van der Horn, H J; Liemburg, E J; Scheenen, M E; de Koning, M E; Marsman, J B; Spikman, J M; van der Naalt, J
Brain network dysregulation, emotion, and complaints after mild traumatic brain injury Journal Article
In: Human Brain Mapping, vol. 37, no. 4, pp. 1645–1654, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], *Emotions, *MAGNETIC resonance imaging, *Nerve Net/pp [Physiopathology], Adolescent, adult, Brain Concussion/px [Psychology], Emotions/ph [Physiology], Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging/mt [Methods], Male, middle aged, Prospective Studies, Young Adult
@article{VanderHorn2016,
title = {Brain network dysregulation, emotion, and complaints after mild traumatic brain injury},
author = {van der Horn, H J and Liemburg, E J and Scheenen, M E and de Koning, M E and Marsman, J B and Spikman, J M and van der Naalt, J},
year = {2016},
date = {2016-01-01},
journal = {Human Brain Mapping},
volume = {37},
number = {4},
pages = {1645--1654},
abstract = {OBJECTIVES: To assess the role of brain networks in emotion regulation and post-traumatic complaints in the sub-acute phase after non-complicated mild traumatic brain injury (mTBI). EXPERIMENTAL DESIGN: Fifty-four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group-matched for age, sex, education, and handedness) were included. Resting-state fMRI was performed at four weeks post-injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS-A) and depression (HADS-D). PRINCIPAL OBSERVATIONS: Regarding within-network functional connectivity, none of the selected brain networks were different between groups. Regarding between-network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS-D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS-D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS-A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network. CONCLUSIONS: Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.Copyright © 2016 Wiley Periodicals, Inc.},
keywords = {*Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], *Emotions, *MAGNETIC resonance imaging, *Nerve Net/pp [Physiopathology], Adolescent, adult, Brain Concussion/px [Psychology], Emotions/ph [Physiology], Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging/mt [Methods], Male, middle aged, Prospective Studies, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Stewart, W; McNamara, P H; Lawlor, B; Hutchinson, S; Farrell, M
Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union? Journal Article
In: Qjm, vol. 109, no. 1, pp. 11–15, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Brain/pp [Physiopathology], *Football/in [Injuries], *Neurodegenerative Diseases/pp [Physiopathology], Chronic/pa [Pathology], Humans, Magnetic Resonance Imaging, Male, middle aged, neurologic examination
@article{Stewart2016,
title = {Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union?},
author = {Stewart, W and McNamara, P H and Lawlor, B and Hutchinson, S and Farrell, M},
year = {2016},
date = {2016-01-01},
journal = {Qjm},
volume = {109},
number = {1},
pages = {11--15},
abstract = {The association between exposure to head injury and increased risk of neurodegenerative disease, specifically chronic traumatic encephalopathy (CTE), is widely recognized. Historically, this was largely considered a phenomenon restricted to boxers, with more recent case series identifying further 'high risk' individuals, such as former American footballers, or military personnel. However, in all cases thus far reported, it is clear that it is the exposure to head injury which is associated with increased dementia risk, and not the circumstances or environment of exposure. As such, there is considerable potential for under-recognition of CTE in patients presenting with neurodegenerative disease, particularly where head injury exposure might have been historical and through sport. This article reviews current understanding of CTE and, via an illustrative case in rugby union, highlights the value of a detailed history on head injury and also draws attention to imaging studies in assessing patients with neurodegenerative disease. Copyright © The Author 2015. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Brain/pp [Physiopathology], *Football/in [Injuries], *Neurodegenerative Diseases/pp [Physiopathology], Chronic/pa [Pathology], Humans, Magnetic Resonance Imaging, Male, middle aged, neurologic examination},
pubstate = {published},
tppubtype = {article}
}
Czerniak, S M; Sikoglu, E M; Liso Navarro, A A; McCafferty, J; Eisenstock, J; Stevenson, J H; King, J A; Moore, C M
A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270] Journal Article
In: Brain Imaging & Behavior, vol. 9, no. 2, pp. 323–332, 2015.
