contusion, Craniocerebral Trauma, economic evaluation, economics, follow up, football, Football/economics, Football/economics/cost analysis, Football/injuries (MeSH terms), fracture, Fractures, head injury, Health, health care cost, Health Care Costs, health insurance, human, Humans, Injuries, injury, injury scale, Insurance, laceration, legal guardian, Lower Extremity, lower limb, major clinical study, Male, MEDICAL care, muscle cramp, muscle strain, Neck Injuries, neck injury, Occupational Therapy, Parent, physical medicine, physiotherapy, radiodiagnosis, rugby, skin bruising, SOUTH Africa, sport injury, Trauma Severity Indices, Upper Extremity, upper limb, Wounds and Injuries
@article{Brown2015b,
title = {The economic burden of time-loss injuries to youth players participating in week-long rugby union tournaments},
author = {Brown, J C and Viljoen, W and Lambert, M I and Readhead, C and Fuller, C and {Van Mechelen}, W and Verhagen, E},
doi = {10.1016/j.jsams.2014.06.015},
year = {2015},
date = {2015-01-01},
journal = {Journal of Science \& Medicine in Sport},
volume = {18},
number = {4},
pages = {394--399},
abstract = {Objectives: Rugby Union ("rugby") is a popular sport with high injury risk. Burden of injury is described by the incidence and severity of injury. However reports have ignored the monetary cost of injuries. Therefore the aim of this study was to describe the monetary cost associated with youth rugby injuries. Design: This descriptive study quantified medical treatments of injured players at the South African Rugby Union Youth tournaments in 2011/2012 and the days of work parents missed as a result of the injuries. A health insurer used these data to calculate associated costs. Methods: Legal guardians of the 421 injured players were contacted telephonically on a weekly basis until they returned to play. Treatments costs were estimated in South African Rands based on 2013 insurance rates and converted to US$ using purchasing power parities. Results: Of the 3652 players, 2% (n=71) sought medical care after the tournament. For these players, average treatment costs were high (US$731 per player, 95% CI: US$425-US$1096), with fractures being the most expensive type of injury. Players with medical insurance had higher costs (US$937, 95% CI: US$486-US$1500) than those without (US$220, 95% CI: US$145-US$302). Conclusions: Although a minority of players sought follow-up treatment after the tournaments, the cost of these injuries was high. Players without medical insurance having lower costs may indicate that these players did not receive adequate treatment for their injuries. Injury prevention efforts should consider injuries with high costs and the treatment of players without medical insurance. © 2014 Sports Medicine Australia.},
keywords = {Absenteeism, Adolescent, adult, Article, Athletic Injuries, Back Injuries, biokinetics, bone, Child, competition, Concussion, contusion, Craniocerebral Trauma, economic evaluation, economics, follow up, football, Football/economics, Football/economics/cost analysis, Football/injuries (MeSH terms), fracture, Fractures, head injury, Health, health care cost, Health Care Costs, health insurance, human, Humans, Injuries, injury, injury scale, Insurance, laceration, legal guardian, Lower Extremity, lower limb, major clinical study, Male, MEDICAL care, muscle cramp, muscle strain, Neck Injuries, neck injury, Occupational Therapy, Parent, physical medicine, physiotherapy, radiodiagnosis, rugby, skin bruising, SOUTH Africa, sport injury, Trauma Severity Indices, Upper Extremity, upper limb, Wounds and Injuries},
pubstate = {published},
tppubtype = {article}
}
Barrio, J R; Small, G W; Wong, K P; Huang, S C; Liu, J; Merrill, D A; Giza, C C; Fitzsimmons, R P; Omalu, B; Bailes, J; Kepe, V
In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging.[Erratum appears in Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2981; PMID: 25964344] Journal Article
In: Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 16, pp. E2039–47, 2015.
Abstract | BibTeX | Tags: *Brain Injury, *Brain/pa [Pathology], *Brain/ri [Radionuclide Imaging], *Nitriles, *Positron-Emission Tomography, 0 (2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphth, 0 (Nitriles), 80 and over, adult, aged, Alzheimer Disease/ri [Radionuclide Imaging], Amygdala/mi [Microbiology], Amygdala/pa [Pathology], autopsy, Case-Control Studies, Chronic/ri [Radionuclide Imaging], Demography, Humans, Male, Mesencephalon/mi [Microbiology], Mesencephalon/pa [Pathology], middle aged
@article{Barrio2015,
title = {In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging.[Erratum appears in Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2981; PMID: 25964344]},
author = {Barrio, J R and Small, G W and Wong, K P and Huang, S C and Liu, J and Merrill, D A and Giza, C C and Fitzsimmons, R P and Omalu, B and Bailes, J and Kepe, V},
year = {2015},
date = {2015-01-01},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
volume = {112},
number = {16},
pages = {E2039--47},
abstract = {Chronic traumatic encephalopathy (CTE) is an acquired primary tauopathy with a variety of cognitive, behavioral, and motor symptoms linked to cumulative brain damage sustained from single, episodic, or repetitive traumatic brain injury (TBI). No definitive clinical diagnosis for this condition exists. In this work, we used [F-18]FDDNP PET to detect brain patterns of neuropathology distribution in retired professional American football players with suspected CTE (n = 14) and compared results with those of cognitively intact controls (n = 28) and patients with Alzheimer's dementia (AD) (n = 24), a disease that has been cognitively associated with CTE. [F-18]FDDNP PET imaging results in the retired players suggested the presence of neuropathological patterns consistent with models of concussion wherein brainstem white matter tracts undergo early axonal damage and cumulative axonal injuries along subcortical, limbic, and cortical brain circuitries supporting mood, emotions, and behavior. This deposition pattern is distinctively different from the progressive pattern of neuropathology [paired helical filament (PHF)-tau and amyloid-beta] in AD, which typically begins in the medial temporal lobe progressing along the cortical default mode network, with no or minimal involvement of subcortical structures. This particular [F-18]FDDNP PET imaging pattern in cases of suspected CTE also is primarily consistent with PHF-tau distribution observed at autopsy in subjects with a history of mild TBI and autopsy-confirmed diagnosis of CTE.},
keywords = {*Brain Injury, *Brain/pa [Pathology], *Brain/ri [Radionuclide Imaging], *Nitriles, *Positron-Emission Tomography, 0 (2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphth, 0 (Nitriles), 80 and over, adult, aged, Alzheimer Disease/ri [Radionuclide Imaging], Amygdala/mi [Microbiology], Amygdala/pa [Pathology], autopsy, Case-Control Studies, Chronic/ri [Radionuclide Imaging], Demography, Humans, Male, Mesencephalon/mi [Microbiology], Mesencephalon/pa [Pathology], middle aged},
pubstate = {published},
tppubtype = {article}
}
Vassilyadi, M; Macartney, G; Barrowman, N; Anderson, P; Dube, K
Symptom experience and quality of life in children after sport-related head injuries: A cross-sectional study Journal Article
In: Pediatric Neurosurgery, vol. 50, no. 4, pp. 196–203, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, adult, affect, Article, Athletic Injuries, behavior disorder, brain concussion, Child, clinical article, clinical assessment, cognitive defect, Cognitive Efficiency Index, complication, Concussion, Concussion Symptom Scale, controlled study, Craniocerebral Trauma, Cross-Sectional Studies, cross-sectional study, fatigue, Female, head injury, headache, human, Humans, Immediate Postconcussion Assessment and Cognitive, Likert scale, Male, memory disorder, mild traumatic brain injury, neuropsychological test, noise, Paediatric patients, Pediatric Quality of Life Inventory, postconcussion syndrome, priority journal, psychology, quality of life, rating scale, scoring system, Sport, sport injury, Sports, symptom, time factor, Time Factors, traumatic brain injury, trends
@article{Vassilyadi2015,
title = {Symptom experience and quality of life in children after sport-related head injuries: A cross-sectional study},
author = {Vassilyadi, M and Macartney, G and Barrowman, N and Anderson, P and Dube, K},
doi = {10.1159/000431232},
year = {2015},
date = {2015-01-01},
journal = {Pediatric Neurosurgery},
volume = {50},
number = {4},
pages = {196--203},
abstract = {Background: Sports are a major cause of concussions, and little is known about the symptom experience and health-related quality of life (HRQL) in children who remain symptomatic for over 3 months following such head injuries. Methods: A cross-sectional study of children aged 10-18 years was performed who were referred to the Neurosurgery Clinic at our centre following a head injury. Symptom experience was measured using the modified Concussion Symptom Scale, and HRQL was measured using the Pediatric Quality of Life Inventory (PedsQL). The Immediate Postconcussion Assessment and Cognitive Test (ImPACT) was administered to assess neurocognitive and neurobehavioural sequelae. Results: Symptoms with the highest mean symptom scores on a Likert scale of 0-6 in 35 children at the time of assessment included headaches (3.1), poor concentration (2.7), memory problems (2.1), fatigue (2.1) and sensitivity to noise (2.0). Compared with normative data, children in this study had ImPACT summary scores between the 28th and 38th percentiles and a comparably low Cognitive Efficiency Index score. Mean scores for females were consistently statistically significantly lower (p \< 0.05) than for males across all of the HRQL domains. Trouble falling asleep and memory problems explained 62% of the variance in the PedsQL total scores. Conclusions: Children continue to experience many symptoms at least 3 months following sport-related head injuries that significantly impact their HRQL and neurocognitive abilities. © 2015 S. Karger AG, Basel.},
keywords = {Adolescent, adult, affect, Article, Athletic Injuries, behavior disorder, brain concussion, Child, clinical article, clinical assessment, cognitive defect, Cognitive Efficiency Index, complication, Concussion, Concussion Symptom Scale, controlled study, Craniocerebral Trauma, Cross-Sectional Studies, cross-sectional study, fatigue, Female, head injury, headache, human, Humans, Immediate Postconcussion Assessment and Cognitive, Likert scale, Male, memory disorder, mild traumatic brain injury, neuropsychological test, noise, Paediatric patients, Pediatric Quality of Life Inventory, postconcussion syndrome, priority journal, psychology, quality of life, rating scale, scoring system, Sport, sport injury, Sports, symptom, time factor, Time Factors, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Gouttebarge, V; Ooms, W; Tummers, T; Inklaar, H
Mortality in international professional football (soccer): a descriptive study Journal Article
In: Journal of Sports Medicine & Physical Fitness, vol. 55, no. 11, pp. 1376–1382, 2015.
Abstract | BibTeX | Tags: *Athletes/sn [Statistics & Numerical Data], *Death, *Soccer, adult, Cardiac/ep [Epidemiology], Cause of Death/td [Trends], Humans, Male, middle aged, Netherlands/ep [Epidemiology], Prospective Studies, Sudden
@article{Gouttebarge2015,
title = {Mortality in international professional football (soccer): a descriptive study},
author = {Gouttebarge, V and Ooms, W and Tummers, T and Inklaar, H},
year = {2015},
date = {2015-01-01},
journal = {Journal of Sports Medicine \& Physical Fitness},
volume = {55},
number = {11},
pages = {1376--1382},
abstract = {The objective of this study was to describe the characteristics of mortalities from 2007 to 2013 in active (during career) and recently retired (post career) professional footballers. An observational prospective study was conducted. From 2007, the World Footballers' Union (FIFPro) and its related national footballers' unions (more than 70 countries distributed across all continents) collected descriptive data (football-related, cause, etc.) on mortality of active (during career) and recently retired (postcareer before reaching 45 years of age) professional footballers by means of several official sources. A total of 214 deaths were recorded among active and recently retired professional footballers, leading to an overall mortality rate of 0.47 per 1000 footballers per year. Of the 214 deaths, 183 were recorded among active players and 31 among recently retired players. Among the active players, 17% of the fatalities were related to football participation. Disease was the leading cause of death among professional footballers (55%), of which up to 33% accounted for suspected cardiac pathology. Accidents accounted for 25% of the overall deaths, and suicide for 11%. From 2007 to 2013, 214 deaths were recorded among active (during career) and recently retired (post career) professional footballers. Leading cause of death was disease (55%), one third of which were accounted for by suspected cardiac pathology, while accidents accounted for 25% of all deaths, and suicide for 11%. Attention to the predictive validity and application of heart-related precompetition medical assessment should be given, and mental health support should be developed and implemented both during and after a professional football career to prevent potential suicidal behaviors.},
keywords = {*Athletes/sn [Statistics \& Numerical Data], *Death, *Soccer, adult, Cardiac/ep [Epidemiology], Cause of Death/td [Trends], Humans, Male, middle aged, Netherlands/ep [Epidemiology], Prospective Studies, Sudden},
pubstate = {published},
tppubtype = {article}
}
Oeur, R A; Karton, C; Post, A; Rousseau, P; Hoshizaki, T B; Marshall, S; Brien, S E; Smith, A; Cusimano, M D; Gilchrist, M D
In: Journal of Neurosurgery, vol. 123, no. 2, pp. 415–422, 2015.
Abstract | Links | BibTeX | Tags: accident, Accident reconstruction, accidental injury, Accidents, Adolescent, adult, Article, Biomechanical Phenomena, Biomechanics, brain, brain concussion, brain stem, brain tissue, Cerebellum, clinical article, comparative study, Concussion, controlled study, Female, finite element analysis, Finite element modelling, gray matter, Hematoma, human, Humans, Hybrid iii headform, injury severity, laboratory test, Male, Mechanical, mechanical stress, middle aged, pathology, Pathophysiology, Persistent postconcussive symptoms, PHYSIOLOGY, Post Hoc Analysis, Post-Concussion Syndrome, postconcussion syndrome, priority journal, shear stress, simulation, SPORTS medicine, STATISTICAL significance, Stress, stress strain relationship, Subdural, subdural hematoma, traumatic brain injury, white matter, Young Adult
@article{Oeur2015,
title = {A comparison of head dynamic response and brain tissue stress and strain using accident reconstructions for concussion, concussion with persistent postconcussive symptoms, and subdural hematoma},
author = {Oeur, R A and Karton, C and Post, A and Rousseau, P and Hoshizaki, T B and Marshall, S and Brien, S E and Smith, A and Cusimano, M D and Gilchrist, M D},
doi = {10.3171/2014.10.JNS14440},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurosurgery},
volume = {123},
number = {2},
pages = {415--422},
abstract = {Object Concussions typically resolve within several days, but in a few cases the symptoms last for a month or longer and are termed persistent postconcussive symptoms (PPCS). These persisting symptoms may also be associated with more serious brain trauma similar to subdural hematoma (SDH). The objective of this study was to investigate the head dynamic and brain tissue responses of injury reconstructions resulting in concussion, PPCS, and SDH. Methods Reconstruction cases were obtained from sports medicine clinics and hospitals. All subjects received a direct blow to the head resulting in symptoms. Those symptoms that resolved in 9 days or fewer were defined as concussions (n = 3). Those with symptoms lasting longer than 18 months were defined as PPCS (n = 3), and 3 patients presented with SDHs (n = 3). A Hybrid III headform was used in reconstruction to obtain linear and rotational accelerations of the head. These dynamic response data were then input into the University College Dublin Brain Trauma Model to calculate maximum principal strain and von Mises stress. A Kruskal-Wallis test followed by Tukey post hoc tests were used to compare head dynamic and brain tissue responses between injury groups. Statistical significance was set at p \< 0.05. Results A significant difference was identified for peak resultant linear and rotational acceleration between injury groups. Post hoc analyses revealed the SDH group had higher linear and rotational acceleration responses (316 g and 23,181 rad/sec2, respectively) than the concussion group (149 g and 8111 rad/sec2, respectively; p \< 0.05). No significant differences were found between groups for either brain tissue measures of maximum principal strain or von Mises stress. Conclusions The reconstruction of accidents resulting in a concussion with transient symptoms (low severity) and SDHs revealed a positive relationship between an increase in head dynamic response and the risk for more serious brain injury. This type of relationship was not found for brain tissue stress and strain results derived by finite element analysis. Future research should be undertaken using a larger sample size to confirm these initial findings. Understanding the relationship between the head dynamic and brain tissue response and the nature of the injury provides important information for developing strategies for injury prevention. © AANS, 2015.},
keywords = {accident, Accident reconstruction, accidental injury, Accidents, Adolescent, adult, Article, Biomechanical Phenomena, Biomechanics, brain, brain concussion, brain stem, brain tissue, Cerebellum, clinical article, comparative study, Concussion, controlled study, Female, finite element analysis, Finite element modelling, gray matter, Hematoma, human, Humans, Hybrid iii headform, injury severity, laboratory test, Male, Mechanical, mechanical stress, middle aged, pathology, Pathophysiology, Persistent postconcussive symptoms, PHYSIOLOGY, Post Hoc Analysis, Post-Concussion Syndrome, postconcussion syndrome, priority journal, shear stress, simulation, SPORTS medicine, STATISTICAL significance, Stress, stress strain relationship, Subdural, subdural hematoma, traumatic brain injury, white matter, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Caryn, R C; Hazell, T J; Dickey, J P
Transmission of acceleration from a synchronous vibration exercise platform to the head Journal Article
In: International Journal of Sports Medicine, vol. 35, no. 4, pp. 330–338, 2014.
Abstract | BibTeX | Tags: *Exercise/ph [Physiology], *HEAD, *Knee Joint/ph [Physiology], *Posture/ph [Physiology], *Sports Equipment, *Vibration, Acceleration, adult, Humans, Male
@article{Caryn2014,
title = {Transmission of acceleration from a synchronous vibration exercise platform to the head},
author = {Caryn, R C and Hazell, T J and Dickey, J P},
year = {2014},
date = {2014-01-01},
journal = {International Journal of Sports Medicine},
volume = {35},
number = {4},
pages = {330--338},
abstract = {Exercise vibration platforms are becoming commonplace in homes and fitness centers. However, excessive mechanical energy transferred to the head and eye can cause injury. The purpose of this study was to evaluate how changes in platform frequency and knee flexion angle affect acceleration transmission to the head. Participants (N=12) stood on a whole-body vibration platform with knee flexion angles of 0degree, 20degree, and 40degree to evaluate how changes in knee flexion affected head acceleration. 7 specific platform frequencies were tested between 20-50Hz at 2 peak-to-peak displacement settings (1 and 2mm nominal). Accelerations were measured with triaxial accelerometers at the platform and head to generate transmissibility ratios. Platform-to-head transmissibility was not significantly different between the 2 platform peak-to-peak amplitudes (P\>0.05). Transmissibility measures varied depending on platform frequency and knee angle (P\<0.05). Flexing the knees resulted in reduced head transmissibility at all frequencies (P\<0.05). Platform-to-head transmissibility values exceeded 1.0 at both 20 and 25Hz platform vibration frequencies with the knees in full extension. To reduce the risk of injury to structures of the head during vibration exercise, using platforms frequencies below 30Hz with small knee flexion angles (\<40degree) should be avoided. Copyright © Georg Thieme Verlag KG Stuttgart . New York.},
keywords = {*Exercise/ph [Physiology], *HEAD, *Knee Joint/ph [Physiology], *Posture/ph [Physiology], *Sports Equipment, *Vibration, Acceleration, adult, Humans, Male},
pubstate = {published},
tppubtype = {article}
}
Mitsis, E M; Riggio, S; Kostakoglu, L; Dickstein, D L; Machac, J; Delman, B; Goldstein, M; Jennings, D; D'Antonio, E; Martin, J; Naidich, T P; Aloysi, A; Fernandez, C; Seibyl, J; DeKosky, S T; Elder, G A; Marek, K; Gordon, W; Hof, P R; Sano, M; Gandy, S
In: Translational Psychiatry, vol. 4, no. 9, 2014.
Abstract | Links | BibTeX | Tags: adult, aged, amyloid plaque, arachnoid cyst, Article, case report, Chronic Traumatic Encephalopathy florbetapir f 18, Concussion, diagnostic accuracy, eye movement, football, frontotemporal dementia, head injury, human, injury severity, ligand binding, Male, memory disorder, middle aged, molecular imaging, motor dysfunction, muscle tone, personality disorder, positron emission tomography, short term memory, subdural hematoma, tauopathy, traumatic brain injury
@article{Mitsis2014,
title = {Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: Studies of a retired NFL player and of a man with FTD and a severe head injury},
author = {Mitsis, E M and Riggio, S and Kostakoglu, L and Dickstein, D L and Machac, J and Delman, B and Goldstein, M and Jennings, D and D'Antonio, E and Martin, J and Naidich, T P and Aloysi, A and Fernandez, C and Seibyl, J and DeKosky, S T and Elder, G A and Marek, K and Gordon, W and Hof, P R and Sano, M and Gandy, S},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84918535750\&partnerID=40\&md5=704b918a7429432cbd631e703c44eb63},
doi = {10.1038/tp.2014.91},
year = {2014},
date = {2014-01-01},
journal = {Translational Psychiatry},
volume = {4},
number = {9},
abstract = {Single, severe traumatic brain injury (TBI) which elevates CNS amyloid, increases the risk of Alzheimer's disease (AD); while repetitive concussive and subconcussive events as observed in athletes and military personnel, may increase the risk of chronic traumatic encephalopathy (CTE). We describe two clinical cases, one with a history of multiple concussions during a career in the National Football League (NFL) and the second with frontotemporal dementia and a single, severe TBI. Both patients presented with cognitive decline and underwent [18F]-Florbetapir positron emission tomography (PET) imaging for amyloid plaques; the retired NFL player also underwent [18F]-T807 PET imaging, a new ligand binding to tau, the main constituent of neurofibrillary tangles (NFT). Case 1, the former NFL player, was 71 years old when he presented with memory impairment and a clinical profile highly similar to AD. [18F]-Florbetapir PET imaging was negative, essentially excluding AD as a diagnosis. CTE was suspected clinically, and [18F]-T807 PET imaging revealed striatal and nigral [18F]-T807 retention consistent with the presence of tauopathy. Case 2 was a 56- year-old man with personality changes and cognitive decline who had sustained a fall complicated by a subdural hematoma. At 1 year post injury, [18F]-Florbetapir PET imaging was negative for an AD pattern of amyloid accumulation in this subject. Focal [18F]- Florbetapir retention was noted at the site of impact. In case 1, amyloid imaging provided improved diagnostic accuracy where standard clinical and laboratory criteria were inadequate. In that same case, tau imaging with [18F]-T807 revealed a subcortical tauopathy that we interpret as a novel form of CTE with a distribution of tauopathy that mimics, to some extent, that of progressive supranuclear palsy (PSP), despite a clinical presentation of amnesia without any movement disorder complaints or signs. A key distinguishing feature is that our patient presented with hippocampal involvement, which is more frequently seen in CTE than in PSP. In case 2, focal [18F]-Florbetapir retention at the site of injury in an otherwise negative scan suggests focal amyloid aggregation. In each of these complex cases, a combination of [18F]-fluorodeoxyglucose, [18F]-Florbetapir and/or [18F]-T807 PET molecular imaging improved the accuracy of diagnosis and prevented inappropriate interventions. © 2014 Macmillan Publishers Limited.},
keywords = {adult, aged, amyloid plaque, arachnoid cyst, Article, case report, Chronic Traumatic Encephalopathy florbetapir f 18, Concussion, diagnostic accuracy, eye movement, football, frontotemporal dementia, head injury, human, injury severity, ligand binding, Male, memory disorder, middle aged, molecular imaging, motor dysfunction, muscle tone, personality disorder, positron emission tomography, short term memory, subdural hematoma, tauopathy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Jadischke, R; Viano, D C; Dau, N; King, A I; McCarthy, J
On the accuracy of the Head Impact Telemetry (HIT) System used in football helmets Journal Article
In: Journal of Biomechanics, vol. 46, no. 13, pp. 2310–2315, 2013.
Abstract | BibTeX | Tags: *Head Protective Devices/st [Standards], *Materials Testing, *Sports Equipment/st [Standards], *Telemetry/is [Instrumentation], Adolescent, adult, Equipment Design, football, Humans, Male, Pressure, Young Adult
@article{Jadischke2013,
title = {On the accuracy of the Head Impact Telemetry (HIT) System used in football helmets},
author = {Jadischke, R and Viano, D C and Dau, N and King, A I and McCarthy, J},
year = {2013},
date = {2013-01-01},
journal = {Journal of Biomechanics},
volume = {46},
number = {13},
pages = {2310--2315},
abstract = {On-field measurement of head impacts has relied on the Head Impact Telemetry (HIT) System, which uses helmet mounted accelerometers to determine linear and angular head accelerations. HIT is used in youth and collegiate football to assess the frequency and severity of helmet impacts. This paper evaluates the accuracy of HIT for individual head impacts. Most HIT validations used a medium helmet on a Hybrid III head. However, the appropriate helmet is large based on the Hybrid III head circumference (58 cm) and manufacturer's fitting instructions. An instrumented skull cap was used to measure the pressure between the head of football players (n=63) and their helmet. The average pressure with a large helmet on the Hybrid III was comparable to the average pressure from helmets used by players. A medium helmet on the Hybrid III produced average pressures greater than the 99th percentile volunteer pressure level. Linear impactor tests were conducted using a large and medium helmet on the Hybrid III. Testing was conducted by two independent laboratories. HIT data were compared to data from the Hybrid III equipped with a 3-2-2-2 accelerometer array. The absolute and root mean square error (RMSE) for HIT were computed for each impact (n=90). Fifty-five percent (n=49) had an absolute error greater than 15% while the RMSE was 59.1% for peak linear acceleration. Copyright © 2013 Elsevier Ltd. All rights reserved.},
keywords = {*Head Protective Devices/st [Standards], *Materials Testing, *Sports Equipment/st [Standards], *Telemetry/is [Instrumentation], Adolescent, adult, Equipment Design, football, Humans, Male, Pressure, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Matthews, S; Simmons, A; Strigo, I
The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131] Journal Article
In: Psychiatry Research, vol. 191, no. 1, pp. 76–79, 2011.
Abstract | BibTeX | Tags: *Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs & Derivatives], Urea/bl [Blood], Young Adult
@article{Matthews2011a,
title = {The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131]},
author = {Matthews, S and Simmons, A and Strigo, I},
year = {2011},
date = {2011-01-01},
journal = {Psychiatry Research},
volume = {191},
number = {1},
pages = {76--79},
abstract = {In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC. Copyright Published by Elsevier Ireland Ltd.},
keywords = {*Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs \& Derivatives], Urea/bl [Blood], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Barlow, Michael; Schlabach, Drew; Peiffer, Jeffrey; Cook, Chad
Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p] Journal Article
In: International Journal of Sports Physical Therapy, vol. 6, no. 3, pp. 150–157, 2011, ISBN: 2159-2896.
Abstract | BibTeX | Tags: ADOLESCENCE, adult, Brain Concussion -- Diagnosis, Child, Data Analysis Software, Disability Evaluation, Female, human, Instrument Validation, Male, Middle, Ohio, Postconcussion Syndrome -- Risk Factors, Predictive Value of Tests, Record Review, Recovery, Retrospective Design, ROC Curve, Scales, Schools, Secondary, validity
@article{Barlow2011,
title = {Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p]},
author = {Barlow, Michael and Schlabach, Drew and Peiffer, Jeffrey and Cook, Chad},
isbn = {2159-2896},
year = {2011},
date = {2011-01-01},
journal = {International Journal of Sports Physical Therapy},
volume = {6},
number = {3},
pages = {150--157},
publisher = {North American Journal of Sports Physical Therapy},
address = {Indianapolis, Indiana},
abstract = {Background: A battery of tests is commonly used to measure disability with and recovery from concussion. A number of different concussion-oriented assessment tests exist and each is considered useful. To the authors' knowledge, no study has compared the scores of these tests during recovery in the middle school and high school aged population to see how each change over time. Purpose: The purposes of this study were to analyze clinical data of concussed middle school and high school aged athletes to determine the concurrent and predictive validity for post-concussion syndrome (PCS) of the Post-Concussion Symptom Scale (PCSS), Balance Error Scoring System (BESS), and the five subscales of the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). Methods: The study was a retrospective chart review performed on middle school and high school aged individuals with a diagnosis of concussion from the years 2008-2010 within the Akron Children's Hospital Sports Medicine system. To be eligible for inclusion in the dataset, each subject required a baseline measurement for each of the three tests (and all five subscales of the ImPACT) and a post-test measure. The mean age of the population was 15.38 years (SD=1.7) and ranged from 11 to 19 years. Pearson product correlation tests (correlation matrix) were used to analyze the concurrent validity of the test items during recovery following a concussion. Receiver operating characteristics (ROC) curves were used to determine the predictive validity of initial scores for developing PCS. Results: The correlation matrix captured five statistically significant findings; however, these suggested only weak to mild correlations. Five test items yielded an area under the curve (AUC) greater than 0.50 but only one was statistically significant. After qualitative evaluation, only one of the three tests (including the five subscales of the ImPACT) was useful in predicting post-concussion syndrome. Conclusion: This study suggests that there is poor concurrent validity among three commonly used concussion tests and there is no baseline score that predicts whether post-concussion syndrome will occur.},
keywords = {ADOLESCENCE, adult, Brain Concussion -- Diagnosis, Child, Data Analysis Software, Disability Evaluation, Female, human, Instrument Validation, Male, Middle, Ohio, Postconcussion Syndrome -- Risk Factors, Predictive Value of Tests, Record Review, Recovery, Retrospective Design, ROC Curve, Scales, Schools, Secondary, validity},
pubstate = {published},
tppubtype = {article}
}
Estevan, I; Alvarez, O; Falco, C; Molina-Garcia, J; Castillo, I
Impact force and time analysis influenced by execution distance in a roundhouse kick to the head in taekwondo Journal Article
In: Journal of Strength & Conditioning Research, vol. 25, no. 10, pp. 2851–2856, 2011.
Abstract | BibTeX | Tags: *HEAD, *Martial Arts/ph [Physiology], *Task Performance and Analysis, adult, Biomechanical Phenomena, Humans, Male, Young Adult
@article{Estevan2011,
title = {Impact force and time analysis influenced by execution distance in a roundhouse kick to the head in taekwondo},
author = {Estevan, I and Alvarez, O and Falco, C and Molina-Garcia, J and Castillo, I},
year = {2011},
date = {2011-01-01},
journal = {Journal of Strength \& Conditioning Research},
volume = {25},
number = {10},
pages = {2851--2856},
abstract = {The execution distance is a tactic factor that affects mechanical performance and execution technique in taekwondo. This study analyzes the roundhouse kick to the head by comparing the maximum impact force, execution time, and impact time in 3 distances according to the athletes' competition level. It also analyzes the relationship between impact force and weight in each group. It examines whether the execution distance affects the maximum impact force, execution time, and impact time, in each level group or 2 different competition levels. Participants were 27 male taekwondo players (13 medallists and 14 nonmedallists). The medallists executed the roundhouse kick to the head with greater impact force and in a shorter execution time than did the nonmedallists when they kicked from any distance different to their combat distance. However, the results showed that the execution distance is influential in the execution time and impact time in the nonmedallist group. It is considered appropriate to orientate the high-level competitors to train for offensive actions from any distance similar to the long execution distance because it offers equally effectiveness and a greater security against the opponent. Also, practitioners should focus their training to improve time performance because it is more affected by distance than impact force.},
keywords = {*HEAD, *Martial Arts/ph [Physiology], *Task Performance and Analysis, adult, Biomechanical Phenomena, Humans, Male, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Omalu, B; Hammers, J L; Bailes, J; Hamilton, R L; Kamboh, M I; Webster, G; Fitzsimmons, R P
Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide Journal Article
In: Neurosurgical Focus, vol. 31, no. 5, pp. E3, 2011.
Abstract | BibTeX | Tags: *Blast Injuries/pa [Pathology], *Blast Injuries/pp [Physiopathology], *Brain Injury, *Combat Disorders/pp [Physiopathology], *Suicide/px [Psychology], 2003-2011, adult, Blast Injuries/co [Complications], Brain Injury, Chronic/co [Complications], Chronic/pa [Pathology], Chronic/pp [Physiopathology], Combat Disorders/px [Psychology], Humans, Iraq War, Male, Post-Traumatic/pp [Physiopatholo, Post-Traumatic/px [Psychology], Stress Disorders, Suicide/pc [Prevention & Control]
@article{Omalu2011,
title = {Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide},
author = {Omalu, B and Hammers, J L and Bailes, J and Hamilton, R L and Kamboh, M I and Webster, G and Fitzsimmons, R P},
year = {2011},
date = {2011-01-01},
journal = {Neurosurgical Focus},
volume = {31},
number = {5},
pages = {E3},
abstract = {Following his discovery of chronic traumatic encephalopathy (CTE) in football players in 2002, Dr. Bennet Omalu hypothesized that posttraumatic stress disorder (PTSD) in military veterans may belong to the CTE spectrum of diseases. The CTE surveillance at the Brain Injury Research Institute was therefore expanded to include deceased military veterans diagnosed with PTSD. The authors report the case of a 27-year-old United States Marine Corps (USMC) Iraqi war veteran, an amphibious assault vehicle crewman, who committed suicide by hanging after two deployments to Fallujah and Ramadi. He experienced combat and was exposed to mortar blasts and improvised explosive device blasts less than 50 m away. Following his second deployment he developed a progressive history of cognitive impairment, impaired memory, behavioral and mood disorders, and alcohol abuse. Neuropsychiatric assessment revealed a diagnosis of PTSD with hyperarousal (irritability and insomnia) and numbing. He committed suicide approximately 8 months after his honorable discharge from the USMC. His brain at autopsy appeared grossly unremarkable except for congestive brain swelling. There was no atrophy or remote focal traumatic brain injury such as contusional necrosis or hemorrhage. Histochemical and immunohistochemical brain tissue analysis revealed CTE changes comprising multifocal, neocortical, and subcortical neurofibrillary tangles and neuritic threads (ranging from none, to sparse, to frequent) with the skip phenomenon, accentuated in the depths of sulci and in the frontal cortex. The subcortical white matter showed mild rarefaction, sparse perivascular and neuropil infiltration by histiocytes, and mild fibrillary astrogliosis. Apolipoprotein E genotype was 3/4. The authors report this case as a sentinel case of CTE in an Iraqi war veteran diagnosed with PTSD to possibly stimulate new lines of thought and research in the possible pathoetiology and pathogenesis of PTSD in military veterans as part of the CTE spectrum of diseases, and as chronic sequelae and outcomes of repetitive traumatic brain injuries.},
keywords = {*Blast Injuries/pa [Pathology], *Blast Injuries/pp [Physiopathology], *Brain Injury, *Combat Disorders/pp [Physiopathology], *Suicide/px [Psychology], 2003-2011, adult, Blast Injuries/co [Complications], Brain Injury, Chronic/co [Complications], Chronic/pa [Pathology], Chronic/pp [Physiopathology], Combat Disorders/px [Psychology], Humans, Iraq War, Male, Post-Traumatic/pp [Physiopatholo, Post-Traumatic/px [Psychology], Stress Disorders, Suicide/pc [Prevention \& Control]},
pubstate = {published},
tppubtype = {article}
}
Wise, E K; Mathews-Dalton, C; Dikmen, S; Temkin, N; Machamer, J; Bell, K; Powell, J M
Impact of traumatic brain injury on participation in leisure activities Journal Article
In: Archives of Physical Medicine & Rehabilitation, vol. 91, no. 9, pp. 1357–1362, 2010.
Abstract | BibTeX | Tags: *Brain Injuries/rh [Rehabilitation], *Recreation, adult, Age Factors, Female, Humans, Male, Prospective Studies, Sex Factors, treatment outcome, Washington
@article{Wise2010,
title = {Impact of traumatic brain injury on participation in leisure activities},
author = {Wise, E K and Mathews-Dalton, C and Dikmen, S and Temkin, N and Machamer, J and Bell, K and Powell, J M},
year = {2010},
date = {2010-01-01},
journal = {Archives of Physical Medicine \& Rehabilitation},
volume = {91},
number = {9},
pages = {1357--1362},
abstract = {OBJECTIVE: To determine how participation in leisure activities for people with traumatic brain injury (TBI) changes from before injury to 1 year after injury. DESIGN: Prospective evaluation of leisure participation at 1 year after TBI. SETTING: Level I trauma center. PARTICIPANTS: Rehabilitation inpatients (mean age, 35.3 years; 77% male; 77% white) with moderate to severe TBI (N=160). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Functional Status Examination. RESULTS: At 1 year after injury, 81% had not returned to preinjury levels of leisure participation. Activities most frequently discontinued included partying, drug and alcohol use, and various sports. The activity most often reported as new after injury was watching television. Of the small fraction who returned to preinjury levels, 70% did so within 4 months of injury. Sixty percent of those who did not return to preinjury levels were moderately to severely bothered by the changes. CONCLUSIONS: At 1 year after injury, many TBI survivors engage in a reduced number of leisure activities, which are more sedentary and less social, with a substantial fraction dissatisfied with these changes. While discontinuing some activities may be viewed as a positive change, there are few new ones to replace them.},
keywords = {*Brain Injuries/rh [Rehabilitation], *Recreation, adult, Age Factors, Female, Humans, Male, Prospective Studies, Sex Factors, treatment outcome, Washington},
pubstate = {published},
tppubtype = {article}
}
Vent, J; Koenig, J; Hellmich, M; Huettenbrink, K B; Damm, M
Impact of recurrent head trauma on olfactory function in boxers: a matched pairs analysis Journal Article
In: Brain Research, vol. 1320, pp. 1–6, 2010.
Abstract | BibTeX | Tags: *Athletes, *Boxing, *Craniocerebral Trauma/co [Complications], *Olfactory Perception, Adolescent, adult, Discrimination (Psychology), Humans, Male, Matched-Pair Analysis, middle aged, Neuropsychological Tests, Olfaction Disorders/et [Etiology], PROTECTIVE clothing, Sensory Thresholds, Young Adult
@article{Vent2010,
title = {Impact of recurrent head trauma on olfactory function in boxers: a matched pairs analysis},
author = {Vent, J and Koenig, J and Hellmich, M and Huettenbrink, K B and Damm, M},
year = {2010},
date = {2010-01-01},
journal = {Brain Research},
volume = {1320},
pages = {1--6},
abstract = {Recently, interest in the health of boxers has been raised by a petition of the British Medical Association to restrict boxing. However, scientific data on permanent damage are rare and typical localisations of injuries were yet to be defined. The aim of this study was to determine whether there are changes in the sense of smell in people undergoing recurrent head traumas. The hypothesis to be tested was if boxers had a reduced olfactory function. We used a matched pairs analysis design. Fifty healthy, male athletes underwent subjective olfactometry using Sniffin'Sticks testing (including threshold, discrimination and identification, TDI). Nasal endoscopy was performed and a thorough, questionnaire-based history was obtained. These data were correlated with normative data from healthy subjects. Statistical analysis was based on matched pairs analysis by t-tests, i.e. boxers and healthy (non-boxing) subjects. Boxers showed a mean TDI score of 32.5 compared to 35.1 of non-boxing controls (p=0.003). The olfactory threshold (p\<0.001) and odour identification (p\<0.05) were significantly decreased in boxers; whereas odour discrimination was unaffected. Performance of odour identification showed a correlation with cushioning of the gloves (p\<0.05), and thus seems a protective measure regarding the sense of smell. Boxing seems to affect olfactory function, particularly by reducing the olfactory threshold. Furthermore, cushioning of the gloves can be protective and should be increased to safeguard sportsmen from physical damage. Boxing can serve as a model for central regeneration after trauma. Copyright 2010 Elsevier B.V. All rights reserved.},
keywords = {*Athletes, *Boxing, *Craniocerebral Trauma/co [Complications], *Olfactory Perception, Adolescent, adult, Discrimination (Psychology), Humans, Male, Matched-Pair Analysis, middle aged, Neuropsychological Tests, Olfaction Disorders/et [Etiology], PROTECTIVE clothing, Sensory Thresholds, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Thornton, A E; Cox, D N; Whitfield, K; Fouladi, R T
Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 30, no. 4, pp. 398–409, 2008.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *COGNITION, *Cognition Disorders/et [Etiology], *Football/in [Injuries], adult, Age Factors, aged, Brain Concussion/di [Diagnosis], Female, Humans, Male, middle aged, Neuropsychological Tests, Predictive Value of Tests, REGRESSION analysis, Surveys and Questionnaires, Trauma Severity Indices
@article{Thornton2008a,
title = {Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes},
author = {Thornton, A E and Cox, D N and Whitfield, K and Fouladi, R T},
year = {2008},
date = {2008-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {30},
number = {4},
pages = {398--409},
abstract = {A total of 111 rugby players underwent comprehensive testing to determine the impact of self-reported concussion exposure. Reliable estimates of concussion exposure were associated with an increase in postconcussion symptoms (PCS), but not diminished neurocognitive functioning. Importantly, the effects of concussion exposure on PCS varied as a function of player status. More specifically, extent of concussion exposure was associated with increased memory complaints and overall PCS endorsements in a dose-dependent manner for retired and older recreational players, but not for those who were younger and playing at more competitive levels. Future work should systematically evaluate the constituent participant factors that may influence differential concussion outcomes.},
keywords = {*Brain Concussion/co [Complications], *COGNITION, *Cognition Disorders/et [Etiology], *Football/in [Injuries], adult, Age Factors, aged, Brain Concussion/di [Diagnosis], Female, Humans, Male, middle aged, Neuropsychological Tests, Predictive Value of Tests, REGRESSION analysis, Surveys and Questionnaires, Trauma Severity Indices},
pubstate = {published},
tppubtype = {article}
}
McLeod, P; Reed, N; Gilson, S; Glennerster, A
How soccer players head the ball: a test of Optic Acceleration Cancellation theory with virtual reality Journal Article
In: Vision Research, vol. 48, no. 13, pp. 1479–1487, 2008.
Abstract | BibTeX | Tags: *Head Movements/ph [Physiology], *Motion Perception/ph [Physiology], *Soccer/ph [Physiology], Acceleration, adult, Humans, Male, psychomotor performance, Reaction Time/ph [Physiology], User-Computer Interface
@article{McLeod2008,
title = {How soccer players head the ball: a test of Optic Acceleration Cancellation theory with virtual reality},
author = {McLeod, P and Reed, N and Gilson, S and Glennerster, A},
year = {2008},
date = {2008-01-01},
journal = {Vision Research},
volume = {48},
number = {13},
pages = {1479--1487},
abstract = {We measured the movements of soccer players heading a football in a fully immersive virtual reality environment. In mid-flight the ball's trajectory was altered from its normal quasi-parabolic path to a linear one, producing a jump in the rate of change of the angle of elevation of gaze (alpha) from player to ball. One reaction time later the players adjusted their speed so that the rate of change of alpha increased when it had been reduced and reduced it when it had been increased. Since the result of the player's movement was to regain a value of the rate of change close to that before the disturbance, the data suggest that the players have an expectation of, and memory for, the pattern that the rate of change of alpha will follow during the flight. The results support the general claim that players intercepting balls use servo control strategies and are consistent with the particular claim of Optic Acceleration Cancellation theory that the servo strategy is to allow alpha to increase at a steadily decreasing rate.},
keywords = {*Head Movements/ph [Physiology], *Motion Perception/ph [Physiology], *Soccer/ph [Physiology], Acceleration, adult, Humans, Male, psychomotor performance, Reaction Time/ph [Physiology], User-Computer Interface},
pubstate = {published},
tppubtype = {article}
}
Chiu, W T; Huang, S J; Tsai, S H; Lin, J W; Tsai, M D; Lin, T J; Huang, W C
The impact of time, legislation, and geography on the epidemiology of traumatic brain injury Journal Article
In: Journal of Clinical Neuroscience, vol. 14, no. 10, pp. 930–935, 2007.
Abstract | BibTeX | Tags: *Accidents, *Brain Injuries/ep [Epidemiology], *Legislation as Topic/sn [Statistics & Numerical D, *Rural Population/sn [Statistics & Numerical Data], *Urban Population/sn [Statistics & Numerical Data], Accidents, adult, age distribution, aged, Cohort Studies, Female, Head Protective Devices/sn [Statistics & Numerical, Head Protective Devices/st [Standards], Humans, Incidence, Legislation as Topic/td [Trends], Male, middle aged, Motorcycles/lj [Legislation & Jurisprudence], Motorcycles/sn [Statistics & Numerical Data], Motorcycles/st [Standards], Prospective Studies, Rural Population/td [Trends], Sex Distribution, Taiwan/ep [Epidemiology], Time Factors, Traffic/lj [Legislation & Jurisprudence, Traffic/pc [Prevention & Control], Traffic/sn [Statistics & Numerical Dat, Trauma Severity Indices, Urban Population/td [Trends]
@article{Chiu2007,
title = {The impact of time, legislation, and geography on the epidemiology of traumatic brain injury},
author = {Chiu, W T and Huang, S J and Tsai, S H and Lin, J W and Tsai, M D and Lin, T J and Huang, W C},
year = {2007},
date = {2007-01-01},
journal = {Journal of Clinical Neuroscience},
volume = {14},
number = {10},
pages = {930--935},
abstract = {In 1991, a population-based epidemiologic traumatic brain injury (TBI) study was done in urban and rural areas of Taiwan; this was 5 years before the helmet use law was passed and 8 years before the drink driving law was passed. In order to evaluate the impact of three major determinants (time, geography, and legislation) on the epidemiology of TBI, we conducted a prospective study in 2001 and used the 1991 data to examine the differences in TBI distribution in urban and rural Taiwan a decade after these laws were passed. In 2001, 5754 TBI cases were collected from the urban area of Taipei City, and 1474 TBI cases were collected from the rural area of Hualien County. The TBI incidence rate in Taipei City in 2001 was estimated to be 218/100,000 population (285/100,000 for males and 152/100,000 for females). When compared to the 1991 data, the incidence rate in 2001 had increased by 20%. The TBI incidence rate in Hualien County in 2001 was estimated to be 417/100,000 population (516/100,000 for males and 306/100,000 for females); this was a 37% increase over the 1991 data. Our study found that the distribution of causes and age distribution had shifted significantly over the 10-year period. In 2001, the age group with the highest incidence was 20-29 years, while in 1991 it had been the over 70 years age group. While traffic-related TBI had decreased, falls and assaults had increased in 2001. We also found that legislation, such as the helmet law, affects TBI distribution by decreasing the traffic-related TBI rate, decreasing the admission severity of TBI, and reducing TBI-related mortality. Finally, geography plays a crucial role in the outcome of TBI; over the 10 year period, Taipei had an increase in moderately severe outcomes, while Hualien had an increase in more severe outcomes. Comparative studies of TBI in urban and rural areas have shown that time, legislation, and geography are crucial determinants of TBI epidemiology. Although time and legal interventions seem to have more of an impact, geography does affect TBI outcomes.},
keywords = {*Accidents, *Brain Injuries/ep [Epidemiology], *Legislation as Topic/sn [Statistics \& Numerical D, *Rural Population/sn [Statistics \& Numerical Data], *Urban Population/sn [Statistics \& Numerical Data], Accidents, adult, age distribution, aged, Cohort Studies, Female, Head Protective Devices/sn [Statistics \& Numerical, Head Protective Devices/st [Standards], Humans, Incidence, Legislation as Topic/td [Trends], Male, middle aged, Motorcycles/lj [Legislation \& Jurisprudence], Motorcycles/sn [Statistics \& Numerical Data], Motorcycles/st [Standards], Prospective Studies, Rural Population/td [Trends], Sex Distribution, Taiwan/ep [Epidemiology], Time Factors, Traffic/lj [Legislation \& Jurisprudence, Traffic/pc [Prevention \& Control], Traffic/sn [Statistics \& Numerical Dat, Trauma Severity Indices, Urban Population/td [Trends]},
pubstate = {published},
tppubtype = {article}
}
for Disease Control, Centers; Prevention,
Nonfatal traumatic brain injuries from sports and recreation activities--United States, 2001-2005 Journal Article
In: MMWR - Morbidity & Mortality Weekly Report, vol. 56, no. 29, pp. 733–737, 2007.
Abstract | BibTeX | Tags: *Athletic Injuries/ep [Epidemiology], *Brain Injuries/ep [Epidemiology], Adolescent, adult, Child, Chronic traumatic encephalopathy, Female, Humans, Incidence/Epidemiology, Infant, Male, middle aged, Population Surveillance, Preschool, recreation, United States/ep [Epidemiology]
@article{CentersforDiseaseControlandPrevention2007,
title = {Nonfatal traumatic brain injuries from sports and recreation activities--United States, 2001-2005},
author = {{Centers for Disease Control and Prevention}},
year = {2007},
date = {2007-01-01},
journal = {MMWR - Morbidity \& Mortality Weekly Report},
volume = {56},
number = {29},
pages = {733--737},
abstract = {Each year in the United States, an estimated 38 million children and adolescents participate in organized sports, and approximately 170 million adults participate in some type of physical activity not related to work. The health benefits of these activities are tempered by the risk for injury, including traumatic brain injury (TBI). CDC estimates that 1.1 million persons with TBIs are treated and released from U.S. hospital emergency departments (EDs) each year, and an additional 235,000 are hospitalized for these injuries. TBIs can result in long-term, negative health effects (e.g., memory loss and behavioral changes). To characterize sports- and recreation-related (SR-related) TBIs among patients treated in U.S. hospital EDs, CDC analyzed data from the National Electronic Injury Surveillance System--All Injury Program (NEISS-AIP) for the period 2001-2005. This report summarizes the results of that analysis, which indicated that an estimated 207,830 patients with nonfatal SR-related TBIs were treated in EDs each year during this period. The highest rates of SR-related TBI ED visits for both males and females occurred among those aged 10-14 years. Increased awareness of TBI risks, prevention strategies, and the importance of timely identification and management is essential for reducing the incidence, severity, and long-term negative health effects of this type of injury.},
keywords = {*Athletic Injuries/ep [Epidemiology], *Brain Injuries/ep [Epidemiology], Adolescent, adult, Child, Chronic traumatic encephalopathy, Female, Humans, Incidence/Epidemiology, Infant, Male, middle aged, Population Surveillance, Preschool, recreation, United States/ep [Epidemiology]},
pubstate = {published},
tppubtype = {article}
}
Butcher, I; McHugh, G S; Lu, J; Steyerberg, E W; Hernandez, A V; Mushkudiani, N; Maas, A I; Marmarou, A; Murray, G D
Prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study Journal Article
In: Journal of Neurotrauma, vol. 24, no. 2, pp. 281–286, 2007.