Abstract | BibTeX | Tags: *Athletic Injuries/pp [Physiopathology], *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], Adolescent, Athletes, BRAIN mapping, Female, Humans, interview, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychological, rest, Young Adult
@article{Czerniak2015b,
title = {A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270]},
author = {Czerniak, S M and Sikoglu, E M and {Liso Navarro}, A A and McCafferty, J and Eisenstock, J and Stevenson, J H and King, J A and Moore, C M},
year = {2015},
date = {2015-01-01},
journal = {Brain Imaging \& Behavior},
volume = {9},
number = {2},
pages = {323--332},
abstract = {Sports-related concussions are currently diagnosed through multi-domain assessment by a medical professional and may utilize neurocognitive testing as an aid. However, these tests have only been able to detect differences in the days to week post-concussion. Here, we investigate a measure of brain function, namely resting state functional connectivity, which may detect residual brain differences in the weeks to months after concussion. Twenty-one student athletes (9 concussed within 6 months of enrollment; 12 non-concussed; between ages 18 and 22 years) were recruited for this study. All participants completed the Wisconsin Card Sorting Task and the Color-Word Interference Test. Neuroimaging data, specifically resting state functional Magnetic Resonance Imaging data, were acquired to examine resting state functional connectivity. Two sample t-tests were used to compare the neurocognitive scores and resting state functional connectivity patterns among concussed and non-concussed participants. Correlations between neurocognitive scores and resting state functional connectivity measures were also determined across all subjects. There were no significant differences in neurocognitive performance between concussed and non-concussed groups. Concussed subjects had significantly increased connections between areas of the brain that underlie executive function. Across all subjects, better neurocognitive performance corresponded to stronger brain connectivity. Even at rest, brains of concussed athletes may have to 'work harder' than their healthy peers to achieve similar neurocognitive results. Resting state brain connectivity may be able to detect prolonged brain differences in concussed athletes in a more quantitative manner than neurocognitive test scores.},
keywords = {*Athletic Injuries/pp [Physiopathology], *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], Adolescent, Athletes, BRAIN mapping, Female, Humans, interview, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychological, rest, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Matthews, S; Simmons, A; Strigo, I
The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131] Journal Article
In: Psychiatry Research, vol. 191, no. 1, pp. 76–79, 2011.
Abstract | BibTeX | Tags: *Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs & Derivatives], Urea/bl [Blood], Young Adult
@article{Matthews2011a,
title = {The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131]},
author = {Matthews, S and Simmons, A and Strigo, I},
year = {2011},
date = {2011-01-01},
journal = {Psychiatry Research},
volume = {191},
number = {1},
pages = {76--79},
abstract = {In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC. Copyright Published by Elsevier Ireland Ltd.},
keywords = {*Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs \& Derivatives], Urea/bl [Blood], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Kiraly, M; Kiraly, S J
Traumatic brain injury and delayed sequelae: a review--traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia Journal Article
In: TheScientificWorldJournal, vol. 7, pp. 1768–1776, 2007.
Abstract | BibTeX | Tags: *Brain Injuries/co [Complications], *Brain Injuries/pp [Physiopathology], *Brain/pp [Physiopathology], *Dementia/et [Etiology], *Dementia/pp [Physiopathology], *Models, Animals, Humans, Neurological
@article{Kiraly2007,
title = {Traumatic brain injury and delayed sequelae: a review--traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia},
author = {Kiraly, M and Kiraly, S J},
year = {2007},
date = {2007-01-01},
journal = {TheScientificWorldJournal},
volume = {7},
pages = {1768--1776},
abstract = {Brain injuries are too common. Most people are unaware of the incidence of and horrendous consequences of traumatic brain injury (TBI) and mild traumatic brain injury (MTBI). Research and the advent of sophisticated imaging have led to progression in the understanding of brain pathophysiology following TBI. Seminal evidence from animal and human experiments demonstrate links between TBI and the subsequent onset of premature, psychiatric syndromes and neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Objectives of this summary are, therefore, to instill appreciation regarding the importance of brain injury prevention, diagnosis, and treatment, and to increase awareness regarding the long-term delayed consequences following TBI. [References: 88]},
keywords = {*Brain Injuries/co [Complications], *Brain Injuries/pp [Physiopathology], *Brain/pp [Physiopathology], *Dementia/et [Etiology], *Dementia/pp [Physiopathology], *Models, Animals, Humans, Neurological},
pubstate = {published},
tppubtype = {article}
}
van der Horn, H J; Liemburg, E J; Scheenen, M E; de Koning, M E; Marsman, J B; Spikman, J M; van der Naalt, J
Brain network dysregulation, emotion, and complaints after mild traumatic brain injury Journal Article
In: Human Brain Mapping, vol. 37, no. 4, pp. 1645–1654, 2016.