Abstract | BibTeX | Tags: *Brain Injuries/di [Diagnosis], *Brain Injuries/et [Etiology], Accidents, adult, Age Factors, Athletic Injuries/co [Complications], Athletic Injuries/di [Diagnosis], Databases, Factual, Glasgow Outcome Scale, Humans, middle aged, Predictive Value of Tests, Prognosis, violence
@article{Butcher2007,
title = {Prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study},
author = {Butcher, I and McHugh, G S and Lu, J and Steyerberg, E W and Hernandez, A V and Mushkudiani, N and Maas, A I and Marmarou, A and Murray, G D},
year = {2007},
date = {2007-01-01},
journal = {Journal of Neurotrauma},
volume = {24},
number = {2},
pages = {281--286},
abstract = {We aimed to describe and quantify the relationship between cause of injury and final outcome following traumatic brain injury (TBI). Individual patient data (N = 8708) from eight therapeutic Phase III randomized clinical trials in moderate or severe TBI, and three TBI surveys were used to investigate the relationship between cause of injury and outcome, as assessed by the Glasgow Outcome Scale (GOS) at 6 months. Proportional odds methodology was applied to quantify the strength of the association and expressed as an odds ratio in a meta-analysis. Heterogeneity across studies was assessed and associations with other predictive factors explored. In a univariate analysis, a strong association between the cause of injury and long-term outcome in moderate to severe TBI patients was observed, with consistent results across the studies. Road traffic accidents (OR 0.66, 95% CI 0.60-0.73), assaults (OR 0.66, 95% CI 0.52-0.84), and injuries sustained during sporting or recreational activities (OR 0.45, 95% CI 0.28-0.71) were all associated with better outcomes than the reference category of falls. Falls were found to be associated with an older age and with a higher incidence of mass lesions. Following adjustment for age in the analysis, the relationship between cause of injury and outcome was lost.},
keywords = {*Brain Injuries/di [Diagnosis], *Brain Injuries/et [Etiology], Accidents, adult, Age Factors, Athletic Injuries/co [Complications], Athletic Injuries/di [Diagnosis], Databases, Factual, Glasgow Outcome Scale, Humans, middle aged, Predictive Value of Tests, Prognosis, violence},
pubstate = {published},
tppubtype = {article}
}
Kerr, J; Swann, I J; Pentland, B
A survey of information given to head-injured patients on direct discharge from emergency departments in Scotland Journal Article
In: Emergency Medicine Journal, vol. 24, no. 5, pp. 330–332, 2007, ISBN: 1472-0205.
Abstract | Links | BibTeX | Tags: adult, Child, Emergency Service, Head Injuries, human, Pamphlets, Patient Discharge Education -- Evaluation, postconcussion syndrome, Scotland
@article{Kerr2007,
title = {A survey of information given to head-injured patients on direct discharge from emergency departments in Scotland},
author = {Kerr, J and Swann, I J and Pentland, B},
doi = {10.1136/emj.2006.044230},
isbn = {1472-0205},
year = {2007},
date = {2007-01-01},
journal = {Emergency Medicine Journal},
volume = {24},
number = {5},
pages = {330--332},
publisher = {BMJ Publishing Group},
abstract = {AIM: To survey the information provided to head-injured patients on discharge from emergency departments (EDs) in Scotland. METHODS: EDs throughout Scotland were asked to supply a copy of their head injury advice pamphlet for analysis. Each pamphlet was assessed against a template and an Excel spreadsheet was created. RESULTS: All 30 (100%) Scottish EDs responded. The frequency with which specific features appeared varied widely, with most pamphlets concentrating on emergency features, with less emphasis on postconcussion symptoms. CONCLUSIONS: Head injury discharge advice should be standardised throughout EDs, with more emphasis given to postconcussion features.},
keywords = {adult, Child, Emergency Service, Head Injuries, human, Pamphlets, Patient Discharge Education -- Evaluation, postconcussion syndrome, Scotland},
pubstate = {published},
tppubtype = {article}
}
Falconer, E K; Geffen, G M; Olsen, S L; McFarland, K
The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research Journal Article
In: Brain Injury, vol. 20, no. 12, pp. 1251–1263, 2006.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Mass Screening/mt [Methods], *Neuropsychological Tests, Adolescent, adult, Brain Concussion/et [Etiology], Brain Concussion/px [Psychology], Brain Injuries/co [Complications], Brain Injuries/px [Psychology], Female, Humans, Male, Mental Recall, middle aged, Reproducibility of Results, Sensitivity and Specificity, Verbal Learning
@article{Falconer2006,
title = {The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research},
author = {Falconer, E K and Geffen, G M and Olsen, S L and McFarland, K},
year = {2006},
date = {2006-01-01},
journal = {Brain Injury},
volume = {20},
number = {12},
pages = {1251--1263},
abstract = {PRIMARY OBJECTIVES: (1) To investigate the Nonword Repetition test (NWR) as an index of sub-vocal rehearsal deficits after mild traumatic brain injury (mTBI); (2) to assess the reliability, validity and sensitivity of the NWR; and (3) to compare the NWR to more sensitive tests of verbal memory. RESEARCH DESIGN: An independent groups design. METHODS AND PROCEDURES: Study 1 administered the NWR to 46 mTBI and 61 uninjured controls with the Rapid Screen of Concussion (RSC). Study 2 compared mTBI, orthopaedic and uninjured participants on the NWR and the Hopkins Verbal Learning Test (HVLT-R). MAIN OUTCOMES AND RESULTS: The NWR did not improve the diagnostic accuracy of the RSC. However, it is reliable and indexes sub-vocal rehearsal speed. These findings provide evidence that although the current form of the NWR lacks sensitivity to the impact of mTBI, the development of a more sensitive test of sub-vocal rehearsal deficits following mTBI is warranted.},
keywords = {*Brain Concussion/di [Diagnosis], *Mass Screening/mt [Methods], *Neuropsychological Tests, Adolescent, adult, Brain Concussion/et [Etiology], Brain Concussion/px [Psychology], Brain Injuries/co [Complications], Brain Injuries/px [Psychology], Female, Humans, Male, Mental Recall, middle aged, Reproducibility of Results, Sensitivity and Specificity, Verbal Learning},
pubstate = {published},
tppubtype = {article}
}
De Monte, V E; Geffen, G M; May, C R; McFarland, K; Heath, P; Neralic, M
The acute effects of mild traumatic brain injury on finger tapping with and without word repetition Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 27, no. 2, pp. 224–239, 2005.
Abstract | BibTeX | Tags: *Brain Injuries/pp [Physiopathology], *Fingers/pp [Physiopathology], *Psychomotor Performance/ph [Physiology], *Verbal Learning/ph [Physiology], Adolescent, adult, Demography, Discrimination (Psychology)/ph [Physiology], Female, Fingers/ir [Innervation], Glasgow Coma Scale, Hand Deformities/pp [Physiopathology], Humans, Male, Mental Recall/ph [Physiology], middle aged, Neuropsychological Tests/sn [Statistics & Numerica, Sensitivity and Specificity, Sex Factors, Task Performance and Analysis, Word Association Tests/sn [Statistics & Numerical
@article{DeMonte2005,
title = {The acute effects of mild traumatic brain injury on finger tapping with and without word repetition},
author = {{De Monte}, V E and Geffen, G M and May, C R and McFarland, K and Heath, P and Neralic, M},
year = {2005},
date = {2005-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {27},
number = {2},
pages = {224--239},
abstract = {This study aimed to investigate the acute effects of mild Traumatic Brain Injury (mTBI) on the performance of a finger tapping and word repetition dual task in order to determine working memory impairment in mTBI. Sixty-four (50 male, 14 female) right-handed cases of mTBI and 26 (18 male and 8 female) right-handed cases of orthopaedic injuries were tested within 24 hours of injury. Patients with mTBI completed fewer correct taps in 10 seconds than patients with orthopaedic injuries, and female mTBI cases repeated fewer words. The size of the dual task decrement did not vary between groups. When added to a test battery including the Rapid Screen of Concussion (RSC; Comerford, Geffen, May, Medland \& Geffen, 2002) and the Digit Symbol Substitution Test, finger tapping speed accounted for 1% of between groups variance and did not improve classification rates of male participants. While the addition of tapping rate did not improve the sensitivity and specificity of the RSC and DSST to mTBI in males, univariate analysis of motor performance in females indicated that dual task performance might be diagnostic. An increase in female sample size is warranted. These results confirm the view that there is a generalized slowing of processing ability following mTBI.},
keywords = {*Brain Injuries/pp [Physiopathology], *Fingers/pp [Physiopathology], *Psychomotor Performance/ph [Physiology], *Verbal Learning/ph [Physiology], Adolescent, adult, Demography, Discrimination (Psychology)/ph [Physiology], Female, Fingers/ir [Innervation], Glasgow Coma Scale, Hand Deformities/pp [Physiopathology], Humans, Male, Mental Recall/ph [Physiology], middle aged, Neuropsychological Tests/sn [Statistics \& Numerica, Sensitivity and Specificity, Sex Factors, Task Performance and Analysis, Word Association Tests/sn [Statistics \& Numerical},
pubstate = {published},
tppubtype = {article}
}
Macpherson, A K; To, T M; Macarthur, C; Chipman, M L; Wright, J G; Parkin, P C
Impact of mandatory helmet legislation on bicycle-related head injuries in children: a population-based study Journal Article
In: Pediatrics, vol. 110, no. 5, pp. e60, 2002.
Abstract | BibTeX | Tags: *Bicycling/in [Injuries], *Bicycling/lj [Legislation & Jurisprudence], *Craniocerebral Trauma/pc [Prevention & Control], *Head Protective Devices/ut [Utilization], Accidents, Adolescent, adult, Bicycling/sn [Statistics & Numerical Data], Canada/ep [Epidemiology], Child, Cohort Studies, Craniocerebral Trauma/di [Diagnosis], Craniocerebral Trauma/ep [Epidemiology], Female, Hospitalized/sn [Statistics & Numerical Dat, Humans, Incidence, Legislation as Topic/sn [Statistics & Numerical Da, Male, Preschool, Public Policy, Traffic/sn [Statistics & Numerical Data, Trauma Severity Indices
@article{Macpherson2002,
title = {Impact of mandatory helmet legislation on bicycle-related head injuries in children: a population-based study},
author = {Macpherson, A K and To, T M and Macarthur, C and Chipman, M L and Wright, J G and Parkin, P C},
year = {2002},
date = {2002-01-01},
journal = {Pediatrics},
volume = {110},
number = {5},
pages = {e60},
abstract = {OBJECTIVE: Childhood bicycle-related head injuries can be prevented through the use of helmets. Although helmet legislation has proved to be a successful strategy for the adoption of helmets, its effect on the rates of head injury is uncertain. In Canada, 4 provinces have such legislation. The objective of this study was to measure the impact of helmet legislation on bicycle-related head injuries in Canadian children. METHODS: Routinely collected data from the Canadian Institute for Health Information identified all Canadian children (5-19 years) who were hospitalized for bicycling-related injuries from 1994-1998. Children were categorized as head or other injury on the basis of International Classification of Diseases, Ninth Revision, codes. Rates of head injuries and other injuries were compared over time in provinces that adopted legislation and those that did not. RESULTS: Of the 9650 children who were hospitalized because of a bicycle-related injury, 3426 sustained injuries to the head and face and the remaining 6224 had other injuries. The bicycle-related head injury rate declined significantly (45% reduction) in provinces where legislation had been adopted compared with provinces and territories that did not adopt legislation (27% reduction). CONCLUSION: This country-wide study compared rates of head injury in regions with and without mandatory helmet legislation. Comparing head injuries with other non-head-injured children controlled for potential differences in children's cycling habits. The strong protective association between helmet legislation and head injuries supports the adoption of helmet legislation as an effective tool in the prevention of childhood bicycle-related head injuries.},
keywords = {*Bicycling/in [Injuries], *Bicycling/lj [Legislation \& Jurisprudence], *Craniocerebral Trauma/pc [Prevention \& Control], *Head Protective Devices/ut [Utilization], Accidents, Adolescent, adult, Bicycling/sn [Statistics \& Numerical Data], Canada/ep [Epidemiology], Child, Cohort Studies, Craniocerebral Trauma/di [Diagnosis], Craniocerebral Trauma/ep [Epidemiology], Female, Hospitalized/sn [Statistics \& Numerical Dat, Humans, Incidence, Legislation as Topic/sn [Statistics \& Numerical Da, Male, Preschool, Public Policy, Traffic/sn [Statistics \& Numerical Data, Trauma Severity Indices},
pubstate = {published},
tppubtype = {article}
}
Bigler, E D; Rosa, L; Schultz, F; Hall, S; Harris, J
Rey-Auditory Verbal Learning and Rey-Osterrieth Complex Figure Design performance in Alzheimer's disease and closed head injury.[Erratum appears in J Clin Psychol 1989 Nov;45(6):1013] Journal Article
In: Journal of Clinical Psychology, vol. 45, no. 2, pp. 277–280, 1989.
Abstract | BibTeX | Tags: *Alzheimer Disease/px [Psychology], *Brain Concussion/px [Psychology], *Form Perception, *MEMORY, *Mental Recall, *Neurocognitive Disorders/px [Psychology], *Neuropsychological Tests, *Pattern Recognition, *Verbal Learning, 80 and over, adult, aged, attention, Female, Humans, Male, middle aged, Psychometrics, SPEECH perception, Visual
@article{Bigler1989,
title = {Rey-Auditory Verbal Learning and Rey-Osterrieth Complex Figure Design performance in Alzheimer's disease and closed head injury.[Erratum appears in J Clin Psychol 1989 Nov;45(6):1013]},
author = {Bigler, E D and Rosa, L and Schultz, F and Hall, S and Harris, J},
year = {1989},
date = {1989-01-01},
journal = {Journal of Clinical Psychology},
volume = {45},
number = {2},
pages = {277--280},
abstract = {Performance on the Rey-Auditory Verbal Learning (R-AVL) and Rey-Osterrieth Complex Figure Design (R-O CFD) tests was examined in patients (N = 94) with dementia of the Alzheimer's type (DAT) and closed head injury (CHI). On the R-AVL, DAT patients demonstrated considerably greater impairment than CHI patients, along with a flat learning/retention curve that showed negligible improvement with repeated trials, recency effects only, and an excessive number of word intrusions (confabulation) on the recognition trial. CHI patients demonstrated both a recency and primacy effect along with improvement over repeated trials (positive slope learning curve). Both groups demonstrated impairment R-O CFD recall; the DAT group again displayed substantially greater copying and recall deficits. Clinical guidelines are given for the use of the R-AVL and R-O CFD for these two patient populations.},
keywords = {*Alzheimer Disease/px [Psychology], *Brain Concussion/px [Psychology], *Form Perception, *MEMORY, *Mental Recall, *Neurocognitive Disorders/px [Psychology], *Neuropsychological Tests, *Pattern Recognition, *Verbal Learning, 80 and over, adult, aged, attention, Female, Humans, Male, middle aged, Psychometrics, SPEECH perception, Visual},
pubstate = {published},
tppubtype = {article}
}
Heinrichs, R W; Celinski, M J
Frequency of occurrence of a WAIS dementia profile in male head trauma patients Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 9, no. 2, pp. 187–190, 1987.
Abstract | BibTeX | Tags: *Brain Injuries/di [Diagnosis], *Dementia/di [Diagnosis], *Wechsler Scales, adult, Brain Concussion/di [Diagnosis], Cerebral Hemorrhage/di [Diagnosis], Humans, middle aged, Psychometrics
@article{Heinrichs1987,
title = {Frequency of occurrence of a WAIS dementia profile in male head trauma patients},
author = {Heinrichs, R W and Celinski, M J},
year = {1987},
date = {1987-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {9},
number = {2},
pages = {187--190},
abstract = {This study investigated Fuld's (1983) contention that a WAIS dementia profile occurs infrequently in conditions other than Alzheimer's Disease. A sample of 50 male head trauma patients was examined for incidence of the profile. The WAIS profile occurred in five cases (10%) of the patients. This compares favourably with the figures reported for patients with multiple infarcts and is consistent with Fuld's position.},
keywords = {*Brain Injuries/di [Diagnosis], *Dementia/di [Diagnosis], *Wechsler Scales, adult, Brain Concussion/di [Diagnosis], Cerebral Hemorrhage/di [Diagnosis], Humans, middle aged, Psychometrics},
pubstate = {published},
tppubtype = {article}
}
Koerte, I K; Hufschmidt, J; Muehlmann, M; Tripodis, Y; Stamm, J M; Pasternak, O; Giwerc, M Y; Coleman, M J; Baugh, C M; Fritts, N G; Heinen, F; Lin, A; Stern, R A; Shenton, M E
Cavum Septi Pellucidi in Symptomatic Former Professional Football Players Journal Article
In: Journal of Neurotrauma, vol. 33, no. 4, pp. 346–353, 2016.
@article{Koerte2016,
title = {Cavum Septi Pellucidi in Symptomatic Former Professional Football Players},
author = {Koerte, I K and Hufschmidt, J and Muehlmann, M and Tripodis, Y and Stamm, J M and Pasternak, O and Giwerc, M Y and Coleman, M J and Baugh, C M and Fritts, N G and Heinen, F and Lin, A and Stern, R A and Shenton, M E},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurotrauma},
volume = {33},
number = {4},
pages = {346--353},
abstract = {Post-mortem studies reveal a high rate of cavum septi pellucidi (CSP) in chronic traumatic encephalopathy (CTE). It remains, however, to be determined whether or not the presence of CSP may be a potential in vivo imaging marker in populations at high risk to develop CTE. The aim of this study was to evaluate CSP in former professional American football players presenting with cognitive and behavioral symptoms compared with noncontact sports athletes. Seventy-two symptomatic former professional football players (mean age 54.53 years, standard deviation [SD] 7.97) as well as 14 former professional noncontact sports athletes (mean age 57.14 years, SD 7.35) underwent high-resolution structural 3T magnetic resonance imaging. Two raters independently evaluated the CSP, and interrater reliability was calculated. Within National Football League players, an association of CSP measures with cognitive and behavioral functioning was evaluated using a multivariate mixed effects model. The measurements of the two raters were highly correlated (CSP length: rho = 0.98; Intraclass Correlation Coefficient [ICC] 0.99; p \< 0.0001; septum length: rho = 0.93; ICC 0.96; p \< 0.0001). For presence versus absence of CSP, there was high agreement (Cohen kappa = 0.83, p \< 0.0001). A higher rate of CSP, a greater length of CSP, as well as a greater ratio of CSP length to septum length was found in symptomatic former professional football players compared with athlete controls. In addition, a greater length of CSP was associated with decreased performance on a list learning task (Neuropsychological Assessment Battery List A Immediate Recall},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Auerbach, P S; Waggoner 2nd, W H
It's Time to Change the Rules Journal Article
In: JAMA, vol. 316, no. 12, pp. 1260–1261, 2016.
@article{Auerbach2016,
title = {It's Time to Change the Rules},
author = {Auerbach, P S and {Waggoner 2nd}, W H},
year = {2016},
date = {2016-01-01},
journal = {JAMA},
volume = {316},
number = {12},
pages = {1260--1261},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Silverberg, N D; Berkner, P D; Atkins, J E; Zafonte, R; Iverson, G L
Relationship between Short Sleep Duration and Preseason Concussion Testing Journal Article
In: Clinical Journal of Sport Medicine, vol. 26, no. 3, pp. 226–231, 2016.
@article{Silverberg2016,
title = {Relationship between Short Sleep Duration and Preseason Concussion Testing},
author = {Silverberg, N D and Berkner, P D and Atkins, J E and Zafonte, R and Iverson, G L},
doi = {10.1097/JSM.0000000000000241},
year = {2016},
date = {2016-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {26},
number = {3},
pages = {226--231},
abstract = {Objective: Baseline, preseason assessment of cognition, symptoms, and balance has been recommended as part of a comprehensive sport concussion management program. We examined the relationship between sleep and baseline test results. We hypothesized that adolescents who slept fewer hours the night before would report more symptoms and perform more poorly on cognitive testing than students who had a full night sleep. Design: Cross-sectional observation study. Setting: Preseason concussion testing for high school athletes. Participants: A large sample (n 2928) of student athletes from Maine, USA, between the ages of 13 and 18 years completed preseason testing. Participants with developmental problems, a history of treatment for neurological or psychiatric problems, recent concussion, or 3 or more prior concussions were excluded. Assessment of Risk Factors: Athletes were divided into 4 groups based on their sleep duration the night before testing. Main Outcome Measures: Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT; ImPACT Applications, Inc, Pittsburgh, PA) cognitive composite scores and the embedded Post-Concussion Symptom Scale. Results: Sleep was not related to any ImPACT cognitive composite score, after covarying for age and controlling for multiple comparisons. In contrast, there were sleep duration, sex, and sleep duration by sex effects on the Post-Concussion Symptom Scale. The effect of sleep duration on symptom reporting was more pronounced in girls. Supplementary analyses suggested that sleep insufficiency was associated with a diverse array of postconcussion-like symptoms. Conclusions: Poor sleep the night before baseline or postinjury testing may be an important confound when assessing postconcussion symptoms. Girls may be more vulnerable to experiencing and reporting symptoms following insufficient sleep. Clinical Relevance: Clinicians should routinely ask how the athlete slept the night before preseason baseline testing and consider deferring the symptom assessment or later retesting athletes who slept poorly. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Armistead-Jehle, P; Cooper, D B; Vanderploeg, R D
The role of performance validity tests in the assessment of cognitive functioning after military concussion: A replication and extension Journal Article
In: Applied Neuropsychology. Adult, vol. 23, no. 4, pp. 264–273, 2016.
@article{Armistead-Jehle2016,
title = {The role of performance validity tests in the assessment of cognitive functioning after military concussion: A replication and extension},
author = {Armistead-Jehle, P and Cooper, D B and Vanderploeg, R D},
year = {2016},
date = {2016-01-01},
journal = {Applied Neuropsychology. Adult},
volume = {23},
number = {4},
pages = {264--273},
abstract = {The current investigation is a replication and extension of a previously published study by Cooper, Vanderploeg, Armistead-Jehle, Lewis, and Bowles (2014) demonstrating that performance validity test scores accounted for more variance in cognitive testing among service members with a history of concussion than did demographic variables, etiology of and time since injury, and symptom severity. The present study included a sample of 142 active-duty service members evaluated following a suspected or confirmed history of mild traumatic brain injury. Participants completed a battery of neuropsychological measures that included scales of performance and symptom validity (specifically the Medical Symptom Validity Test, Nonverbal Medical Symptom Validity Test, and Personality Assessment Inventory). Among the factors considered in the current study, performance validity test results accounted for the most variance in cognitive test scores, above demographic, concussion history, symptom validity, and psychological distress variables. Performance validity test results were modestly related to symptom validity as measured by the Personality Assessment Inventory Negative Impression Management scale. In sum, the current results replicated the original Cooper et al. study and highlight the importance of including performance validity tests as part of neurocognitive evaluation, even in clinical contexts, within this population.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bailie, J M; Kennedy, J E; French, L M; Marshall, K; Prokhorenko, O; Asmussen, S; Reid, M W; Qashu, F; Brickell, T A; Lange, R T
Profile Analysis of the Neurobehavioral and Psychiatric Symptoms Following Combat-Related Mild Traumatic Brain Injury: Identification of Subtypes Journal Article
In: Journal of Head Trauma Rehabilitation, vol. 31, no. 1, pp. 2–12, 2016.
@article{Bailie2016,
title = {Profile Analysis of the Neurobehavioral and Psychiatric Symptoms Following Combat-Related Mild Traumatic Brain Injury: Identification of Subtypes},
author = {Bailie, J M and Kennedy, J E and French, L M and Marshall, K and Prokhorenko, O and Asmussen, S and Reid, M W and Qashu, F and Brickell, T A and Lange, R T},
year = {2016},
date = {2016-01-01},
journal = {Journal of Head Trauma Rehabilitation},
volume = {31},
number = {1},
pages = {2--12},
abstract = {OBJECTIVE: To explore the taxonomy of combat-related mild traumatic brain injury (mTBI) based on symptom patterns. PARTICIPANTS: Up to 1341 military personnel who experienced a combat-related mTBI within 2 years of evaluation. MEASURES: Neurobehavioral Symptom Inventory and PTSD Checklist-Civilian Version (PCL-C). RESULTS: Cluster analysis revealed the following 4 subtypes: primarily psychiatric (posttraumatic stress disorder) group, a cognitive group, a mixed symptom group, and a good recovery group. The posttraumatic stress disorder cluster (21.9% of the sample) reported symptoms related to hyperarousal and dissociation/depression with few complaints related to cognition or headaches. The cognitive group (21.5% of the sample) had primarily cognitive and headache complaints with few mood symptoms. The mixed profile cluster included 18.6% of the sample and was characterized by a combination of mood complaints (hyperarousal and dissociation/depression), cognitive complaints, and headaches. The largest cluster (37.8% of the sample) had an overall low symptom profile and was labeled the "good recovery" group. CONCLUSIONS: The results support a unique taxonomy for combat-related mTBI. The clinical differences among these subtypes indicate a need for unique treatment resources and programs.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Schulte, S; Rasmussen, N N; McBeth, J W; Richards, P Q; Yochem, E; Petron, D J; Strathmann, F G
In: EPMA Journal, vol. 7, no. 1, 2016.