@article{VanderHorn2016,
title = {Brain network dysregulation, emotion, and complaints after mild traumatic brain injury},
author = {van der Horn, H J and Liemburg, E J and Scheenen, M E and de Koning, M E and Marsman, J B and Spikman, J M and van der Naalt, J},
year = {2016},
date = {2016-01-01},
journal = {Human Brain Mapping},
volume = {37},
number = {4},
pages = {1645--1654},
abstract = {OBJECTIVES: To assess the role of brain networks in emotion regulation and post-traumatic complaints in the sub-acute phase after non-complicated mild traumatic brain injury (mTBI). EXPERIMENTAL DESIGN: Fifty-four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group-matched for age, sex, education, and handedness) were included. Resting-state fMRI was performed at four weeks post-injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS-A) and depression (HADS-D). PRINCIPAL OBSERVATIONS: Regarding within-network functional connectivity, none of the selected brain networks were different between groups. Regarding between-network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS-D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS-D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS-A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network. CONCLUSIONS: Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.Copyright © 2016 Wiley Periodicals, Inc.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Stewart, W; McNamara, P H; Lawlor, B; Hutchinson, S; Farrell, M
Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union? Journal Article
In: Qjm, vol. 109, no. 1, pp. 11–15, 2016.
@article{Stewart2016,
title = {Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union?},
author = {Stewart, W and McNamara, P H and Lawlor, B and Hutchinson, S and Farrell, M},
year = {2016},
date = {2016-01-01},
journal = {Qjm},
volume = {109},
number = {1},
pages = {11--15},
abstract = {The association between exposure to head injury and increased risk of neurodegenerative disease, specifically chronic traumatic encephalopathy (CTE), is widely recognized. Historically, this was largely considered a phenomenon restricted to boxers, with more recent case series identifying further 'high risk' individuals, such as former American footballers, or military personnel. However, in all cases thus far reported, it is clear that it is the exposure to head injury which is associated with increased dementia risk, and not the circumstances or environment of exposure. As such, there is considerable potential for under-recognition of CTE in patients presenting with neurodegenerative disease, particularly where head injury exposure might have been historical and through sport. This article reviews current understanding of CTE and, via an illustrative case in rugby union, highlights the value of a detailed history on head injury and also draws attention to imaging studies in assessing patients with neurodegenerative disease. Copyright © The Author 2015. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Czerniak, S M; Sikoglu, E M; Liso Navarro, A A; McCafferty, J; Eisenstock, J; Stevenson, J H; King, J A; Moore, C M
A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270] Journal Article
In: Brain Imaging & Behavior, vol. 9, no. 2, pp. 323–332, 2015.