@article{Schulte2016b,
title = {Utilization of the clinical laboratory for the implementation of concussion biomarkers in collegiate football and the necessity of personalized and predictive athlete specific reference intervals},
author = {Schulte, S and Rasmussen, N N and McBeth, J W and Richards, P Q and Yochem, E and Petron, D J and Strathmann, F G},
doi = {10.1186/s13167-016-0050-x},
year = {2016},
date = {2016-01-01},
journal = {EPMA Journal},
volume = {7},
number = {1},
abstract = {Background: A continued interest in concussion biomarkers makes the eventual implementation of identified biomarkers into routine concussion assessment an eventual reality. We sought to develop and test an interdisciplinary approach that could be used to integrate blood-based biomarkers into the established concussion management program for a collegiate football team. Methods: We used a CLIA-certified laboratory for all testing and chose biomarkers where clinically validated testing was available as would be required for results used in clinical decision making. We summarized the existing methods and results for concussion assessment across an entire season to identify and demonstrate the challenges with the eventual integration of a parallel process using blood-based tests for concussion management. We analyzed the results of the biomarkers chosen for trends consistent with the outcome assessments provided from the current concussion management protocols. Results: Baseline samples were collected with three additional post-concussion samples collected at three separate time points from players with a diagnosed concussion (n = 12). A summary of results from currently used concussion assessment tools were compared to the representative biomarkers S100B and NSE results. Nine sport-related concussions occurred during practice and three during play. For S100B, 50% had follow-up testing results lower than the post-injury result. In contrast, 92% of NSE follow-up results were lower than post-injury. One hundred percent of the results for S100B and NSE were within the athlete-derived reference intervals upon return-to-play and season end. Conclusions: The reported workflow provides a framework for the eventual implementation of biomarkers for concussion assessment into existing assessment protocols and strengthens the need for reliance on clinical laboratory testing. Athlete-specific reference intervals will be required to adequately interpret results. © 2016 Schulte et al.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wu, L C; Nangia, V; Bui, K; Hammoor, B; Kurt, M; Hernandez, F; Kuo, C; Camarillo, D B
In Vivo Evaluation of Wearable Head Impact Sensors Journal Article
In: Annals of Biomedical Engineering, vol. 44, no. 4, pp. 1234–1245, 2016.
@article{Wu2016,
title = {In Vivo Evaluation of Wearable Head Impact Sensors},
author = {Wu, L C and Nangia, V and Bui, K and Hammoor, B and Kurt, M and Hernandez, F and Kuo, C and Camarillo, D B},
year = {2016},
date = {2016-01-01},
journal = {Annals of Biomedical Engineering},
volume = {44},
number = {4},
pages = {1234--1245},
abstract = {Inertial sensors are commonly used to measure human head motion. Some sensors have been tested with dummy or cadaver experiments with mixed results, and methods to evaluate sensors in vivo are lacking. Here we present an in vivo method using high speed video to test teeth-mounted (mouthguard), soft tissue-mounted (skin patch), and headgear-mounted (skull cap) sensors during 6-13 g sagittal soccer head impacts. Sensor coupling to the skull was quantified by displacement from an ear-canal reference. Mouthguard displacements were within video measurement error (\<1 mm), while the skin patch and skull cap displaced up to 4 and 13 mm from the ear-canal reference, respectively. We used the mouthguard, which had the least displacement from skull, as the reference to assess 6-degree-of-freedom skin patch and skull cap measurements. Linear and rotational acceleration magnitudes were over-predicted by both the skin patch (with 120% NRMS error for a(mag), 290% for alpha(mag)) and the skull cap (320% NRMS error for a(mag), 500% for alpha(mag)). Such over-predictions were largely due to out-of-plane motion. To model sensor error, we found that in-plane skin patch linear acceleration in the anterior-posterior direction could be modeled by an underdamped viscoelastic system. In summary, the mouthguard showed tighter skull coupling than the other sensor mounting approaches. Furthermore, the in vivo methods presented are valuable for investigating skull acceleration sensor technologies.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Williams, J M; Langdon, J L; McMillan, J L; Buckley, T A
English professional football players concussion knowledge and attitude Journal Article
In: Journal of Sport and Health Science, vol. 5, no. 2, pp. 197–204, 2016.
@article{Williams2016,
title = {English professional football players concussion knowledge and attitude},
author = {Williams, J M and Langdon, J L and McMillan, J L and Buckley, T A},
doi = {10.1016/j.jshs.2015.01.009},
year = {2016},
date = {2016-01-01},
journal = {Journal of Sport and Health Science},
volume = {5},
number = {2},
pages = {197--204},
abstract = {Background: Concussions are a common pathology in football and multiple misconceptions exist amongst the players and managers. To address these misconceptions, and potentially reduce concussion associated sequela, effective educational interventions need to be developed. However, the current knowledge and attitude status must be ascertained to appropriately develop these interventions. The purpose of this study was to assess the concussion knowledge and attitude of English professional footballers. Methods: Twenty-six participants from one English Football League Championship club completed the study. A mixed methods approach included the Rosenbaum Concussion Knowledge and Attitudes Survey (RoCKAS) and a semi-structured interview. The RoCKAS contains separate knowledge (0-25) and attitude (15-75) scores and was followed by a semi-structured interview consisting of concussion knowledge, attitude, and behavior related questions. Results: The mean score on the RoCKAS knowledge was 16.4 ± 2.9 (range 11-22) and the attitude score was 59.6 ± 8.5 (range 41-71). The interview responses identified inconsistencies between the RoCKAS and the intended behaviors, endorsing multiple concussion misconceptions, and revealed barriers to concussion reporting. Conclusion: The results of this study suggest that Championship Level English footballers have moderate concussion knowledge, safe attitudes, and good concussion symptom recognition when assessed with pen and paper questionnaires. However, within the semi-structured interview many respondents reported unsafe concussion behaviors despite accurately identifying the potential risks. Further, multiple barriers to concussion reporting were identified which included perceived severity of the injury, game situations, and the substitution rule. These findings can help form the foundation of educational interventions to potentially improve concussion reporting behaviors amongst professional footballers. © 2016.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Calcagnile, O; Anell, A; Unden, J
The addition of S100B to guidelines for management of mild head injury is potentially cost saving Journal Article
In: BMC Neurology, vol. 16, no. 1, pp. 200, 2016.
@article{Calcagnile2016,
title = {The addition of S100B to guidelines for management of mild head injury is potentially cost saving},
author = {Calcagnile, O and Anell, A and Unden, J},
year = {2016},
date = {2016-01-01},
journal = {BMC Neurology},
volume = {16},
number = {1},
pages = {200},
abstract = {BACKGROUND: Mild traumatic brain injury (TBI) is associated with substantial costs due to over-triage of patients to computed tomography (CT) scanning, despite validated decision rules. Serum biomarker S100B has shown promise for safely omitting CT scans but the economic impact from clinical use has never been reported. In 2007, S100B was adapted into the existing Scandinavian management guidelines in Halmstad, Sweden, in an attempt to reduce CT scans and save costs. METHODS: Consecutive adult patients with mild TBI (GCS 14-15, loss of consciousness and/or amnesia), managed with the aid of S100B, were prospectively included in this study. Patients were followed up after 3 months with a standardized questionnaire. Theoretical and actual cost differences were calculated. RESULTS: Seven hundred twenty-six patients were included and 29 (4.7 %) showed traumatic abnormalities on CT. No further significant intracranial complications were discovered on follow-up. Two hundred twenty-nine patients (27 %) had normal S100B levels and 497 patients (73 %) showed elevated S100B levels. Over-triage occurred in 73 patients (32 %) and under-triage occurred in 39 patients (7 %). No significant intracranial complications were missed. The introduction of S100B could save 71 per patient if guidelines were strictly followed. As compliance to the guidelines was not perfect, the actual cost saving was 39 per patient. CONCLUSION: Adding S100B to existing guidelines for mild TBI seems to reduce CT usage and costs, especially if guideline compliance could be increased.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
King, J B; Lopez-Larson, M P; Yurgelun-Todd, D A
Mean cortical curvature reflects cytoarchitecture restructuring in mild traumatic brain injury Journal Article
In: NeuroImage Clinical, vol. 11, pp. 81–89, 2016.
@article{King2016a,
title = {Mean cortical curvature reflects cytoarchitecture restructuring in mild traumatic brain injury},
author = {King, J B and Lopez-Larson, M P and Yurgelun-Todd, D A},
year = {2016},
date = {2016-01-01},
journal = {NeuroImage Clinical},
volume = {11},
pages = {81--89},
abstract = {In the United States alone, the number of persons living with the enduring consequences of traumatic brain injuries is estimated to be between 3.2 and 5 million. This number does not include individuals serving in the United States military or seeking care at Veterans Affairs hospitals. The importance of understanding the neurobiological consequences of mild traumatic brain injury (mTBI) has increased with the return of veterans from conflicts overseas, many of who have suffered this type of brain injury. However, identifying the neuroanatomical regions most affected by mTBI continues to prove challenging. The aim of this study was to assess the use of mean cortical curvature as a potential indicator of progressive tissue loss in a cross-sectional sample of 54 veterans with mTBI compared to 31 controls evaluated with MRI. It was hypothesized that mean cortical curvature would be increased in veterans with mTBI, relative to controls, due in part to cortical restructuring related to tissue volume loss. Mean cortical curvature was assessed in 60 bilateral regions (31 sulcal, 29 gyral). Of the 120 regions investigated, nearly 50% demonstrated significantly increased mean cortical curvature in mTBI relative to controls with 25% remaining significant following multiple comparison correction (all, pFDR \< .05). These differences were most prominent in deep gray matter regions of the cortex. Additionally, significant relationships were found between mean cortical curvature and gray and white matter volumes (all, p \< .05). These findings suggest potentially unique patterns of atrophy by region and indicate that changes in brain microstructure due to mTBI are sensitive to measures of mean curvature.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Puvenna, V; Engeler, M; Banjara, M; Brennan, C; Schreiber, P; Dadas, A; Bahrami, A; Solanki, J; Bandyopadhyay, A; Morris, J K; Bernick, C; Ghosh, C; Rapp, E; Bazarian, J J; Janigro, D
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy Journal Article
In: Brain Research, vol. 1630, pp. 225–240, 2016.
@article{Puvenna2016,
title = {Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy},
author = {Puvenna, V and Engeler, M and Banjara, M and Brennan, C and Schreiber, P and Dadas, A and Bahrami, A and Solanki, J and Bandyopadhyay, A and Morris, J K and Bernick, C and Ghosh, C and Rapp, E and Bazarian, J J and Janigro, D},
year = {2016},
date = {2016-01-01},
journal = {Brain Research},
volume = {1630},
pages = {225--240},
abstract = {Repetitive traumatic brain injury (rTBI) is one of the major risk factors for the abnormal deposition of phosphorylated tau (PT) in the brain and chronic traumatic encephalopathy (CTE). CTE and temporal lobe epilepsy (TLE) affect the limbic system, but no comparative studies on PT distribution in TLE and CTE are available. It is also unclear whether PT pathology results from repeated head hits (rTBI). These gaps prevent a thorough understanding of the pathogenesis and clinical significance of PT, limiting our ability to develop preventative and therapeutic interventions. We quantified PT in TLE and CTE to unveil whether a history of rTBI is a prerequisite for PT accumulation in the brain. Six postmortem CTE (mean 73.3 years) and age matched control samples were compared to 19 surgically resected TLE brain specimens (4 months-58 years; mean 27.6 years). No history of TBI was present in TLE or control; all CTE patients had a history of rTBI. TLE and CTE brain displayed increased levels of PT as revealed by immunohistochemistry. No age-dependent changes were noted, as PT was present as early as 4 months after birth. In TLE and CTE, cortical neurons, perivascular regions around penetrating pial vessels and meninges were immunopositive for PT; white matter tracts also displayed robust expression of extracellular PT organized in bundles parallel to venules. Microscopically, there were extensive tau-immunoreactive neuronal, astrocytic and degenerating neurites throughout the brain. In CTE perivascular tangles were most prominent. Overall, significant differences in staining intensities were found between CTE and control (P\<0.01) but not between CTE and TLE (P=0.08). pS199 tau analysis showed that CTE had the most high molecular weight tangle-associated tau, whereas epileptic brain contained low molecular weight tau. Tau deposition may not be specific to rTBI since TLE recapitulated most of the pathological features of CTE. Copyright © 2015 Elsevier B.V. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Stern, R A; Tripodis, Y; Baugh, C M; Fritts, N G; Martin, B M; Chaisson, C; Cantu, R C; Joyce, J A; Shah, S; Ikezu, T; Zhang, J; Gercel-Taylor, C; Taylor, D D
Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy Journal Article
In: Journal of Alzheimer's Disease, vol. 51, no. 4, pp. 1099–1109, 2016.
@article{Stern2016,
title = {Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy},
author = {Stern, R A and Tripodis, Y and Baugh, C M and Fritts, N G and Martin, B M and Chaisson, C and Cantu, R C and Joyce, J A and Shah, S and Ikezu, T and Zhang, J and Gercel-Taylor, C and Taylor, D D},
year = {2016},
date = {2016-01-01},
journal = {Journal of Alzheimer's Disease},
volume = {51},
number = {4},
pages = {1099--1109},
abstract = {BACKGROUND: Chronic traumatic encephalopathy (CTE) is a tauopathy associated with prior exposure to repetitive head impacts, such as those incurred through American football and other collision sports. Diagnosis is made through neuropathological examination. Many of the clinical features of CTE are common in the general population, with and without a history of head impact exposure, making clinical diagnosis difficult. As is now common in the diagnosis of other neurodegenerative disorders, such as Alzheimer's disease, there is a need for methods to diagnose CTE during life through objective biomarkers. OBJECTIVE: The aim of this study was to examine tau-positive exosomes in plasma as a potential CTE biomarker. METHODS: Subjects were 78 former National Football League (NFL) players and 16 controls. Extracellular vesicles were isolated from plasma. Fluorescent nanoparticle tracking analysis was used to determine the number of vesicles staining positive for tau. RESULTS: The NFL group had higher exosomal tau than the control group (p \< 0.0001). Exosomal tau discriminated between the groups, with 82% sensitivity, 100% specificity, 100% positive predictive value, and 53% negative predictive value. Within the NFL group, higher exosomal tau was associated with worse performance on tests of memory (p = 0.0126) and psychomotor speed (p = 0.0093). CONCLUSION: These preliminary findings suggest that exosomal tau in plasma may be an accurate, noninvasive CTE biomarker.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Clark, J M; Hoshizaki, T B
The Ability of Men's Lacrosse Helmets to Reduce the Dynamic Impact Response for Different Striking Techniques in Women's Field Lacrosse Journal Article
In: American Journal of Sports Medicine, vol. 44, no. 4, pp. 1047–1055, 2016.
@article{Clark2016,
title = {The Ability of Men's Lacrosse Helmets to Reduce the Dynamic Impact Response for Different Striking Techniques in Women's Field Lacrosse},
author = {Clark, J M and Hoshizaki, T B},
year = {2016},
date = {2016-01-01},
journal = {American Journal of Sports Medicine},
volume = {44},
number = {4},
pages = {1047--1055},
abstract = {BACKGROUND: Women's field lacrosse is described as a noncontact game relying primarily on rules to decrease the risk of head injuries. Despite not allowing head contact, however, concussions continue to be reported in women's field lacrosse. PURPOSE: To assess the ability of men's lacrosse helmets to decrease linear and angular acceleration for different striking techniques in women's field lacrosse. STUDY DESIGN: Controlled laboratory study. METHODS: A helmeted and unhelmeted Hybrid III 50th Percentile headform was attached to a Hybrid III neckform and were subjected to impacts by 8 striking techniques. Eleven athletic females completed 5 slashing techniques, while physical reconstruction equipment was used to simulate falls and shoulder and ball impacts to the head. Three trials were conducted for each condition, and peak resultant linear and angular accelerations of the headform were measured. RESULTS: Falls produced the highest linear and angular acceleration, followed by ball and high-velocity stick impacts. Low-velocity stick impacts were found to produce the lowest linear and angular accelerations. Men's lacrosse helmets significantly decreased linear and angular accelerations in all conditions, while unhelmeted impacts were associated with high accelerations. CONCLUSION: If women's field lacrosse is played within the rules, only falls were found to produce high linear and angular acceleration. However, ball and high-velocity stick impacts were found to produce high linear and angular accelerations. These linear and angular accelerations were found to be within the ranges reported for concussion. When the game is not played within the rules, men's lacrosse helmets provide an effective method of reducing linear and angular accelerations. Thus, women's field lacrosse may be able to reduce the occurrence of high linear and angular acceleration impacts by having governing bodies improving rules, implementing the use of helmets, or both. CLINICAL RELEVANCE: Identifying striking techniques that produce high linear and angular acceleration specific to women's lacrosse and measuring the capacity of a men's lacrosse helmet to reduce linear and angular acceleration.Copyright © 2016 The Author(s).},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lucke-Wold, B P; Turner, R C; Logsdon, A F; Nguyen, L; Bailes, J E; Lee, J M; Robson, M J; Omalu, B I; Huber, J D; Rosen, C L
Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy Journal Article
In: Journal of Neurosurgery, vol. 124, no. 3, pp. 687–702, 2016.
@article{Lucke-Wold2016,
title = {Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy},
author = {Lucke-Wold, B P and Turner, R C and Logsdon, A F and Nguyen, L and Bailes, J E and Lee, J M and Robson, M J and Omalu, B I and Huber, J D and Rosen, C L},
year = {2016},
date = {2016-01-01},
journal = {Journal of Neurosurgery},
volume = {124},
number = {3},
pages = {687--702},
abstract = {OBJECTIVE: Chronic traumatic encephalopathy is a progressive neurodegenerative disease characterized by neurofibrillary tau tangles following repetitive neurotrauma. The underlying mechanism linking traumatic brain injury to chronic traumatic encephalopathy has not been elucidated. The authors investigate the role of endoplasmic reticulum stress as a link between acute neurotrauma and chronic neurodegeneration. METHODS: The authors used pharmacological, biochemical, and behavioral tools to assess the role of endoplasmic reticulum stress in linking acute repetitive traumatic brain injury to the development of chronic neurodegeneration. Data from the authors' clinically relevant and validated rodent blast model were compared with those obtained from postmortem human chronic traumatic encephalopathy specimens from a National Football League player and World Wrestling Entertainment wrestler. RESULTS: The results demonstrated strong correlation of endoplasmic reticulum stress activation with subsequent tau hyperphosphorylation. Various endoplasmic reticulum stress markers were increased in human chronic traumatic encephalopathy specimens, and the endoplasmic reticulum stress response was associated with an increase in the tau kinase, glycogen synthase kinase-3beta. Docosahexaenoic acid, an endoplasmic reticulum stress inhibitor, improved cognitive performance in the rat model 3 weeks after repetitive blast exposure. The data showed that docosahexaenoic acid administration substantially reduced tau hyperphosphorylation (t = 4.111, p \< 0.05), improved cognition (t = 6.532, p \< 0.001), and inhibited C/EBP homology protein activation (t = 5.631, p \< 0.01). Additionally the data showed, for the first time, that endoplasmic reticulum stress is involved in the pathophysiology of chronic traumatic encephalopathy. CONCLUSIONS: Docosahexaenoic acid therefore warrants further investigation as a potential therapeutic agent for the prevention of chronic traumatic encephalopathy.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Underwood, E
NEUROSCIENCE. Can brain scans reveal concussion-linked disease? Journal Article
In: Science, vol. 352, no. 6288, pp. 881, 2016.
@article{Underwood2016,
title = {NEUROSCIENCE. Can brain scans reveal concussion-linked disease?},
author = {Underwood, E},
year = {2016},
date = {2016-01-01},
journal = {Science},
volume = {352},
number = {6288},
pages = {881},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gardner, A J; Tan, C O; Ainslie, P N; Van Donkelaar, P; Stanwell, P; Levi, C R; Iverson, G L
Cerebrovascular reactivity assessed by transcranial Doppler ultrasound in sport-related concussion: A systematic review Journal Article
In: British Journal of Sports Medicine, vol. 49, no. 16, pp. 1050–1055, 2015.
@article{Gardner2015bb,
title = {Cerebrovascular reactivity assessed by transcranial Doppler ultrasound in sport-related concussion: A systematic review},
author = {Gardner, A J and Tan, C O and Ainslie, P N and {Van Donkelaar}, P and Stanwell, P and Levi, C R and Iverson, G L},
doi = {10.1136/bjsports-2014-093901},
year = {2015},
date = {2015-01-01},
journal = {British Journal of Sports Medicine},
volume = {49},
number = {16},
pages = {1050--1055},
abstract = {Background: Traumatic brain injury influences regulation of cerebral blood flow in animal models and in human studies. We reviewed the use of transcranial Doppler ultrasound (US) to monitor cerebrovascular reactivity following sport-related concussion. Review method: A narrative and systematic review of articles published in the English language, from December 1982 to October 2013. Data sources: Articles were retrieved via numerous databases using relevant key terms. Observational, cohort, correlational, cross-sectional and longitudinal studies were included. Results: Three publications met the criteria for inclusion; these provided data from 42 athletes and 33 controls. All three studies reported reductions in cerebrovascular reactivity via transcranial Doppler US. Conclusions: These initial results support the use of cerebrovascular reactivity as a research tool for identifying altered neurophysiology and monitoring recovery in adult athletes. Larger cross-sectional, prospective and longitudinal studies are required to understand the sensitivity and prognostic value of cerebrovascular reactivity in sport-related concussion. © 2015, BMJ Publishing Group. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Smith, A M; Stuart, M J; Dodick, D W; Roberts, W O; Alford, P W; Ashare, A B; Aubrey, M; Benson, B W; Burke, C J; Dick, R; Eickhoff, C; Emery, C A; Flashman, L A; Gaz, D; Giza, C C; Greenwald, R M; Herring, S; Hoshizaki, T B; Hudziak, J J; Huston 3rd, J; Krause, D; LaVoi, N; Leaf, M; Leddy, J J; MacPherson, A; McKee, A C; Mihalik, J P; Moessner, A M; Montelpare, W J; Putukian, M; Schneider, K J; Szalkowski, R; Tabrum, M; Whitehead, J; Wiese-Bjornstal, D M
Ice Hockey Summit II: zero tolerance for head hits and fighting.[Erratum appears in Clin J Sport Med. 2015 Jul;25(4):379] Journal Article
In: Clinical Journal of Sport Medicine, vol. 25, no. 2, pp. 78–87, 2015.
@article{Smith2015a,
title = {Ice Hockey Summit II: zero tolerance for head hits and fighting.[Erratum appears in Clin J Sport Med. 2015 Jul;25(4):379]},
author = {Smith, A M and Stuart, M J and Dodick, D W and Roberts, W O and Alford, P W and Ashare, A B and Aubrey, M and Benson, B W and Burke, C J and Dick, R and Eickhoff, C and Emery, C A and Flashman, L A and Gaz, D and Giza, C C and Greenwald, R M and Herring, S and Hoshizaki, T B and Hudziak, J J and {Huston 3rd}, J and Krause, D and LaVoi, N and Leaf, M and Leddy, J J and MacPherson, A and McKee, A C and Mihalik, J P and Moessner, A M and Montelpare, W J and Putukian, M and Schneider, K J and Szalkowski, R and Tabrum, M and Whitehead, J and Wiese-Bjornstal, D M},
year = {2015},
date = {2015-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {25},
number = {2},
pages = {78--87},
abstract = {OBJECTIVE: To present currently known basic science and on-ice influences of sport-related concussion (SRC) in hockey, building on the Ice Hockey Summit I action plan (2011) to reduce SRC. METHODS: The prior summit proceedings included an action plan intended to reduce SRC. As such, the proceedings from Summit I served as a point of departure, for the science and discussion held during Summit II (Mayo Clinic, Rochester MN, October 2013). Summit II focused on (1) Basic Science of Concussions in Ice Hockey: Taking Science Forward; (2) Acute and Chronic Concussion Care: Making a Difference; (3) Preventing Concussions via Behavior, Rules, Education and Measuring Effectiveness; (4) Updates in Equipment: their Relationship to Industry Standards; and (5) Policies and Plans at State, National and Federal Levels to reduce SRC. Action strategies derived from the presentations and discussion described in these sectors were subsequently voted on for purposes of prioritization. The following proceedings include knowledge and research shared by invited faculty, many of whom are health care providers and clinical investigators. RESULTS: The Summit II evidence-based action plan emphasizes the rapidly evolving scientific content of hockey SRC. It includes the most highly prioritized strategies voted on for implementation to decrease concussion. CONCLUSIONS: The highest priority action items identified from the Summit includes the following: (1) eliminate head hits from all levels of ice hockey, (2) change body-checking policies, and (3) eliminate fighting in all amateur and professional hockey.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Meehan, W P; Jordaan, M; Prabhu, S P; Carew, L; Mannix, R C; Proctor, M R
Risk of athletes with chiari malformations suffering catastrophic injuries during sports participation is low Journal Article
In: Clinical Journal of Sport Medicine, vol. 25, no. 2, pp. 133–137, 2015.
@article{Meehan2015,
title = {Risk of athletes with chiari malformations suffering catastrophic injuries during sports participation is low},
author = {Meehan, W P and Jordaan, M and Prabhu, S P and Carew, L and Mannix, R C and Proctor, M R},
doi = {10.1097/JSM.0000000000000107},
year = {2015},
date = {2015-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {25},
number = {2},
pages = {133--137},
abstract = {Objective: To estimate the risk of athletes with Chiari malformations sustaining a catastrophic injury. Design: Retrospective, descriptive cohort study. Participants: All patients diagnosed with Chiari malformation at our institution between June 2008 and November 2011. Assessment of Risk Factors: Participants were mailed a questionnaire regarding the number of seasons they participated in organized athletics. Magnetic resonance images were reviewed to describe the characteristics of respondent's Chiari malformations. Main Outcome Measures: Whether or not the patient had sustained an injury resulting in death, coma, or paralysis. Results: We had a 53% (N = 147) response rate. Respondents were of a mean age of 15 years (SD, 2 years) at the time of diagnosis. The mean length of protrusion of the cerebellar tonsils below the foramen magnum was 11.2 mm (SD, 5.7 mm). Most of the respondents had pointed cerebellar tonsils and some degree of crowding within the foramen magnum. During a total of 1627 athletic seasons played by patients with Chiari malformation, 0 respondents [95% confidence interval (CI), 0.0000-0.0023] sustained an injury resulting in death, coma, or paralysis. Likewise, during 191 collision sport athletic seasons, 0 (95% CI, 0.0000-0.0191) respondents sustained an injury resulting in death, coma, or paralysis. Conclusions: The risk of athletes with Chiari malformations suffering catastrophic injuries during sports participation is low. This estimate of risk should be considered when making return-toplay decisions. Given the variability of anatomical consideration for patients with Chiari malformations, however, each return-to-play decision must continue to be made on a case-by-case basis, considering all of the available information. Clinical Relevance: The low risk of athletes with Chiari malformations suffering catastrophic injuries in sports should be considered when making return-to-play decisions. © 2014 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Stein, T D; Montenigro, P H; Alvarez, V E; Xia, W; Crary, J F; Tripodis, Y; Daneshvar, D H; Mez, J; Solomon, T; Meng, G; Kubilus, C A; Cormier, K A; Meng, S; Babcock, K; Kiernan, P; Murphy, L; Nowinski, C J; Martin, B; Dixon, D; Stern, R A; Cantu, R C; Kowall, N W; McKee, A C
Beta-amyloid deposition in chronic traumatic encephalopathy Journal Article
In: Acta Neuropathologica, vol. 130, no. 1, pp. 21–34, 2015.
@article{Stein2015b,
title = {Beta-amyloid deposition in chronic traumatic encephalopathy},
author = {Stein, T D and Montenigro, P H and Alvarez, V E and Xia, W and Crary, J F and Tripodis, Y and Daneshvar, D H and Mez, J and Solomon, T and Meng, G and Kubilus, C A and Cormier, K A and Meng, S and Babcock, K and Kiernan, P and Murphy, L and Nowinski, C J and Martin, B and Dixon, D and Stern, R A and Cantu, R C and Kowall, N W and McKee, A C},
year = {2015},
date = {2015-01-01},
journal = {Acta Neuropathologica},
volume = {130},
number = {1},
pages = {21--34},
abstract = {Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. It is defined pathologically by the abnormal accumulation of tau in a unique pattern that is distinct from other tauopathies, including Alzheimer's disease (AD). Although trauma has been suggested to increase amyloid beta peptide (Abeta) levels, the extent of Abeta deposition in CTE has not been thoroughly characterized. We studied a heterogeneous cohort of deceased athletes and military veterans with neuropathologically diagnosed CTE (n = 114, mean age at death = 60) to test the hypothesis that Abeta deposition is altered in CTE and associated with more severe pathology and worse clinical outcomes. We found that Abeta deposition, either as diffuse or neuritic plaques, was present in 52 % of CTE subjects. Moreover, Abeta deposition in CTE occurred at an accelerated rate and with altered dynamics in CTE compared to a normal aging population (OR = 3.8, p \< 0.001). We also found a clear pathological and clinical dichotomy between those CTE cases with Abeta plaques and those without. Abeta deposition was significantly associated with the presence of the APOE epsilon4 allele (p = 0.035), older age at symptom onset (p \< 0.001), and older age at death (p \< 0.001). In addition, when controlling for age, neuritic plaques were significantly associated with increased CTE tauopathy stage (beta = 2.43},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Maerlender, A; Rieman, W; Lichtenstein, J; Condiracci, C
Programmed physical exertion in recovery from sports-related concussion: A randomized pilot study Journal Article
In: Developmental Neuropsychology, vol. 40, no. 5, pp. 273–278, 2015.
@article{Maerlender2015a,
title = {Programmed physical exertion in recovery from sports-related concussion: A randomized pilot study},
author = {Maerlender, A and Rieman, W and Lichtenstein, J and Condiracci, C},
doi = {10.1080/87565641.2015.1067706},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {5},
pages = {273--278},
abstract = {Although no data exist, general practice recommends only rest following concussion. This randomized clinical trial found that programmed physical exertion during recovery produced no significant differences in recovery time between groups of participants. However, high levels of exertion were deleterious. This study provides initial evidence that moderate physical activity is a safe replacement behavior during recovery. © 2015 Copyright © 2015 Taylor \& Francis Group, LLC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Laksari, K; Wu, L C; Kurt, M; Kuo, C; Camarillo, D C
Resonance of human brain under head acceleration Journal Article
In: Journal of the Royal Society Interface, vol. 12, no. 108, pp. 20150331, 2015.
Abstract | BibTeX | Tags: *Acceleration/ae [Adverse Effects], *BRAIN, *Brain Injuries, *Craniocerebral Trauma, *MAGNETIC resonance imaging, *Skull, adult, Brain Injuries/dg [Diagnostic Imaging], Brain Injuries/pp [Physiopathology], Brain/dg [Diagnostic Imaging], Brain/pp [Physiopathology], Craniocerebral Trauma/dg [Diagnostic Imaging], Craniocerebral Trauma/pp [Physiopathology], Humans, Male, Radiography, Skull/dg [Diagnostic Imaging], Skull/pp [Physiopathology]
@article{Laksari2015,
title = {Resonance of human brain under head acceleration},
author = {Laksari, K and Wu, L C and Kurt, M and Kuo, C and Camarillo, D C},
year = {2015},
date = {2015-01-01},
journal = {Journal of the Royal Society Interface},
volume = {12},
number = {108},
pages = {20150331},
abstract = {Although safety standards have reduced fatal head trauma due to single severe head impacts, mild trauma from repeated head exposures may carry risks of long-term chronic changes in the brain's function and structure. To study the physical sensitivities of the brain to mild head impacts, we developed the first dynamic model of the skull-brain based on in vivo MRI data. We showed that the motion of the brain can be described by a rigid-body with constrained kinematics. We further demonstrated that skull-brain dynamics can be approximated by an under-damped system with a low-frequency resonance at around 15 Hz. Furthermore, from our previous field measurements, we found that head motions in a variety of activities, including contact sports, show a primary frequency of less than 20 Hz. This implies that typical head exposures may drive the brain dangerously close to its mechanical resonance and lead to amplified brain-skull relative motions. Our results suggest a possible cause for mild brain trauma, which could occur due to repetitive low-acceleration head oscillations in a variety of recreational and occupational activities. Copyright © 2015 The Author(s) Published by the Royal Society. All rights reserved.},
keywords = {*Acceleration/ae [Adverse Effects], *BRAIN, *Brain Injuries, *Craniocerebral Trauma, *MAGNETIC resonance imaging, *Skull, adult, Brain Injuries/dg [Diagnostic Imaging], Brain Injuries/pp [Physiopathology], Brain/dg [Diagnostic Imaging], Brain/pp [Physiopathology], Craniocerebral Trauma/dg [Diagnostic Imaging], Craniocerebral Trauma/pp [Physiopathology], Humans, Male, Radiography, Skull/dg [Diagnostic Imaging], Skull/pp [Physiopathology]},
pubstate = {published},
tppubtype = {article}
}
Baker, J G; Leddy, J J; Darling, S R; Rieger, B P; Mashtare, T L; Sharma, T; Willer, B S
Factors Associated with Problems for Adolescents Returning to the Classroom after Sport-Related Concussion Journal Article
In: Clinical Pediatrics, vol. 54, no. 10, pp. 961–968, 2015.
Abstract | Links | BibTeX | Tags: Absenteeism, Adolescent, adolescent disease, adult, Article, athlete, Athletic Injuries, brain concussion, computer testing, Concussion, disease association, disease severity, Female, follow up, Follow-Up Studies, health service, human, Humans, interview, Interviews as Topic, Logistic Models, major clinical study, Male, Pathophysiology, receiver operating characteristic, recovery time, Recurrence, recurrent disease, return to learn, ROC Curve, school, school problems, sport injury, Sport-related concussion, statistical model, Symptoms, telephone interview, Young Adult
@article{Baker2015,
title = {Factors Associated with Problems for Adolescents Returning to the Classroom after Sport-Related Concussion},
author = {Baker, J G and Leddy, J J and Darling, S R and Rieger, B P and Mashtare, T L and Sharma, T and Willer, B S},
doi = {10.1177/0009922815588820},
year = {2015},
date = {2015-01-01},
journal = {Clinical Pediatrics},
volume = {54},
number = {10},
pages = {961--968},
abstract = {The primary objective of this study was to determine factors in the clinic setting associated with concussion-related problems in the school setting. A total of 91 student athletes, 13 to 19 years old, completed the SCAT2 and computerized testing during their initial visit to the clinic. During a follow-up telephone interview, one-third reported problems with return to school. The presence of problems reported in school was associated with severity of concussion as represented by recovery time and the overall number of symptoms at the first clinic visit. Gender, age, and previous concussions were not associated with school problems. Athletes with computerized test scores below the ninth percentile were more likely to report school problems. The current study offers some descriptive information for clinicians and ideas for future research related to adolescent athletes with concussion and problems with return to the classroom. © SAGE Publications.},
keywords = {Absenteeism, Adolescent, adolescent disease, adult, Article, athlete, Athletic Injuries, brain concussion, computer testing, Concussion, disease association, disease severity, Female, follow up, Follow-Up Studies, health service, human, Humans, interview, Interviews as Topic, Logistic Models, major clinical study, Male, Pathophysiology, receiver operating characteristic, recovery time, Recurrence, recurrent disease, return to learn, ROC Curve, school, school problems, sport injury, Sport-related concussion, statistical model, Symptoms, telephone interview, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Fitch, T; Villanueva, G; Quadir, M M; Sagiraju, H K; Alamgir, H
The prevalence and risk factors of Post-Traumatic Stress Disorder among workers injured in Rana Plaza building collapse in Bangladesh Journal Article
In: American Journal of Industrial Medicine, vol. 58, no. 7, pp. 756–763, 2015.
Abstract | BibTeX | Tags: *Occupational Diseases/ep [Epidemiology], *Stress Disorders, *Structure Collapse, *Survivors/px [Psychology], *Textile Industry, adult, Bangladesh/ep [Epidemiology], Employment/px [Psychology], Female, Humans, Logistic Models, Male, Marital Status, Occupational Diseases/et [Etiology], ODDS ratio, Post-Traumatic/ep [Epidemiology, Post-Traumatic/et [Etiology], Prevalence, Risk Factors, Stress Disorders, Work/px [Psychology], Young Adult
@article{Fitch2015,
title = {The prevalence and risk factors of Post-Traumatic Stress Disorder among workers injured in Rana Plaza building collapse in Bangladesh},
author = {Fitch, T and Villanueva, G and Quadir, M M and Sagiraju, H K and Alamgir, H},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Industrial Medicine},
volume = {58},
number = {7},
pages = {756--763},
abstract = {OBJECTIVES: Prevalence and risk factors of PTSD among injured garment workers who survived a major factory collapse. METHODS: Survivors receiving treatment or rehabilitation care at one year post event were surveyed, which included Post Traumatic Stress Disorder Checklist Specific version. RESULTS: The respondents consisted of 181 people with a mean age of 27.8 years and a majority had less than high school education (91.2%). Multivariable logistic regression found that the odds of having PTSD was higher among married (OR: 3.2 [95% CI: 1.3-8.0]), those who used to work more than 70hr/week (OR: 2.4 [1.1-5.3]), workers who used to hold higher job positions (OR: 2.6 [1.2-5.6]) or who had a concussion injury (OR: 3.7 [1.4-9.8]). Among the respondents, 83.4% remained unemployed, and only 57.3% (63 people) reported receiving a quarter or less of what they were promised as compensation. CONCLUSIONS: Probable PTSD was prevalent among surviving workers of the Rana Plaza building collapse in Bangladesh.Copyright © 2015 Wiley Periodicals, Inc.},
keywords = {*Occupational Diseases/ep [Epidemiology], *Stress Disorders, *Structure Collapse, *Survivors/px [Psychology], *Textile Industry, adult, Bangladesh/ep [Epidemiology], Employment/px [Psychology], Female, Humans, Logistic Models, Male, Marital Status, Occupational Diseases/et [Etiology], ODDS ratio, Post-Traumatic/ep [Epidemiology, Post-Traumatic/et [Etiology], Prevalence, Risk Factors, Stress Disorders, Work/px [Psychology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Dretsch, M N; Silverberg, N D; Iverson, G L
Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers Journal Article
In: Journal of Neurotrauma, vol. 32, no. 17, pp. 1301–1306, 2015.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Cognition Disorders/di [Diagnosis], *Military Personnel/sn [Statistics & Numerical Dat, *Post-Concussion Syndrome/di [Diagnosis], adult, Brain Concussion/ep [Epidemiology], Cognition Disorders/ep [Epidemiology], Cognition Disorders/et [Etiology], Female, Humans, Male, Post-Concussion Syndrome/ep [Epidemiology], Post-Concussion Syndrome/et [Etiology], United States/ep [Epidemiology], Young Adult
@article{Dretsch2015,
title = {Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers},
author = {Dretsch, M N and Silverberg, N D and Iverson, G L},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurotrauma},
volume = {32},
number = {17},
pages = {1301--1306},
abstract = {The extent to which multiple past concussions are associated with lingering symptoms or mental health problems in military service members is not well understood. The purpose of this study was to examine the association between lifetime concussion history, cognitive functioning, general health, and psychological health in a large sample of fit-for-duty U.S. Army soldiers preparing for deployment. Data on 458 active-duty soldiers were collected and analyzed. A computerized cognitive screening battery (CNS-Vital Signs()) was used to assess complex attention (CA), reaction time (RT), processing speed (PS), cognitive flexibility (CF), and memory. Health questionnaires included the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Military Version (PCL-M), Zung Depression and Anxiety Scales (ZDS; ZAS), Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and the Alcohol Use and Dependency Identification Test (AUDIT). Soldiers with a history of multiple concussions (i.e., three or more concussions) had significantly greater post-concussive symptom scores compared with those with zero (d=1.83, large effect), one (d=0.64, medium effect), and two (d=0.64, medium effect) prior concussions. Although the group with three or more concussions also reported more traumatic stress symptoms, the results revealed that traumatic stress was a mediator between concussions and post-concussive symptom severity. There were no significant differences on neurocognitive testing between the number of concussions. These results add to the accumulating evidence suggesting that most individuals recover from one or two prior concussions, but there is a greater risk for ongoing symptoms if one exceeds this number of injuries.},
keywords = {*Brain Concussion/co [Complications], *Cognition Disorders/di [Diagnosis], *Military Personnel/sn [Statistics \& Numerical Dat, *Post-Concussion Syndrome/di [Diagnosis], adult, Brain Concussion/ep [Epidemiology], Cognition Disorders/ep [Epidemiology], Cognition Disorders/et [Etiology], Female, Humans, Male, Post-Concussion Syndrome/ep [Epidemiology], Post-Concussion Syndrome/et [Etiology], United States/ep [Epidemiology], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Alexander, D G; Shuttleworth-Edwards, A B; Kidd, M; Malcolm, C M
Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes Journal Article
In: Brain Injury, vol. 29, no. 9, pp. 1113–1125, 2015.
Abstract | Links | BibTeX | Tags: academic achievement, Academic performance, ADOLESCENCE, Adolescent, adolescent disease, adult, Article, Athletic Injuries, brain concussion, Brain Injuries, Child, cognition, Concussion, controlled study, Educational Status, football, human, Humans, Injuries, intelligence test, Intelligence Tests, Longitudinal studies, longitudinal study, major clinical study, Male, mild traumatic brain injury, mTBI, neurocognitive, neuropsychological test, Neuropsychological Tests, Pathophysiology, Prospective Studies, prospective study, psychologic test, psychology, rugby, SOUTH Africa, sport injury, TASK performance, traumatic brain injury, treatment outcome
@article{Alexander2015,
title = {Mild traumatic brain injuries in early adolescent rugby players: Long-term neurocognitive and academic outcomes},
author = {Alexander, D G and Shuttleworth-Edwards, A B and Kidd, M and Malcolm, C M},
doi = {10.3109/02699052.2015.1031699},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {9},
pages = {1113--1125},
abstract = {Background: Information is scant concerning enduring brain injury effects of participation in the contact sport of Rugby Union (hereafter rugby) on early adolescents.Objective: The objective was prospectively to investigate differences between young adolescent male rugby players and non-contact sports controls on neurocognitive test performance over 3 years and academic achievement over 6 years.Method: A sample of boys from the same school and grade was divided into three groups: rugby with seasonal concussions (n = 45), rugby no seasonal concussions (n = 21) and non-contact sports controls (n = 30). Baseline neurocognitive testing was conducted pre-season in Grade 7 and post-season in Grades 8 and 9. Year-end academic grades were documented for Grades 6-9 and 12 (pre-high school to year of school leaving). A mixed model repeated measures ANOVA was conducted to investigate comparative neurocognitive and academic outcomes between the three sub-groups.Results: Compared with controls, both rugby groups were significantly lower on the WISC-III Coding Immediate Recall sub-test. There was a significant interaction effect on the academic measure, with improved scores over time for controls, that was not in evidence for either rugby group.Conclusions: Tentatively, the outcome suggests cognitive vulnerability in association with school level participation in rugby. © 2015 Taylor \& Francis Group, LLC.},
keywords = {academic achievement, Academic performance, ADOLESCENCE, Adolescent, adolescent disease, adult, Article, Athletic Injuries, brain concussion, Brain Injuries, Child, cognition, Concussion, controlled study, Educational Status, football, human, Humans, Injuries, intelligence test, Intelligence Tests, Longitudinal studies, longitudinal study, major clinical study, Male, mild traumatic brain injury, mTBI, neurocognitive, neuropsychological test, Neuropsychological Tests, Pathophysiology, Prospective Studies, prospective study, psychologic test, psychology, rugby, SOUTH Africa, sport injury, TASK performance, traumatic brain injury, treatment outcome},
pubstate = {published},
tppubtype = {article}
}
Biederman, J; Feinberg, L; Chan, J; Adeyemo, B O; Woodworth, K Y; Panis, W; McGrath, N; Bhatnagar, S; Spencer, T J; Uchida, M; Kenworthy, T; Grossman, R; Zafonte, R; Faraone, S V
Mild Traumatic Brain Injury and Attention-Deficit Hyperactivity Disorder in Young Student Athletes Journal Article
In: Journal of Nervous & Mental Disease, vol. 203, no. 11, pp. 813–819, 2015.
Abstract | BibTeX | Tags: *Athletes, *Athletic Injuries/ep [Epidemiology], *Attention Deficit Disorder with Hyperactivity/ep, *Brain Injuries/ep [Epidemiology], *Students, Adolescent, adult, Athletic Injuries/di [Diagnosis], Attention Deficit Disorder with Hyperactivity/di [, Brain Injuries/di [Diagnosis], Child, Female, Humans, Male, Risk Factors, Young Adult
@article{Biederman2015,
title = {Mild Traumatic Brain Injury and Attention-Deficit Hyperactivity Disorder in Young Student Athletes},
author = {Biederman, J and Feinberg, L and Chan, J and Adeyemo, B O and Woodworth, K Y and Panis, W and McGrath, N and Bhatnagar, S and Spencer, T J and Uchida, M and Kenworthy, T and Grossman, R and Zafonte, R and Faraone, S V},
year = {2015},
date = {2015-01-01},
journal = {Journal of Nervous \& Mental Disease},
volume = {203},
number = {11},
pages = {813--819},
abstract = {A recent meta-analysis documented a significant statistical association between mild traumatic brain injury (mTBI) and attention deficit hyperactivity disorder (ADHD) (Adeyemo et al., 2014), but the direction of this effect was unclear. In this study, we hypothesized that ADHD would be an antecedent risk factor for mTBI. Participants were student athletes ages 12 to 25 who had sustained a mTBI and Controls of similar age and sex selected from studies of youth with and without ADHD. Subjects were assessed for symptoms of ADHD, concussion severity, and cognitive function. mTBI subjects had a significantly higher rate of ADHD than Controls, and in all cases the age of onset of ADHD was before mTBI onset. mTBI+ADHD subjects also had more severe concussion symptoms (fatigue and poor concentration) than mTBI-ADHD subjects. These results support ADHD as an antecedent risk factor for mTBI in student athletes and that its presence complicates the course of mTBI.},
keywords = {*Athletes, *Athletic Injuries/ep [Epidemiology], *Attention Deficit Disorder with Hyperactivity/ep, *Brain Injuries/ep [Epidemiology], *Students, Adolescent, adult, Athletic Injuries/di [Diagnosis], Attention Deficit Disorder with Hyperactivity/di [, Brain Injuries/di [Diagnosis], Child, Female, Humans, Male, Risk Factors, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Jackson, K; Rubin, R; Van Hoeck, N; Hauert, T; Lana, V; Wang, H
The effect of selective head-neck cooling on physiological and cognitive functions in healthy volunteers Journal Article
In: Translational Neuroscience, vol. 6, no. 1, pp. 131–138, 2015.
Abstract | Links | BibTeX | Tags: adult, Article, Athletics, body temperature, body temperature measurement, brain, brain temperature, clinical assessment, clinical effectiveness, cognition, cold tolerance, cold treatment, Concussion, diastolic blood pressure, executive function, Feasibility, Female, head neck cooling, Heart Rate, human, human experiment, infrared thermometer, Intervention, Male, mouth temperature, normal human, physiological process, priority journal, pulse oximetry, room temperature, systolic blood pressure, TASK performance, temperature management device, thermoregulation, tympanic temperature, velocity, welkins emt temperature management system, working memory
@article{Jackson2015,
title = {The effect of selective head-neck cooling on physiological and cognitive functions in healthy volunteers},
author = {Jackson, K and Rubin, R and {Van Hoeck}, N and Hauert, T and Lana, V and Wang, H},
doi = {10.1515/tnsci-2015-0012},
year = {2015},
date = {2015-01-01},
journal = {Translational Neuroscience},
volume = {6},
number = {1},
pages = {131--138},
abstract = {In general, brain temperatures are elevated during physical sporting activities; therefore, reducing brain temperature shortly after a sports-related concussion (SRC) could be a promising intervention technique. The main objective of this study was to examine the effects of head and neck cooling on physiological and cognitive function in normal healthy volunteers. Twelve healthy volunteers underwent two different sessions of combined head and neck cooling, one session with a cold pack and one session with a room temperature pack. Physiological measurements included: systolic/diastolic blood pressure, pulse oximetry, heart rate, and sublingual and tympanic temperature. Cognitive assessment included: processing speed, executive function, and working memory tasks. Physiological measurements were taken pre-, mid- and post-cooling, while cognitive assessments were done before and after cooling. The order of the sessions was randomized. There was a significant decrease in tympanic temperature across both sessions; however more cooling occurred when the cold pack was in the device. There was no significant decrease in sublingual temperature across either session. The observed heart rates, pulse oximetry, systolic and diastolic blood pressure during the sessions were all within range of a normal healthy adult. Cognitive assessment remained stable across each session for both pre- and post-cooling. We propose that optimizing brain temperature management after brain injury using head and neck cooling technology may represent a sensible, practical, and effective strategy to potentially enhance recovery and perhaps minimize the subsequent short and long term consequences from SRC. © 2015 Kevin Jackson et al.},
keywords = {adult, Article, Athletics, body temperature, body temperature measurement, brain, brain temperature, clinical assessment, clinical effectiveness, cognition, cold tolerance, cold treatment, Concussion, diastolic blood pressure, executive function, Feasibility, Female, head neck cooling, Heart Rate, human, human experiment, infrared thermometer, Intervention, Male, mouth temperature, normal human, physiological process, priority journal, pulse oximetry, room temperature, systolic blood pressure, TASK performance, temperature management device, thermoregulation, tympanic temperature, velocity, welkins emt temperature management system, working memory},
pubstate = {published},
tppubtype = {article}
}
Billock, R M; Anderegg, J J; Mehan, T J; Chounthirath, T; Smith, G A
Zipline-related injuries treated in US EDs, 1997-2012 Journal Article
In: American Journal of Emergency Medicine, vol. 33, no. 12, pp. 1745–1749, 2015.