@article{Czerniak2015b,
title = {A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270]},
author = {Czerniak, S M and Sikoglu, E M and {Liso Navarro}, A A and McCafferty, J and Eisenstock, J and Stevenson, J H and King, J A and Moore, C M},
year = {2015},
date = {2015-01-01},
journal = {Brain Imaging \& Behavior},
volume = {9},
number = {2},
pages = {323--332},
abstract = {Sports-related concussions are currently diagnosed through multi-domain assessment by a medical professional and may utilize neurocognitive testing as an aid. However, these tests have only been able to detect differences in the days to week post-concussion. Here, we investigate a measure of brain function, namely resting state functional connectivity, which may detect residual brain differences in the weeks to months after concussion. Twenty-one student athletes (9 concussed within 6 months of enrollment; 12 non-concussed; between ages 18 and 22 years) were recruited for this study. All participants completed the Wisconsin Card Sorting Task and the Color-Word Interference Test. Neuroimaging data, specifically resting state functional Magnetic Resonance Imaging data, were acquired to examine resting state functional connectivity. Two sample t-tests were used to compare the neurocognitive scores and resting state functional connectivity patterns among concussed and non-concussed participants. Correlations between neurocognitive scores and resting state functional connectivity measures were also determined across all subjects. There were no significant differences in neurocognitive performance between concussed and non-concussed groups. Concussed subjects had significantly increased connections between areas of the brain that underlie executive function. Across all subjects, better neurocognitive performance corresponded to stronger brain connectivity. Even at rest, brains of concussed athletes may have to 'work harder' than their healthy peers to achieve similar neurocognitive results. Resting state brain connectivity may be able to detect prolonged brain differences in concussed athletes in a more quantitative manner than neurocognitive test scores.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Matthews, S; Simmons, A; Strigo, I
The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131] Journal Article
In: Psychiatry Research, vol. 191, no. 1, pp. 76–79, 2011.
@article{Matthews2011a,
title = {The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131]},
author = {Matthews, S and Simmons, A and Strigo, I},
year = {2011},
date = {2011-01-01},
journal = {Psychiatry Research},
volume = {191},
number = {1},
pages = {76--79},
abstract = {In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC. Copyright Published by Elsevier Ireland Ltd.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Kiraly, M; Kiraly, S J
Traumatic brain injury and delayed sequelae: a review--traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia Journal Article
In: TheScientificWorldJournal, vol. 7, pp. 1768–1776, 2007.
@article{Kiraly2007,
title = {Traumatic brain injury and delayed sequelae: a review--traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia},
author = {Kiraly, M and Kiraly, S J},
year = {2007},
date = {2007-01-01},
journal = {TheScientificWorldJournal},
volume = {7},
pages = {1768--1776},
abstract = {Brain injuries are too common. Most people are unaware of the incidence of and horrendous consequences of traumatic brain injury (TBI) and mild traumatic brain injury (MTBI). Research and the advent of sophisticated imaging have led to progression in the understanding of brain pathophysiology following TBI. Seminal evidence from animal and human experiments demonstrate links between TBI and the subsequent onset of premature, psychiatric syndromes and neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Objectives of this summary are, therefore, to instill appreciation regarding the importance of brain injury prevention, diagnosis, and treatment, and to increase awareness regarding the long-term delayed consequences following TBI. [References: 88]},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
van der Horn, H J; Liemburg, E J; Scheenen, M E; de Koning, M E; Marsman, J B; Spikman, J M; van der Naalt, J
Brain network dysregulation, emotion, and complaints after mild traumatic brain injury Journal Article
In: Human Brain Mapping, vol. 37, no. 4, pp. 1645–1654, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], *Emotions, *MAGNETIC resonance imaging, *Nerve Net/pp [Physiopathology], Adolescent, adult, Brain Concussion/px [Psychology], Emotions/ph [Physiology], Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging/mt [Methods], Male, middle aged, Prospective Studies, Young Adult
@article{VanderHorn2016,
title = {Brain network dysregulation, emotion, and complaints after mild traumatic brain injury},
author = {van der Horn, H J and Liemburg, E J and Scheenen, M E and de Koning, M E and Marsman, J B and Spikman, J M and van der Naalt, J},
year = {2016},
date = {2016-01-01},
journal = {Human Brain Mapping},
volume = {37},
number = {4},
pages = {1645--1654},
abstract = {OBJECTIVES: To assess the role of brain networks in emotion regulation and post-traumatic complaints in the sub-acute phase after non-complicated mild traumatic brain injury (mTBI). EXPERIMENTAL DESIGN: Fifty-four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group-matched for age, sex, education, and handedness) were included. Resting-state fMRI was performed at four weeks post-injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS-A) and depression (HADS-D). PRINCIPAL OBSERVATIONS: Regarding within-network functional connectivity, none of the selected brain networks were different between groups. Regarding between-network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS-D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS-D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS-A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network. CONCLUSIONS: Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.Copyright © 2016 Wiley Periodicals, Inc.},