Abstract | Links | BibTeX | Tags: Accidental Falls, Adolescent, adult, arm fracture, Article, body regions, Child, Concussion, emergency health service, Emergency Service, emergency ward, EPIDEMIOLOGY, falling, Female, head and neck injury, head injury, Hospital, hospitalization, human, Humans, Infant, leg injury, major clinical study, Male, Newborn, Preschool, preschool child, priority journal, recreation, residential area, SAFETY, soft tissue injury, sport injury, sprain, statistics and numerical data, trunk injury, UNITED States, Wounds and Injuries, Young Adult, zipline related injury
@article{Billock2015,
title = {Zipline-related injuries treated in US EDs, 1997-2012},
author = {Billock, R M and Anderegg, J J and Mehan, T J and Chounthirath, T and Smith, G A},
doi = {10.1016/j.ajem.2015.08.022},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Emergency Medicine},
volume = {33},
number = {12},
pages = {1745--1749},
abstract = {Purpose To investigate the epidemiology of zipline-related injuries in the United States. Basic Procedures The National Electronic Injury Surveillance System database was used to examine non-fatal zipline-related injuries treated in US emergency departments (EDs) from 1997 through 2012. Sample weights were applied to calculate national estimates. Main Findings From 1997 through 2012, an estimated 16 850 (95% CI, 13 188-20 512) zipline-related injuries were treated in US EDs. The annual injury rate per 1 million population increased by 52.3% from 7.64 (95% CI, 4.86-10.42) injuries in 2009 (the first year with a stable annual estimate) to 11.64 (95% CI, 7.83-15.45) injuries in 2012. Patients aged 0-9 years accounted for 45.0% of injuries, females made up 53.1% of injuries, and 11.7% of patients required hospitalization. Fractures accounted for the largest proportion of injuries (46.7%), and the upper extremities were the most commonly injured body region (44.1%). Falls were the most common mechanism of injury, accounting for 77.3% of injuries. Among cases where the location of the injury event was known, 30.8% of injuries occurred in a residential setting and 69.2% occurred in a public place. Principal Conclusions This study is the first to characterize the epidemiology of zipline-related injuries using a nationally representative database. The rapid increase in zipline-related injuries in recent years suggests the need for additional safety guidelines and regulations. Commercial ziplines and publicly accessible non-commercial ziplines should be subject to uniform safety standards in all states and jurisdictions across the US, and homemade ziplines should not be used. © 2015 Elsevier Inc.},
keywords = {Accidental Falls, Adolescent, adult, arm fracture, Article, body regions, Child, Concussion, emergency health service, Emergency Service, emergency ward, EPIDEMIOLOGY, falling, Female, head and neck injury, head injury, Hospital, hospitalization, human, Humans, Infant, leg injury, major clinical study, Male, Newborn, Preschool, preschool child, priority journal, recreation, residential area, SAFETY, soft tissue injury, sport injury, sprain, statistics and numerical data, trunk injury, UNITED States, Wounds and Injuries, Young Adult, zipline related injury},
pubstate = {published},
tppubtype = {article}
}
Kerr, Z Y; Mihalik, J P; Guskiewicz, K M; Rosamond, W D; Evenson, K R; Marshall, S W
Agreement between athlete-recalled and clinically documented concussion histories in former collegiate athletes Journal Article
In: American Journal of Sports Medicine, vol. 43, no. 3, pp. 606–613, 2015.
Abstract | Links | BibTeX | Tags: adult, athlete, Athletes, Athletic Injuries, brain concussion, cohort analysis, Cohort Studies, comparative study, concurrent validity, Concussion, EPIDEMIOLOGY, Female, human, Humans, injury, interpersonal communication, medical record, MEDICAL records, Mental Recall, psychology, recall, self report, sex difference, Sex Factors, traumatic brain injury, Truth Disclosure, Universities, university
@article{Kerr2015,
title = {Agreement between athlete-recalled and clinically documented concussion histories in former collegiate athletes},
author = {Kerr, Z Y and Mihalik, J P and Guskiewicz, K M and Rosamond, W D and Evenson, K R and Marshall, S W},
doi = {10.1177/0363546514562180},
year = {2015},
date = {2015-01-01},
journal = {American Journal of Sports Medicine},
volume = {43},
number = {3},
pages = {606--613},
abstract = {Background: Athlete-recalled and clinically documented concussion histories have been used in research on former athletes, but both have limitations. Comparisons of these 2 types of concussion histories are needed to improve the accuracy of estimates of concussion history for future research and clinical care. Purpose: To estimate the agreement between athlete-recalled and clinically documented concussion histories during college and to explore reasons for differences. Study: Cohort study (diagnosis); Level of evidence, 3. Methods: Athlete-recalled concussion histories were provided by a convenience sample of 130 former collegiate athletes using an online questionnaire, and they were individually linked to previously collected clinical data that tracked medically diagnosed concussions at the host institution from 1996 to 2012. The intraclass correlation coefficient (ICC2,1) was used to assess agreement between athlete-recalled and clinically documented concussion histories. Descriptive analyses were performed to assess reasons for disagreement. Results: Agreement between athlete-recalled and clinically documented concussion histories was low (ICC2},
keywords = {adult, athlete, Athletes, Athletic Injuries, brain concussion, cohort analysis, Cohort Studies, comparative study, concurrent validity, Concussion, EPIDEMIOLOGY, Female, human, Humans, injury, interpersonal communication, medical record, MEDICAL records, Mental Recall, psychology, recall, self report, sex difference, Sex Factors, traumatic brain injury, Truth Disclosure, Universities, university},
pubstate = {published},
tppubtype = {article}
}
Register-Mihalik, J K; De Maio, V J; Tibbo-Valeriote, H L; Wooten, J D
Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia Journal Article
In: Clinical Journal of Sport Medicine, vol. 25, no. 6, pp. 502–508, 2015.
Abstract | BibTeX | Tags: Adolescent, adult, amnesia, anamnesis, Article, brain concussion, Child, complication, Concussion, Concussive injury, Cross-Sectional Studies, cross-sectional study, Demography, disease severity, emergency ward, ethnology, Female, head injury, human, Humans, major clinical study, Male, MEDICAL history taking, Memory, ODDS ratio, outcome assessment, postconcussion symptoms, priority journal, race, Retrospective Studies, retrospective study, Risk, risk factor, Risk Factors, unconsciousness
@article{Register-Mihalik2015,
title = {Characteristics of pediatric and adolescent concussion clinic patients with postconcussion amnesia},
author = {Register-Mihalik, J K and {De Maio}, V J and Tibbo-Valeriote, H L and Wooten, J D},
year = {2015},
date = {2015-01-01},
journal = {Clinical Journal of Sport Medicine},
volume = {25},
number = {6},
pages = {502--508},
abstract = {Objective: The current study examines the demographics, injury characteristics, and outcomes associated with the presence of postconcussion amnesia in young concussion clinic patients. Design: Cross-sectional, retrospective clinical cohort. Setting: Concussion services clinic. Patients: Pediatric and adolescent concussion services program patients, presenting within 10 days postinjury, aged 10-18 years, with the goal of returning to sport (n = 245). Assessment of Risk Factors: Age, gender, race, head trauma history, injury mechanism, loss of consciousness (LOC), injuryrelated visit to an emergency department, cognitive and balance scores, symptoms, and management recommendations. Main Outcome Measures: Univariate and multivariate analyses determined adjusted odds ratios for reported presence of any postconcussion amnesia (anterograde or retrograde). Results: Factors associated with amnesia (univariate, P \< 0.10) and included in the multivariate model were race, head trauma history, mechanism of injury, LOC, injury-related visit to an emergency department, management recommendations and time of injury and initial visit symptom severity. Age and gender were also included in the model due to biological significance. Of the 245 patients, 181 had data for all model variables. Of the 181 patients, 58 reported amnesia. History of head trauma [odds ratio (OR), 2.7; 95% confidence interval (CI), 1.3-5.7]; time of injury (TOI) symptom severity \>75th percentile (OR, 2.6; 95% CI, 1.2-5.3) and LOC (OR, 2.2; 95% CI, 1.1-4.6) were found to have significant and independent relationships with amnesia in the multivariate model. Conclusions: This study illustrates that patients presenting with postconcussion amnesia are more likely to have a history of head trauma, LOC, and greater symptom severity. Future research is needed to better understand amnesia following concussion. Clinical Relevance: Amnesia presence, previous head trauma, LOC, and increased symptom severity may aid in identifying patients with a greater initial injury burden who warrant closer observation and more conservative management. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.},
keywords = {Adolescent, adult, amnesia, anamnesis, Article, brain concussion, Child, complication, Concussion, Concussive injury, Cross-Sectional Studies, cross-sectional study, Demography, disease severity, emergency ward, ethnology, Female, head injury, human, Humans, major clinical study, Male, MEDICAL history taking, Memory, ODDS ratio, outcome assessment, postconcussion symptoms, priority journal, race, Retrospective Studies, retrospective study, Risk, risk factor, Risk Factors, unconsciousness},
pubstate = {published},
tppubtype = {article}
}
Brown, J C; Viljoen, W; Lambert, M I; Readhead, C; Fuller, C; Van Mechelen, W; Verhagen, E
The economic burden of time-loss injuries to youth players participating in week-long rugby union tournaments Journal Article
In: Journal of Science & Medicine in Sport, vol. 18, no. 4, pp. 394–399, 2015.
Abstract | Links | BibTeX | Tags: Absenteeism, Adolescent, adult, Article, Athletic Injuries, Back Injuries, biokinetics, bone, Child, competition, Concussion, contusion, Craniocerebral Trauma, economic evaluation, economics, follow up, football, Football/economics, Football/economics/cost analysis, Football/injuries (MeSH terms), fracture, Fractures, head injury, Health, health care cost, Health Care Costs, health insurance, human, Humans, Injuries, injury, injury scale, Insurance, laceration, legal guardian, Lower Extremity, lower limb, major clinical study, Male, MEDICAL care, muscle cramp, muscle strain, Neck Injuries, neck injury, Occupational Therapy, Parent, physical medicine, physiotherapy, radiodiagnosis, rugby, skin bruising, SOUTH Africa, sport injury, Trauma Severity Indices, Upper Extremity, upper limb, Wounds and Injuries
@article{Brown2015b,
title = {The economic burden of time-loss injuries to youth players participating in week-long rugby union tournaments},
author = {Brown, J C and Viljoen, W and Lambert, M I and Readhead, C and Fuller, C and {Van Mechelen}, W and Verhagen, E},
doi = {10.1016/j.jsams.2014.06.015},
year = {2015},
date = {2015-01-01},
journal = {Journal of Science \& Medicine in Sport},
volume = {18},
number = {4},
pages = {394--399},
abstract = {Objectives: Rugby Union ("rugby") is a popular sport with high injury risk. Burden of injury is described by the incidence and severity of injury. However reports have ignored the monetary cost of injuries. Therefore the aim of this study was to describe the monetary cost associated with youth rugby injuries. Design: This descriptive study quantified medical treatments of injured players at the South African Rugby Union Youth tournaments in 2011/2012 and the days of work parents missed as a result of the injuries. A health insurer used these data to calculate associated costs. Methods: Legal guardians of the 421 injured players were contacted telephonically on a weekly basis until they returned to play. Treatments costs were estimated in South African Rands based on 2013 insurance rates and converted to US$ using purchasing power parities. Results: Of the 3652 players, 2% (n=71) sought medical care after the tournament. For these players, average treatment costs were high (US$731 per player, 95% CI: US$425-US$1096), with fractures being the most expensive type of injury. Players with medical insurance had higher costs (US$937, 95% CI: US$486-US$1500) than those without (US$220, 95% CI: US$145-US$302). Conclusions: Although a minority of players sought follow-up treatment after the tournaments, the cost of these injuries was high. Players without medical insurance having lower costs may indicate that these players did not receive adequate treatment for their injuries. Injury prevention efforts should consider injuries with high costs and the treatment of players without medical insurance. © 2014 Sports Medicine Australia.},
keywords = {Absenteeism, Adolescent, adult, Article, Athletic Injuries, Back Injuries, biokinetics, bone, Child, competition, Concussion, contusion, Craniocerebral Trauma, economic evaluation, economics, follow up, football, Football/economics, Football/economics/cost analysis, Football/injuries (MeSH terms), fracture, Fractures, head injury, Health, health care cost, Health Care Costs, health insurance, human, Humans, Injuries, injury, injury scale, Insurance, laceration, legal guardian, Lower Extremity, lower limb, major clinical study, Male, MEDICAL care, muscle cramp, muscle strain, Neck Injuries, neck injury, Occupational Therapy, Parent, physical medicine, physiotherapy, radiodiagnosis, rugby, skin bruising, SOUTH Africa, sport injury, Trauma Severity Indices, Upper Extremity, upper limb, Wounds and Injuries},
pubstate = {published},
tppubtype = {article}
}
Barrio, J R; Small, G W; Wong, K P; Huang, S C; Liu, J; Merrill, D A; Giza, C C; Fitzsimmons, R P; Omalu, B; Bailes, J; Kepe, V
In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging.[Erratum appears in Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2981; PMID: 25964344] Journal Article
In: Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 16, pp. E2039–47, 2015.
Abstract | BibTeX | Tags: *Brain Injury, *Brain/pa [Pathology], *Brain/ri [Radionuclide Imaging], *Nitriles, *Positron-Emission Tomography, 0 (2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphth, 0 (Nitriles), 80 and over, adult, aged, Alzheimer Disease/ri [Radionuclide Imaging], Amygdala/mi [Microbiology], Amygdala/pa [Pathology], autopsy, Case-Control Studies, Chronic/ri [Radionuclide Imaging], Demography, Humans, Male, Mesencephalon/mi [Microbiology], Mesencephalon/pa [Pathology], middle aged
@article{Barrio2015,
title = {In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging.[Erratum appears in Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2981; PMID: 25964344]},
author = {Barrio, J R and Small, G W and Wong, K P and Huang, S C and Liu, J and Merrill, D A and Giza, C C and Fitzsimmons, R P and Omalu, B and Bailes, J and Kepe, V},
year = {2015},
date = {2015-01-01},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
volume = {112},
number = {16},
pages = {E2039--47},
abstract = {Chronic traumatic encephalopathy (CTE) is an acquired primary tauopathy with a variety of cognitive, behavioral, and motor symptoms linked to cumulative brain damage sustained from single, episodic, or repetitive traumatic brain injury (TBI). No definitive clinical diagnosis for this condition exists. In this work, we used [F-18]FDDNP PET to detect brain patterns of neuropathology distribution in retired professional American football players with suspected CTE (n = 14) and compared results with those of cognitively intact controls (n = 28) and patients with Alzheimer's dementia (AD) (n = 24), a disease that has been cognitively associated with CTE. [F-18]FDDNP PET imaging results in the retired players suggested the presence of neuropathological patterns consistent with models of concussion wherein brainstem white matter tracts undergo early axonal damage and cumulative axonal injuries along subcortical, limbic, and cortical brain circuitries supporting mood, emotions, and behavior. This deposition pattern is distinctively different from the progressive pattern of neuropathology [paired helical filament (PHF)-tau and amyloid-beta] in AD, which typically begins in the medial temporal lobe progressing along the cortical default mode network, with no or minimal involvement of subcortical structures. This particular [F-18]FDDNP PET imaging pattern in cases of suspected CTE also is primarily consistent with PHF-tau distribution observed at autopsy in subjects with a history of mild TBI and autopsy-confirmed diagnosis of CTE.},
keywords = {*Brain Injury, *Brain/pa [Pathology], *Brain/ri [Radionuclide Imaging], *Nitriles, *Positron-Emission Tomography, 0 (2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphth, 0 (Nitriles), 80 and over, adult, aged, Alzheimer Disease/ri [Radionuclide Imaging], Amygdala/mi [Microbiology], Amygdala/pa [Pathology], autopsy, Case-Control Studies, Chronic/ri [Radionuclide Imaging], Demography, Humans, Male, Mesencephalon/mi [Microbiology], Mesencephalon/pa [Pathology], middle aged},
pubstate = {published},
tppubtype = {article}
}
Vassilyadi, M; Macartney, G; Barrowman, N; Anderson, P; Dube, K
Symptom experience and quality of life in children after sport-related head injuries: A cross-sectional study Journal Article
In: Pediatric Neurosurgery, vol. 50, no. 4, pp. 196–203, 2015.
Abstract | Links | BibTeX | Tags: Adolescent, adult, affect, Article, Athletic Injuries, behavior disorder, brain concussion, Child, clinical article, clinical assessment, cognitive defect, Cognitive Efficiency Index, complication, Concussion, Concussion Symptom Scale, controlled study, Craniocerebral Trauma, Cross-Sectional Studies, cross-sectional study, fatigue, Female, head injury, headache, human, Humans, Immediate Postconcussion Assessment and Cognitive, Likert scale, Male, memory disorder, mild traumatic brain injury, neuropsychological test, noise, Paediatric patients, Pediatric Quality of Life Inventory, postconcussion syndrome, priority journal, psychology, quality of life, rating scale, scoring system, Sport, sport injury, Sports, symptom, time factor, Time Factors, traumatic brain injury, trends
@article{Vassilyadi2015,
title = {Symptom experience and quality of life in children after sport-related head injuries: A cross-sectional study},
author = {Vassilyadi, M and Macartney, G and Barrowman, N and Anderson, P and Dube, K},
doi = {10.1159/000431232},
year = {2015},
date = {2015-01-01},
journal = {Pediatric Neurosurgery},
volume = {50},
number = {4},
pages = {196--203},
abstract = {Background: Sports are a major cause of concussions, and little is known about the symptom experience and health-related quality of life (HRQL) in children who remain symptomatic for over 3 months following such head injuries. Methods: A cross-sectional study of children aged 10-18 years was performed who were referred to the Neurosurgery Clinic at our centre following a head injury. Symptom experience was measured using the modified Concussion Symptom Scale, and HRQL was measured using the Pediatric Quality of Life Inventory (PedsQL). The Immediate Postconcussion Assessment and Cognitive Test (ImPACT) was administered to assess neurocognitive and neurobehavioural sequelae. Results: Symptoms with the highest mean symptom scores on a Likert scale of 0-6 in 35 children at the time of assessment included headaches (3.1), poor concentration (2.7), memory problems (2.1), fatigue (2.1) and sensitivity to noise (2.0). Compared with normative data, children in this study had ImPACT summary scores between the 28th and 38th percentiles and a comparably low Cognitive Efficiency Index score. Mean scores for females were consistently statistically significantly lower (p \< 0.05) than for males across all of the HRQL domains. Trouble falling asleep and memory problems explained 62% of the variance in the PedsQL total scores. Conclusions: Children continue to experience many symptoms at least 3 months following sport-related head injuries that significantly impact their HRQL and neurocognitive abilities. © 2015 S. Karger AG, Basel.},
keywords = {Adolescent, adult, affect, Article, Athletic Injuries, behavior disorder, brain concussion, Child, clinical article, clinical assessment, cognitive defect, Cognitive Efficiency Index, complication, Concussion, Concussion Symptom Scale, controlled study, Craniocerebral Trauma, Cross-Sectional Studies, cross-sectional study, fatigue, Female, head injury, headache, human, Humans, Immediate Postconcussion Assessment and Cognitive, Likert scale, Male, memory disorder, mild traumatic brain injury, neuropsychological test, noise, Paediatric patients, Pediatric Quality of Life Inventory, postconcussion syndrome, priority journal, psychology, quality of life, rating scale, scoring system, Sport, sport injury, Sports, symptom, time factor, Time Factors, traumatic brain injury, trends},
pubstate = {published},
tppubtype = {article}
}
Gouttebarge, V; Ooms, W; Tummers, T; Inklaar, H
Mortality in international professional football (soccer): a descriptive study Journal Article
In: Journal of Sports Medicine & Physical Fitness, vol. 55, no. 11, pp. 1376–1382, 2015.
Abstract | BibTeX | Tags: *Athletes/sn [Statistics & Numerical Data], *Death, *Soccer, adult, Cardiac/ep [Epidemiology], Cause of Death/td [Trends], Humans, Male, middle aged, Netherlands/ep [Epidemiology], Prospective Studies, Sudden
@article{Gouttebarge2015,
title = {Mortality in international professional football (soccer): a descriptive study},
author = {Gouttebarge, V and Ooms, W and Tummers, T and Inklaar, H},
year = {2015},
date = {2015-01-01},
journal = {Journal of Sports Medicine \& Physical Fitness},
volume = {55},
number = {11},
pages = {1376--1382},
abstract = {The objective of this study was to describe the characteristics of mortalities from 2007 to 2013 in active (during career) and recently retired (post career) professional footballers. An observational prospective study was conducted. From 2007, the World Footballers' Union (FIFPro) and its related national footballers' unions (more than 70 countries distributed across all continents) collected descriptive data (football-related, cause, etc.) on mortality of active (during career) and recently retired (postcareer before reaching 45 years of age) professional footballers by means of several official sources. A total of 214 deaths were recorded among active and recently retired professional footballers, leading to an overall mortality rate of 0.47 per 1000 footballers per year. Of the 214 deaths, 183 were recorded among active players and 31 among recently retired players. Among the active players, 17% of the fatalities were related to football participation. Disease was the leading cause of death among professional footballers (55%), of which up to 33% accounted for suspected cardiac pathology. Accidents accounted for 25% of the overall deaths, and suicide for 11%. From 2007 to 2013, 214 deaths were recorded among active (during career) and recently retired (post career) professional footballers. Leading cause of death was disease (55%), one third of which were accounted for by suspected cardiac pathology, while accidents accounted for 25% of all deaths, and suicide for 11%. Attention to the predictive validity and application of heart-related precompetition medical assessment should be given, and mental health support should be developed and implemented both during and after a professional football career to prevent potential suicidal behaviors.},
keywords = {*Athletes/sn [Statistics \& Numerical Data], *Death, *Soccer, adult, Cardiac/ep [Epidemiology], Cause of Death/td [Trends], Humans, Male, middle aged, Netherlands/ep [Epidemiology], Prospective Studies, Sudden},
pubstate = {published},
tppubtype = {article}
}
Oeur, R A; Karton, C; Post, A; Rousseau, P; Hoshizaki, T B; Marshall, S; Brien, S E; Smith, A; Cusimano, M D; Gilchrist, M D
In: Journal of Neurosurgery, vol. 123, no. 2, pp. 415–422, 2015.
Abstract | Links | BibTeX | Tags: accident, Accident reconstruction, accidental injury, Accidents, Adolescent, adult, Article, Biomechanical Phenomena, Biomechanics, brain, brain concussion, brain stem, brain tissue, Cerebellum, clinical article, comparative study, Concussion, controlled study, Female, finite element analysis, Finite element modelling, gray matter, Hematoma, human, Humans, Hybrid iii headform, injury severity, laboratory test, Male, Mechanical, mechanical stress, middle aged, pathology, Pathophysiology, Persistent postconcussive symptoms, PHYSIOLOGY, Post Hoc Analysis, Post-Concussion Syndrome, postconcussion syndrome, priority journal, shear stress, simulation, SPORTS medicine, STATISTICAL significance, Stress, stress strain relationship, Subdural, subdural hematoma, traumatic brain injury, white matter, Young Adult
@article{Oeur2015,
title = {A comparison of head dynamic response and brain tissue stress and strain using accident reconstructions for concussion, concussion with persistent postconcussive symptoms, and subdural hematoma},
author = {Oeur, R A and Karton, C and Post, A and Rousseau, P and Hoshizaki, T B and Marshall, S and Brien, S E and Smith, A and Cusimano, M D and Gilchrist, M D},
doi = {10.3171/2014.10.JNS14440},
year = {2015},
date = {2015-01-01},
journal = {Journal of Neurosurgery},
volume = {123},
number = {2},
pages = {415--422},
abstract = {Object Concussions typically resolve within several days, but in a few cases the symptoms last for a month or longer and are termed persistent postconcussive symptoms (PPCS). These persisting symptoms may also be associated with more serious brain trauma similar to subdural hematoma (SDH). The objective of this study was to investigate the head dynamic and brain tissue responses of injury reconstructions resulting in concussion, PPCS, and SDH. Methods Reconstruction cases were obtained from sports medicine clinics and hospitals. All subjects received a direct blow to the head resulting in symptoms. Those symptoms that resolved in 9 days or fewer were defined as concussions (n = 3). Those with symptoms lasting longer than 18 months were defined as PPCS (n = 3), and 3 patients presented with SDHs (n = 3). A Hybrid III headform was used in reconstruction to obtain linear and rotational accelerations of the head. These dynamic response data were then input into the University College Dublin Brain Trauma Model to calculate maximum principal strain and von Mises stress. A Kruskal-Wallis test followed by Tukey post hoc tests were used to compare head dynamic and brain tissue responses between injury groups. Statistical significance was set at p \< 0.05. Results A significant difference was identified for peak resultant linear and rotational acceleration between injury groups. Post hoc analyses revealed the SDH group had higher linear and rotational acceleration responses (316 g and 23,181 rad/sec2, respectively) than the concussion group (149 g and 8111 rad/sec2, respectively; p \< 0.05). No significant differences were found between groups for either brain tissue measures of maximum principal strain or von Mises stress. Conclusions The reconstruction of accidents resulting in a concussion with transient symptoms (low severity) and SDHs revealed a positive relationship between an increase in head dynamic response and the risk for more serious brain injury. This type of relationship was not found for brain tissue stress and strain results derived by finite element analysis. Future research should be undertaken using a larger sample size to confirm these initial findings. Understanding the relationship between the head dynamic and brain tissue response and the nature of the injury provides important information for developing strategies for injury prevention. © AANS, 2015.},
keywords = {accident, Accident reconstruction, accidental injury, Accidents, Adolescent, adult, Article, Biomechanical Phenomena, Biomechanics, brain, brain concussion, brain stem, brain tissue, Cerebellum, clinical article, comparative study, Concussion, controlled study, Female, finite element analysis, Finite element modelling, gray matter, Hematoma, human, Humans, Hybrid iii headform, injury severity, laboratory test, Male, Mechanical, mechanical stress, middle aged, pathology, Pathophysiology, Persistent postconcussive symptoms, PHYSIOLOGY, Post Hoc Analysis, Post-Concussion Syndrome, postconcussion syndrome, priority journal, shear stress, simulation, SPORTS medicine, STATISTICAL significance, Stress, stress strain relationship, Subdural, subdural hematoma, traumatic brain injury, white matter, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Caryn, R C; Hazell, T J; Dickey, J P
Transmission of acceleration from a synchronous vibration exercise platform to the head Journal Article
In: International Journal of Sports Medicine, vol. 35, no. 4, pp. 330–338, 2014.
Abstract | BibTeX | Tags: *Exercise/ph [Physiology], *HEAD, *Knee Joint/ph [Physiology], *Posture/ph [Physiology], *Sports Equipment, *Vibration, Acceleration, adult, Humans, Male
@article{Caryn2014,
title = {Transmission of acceleration from a synchronous vibration exercise platform to the head},
author = {Caryn, R C and Hazell, T J and Dickey, J P},
year = {2014},
date = {2014-01-01},
journal = {International Journal of Sports Medicine},
volume = {35},
number = {4},
pages = {330--338},
abstract = {Exercise vibration platforms are becoming commonplace in homes and fitness centers. However, excessive mechanical energy transferred to the head and eye can cause injury. The purpose of this study was to evaluate how changes in platform frequency and knee flexion angle affect acceleration transmission to the head. Participants (N=12) stood on a whole-body vibration platform with knee flexion angles of 0degree, 20degree, and 40degree to evaluate how changes in knee flexion affected head acceleration. 7 specific platform frequencies were tested between 20-50Hz at 2 peak-to-peak displacement settings (1 and 2mm nominal). Accelerations were measured with triaxial accelerometers at the platform and head to generate transmissibility ratios. Platform-to-head transmissibility was not significantly different between the 2 platform peak-to-peak amplitudes (P\>0.05). Transmissibility measures varied depending on platform frequency and knee angle (P\<0.05). Flexing the knees resulted in reduced head transmissibility at all frequencies (P\<0.05). Platform-to-head transmissibility values exceeded 1.0 at both 20 and 25Hz platform vibration frequencies with the knees in full extension. To reduce the risk of injury to structures of the head during vibration exercise, using platforms frequencies below 30Hz with small knee flexion angles (\<40degree) should be avoided. Copyright © Georg Thieme Verlag KG Stuttgart . New York.},
keywords = {*Exercise/ph [Physiology], *HEAD, *Knee Joint/ph [Physiology], *Posture/ph [Physiology], *Sports Equipment, *Vibration, Acceleration, adult, Humans, Male},
pubstate = {published},
tppubtype = {article}
}
Mitsis, E M; Riggio, S; Kostakoglu, L; Dickstein, D L; Machac, J; Delman, B; Goldstein, M; Jennings, D; D'Antonio, E; Martin, J; Naidich, T P; Aloysi, A; Fernandez, C; Seibyl, J; DeKosky, S T; Elder, G A; Marek, K; Gordon, W; Hof, P R; Sano, M; Gandy, S
In: Translational Psychiatry, vol. 4, no. 9, 2014.
Abstract | Links | BibTeX | Tags: adult, aged, amyloid plaque, arachnoid cyst, Article, case report, Chronic Traumatic Encephalopathy florbetapir f 18, Concussion, diagnostic accuracy, eye movement, football, frontotemporal dementia, head injury, human, injury severity, ligand binding, Male, memory disorder, middle aged, molecular imaging, motor dysfunction, muscle tone, personality disorder, positron emission tomography, short term memory, subdural hematoma, tauopathy, traumatic brain injury
@article{Mitsis2014,
title = {Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: Studies of a retired NFL player and of a man with FTD and a severe head injury},
author = {Mitsis, E M and Riggio, S and Kostakoglu, L and Dickstein, D L and Machac, J and Delman, B and Goldstein, M and Jennings, D and D'Antonio, E and Martin, J and Naidich, T P and Aloysi, A and Fernandez, C and Seibyl, J and DeKosky, S T and Elder, G A and Marek, K and Gordon, W and Hof, P R and Sano, M and Gandy, S},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84918535750\&partnerID=40\&md5=704b918a7429432cbd631e703c44eb63},
doi = {10.1038/tp.2014.91},
year = {2014},
date = {2014-01-01},
journal = {Translational Psychiatry},
volume = {4},
number = {9},
abstract = {Single, severe traumatic brain injury (TBI) which elevates CNS amyloid, increases the risk of Alzheimer's disease (AD); while repetitive concussive and subconcussive events as observed in athletes and military personnel, may increase the risk of chronic traumatic encephalopathy (CTE). We describe two clinical cases, one with a history of multiple concussions during a career in the National Football League (NFL) and the second with frontotemporal dementia and a single, severe TBI. Both patients presented with cognitive decline and underwent [18F]-Florbetapir positron emission tomography (PET) imaging for amyloid plaques; the retired NFL player also underwent [18F]-T807 PET imaging, a new ligand binding to tau, the main constituent of neurofibrillary tangles (NFT). Case 1, the former NFL player, was 71 years old when he presented with memory impairment and a clinical profile highly similar to AD. [18F]-Florbetapir PET imaging was negative, essentially excluding AD as a diagnosis. CTE was suspected clinically, and [18F]-T807 PET imaging revealed striatal and nigral [18F]-T807 retention consistent with the presence of tauopathy. Case 2 was a 56- year-old man with personality changes and cognitive decline who had sustained a fall complicated by a subdural hematoma. At 1 year post injury, [18F]-Florbetapir PET imaging was negative for an AD pattern of amyloid accumulation in this subject. Focal [18F]- Florbetapir retention was noted at the site of impact. In case 1, amyloid imaging provided improved diagnostic accuracy where standard clinical and laboratory criteria were inadequate. In that same case, tau imaging with [18F]-T807 revealed a subcortical tauopathy that we interpret as a novel form of CTE with a distribution of tauopathy that mimics, to some extent, that of progressive supranuclear palsy (PSP), despite a clinical presentation of amnesia without any movement disorder complaints or signs. A key distinguishing feature is that our patient presented with hippocampal involvement, which is more frequently seen in CTE than in PSP. In case 2, focal [18F]-Florbetapir retention at the site of injury in an otherwise negative scan suggests focal amyloid aggregation. In each of these complex cases, a combination of [18F]-fluorodeoxyglucose, [18F]-Florbetapir and/or [18F]-T807 PET molecular imaging improved the accuracy of diagnosis and prevented inappropriate interventions. © 2014 Macmillan Publishers Limited.},
keywords = {adult, aged, amyloid plaque, arachnoid cyst, Article, case report, Chronic Traumatic Encephalopathy florbetapir f 18, Concussion, diagnostic accuracy, eye movement, football, frontotemporal dementia, head injury, human, injury severity, ligand binding, Male, memory disorder, middle aged, molecular imaging, motor dysfunction, muscle tone, personality disorder, positron emission tomography, short term memory, subdural hematoma, tauopathy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Jadischke, R; Viano, D C; Dau, N; King, A I; McCarthy, J
On the accuracy of the Head Impact Telemetry (HIT) System used in football helmets Journal Article
In: Journal of Biomechanics, vol. 46, no. 13, pp. 2310–2315, 2013.
Abstract | BibTeX | Tags: *Head Protective Devices/st [Standards], *Materials Testing, *Sports Equipment/st [Standards], *Telemetry/is [Instrumentation], Adolescent, adult, Equipment Design, football, Humans, Male, Pressure, Young Adult
@article{Jadischke2013,
title = {On the accuracy of the Head Impact Telemetry (HIT) System used in football helmets},
author = {Jadischke, R and Viano, D C and Dau, N and King, A I and McCarthy, J},
year = {2013},
date = {2013-01-01},
journal = {Journal of Biomechanics},
volume = {46},
number = {13},
pages = {2310--2315},
abstract = {On-field measurement of head impacts has relied on the Head Impact Telemetry (HIT) System, which uses helmet mounted accelerometers to determine linear and angular head accelerations. HIT is used in youth and collegiate football to assess the frequency and severity of helmet impacts. This paper evaluates the accuracy of HIT for individual head impacts. Most HIT validations used a medium helmet on a Hybrid III head. However, the appropriate helmet is large based on the Hybrid III head circumference (58 cm) and manufacturer's fitting instructions. An instrumented skull cap was used to measure the pressure between the head of football players (n=63) and their helmet. The average pressure with a large helmet on the Hybrid III was comparable to the average pressure from helmets used by players. A medium helmet on the Hybrid III produced average pressures greater than the 99th percentile volunteer pressure level. Linear impactor tests were conducted using a large and medium helmet on the Hybrid III. Testing was conducted by two independent laboratories. HIT data were compared to data from the Hybrid III equipped with a 3-2-2-2 accelerometer array. The absolute and root mean square error (RMSE) for HIT were computed for each impact (n=90). Fifty-five percent (n=49) had an absolute error greater than 15% while the RMSE was 59.1% for peak linear acceleration. Copyright © 2013 Elsevier Ltd. All rights reserved.},
keywords = {*Head Protective Devices/st [Standards], *Materials Testing, *Sports Equipment/st [Standards], *Telemetry/is [Instrumentation], Adolescent, adult, Equipment Design, football, Humans, Male, Pressure, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Matthews, S; Simmons, A; Strigo, I
The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131] Journal Article
In: Psychiatry Research, vol. 191, no. 1, pp. 76–79, 2011.
Abstract | BibTeX | Tags: *Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs & Derivatives], Urea/bl [Blood], Young Adult
@article{Matthews2011a,
title = {The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131]},
author = {Matthews, S and Simmons, A and Strigo, I},
year = {2011},
date = {2011-01-01},
journal = {Psychiatry Research},
volume = {191},
number = {1},
pages = {76--79},
abstract = {In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC. Copyright Published by Elsevier Ireland Ltd.},
keywords = {*Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs \& Derivatives], Urea/bl [Blood], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Barlow, Michael; Schlabach, Drew; Peiffer, Jeffrey; Cook, Chad
Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p] Journal Article
In: International Journal of Sports Physical Therapy, vol. 6, no. 3, pp. 150–157, 2011, ISBN: 2159-2896.
Abstract | BibTeX | Tags: ADOLESCENCE, adult, Brain Concussion -- Diagnosis, Child, Data Analysis Software, Disability Evaluation, Female, human, Instrument Validation, Male, Middle, Ohio, Postconcussion Syndrome -- Risk Factors, Predictive Value of Tests, Record Review, Recovery, Retrospective Design, ROC Curve, Scales, Schools, Secondary, validity
@article{Barlow2011,
title = {Differences in change scores and the predictive validity of three commonly used measures following concussion in the middle school and high school aged population...[corrected] [published erratum appears in INT J SPORTS PHYS THER 2011; 6(4):1p]},
author = {Barlow, Michael and Schlabach, Drew and Peiffer, Jeffrey and Cook, Chad},
isbn = {2159-2896},
year = {2011},
date = {2011-01-01},
journal = {International Journal of Sports Physical Therapy},
volume = {6},
number = {3},
pages = {150--157},
publisher = {North American Journal of Sports Physical Therapy},
address = {Indianapolis, Indiana},
abstract = {Background: A battery of tests is commonly used to measure disability with and recovery from concussion. A number of different concussion-oriented assessment tests exist and each is considered useful. To the authors' knowledge, no study has compared the scores of these tests during recovery in the middle school and high school aged population to see how each change over time. Purpose: The purposes of this study were to analyze clinical data of concussed middle school and high school aged athletes to determine the concurrent and predictive validity for post-concussion syndrome (PCS) of the Post-Concussion Symptom Scale (PCSS), Balance Error Scoring System (BESS), and the five subscales of the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). Methods: The study was a retrospective chart review performed on middle school and high school aged individuals with a diagnosis of concussion from the years 2008-2010 within the Akron Children's Hospital Sports Medicine system. To be eligible for inclusion in the dataset, each subject required a baseline measurement for each of the three tests (and all five subscales of the ImPACT) and a post-test measure. The mean age of the population was 15.38 years (SD=1.7) and ranged from 11 to 19 years. Pearson product correlation tests (correlation matrix) were used to analyze the concurrent validity of the test items during recovery following a concussion. Receiver operating characteristics (ROC) curves were used to determine the predictive validity of initial scores for developing PCS. Results: The correlation matrix captured five statistically significant findings; however, these suggested only weak to mild correlations. Five test items yielded an area under the curve (AUC) greater than 0.50 but only one was statistically significant. After qualitative evaluation, only one of the three tests (including the five subscales of the ImPACT) was useful in predicting post-concussion syndrome. Conclusion: This study suggests that there is poor concurrent validity among three commonly used concussion tests and there is no baseline score that predicts whether post-concussion syndrome will occur.},
keywords = {ADOLESCENCE, adult, Brain Concussion -- Diagnosis, Child, Data Analysis Software, Disability Evaluation, Female, human, Instrument Validation, Male, Middle, Ohio, Postconcussion Syndrome -- Risk Factors, Predictive Value of Tests, Record Review, Recovery, Retrospective Design, ROC Curve, Scales, Schools, Secondary, validity},
pubstate = {published},
tppubtype = {article}
}
Estevan, I; Alvarez, O; Falco, C; Molina-Garcia, J; Castillo, I
Impact force and time analysis influenced by execution distance in a roundhouse kick to the head in taekwondo Journal Article
In: Journal of Strength & Conditioning Research, vol. 25, no. 10, pp. 2851–2856, 2011.
Abstract | BibTeX | Tags: *HEAD, *Martial Arts/ph [Physiology], *Task Performance and Analysis, adult, Biomechanical Phenomena, Humans, Male, Young Adult
@article{Estevan2011,
title = {Impact force and time analysis influenced by execution distance in a roundhouse kick to the head in taekwondo},
author = {Estevan, I and Alvarez, O and Falco, C and Molina-Garcia, J and Castillo, I},
year = {2011},
date = {2011-01-01},
journal = {Journal of Strength \& Conditioning Research},
volume = {25},
number = {10},
pages = {2851--2856},
abstract = {The execution distance is a tactic factor that affects mechanical performance and execution technique in taekwondo. This study analyzes the roundhouse kick to the head by comparing the maximum impact force, execution time, and impact time in 3 distances according to the athletes' competition level. It also analyzes the relationship between impact force and weight in each group. It examines whether the execution distance affects the maximum impact force, execution time, and impact time, in each level group or 2 different competition levels. Participants were 27 male taekwondo players (13 medallists and 14 nonmedallists). The medallists executed the roundhouse kick to the head with greater impact force and in a shorter execution time than did the nonmedallists when they kicked from any distance different to their combat distance. However, the results showed that the execution distance is influential in the execution time and impact time in the nonmedallist group. It is considered appropriate to orientate the high-level competitors to train for offensive actions from any distance similar to the long execution distance because it offers equally effectiveness and a greater security against the opponent. Also, practitioners should focus their training to improve time performance because it is more affected by distance than impact force.},
keywords = {*HEAD, *Martial Arts/ph [Physiology], *Task Performance and Analysis, adult, Biomechanical Phenomena, Humans, Male, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Omalu, B; Hammers, J L; Bailes, J; Hamilton, R L; Kamboh, M I; Webster, G; Fitzsimmons, R P
Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide Journal Article
In: Neurosurgical Focus, vol. 31, no. 5, pp. E3, 2011.
Abstract | BibTeX | Tags: *Blast Injuries/pa [Pathology], *Blast Injuries/pp [Physiopathology], *Brain Injury, *Combat Disorders/pp [Physiopathology], *Suicide/px [Psychology], 2003-2011, adult, Blast Injuries/co [Complications], Brain Injury, Chronic/co [Complications], Chronic/pa [Pathology], Chronic/pp [Physiopathology], Combat Disorders/px [Psychology], Humans, Iraq War, Male, Post-Traumatic/pp [Physiopatholo, Post-Traumatic/px [Psychology], Stress Disorders, Suicide/pc [Prevention & Control]
@article{Omalu2011,
title = {Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide},
author = {Omalu, B and Hammers, J L and Bailes, J and Hamilton, R L and Kamboh, M I and Webster, G and Fitzsimmons, R P},
year = {2011},
date = {2011-01-01},
journal = {Neurosurgical Focus},
volume = {31},
number = {5},
pages = {E3},
abstract = {Following his discovery of chronic traumatic encephalopathy (CTE) in football players in 2002, Dr. Bennet Omalu hypothesized that posttraumatic stress disorder (PTSD) in military veterans may belong to the CTE spectrum of diseases. The CTE surveillance at the Brain Injury Research Institute was therefore expanded to include deceased military veterans diagnosed with PTSD. The authors report the case of a 27-year-old United States Marine Corps (USMC) Iraqi war veteran, an amphibious assault vehicle crewman, who committed suicide by hanging after two deployments to Fallujah and Ramadi. He experienced combat and was exposed to mortar blasts and improvised explosive device blasts less than 50 m away. Following his second deployment he developed a progressive history of cognitive impairment, impaired memory, behavioral and mood disorders, and alcohol abuse. Neuropsychiatric assessment revealed a diagnosis of PTSD with hyperarousal (irritability and insomnia) and numbing. He committed suicide approximately 8 months after his honorable discharge from the USMC. His brain at autopsy appeared grossly unremarkable except for congestive brain swelling. There was no atrophy or remote focal traumatic brain injury such as contusional necrosis or hemorrhage. Histochemical and immunohistochemical brain tissue analysis revealed CTE changes comprising multifocal, neocortical, and subcortical neurofibrillary tangles and neuritic threads (ranging from none, to sparse, to frequent) with the skip phenomenon, accentuated in the depths of sulci and in the frontal cortex. The subcortical white matter showed mild rarefaction, sparse perivascular and neuropil infiltration by histiocytes, and mild fibrillary astrogliosis. Apolipoprotein E genotype was 3/4. The authors report this case as a sentinel case of CTE in an Iraqi war veteran diagnosed with PTSD to possibly stimulate new lines of thought and research in the possible pathoetiology and pathogenesis of PTSD in military veterans as part of the CTE spectrum of diseases, and as chronic sequelae and outcomes of repetitive traumatic brain injuries.},
keywords = {*Blast Injuries/pa [Pathology], *Blast Injuries/pp [Physiopathology], *Brain Injury, *Combat Disorders/pp [Physiopathology], *Suicide/px [Psychology], 2003-2011, adult, Blast Injuries/co [Complications], Brain Injury, Chronic/co [Complications], Chronic/pa [Pathology], Chronic/pp [Physiopathology], Combat Disorders/px [Psychology], Humans, Iraq War, Male, Post-Traumatic/pp [Physiopatholo, Post-Traumatic/px [Psychology], Stress Disorders, Suicide/pc [Prevention \& Control]},
pubstate = {published},
tppubtype = {article}
}
Wise, E K; Mathews-Dalton, C; Dikmen, S; Temkin, N; Machamer, J; Bell, K; Powell, J M
Impact of traumatic brain injury on participation in leisure activities Journal Article
In: Archives of Physical Medicine & Rehabilitation, vol. 91, no. 9, pp. 1357–1362, 2010.
Abstract | BibTeX | Tags: *Brain Injuries/rh [Rehabilitation], *Recreation, adult, Age Factors, Female, Humans, Male, Prospective Studies, Sex Factors, treatment outcome, Washington
@article{Wise2010,
title = {Impact of traumatic brain injury on participation in leisure activities},
author = {Wise, E K and Mathews-Dalton, C and Dikmen, S and Temkin, N and Machamer, J and Bell, K and Powell, J M},
year = {2010},
date = {2010-01-01},
journal = {Archives of Physical Medicine \& Rehabilitation},
volume = {91},
number = {9},
pages = {1357--1362},
abstract = {OBJECTIVE: To determine how participation in leisure activities for people with traumatic brain injury (TBI) changes from before injury to 1 year after injury. DESIGN: Prospective evaluation of leisure participation at 1 year after TBI. SETTING: Level I trauma center. PARTICIPANTS: Rehabilitation inpatients (mean age, 35.3 years; 77% male; 77% white) with moderate to severe TBI (N=160). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Functional Status Examination. RESULTS: At 1 year after injury, 81% had not returned to preinjury levels of leisure participation. Activities most frequently discontinued included partying, drug and alcohol use, and various sports. The activity most often reported as new after injury was watching television. Of the small fraction who returned to preinjury levels, 70% did so within 4 months of injury. Sixty percent of those who did not return to preinjury levels were moderately to severely bothered by the changes. CONCLUSIONS: At 1 year after injury, many TBI survivors engage in a reduced number of leisure activities, which are more sedentary and less social, with a substantial fraction dissatisfied with these changes. While discontinuing some activities may be viewed as a positive change, there are few new ones to replace them.},
keywords = {*Brain Injuries/rh [Rehabilitation], *Recreation, adult, Age Factors, Female, Humans, Male, Prospective Studies, Sex Factors, treatment outcome, Washington},
pubstate = {published},
tppubtype = {article}
}
Vent, J; Koenig, J; Hellmich, M; Huettenbrink, K B; Damm, M
Impact of recurrent head trauma on olfactory function in boxers: a matched pairs analysis Journal Article
In: Brain Research, vol. 1320, pp. 1–6, 2010.
Abstract | BibTeX | Tags: *Athletes, *Boxing, *Craniocerebral Trauma/co [Complications], *Olfactory Perception, Adolescent, adult, Discrimination (Psychology), Humans, Male, Matched-Pair Analysis, middle aged, Neuropsychological Tests, Olfaction Disorders/et [Etiology], PROTECTIVE clothing, Sensory Thresholds, Young Adult
@article{Vent2010,
title = {Impact of recurrent head trauma on olfactory function in boxers: a matched pairs analysis},
author = {Vent, J and Koenig, J and Hellmich, M and Huettenbrink, K B and Damm, M},
year = {2010},
date = {2010-01-01},
journal = {Brain Research},
volume = {1320},
pages = {1--6},
abstract = {Recently, interest in the health of boxers has been raised by a petition of the British Medical Association to restrict boxing. However, scientific data on permanent damage are rare and typical localisations of injuries were yet to be defined. The aim of this study was to determine whether there are changes in the sense of smell in people undergoing recurrent head traumas. The hypothesis to be tested was if boxers had a reduced olfactory function. We used a matched pairs analysis design. Fifty healthy, male athletes underwent subjective olfactometry using Sniffin'Sticks testing (including threshold, discrimination and identification, TDI). Nasal endoscopy was performed and a thorough, questionnaire-based history was obtained. These data were correlated with normative data from healthy subjects. Statistical analysis was based on matched pairs analysis by t-tests, i.e. boxers and healthy (non-boxing) subjects. Boxers showed a mean TDI score of 32.5 compared to 35.1 of non-boxing controls (p=0.003). The olfactory threshold (p\<0.001) and odour identification (p\<0.05) were significantly decreased in boxers; whereas odour discrimination was unaffected. Performance of odour identification showed a correlation with cushioning of the gloves (p\<0.05), and thus seems a protective measure regarding the sense of smell. Boxing seems to affect olfactory function, particularly by reducing the olfactory threshold. Furthermore, cushioning of the gloves can be protective and should be increased to safeguard sportsmen from physical damage. Boxing can serve as a model for central regeneration after trauma. Copyright 2010 Elsevier B.V. All rights reserved.},
keywords = {*Athletes, *Boxing, *Craniocerebral Trauma/co [Complications], *Olfactory Perception, Adolescent, adult, Discrimination (Psychology), Humans, Male, Matched-Pair Analysis, middle aged, Neuropsychological Tests, Olfaction Disorders/et [Etiology], PROTECTIVE clothing, Sensory Thresholds, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Thornton, A E; Cox, D N; Whitfield, K; Fouladi, R T
Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 30, no. 4, pp. 398–409, 2008.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *COGNITION, *Cognition Disorders/et [Etiology], *Football/in [Injuries], adult, Age Factors, aged, Brain Concussion/di [Diagnosis], Female, Humans, Male, middle aged, Neuropsychological Tests, Predictive Value of Tests, REGRESSION analysis, Surveys and Questionnaires, Trauma Severity Indices
@article{Thornton2008a,
title = {Cumulative concussion exposure in rugby players: neurocognitive and symptomatic outcomes},
author = {Thornton, A E and Cox, D N and Whitfield, K and Fouladi, R T},
year = {2008},
date = {2008-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {30},
number = {4},
pages = {398--409},
abstract = {A total of 111 rugby players underwent comprehensive testing to determine the impact of self-reported concussion exposure. Reliable estimates of concussion exposure were associated with an increase in postconcussion symptoms (PCS), but not diminished neurocognitive functioning. Importantly, the effects of concussion exposure on PCS varied as a function of player status. More specifically, extent of concussion exposure was associated with increased memory complaints and overall PCS endorsements in a dose-dependent manner for retired and older recreational players, but not for those who were younger and playing at more competitive levels. Future work should systematically evaluate the constituent participant factors that may influence differential concussion outcomes.},
keywords = {*Brain Concussion/co [Complications], *COGNITION, *Cognition Disorders/et [Etiology], *Football/in [Injuries], adult, Age Factors, aged, Brain Concussion/di [Diagnosis], Female, Humans, Male, middle aged, Neuropsychological Tests, Predictive Value of Tests, REGRESSION analysis, Surveys and Questionnaires, Trauma Severity Indices},
pubstate = {published},
tppubtype = {article}
}
McLeod, P; Reed, N; Gilson, S; Glennerster, A
How soccer players head the ball: a test of Optic Acceleration Cancellation theory with virtual reality Journal Article
In: Vision Research, vol. 48, no. 13, pp. 1479–1487, 2008.