keywords = {*Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], *Emotions, *MAGNETIC resonance imaging, *Nerve Net/pp [Physiopathology], Adolescent, adult, Brain Concussion/px [Psychology], Emotions/ph [Physiology], Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging/mt [Methods], Male, middle aged, Prospective Studies, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Stewart, W; McNamara, P H; Lawlor, B; Hutchinson, S; Farrell, M
Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union? Journal Article
In: Qjm, vol. 109, no. 1, pp. 11–15, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Injury, *Brain/pp [Physiopathology], *Football/in [Injuries], *Neurodegenerative Diseases/pp [Physiopathology], Chronic/pa [Pathology], Humans, Magnetic Resonance Imaging, Male, middle aged, neurologic examination
@article{Stewart2016,
title = {Chronic traumatic encephalopathy: a potential late and under recognized consequence of rugby union?},
author = {Stewart, W and McNamara, P H and Lawlor, B and Hutchinson, S and Farrell, M},
year = {2016},
date = {2016-01-01},
journal = {Qjm},
volume = {109},
number = {1},
pages = {11--15},
abstract = {The association between exposure to head injury and increased risk of neurodegenerative disease, specifically chronic traumatic encephalopathy (CTE), is widely recognized. Historically, this was largely considered a phenomenon restricted to boxers, with more recent case series identifying further 'high risk' individuals, such as former American footballers, or military personnel. However, in all cases thus far reported, it is clear that it is the exposure to head injury which is associated with increased dementia risk, and not the circumstances or environment of exposure. As such, there is considerable potential for under-recognition of CTE in patients presenting with neurodegenerative disease, particularly where head injury exposure might have been historical and through sport. This article reviews current understanding of CTE and, via an illustrative case in rugby union, highlights the value of a detailed history on head injury and also draws attention to imaging studies in assessing patients with neurodegenerative disease. Copyright © The Author 2015. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.},
keywords = {*Brain Concussion/co [Complications], *Brain Injury, *Brain/pp [Physiopathology], *Football/in [Injuries], *Neurodegenerative Diseases/pp [Physiopathology], Chronic/pa [Pathology], Humans, Magnetic Resonance Imaging, Male, middle aged, neurologic examination},
pubstate = {published},
tppubtype = {article}
}
Czerniak, S M; Sikoglu, E M; Liso Navarro, A A; McCafferty, J; Eisenstock, J; Stevenson, J H; King, J A; Moore, C M
A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270] Journal Article
In: Brain Imaging & Behavior, vol. 9, no. 2, pp. 323–332, 2015.
Abstract | BibTeX | Tags: *Athletic Injuries/pp [Physiopathology], *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], Adolescent, Athletes, BRAIN mapping, Female, Humans, interview, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychological, rest, Young Adult
@article{Czerniak2015b,
title = {A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270]},
author = {Czerniak, S M and Sikoglu, E M and {Liso Navarro}, A A and McCafferty, J and Eisenstock, J and Stevenson, J H and King, J A and Moore, C M},
year = {2015},
date = {2015-01-01},
journal = {Brain Imaging \& Behavior},
volume = {9},
number = {2},
pages = {323--332},
abstract = {Sports-related concussions are currently diagnosed through multi-domain assessment by a medical professional and may utilize neurocognitive testing as an aid. However, these tests have only been able to detect differences in the days to week post-concussion. Here, we investigate a measure of brain function, namely resting state functional connectivity, which may detect residual brain differences in the weeks to months after concussion. Twenty-one student athletes (9 concussed within 6 months of enrollment; 12 non-concussed; between ages 18 and 22 years) were recruited for this study. All participants completed the Wisconsin Card Sorting Task and the Color-Word Interference Test. Neuroimaging data, specifically resting state functional Magnetic Resonance Imaging data, were acquired to examine resting state functional connectivity. Two sample t-tests were used to compare the neurocognitive scores and resting state functional connectivity patterns among concussed and non-concussed participants. Correlations between neurocognitive scores and resting state functional connectivity measures were also determined across all subjects. There were no significant differences in neurocognitive performance between concussed and non-concussed groups. Concussed subjects had significantly increased connections between areas of the brain that underlie executive function. Across all subjects, better neurocognitive performance corresponded to stronger brain connectivity. Even at rest, brains of concussed athletes may have to 'work harder' than their healthy peers to achieve similar neurocognitive results. Resting state brain connectivity may be able to detect prolonged brain differences in concussed athletes in a more quantitative manner than neurocognitive test scores.},
keywords = {*Athletic Injuries/pp [Physiopathology], *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], Adolescent, Athletes, BRAIN mapping, Female, Humans, interview, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychological, rest, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Matthews, S; Simmons, A; Strigo, I
The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131] Journal Article
In: Psychiatry Research, vol. 191, no. 1, pp. 76–79, 2011.