Abstract | BibTeX | Tags: *Head Movements/ph [Physiology], *Motion Perception/ph [Physiology], *Soccer/ph [Physiology], Acceleration, adult, Humans, Male, psychomotor performance, Reaction Time/ph [Physiology], User-Computer Interface
@article{McLeod2008,
title = {How soccer players head the ball: a test of Optic Acceleration Cancellation theory with virtual reality},
author = {McLeod, P and Reed, N and Gilson, S and Glennerster, A},
year = {2008},
date = {2008-01-01},
journal = {Vision Research},
volume = {48},
number = {13},
pages = {1479--1487},
abstract = {We measured the movements of soccer players heading a football in a fully immersive virtual reality environment. In mid-flight the ball's trajectory was altered from its normal quasi-parabolic path to a linear one, producing a jump in the rate of change of the angle of elevation of gaze (alpha) from player to ball. One reaction time later the players adjusted their speed so that the rate of change of alpha increased when it had been reduced and reduced it when it had been increased. Since the result of the player's movement was to regain a value of the rate of change close to that before the disturbance, the data suggest that the players have an expectation of, and memory for, the pattern that the rate of change of alpha will follow during the flight. The results support the general claim that players intercepting balls use servo control strategies and are consistent with the particular claim of Optic Acceleration Cancellation theory that the servo strategy is to allow alpha to increase at a steadily decreasing rate.},
keywords = {*Head Movements/ph [Physiology], *Motion Perception/ph [Physiology], *Soccer/ph [Physiology], Acceleration, adult, Humans, Male, psychomotor performance, Reaction Time/ph [Physiology], User-Computer Interface},
pubstate = {published},
tppubtype = {article}
}
Chiu, W T; Huang, S J; Tsai, S H; Lin, J W; Tsai, M D; Lin, T J; Huang, W C
The impact of time, legislation, and geography on the epidemiology of traumatic brain injury Journal Article
In: Journal of Clinical Neuroscience, vol. 14, no. 10, pp. 930–935, 2007.
Abstract | BibTeX | Tags: *Accidents, *Brain Injuries/ep [Epidemiology], *Legislation as Topic/sn [Statistics & Numerical D, *Rural Population/sn [Statistics & Numerical Data], *Urban Population/sn [Statistics & Numerical Data], Accidents, adult, age distribution, aged, Cohort Studies, Female, Head Protective Devices/sn [Statistics & Numerical, Head Protective Devices/st [Standards], Humans, Incidence, Legislation as Topic/td [Trends], Male, middle aged, Motorcycles/lj [Legislation & Jurisprudence], Motorcycles/sn [Statistics & Numerical Data], Motorcycles/st [Standards], Prospective Studies, Rural Population/td [Trends], Sex Distribution, Taiwan/ep [Epidemiology], Time Factors, Traffic/lj [Legislation & Jurisprudence, Traffic/pc [Prevention & Control], Traffic/sn [Statistics & Numerical Dat, Trauma Severity Indices, Urban Population/td [Trends]
@article{Chiu2007,
title = {The impact of time, legislation, and geography on the epidemiology of traumatic brain injury},
author = {Chiu, W T and Huang, S J and Tsai, S H and Lin, J W and Tsai, M D and Lin, T J and Huang, W C},
year = {2007},
date = {2007-01-01},
journal = {Journal of Clinical Neuroscience},
volume = {14},
number = {10},
pages = {930--935},
abstract = {In 1991, a population-based epidemiologic traumatic brain injury (TBI) study was done in urban and rural areas of Taiwan; this was 5 years before the helmet use law was passed and 8 years before the drink driving law was passed. In order to evaluate the impact of three major determinants (time, geography, and legislation) on the epidemiology of TBI, we conducted a prospective study in 2001 and used the 1991 data to examine the differences in TBI distribution in urban and rural Taiwan a decade after these laws were passed. In 2001, 5754 TBI cases were collected from the urban area of Taipei City, and 1474 TBI cases were collected from the rural area of Hualien County. The TBI incidence rate in Taipei City in 2001 was estimated to be 218/100,000 population (285/100,000 for males and 152/100,000 for females). When compared to the 1991 data, the incidence rate in 2001 had increased by 20%. The TBI incidence rate in Hualien County in 2001 was estimated to be 417/100,000 population (516/100,000 for males and 306/100,000 for females); this was a 37% increase over the 1991 data. Our study found that the distribution of causes and age distribution had shifted significantly over the 10-year period. In 2001, the age group with the highest incidence was 20-29 years, while in 1991 it had been the over 70 years age group. While traffic-related TBI had decreased, falls and assaults had increased in 2001. We also found that legislation, such as the helmet law, affects TBI distribution by decreasing the traffic-related TBI rate, decreasing the admission severity of TBI, and reducing TBI-related mortality. Finally, geography plays a crucial role in the outcome of TBI; over the 10 year period, Taipei had an increase in moderately severe outcomes, while Hualien had an increase in more severe outcomes. Comparative studies of TBI in urban and rural areas have shown that time, legislation, and geography are crucial determinants of TBI epidemiology. Although time and legal interventions seem to have more of an impact, geography does affect TBI outcomes.},
keywords = {*Accidents, *Brain Injuries/ep [Epidemiology], *Legislation as Topic/sn [Statistics \& Numerical D, *Rural Population/sn [Statistics \& Numerical Data], *Urban Population/sn [Statistics \& Numerical Data], Accidents, adult, age distribution, aged, Cohort Studies, Female, Head Protective Devices/sn [Statistics \& Numerical, Head Protective Devices/st [Standards], Humans, Incidence, Legislation as Topic/td [Trends], Male, middle aged, Motorcycles/lj [Legislation \& Jurisprudence], Motorcycles/sn [Statistics \& Numerical Data], Motorcycles/st [Standards], Prospective Studies, Rural Population/td [Trends], Sex Distribution, Taiwan/ep [Epidemiology], Time Factors, Traffic/lj [Legislation \& Jurisprudence, Traffic/pc [Prevention \& Control], Traffic/sn [Statistics \& Numerical Dat, Trauma Severity Indices, Urban Population/td [Trends]},
pubstate = {published},
tppubtype = {article}
}
for Disease Control, Centers; Prevention,
Nonfatal traumatic brain injuries from sports and recreation activities--United States, 2001-2005 Journal Article
In: MMWR - Morbidity & Mortality Weekly Report, vol. 56, no. 29, pp. 733–737, 2007.
Abstract | BibTeX | Tags: *Athletic Injuries/ep [Epidemiology], *Brain Injuries/ep [Epidemiology], Adolescent, adult, Child, Chronic traumatic encephalopathy, Female, Humans, Incidence/Epidemiology, Infant, Male, middle aged, Population Surveillance, Preschool, recreation, United States/ep [Epidemiology]
@article{CentersforDiseaseControlandPrevention2007,
title = {Nonfatal traumatic brain injuries from sports and recreation activities--United States, 2001-2005},
author = {{Centers for Disease Control and Prevention}},
year = {2007},
date = {2007-01-01},
journal = {MMWR - Morbidity \& Mortality Weekly Report},
volume = {56},
number = {29},
pages = {733--737},
abstract = {Each year in the United States, an estimated 38 million children and adolescents participate in organized sports, and approximately 170 million adults participate in some type of physical activity not related to work. The health benefits of these activities are tempered by the risk for injury, including traumatic brain injury (TBI). CDC estimates that 1.1 million persons with TBIs are treated and released from U.S. hospital emergency departments (EDs) each year, and an additional 235,000 are hospitalized for these injuries. TBIs can result in long-term, negative health effects (e.g., memory loss and behavioral changes). To characterize sports- and recreation-related (SR-related) TBIs among patients treated in U.S. hospital EDs, CDC analyzed data from the National Electronic Injury Surveillance System--All Injury Program (NEISS-AIP) for the period 2001-2005. This report summarizes the results of that analysis, which indicated that an estimated 207,830 patients with nonfatal SR-related TBIs were treated in EDs each year during this period. The highest rates of SR-related TBI ED visits for both males and females occurred among those aged 10-14 years. Increased awareness of TBI risks, prevention strategies, and the importance of timely identification and management is essential for reducing the incidence, severity, and long-term negative health effects of this type of injury.},
keywords = {*Athletic Injuries/ep [Epidemiology], *Brain Injuries/ep [Epidemiology], Adolescent, adult, Child, Chronic traumatic encephalopathy, Female, Humans, Incidence/Epidemiology, Infant, Male, middle aged, Population Surveillance, Preschool, recreation, United States/ep [Epidemiology]},
pubstate = {published},
tppubtype = {article}
}
Butcher, I; McHugh, G S; Lu, J; Steyerberg, E W; Hernandez, A V; Mushkudiani, N; Maas, A I; Marmarou, A; Murray, G D
Prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study Journal Article
In: Journal of Neurotrauma, vol. 24, no. 2, pp. 281–286, 2007.
Abstract | BibTeX | Tags: *Brain Injuries/di [Diagnosis], *Brain Injuries/et [Etiology], Accidents, adult, Age Factors, Athletic Injuries/co [Complications], Athletic Injuries/di [Diagnosis], Databases, Factual, Glasgow Outcome Scale, Humans, middle aged, Predictive Value of Tests, Prognosis, violence
@article{Butcher2007,
title = {Prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study},
author = {Butcher, I and McHugh, G S and Lu, J and Steyerberg, E W and Hernandez, A V and Mushkudiani, N and Maas, A I and Marmarou, A and Murray, G D},
year = {2007},
date = {2007-01-01},
journal = {Journal of Neurotrauma},
volume = {24},
number = {2},
pages = {281--286},
abstract = {We aimed to describe and quantify the relationship between cause of injury and final outcome following traumatic brain injury (TBI). Individual patient data (N = 8708) from eight therapeutic Phase III randomized clinical trials in moderate or severe TBI, and three TBI surveys were used to investigate the relationship between cause of injury and outcome, as assessed by the Glasgow Outcome Scale (GOS) at 6 months. Proportional odds methodology was applied to quantify the strength of the association and expressed as an odds ratio in a meta-analysis. Heterogeneity across studies was assessed and associations with other predictive factors explored. In a univariate analysis, a strong association between the cause of injury and long-term outcome in moderate to severe TBI patients was observed, with consistent results across the studies. Road traffic accidents (OR 0.66, 95% CI 0.60-0.73), assaults (OR 0.66, 95% CI 0.52-0.84), and injuries sustained during sporting or recreational activities (OR 0.45, 95% CI 0.28-0.71) were all associated with better outcomes than the reference category of falls. Falls were found to be associated with an older age and with a higher incidence of mass lesions. Following adjustment for age in the analysis, the relationship between cause of injury and outcome was lost.},
keywords = {*Brain Injuries/di [Diagnosis], *Brain Injuries/et [Etiology], Accidents, adult, Age Factors, Athletic Injuries/co [Complications], Athletic Injuries/di [Diagnosis], Databases, Factual, Glasgow Outcome Scale, Humans, middle aged, Predictive Value of Tests, Prognosis, violence},
pubstate = {published},
tppubtype = {article}
}
Kerr, J; Swann, I J; Pentland, B
A survey of information given to head-injured patients on direct discharge from emergency departments in Scotland Journal Article
In: Emergency Medicine Journal, vol. 24, no. 5, pp. 330–332, 2007, ISBN: 1472-0205.
Abstract | Links | BibTeX | Tags: adult, Child, Emergency Service, Head Injuries, human, Pamphlets, Patient Discharge Education -- Evaluation, postconcussion syndrome, Scotland
@article{Kerr2007,
title = {A survey of information given to head-injured patients on direct discharge from emergency departments in Scotland},
author = {Kerr, J and Swann, I J and Pentland, B},
doi = {10.1136/emj.2006.044230},
isbn = {1472-0205},
year = {2007},
date = {2007-01-01},
journal = {Emergency Medicine Journal},
volume = {24},
number = {5},
pages = {330--332},
publisher = {BMJ Publishing Group},
abstract = {AIM: To survey the information provided to head-injured patients on discharge from emergency departments (EDs) in Scotland. METHODS: EDs throughout Scotland were asked to supply a copy of their head injury advice pamphlet for analysis. Each pamphlet was assessed against a template and an Excel spreadsheet was created. RESULTS: All 30 (100%) Scottish EDs responded. The frequency with which specific features appeared varied widely, with most pamphlets concentrating on emergency features, with less emphasis on postconcussion symptoms. CONCLUSIONS: Head injury discharge advice should be standardised throughout EDs, with more emphasis given to postconcussion features.},
keywords = {adult, Child, Emergency Service, Head Injuries, human, Pamphlets, Patient Discharge Education -- Evaluation, postconcussion syndrome, Scotland},
pubstate = {published},
tppubtype = {article}
}
Falconer, E K; Geffen, G M; Olsen, S L; McFarland, K
The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research Journal Article
In: Brain Injury, vol. 20, no. 12, pp. 1251–1263, 2006.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Mass Screening/mt [Methods], *Neuropsychological Tests, Adolescent, adult, Brain Concussion/et [Etiology], Brain Concussion/px [Psychology], Brain Injuries/co [Complications], Brain Injuries/px [Psychology], Female, Humans, Male, Mental Recall, middle aged, Reproducibility of Results, Sensitivity and Specificity, Verbal Learning
@article{Falconer2006,
title = {The rapid screen of concussion: an evaluation of the non-word repetition test for use in mTBI research},
author = {Falconer, E K and Geffen, G M and Olsen, S L and McFarland, K},
year = {2006},
date = {2006-01-01},
journal = {Brain Injury},
volume = {20},
number = {12},
pages = {1251--1263},
abstract = {PRIMARY OBJECTIVES: (1) To investigate the Nonword Repetition test (NWR) as an index of sub-vocal rehearsal deficits after mild traumatic brain injury (mTBI); (2) to assess the reliability, validity and sensitivity of the NWR; and (3) to compare the NWR to more sensitive tests of verbal memory. RESEARCH DESIGN: An independent groups design. METHODS AND PROCEDURES: Study 1 administered the NWR to 46 mTBI and 61 uninjured controls with the Rapid Screen of Concussion (RSC). Study 2 compared mTBI, orthopaedic and uninjured participants on the NWR and the Hopkins Verbal Learning Test (HVLT-R). MAIN OUTCOMES AND RESULTS: The NWR did not improve the diagnostic accuracy of the RSC. However, it is reliable and indexes sub-vocal rehearsal speed. These findings provide evidence that although the current form of the NWR lacks sensitivity to the impact of mTBI, the development of a more sensitive test of sub-vocal rehearsal deficits following mTBI is warranted.},
keywords = {*Brain Concussion/di [Diagnosis], *Mass Screening/mt [Methods], *Neuropsychological Tests, Adolescent, adult, Brain Concussion/et [Etiology], Brain Concussion/px [Psychology], Brain Injuries/co [Complications], Brain Injuries/px [Psychology], Female, Humans, Male, Mental Recall, middle aged, Reproducibility of Results, Sensitivity and Specificity, Verbal Learning},
pubstate = {published},
tppubtype = {article}
}
De Monte, V E; Geffen, G M; May, C R; McFarland, K; Heath, P; Neralic, M
The acute effects of mild traumatic brain injury on finger tapping with and without word repetition Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 27, no. 2, pp. 224–239, 2005.
Abstract | BibTeX | Tags: *Brain Injuries/pp [Physiopathology], *Fingers/pp [Physiopathology], *Psychomotor Performance/ph [Physiology], *Verbal Learning/ph [Physiology], Adolescent, adult, Demography, Discrimination (Psychology)/ph [Physiology], Female, Fingers/ir [Innervation], Glasgow Coma Scale, Hand Deformities/pp [Physiopathology], Humans, Male, Mental Recall/ph [Physiology], middle aged, Neuropsychological Tests/sn [Statistics & Numerica, Sensitivity and Specificity, Sex Factors, Task Performance and Analysis, Word Association Tests/sn [Statistics & Numerical
@article{DeMonte2005,
title = {The acute effects of mild traumatic brain injury on finger tapping with and without word repetition},
author = {{De Monte}, V E and Geffen, G M and May, C R and McFarland, K and Heath, P and Neralic, M},
year = {2005},
date = {2005-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {27},
number = {2},
pages = {224--239},
abstract = {This study aimed to investigate the acute effects of mild Traumatic Brain Injury (mTBI) on the performance of a finger tapping and word repetition dual task in order to determine working memory impairment in mTBI. Sixty-four (50 male, 14 female) right-handed cases of mTBI and 26 (18 male and 8 female) right-handed cases of orthopaedic injuries were tested within 24 hours of injury. Patients with mTBI completed fewer correct taps in 10 seconds than patients with orthopaedic injuries, and female mTBI cases repeated fewer words. The size of the dual task decrement did not vary between groups. When added to a test battery including the Rapid Screen of Concussion (RSC; Comerford, Geffen, May, Medland \& Geffen, 2002) and the Digit Symbol Substitution Test, finger tapping speed accounted for 1% of between groups variance and did not improve classification rates of male participants. While the addition of tapping rate did not improve the sensitivity and specificity of the RSC and DSST to mTBI in males, univariate analysis of motor performance in females indicated that dual task performance might be diagnostic. An increase in female sample size is warranted. These results confirm the view that there is a generalized slowing of processing ability following mTBI.},
keywords = {*Brain Injuries/pp [Physiopathology], *Fingers/pp [Physiopathology], *Psychomotor Performance/ph [Physiology], *Verbal Learning/ph [Physiology], Adolescent, adult, Demography, Discrimination (Psychology)/ph [Physiology], Female, Fingers/ir [Innervation], Glasgow Coma Scale, Hand Deformities/pp [Physiopathology], Humans, Male, Mental Recall/ph [Physiology], middle aged, Neuropsychological Tests/sn [Statistics \& Numerica, Sensitivity and Specificity, Sex Factors, Task Performance and Analysis, Word Association Tests/sn [Statistics \& Numerical},
pubstate = {published},
tppubtype = {article}
}
Macpherson, A K; To, T M; Macarthur, C; Chipman, M L; Wright, J G; Parkin, P C
Impact of mandatory helmet legislation on bicycle-related head injuries in children: a population-based study Journal Article
In: Pediatrics, vol. 110, no. 5, pp. e60, 2002.
Abstract | BibTeX | Tags: *Bicycling/in [Injuries], *Bicycling/lj [Legislation & Jurisprudence], *Craniocerebral Trauma/pc [Prevention & Control], *Head Protective Devices/ut [Utilization], Accidents, Adolescent, adult, Bicycling/sn [Statistics & Numerical Data], Canada/ep [Epidemiology], Child, Cohort Studies, Craniocerebral Trauma/di [Diagnosis], Craniocerebral Trauma/ep [Epidemiology], Female, Hospitalized/sn [Statistics & Numerical Dat, Humans, Incidence, Legislation as Topic/sn [Statistics & Numerical Da, Male, Preschool, Public Policy, Traffic/sn [Statistics & Numerical Data, Trauma Severity Indices
@article{Macpherson2002,
title = {Impact of mandatory helmet legislation on bicycle-related head injuries in children: a population-based study},
author = {Macpherson, A K and To, T M and Macarthur, C and Chipman, M L and Wright, J G and Parkin, P C},
year = {2002},
date = {2002-01-01},
journal = {Pediatrics},
volume = {110},
number = {5},
pages = {e60},
abstract = {OBJECTIVE: Childhood bicycle-related head injuries can be prevented through the use of helmets. Although helmet legislation has proved to be a successful strategy for the adoption of helmets, its effect on the rates of head injury is uncertain. In Canada, 4 provinces have such legislation. The objective of this study was to measure the impact of helmet legislation on bicycle-related head injuries in Canadian children. METHODS: Routinely collected data from the Canadian Institute for Health Information identified all Canadian children (5-19 years) who were hospitalized for bicycling-related injuries from 1994-1998. Children were categorized as head or other injury on the basis of International Classification of Diseases, Ninth Revision, codes. Rates of head injuries and other injuries were compared over time in provinces that adopted legislation and those that did not. RESULTS: Of the 9650 children who were hospitalized because of a bicycle-related injury, 3426 sustained injuries to the head and face and the remaining 6224 had other injuries. The bicycle-related head injury rate declined significantly (45% reduction) in provinces where legislation had been adopted compared with provinces and territories that did not adopt legislation (27% reduction). CONCLUSION: This country-wide study compared rates of head injury in regions with and without mandatory helmet legislation. Comparing head injuries with other non-head-injured children controlled for potential differences in children's cycling habits. The strong protective association between helmet legislation and head injuries supports the adoption of helmet legislation as an effective tool in the prevention of childhood bicycle-related head injuries.},
keywords = {*Bicycling/in [Injuries], *Bicycling/lj [Legislation \& Jurisprudence], *Craniocerebral Trauma/pc [Prevention \& Control], *Head Protective Devices/ut [Utilization], Accidents, Adolescent, adult, Bicycling/sn [Statistics \& Numerical Data], Canada/ep [Epidemiology], Child, Cohort Studies, Craniocerebral Trauma/di [Diagnosis], Craniocerebral Trauma/ep [Epidemiology], Female, Hospitalized/sn [Statistics \& Numerical Dat, Humans, Incidence, Legislation as Topic/sn [Statistics \& Numerical Da, Male, Preschool, Public Policy, Traffic/sn [Statistics \& Numerical Data, Trauma Severity Indices},
pubstate = {published},
tppubtype = {article}
}
Bigler, E D; Rosa, L; Schultz, F; Hall, S; Harris, J
Rey-Auditory Verbal Learning and Rey-Osterrieth Complex Figure Design performance in Alzheimer's disease and closed head injury.[Erratum appears in J Clin Psychol 1989 Nov;45(6):1013] Journal Article
In: Journal of Clinical Psychology, vol. 45, no. 2, pp. 277–280, 1989.
Abstract | BibTeX | Tags: *Alzheimer Disease/px [Psychology], *Brain Concussion/px [Psychology], *Form Perception, *MEMORY, *Mental Recall, *Neurocognitive Disorders/px [Psychology], *Neuropsychological Tests, *Pattern Recognition, *Verbal Learning, 80 and over, adult, aged, attention, Female, Humans, Male, middle aged, Psychometrics, SPEECH perception, Visual
@article{Bigler1989,
title = {Rey-Auditory Verbal Learning and Rey-Osterrieth Complex Figure Design performance in Alzheimer's disease and closed head injury.[Erratum appears in J Clin Psychol 1989 Nov;45(6):1013]},
author = {Bigler, E D and Rosa, L and Schultz, F and Hall, S and Harris, J},
year = {1989},
date = {1989-01-01},
journal = {Journal of Clinical Psychology},
volume = {45},
number = {2},
pages = {277--280},
abstract = {Performance on the Rey-Auditory Verbal Learning (R-AVL) and Rey-Osterrieth Complex Figure Design (R-O CFD) tests was examined in patients (N = 94) with dementia of the Alzheimer's type (DAT) and closed head injury (CHI). On the R-AVL, DAT patients demonstrated considerably greater impairment than CHI patients, along with a flat learning/retention curve that showed negligible improvement with repeated trials, recency effects only, and an excessive number of word intrusions (confabulation) on the recognition trial. CHI patients demonstrated both a recency and primacy effect along with improvement over repeated trials (positive slope learning curve). Both groups demonstrated impairment R-O CFD recall; the DAT group again displayed substantially greater copying and recall deficits. Clinical guidelines are given for the use of the R-AVL and R-O CFD for these two patient populations.},
keywords = {*Alzheimer Disease/px [Psychology], *Brain Concussion/px [Psychology], *Form Perception, *MEMORY, *Mental Recall, *Neurocognitive Disorders/px [Psychology], *Neuropsychological Tests, *Pattern Recognition, *Verbal Learning, 80 and over, adult, aged, attention, Female, Humans, Male, middle aged, Psychometrics, SPEECH perception, Visual},
pubstate = {published},
tppubtype = {article}
}
Heinrichs, R W; Celinski, M J
Frequency of occurrence of a WAIS dementia profile in male head trauma patients Journal Article
In: Journal of Clinical & Experimental Neuropsychology, vol. 9, no. 2, pp. 187–190, 1987.
Abstract | BibTeX | Tags: *Brain Injuries/di [Diagnosis], *Dementia/di [Diagnosis], *Wechsler Scales, adult, Brain Concussion/di [Diagnosis], Cerebral Hemorrhage/di [Diagnosis], Humans, middle aged, Psychometrics
@article{Heinrichs1987,
title = {Frequency of occurrence of a WAIS dementia profile in male head trauma patients},
author = {Heinrichs, R W and Celinski, M J},
year = {1987},
date = {1987-01-01},
journal = {Journal of Clinical \& Experimental Neuropsychology},
volume = {9},
number = {2},
pages = {187--190},
abstract = {This study investigated Fuld's (1983) contention that a WAIS dementia profile occurs infrequently in conditions other than Alzheimer's Disease. A sample of 50 male head trauma patients was examined for incidence of the profile. The WAIS profile occurred in five cases (10%) of the patients. This compares favourably with the figures reported for patients with multiple infarcts and is consistent with Fuld's position.},
keywords = {*Brain Injuries/di [Diagnosis], *Dementia/di [Diagnosis], *Wechsler Scales, adult, Brain Concussion/di [Diagnosis], Cerebral Hemorrhage/di [Diagnosis], Humans, middle aged, Psychometrics},
pubstate = {published},
tppubtype = {article}
}