Abstract | BibTeX | Tags: *Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs & Derivatives], Urea/bl [Blood], Young Adult
@article{Matthews2011a,
title = {The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.[Erratum appears in Psychiatry Res. 2011 May 31;192(2):131]},
author = {Matthews, S and Simmons, A and Strigo, I},
year = {2011},
date = {2011-01-01},
journal = {Psychiatry Research},
volume = {191},
number = {1},
pages = {76--79},
abstract = {In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC. Copyright Published by Elsevier Ireland Ltd.},
keywords = {*Brain Concussion/pa [Pathology], *Brain Mapping, *Brain/pp [Physiopathology], *Consciousness/ph [Physiology], *Inhibition (Psychology), *Unconsciousness/pp [Physiopathology], 0 (Peroxides), 31PZ2VAU81 (carbamide peroxide), 8W8T17847W (Urea), adult, Blast Injuries/co [Complications], Brain Concussion/et [Etiology], Brain/bs [Blood Supply], Computer-Assisted/mt [Methods], Humans, image processing, Magnetic Resonance Imaging/mt [Methods], Male, Monte Carlo Method, Peroxides/bl [Blood], Unconsciousness/pa [Pathology], Urea/aa [Analogs \& Derivatives], Urea/bl [Blood], Young Adult},
pubstate = {published},
tppubtype = {article}
}
Kiraly, M; Kiraly, S J
Traumatic brain injury and delayed sequelae: a review--traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia Journal Article
In: TheScientificWorldJournal, vol. 7, pp. 1768–1776, 2007.
Abstract | BibTeX | Tags: *Brain Injuries/co [Complications], *Brain Injuries/pp [Physiopathology], *Brain/pp [Physiopathology], *Dementia/et [Etiology], *Dementia/pp [Physiopathology], *Models, Animals, Humans, Neurological
@article{Kiraly2007,
title = {Traumatic brain injury and delayed sequelae: a review--traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia},
author = {Kiraly, M and Kiraly, S J},
year = {2007},
date = {2007-01-01},
journal = {TheScientificWorldJournal},
volume = {7},
pages = {1768--1776},
abstract = {Brain injuries are too common. Most people are unaware of the incidence of and horrendous consequences of traumatic brain injury (TBI) and mild traumatic brain injury (MTBI). Research and the advent of sophisticated imaging have led to progression in the understanding of brain pathophysiology following TBI. Seminal evidence from animal and human experiments demonstrate links between TBI and the subsequent onset of premature, psychiatric syndromes and neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Objectives of this summary are, therefore, to instill appreciation regarding the importance of brain injury prevention, diagnosis, and treatment, and to increase awareness regarding the long-term delayed consequences following TBI. [References: 88]},
keywords = {*Brain Injuries/co [Complications], *Brain Injuries/pp [Physiopathology], *Brain/pp [Physiopathology], *Dementia/et [Etiology], *Dementia/pp [Physiopathology], *Models, Animals, Humans, Neurological},
pubstate = {published},
tppubtype = {article}
}