Hilz, M J; Liu, M; Koehn, J; Wang, R; Ammon, F; Flanagan, S R; Hosl, K M
Valsalva maneuver unveils central baroreflex dysfunction with altered blood pressure control in persons with a history of mild traumatic brain injury Journal Article
In: BMC Neurology, vol. 16, pp. 61, 2016.
Abstract | BibTeX | Tags: *Autonomic Nervous System Diseases/pp [Physiopatho, *Baroreflex, *Blood Pressure, *Brain Concussion/pp [Physiopathology], *Valsalva Maneuver, adult, Case-Control Studies, Female, Heart Rate/ph [Physiology], Humans, Male, Respiration
@article{Hilz2016,
title = {Valsalva maneuver unveils central baroreflex dysfunction with altered blood pressure control in persons with a history of mild traumatic brain injury},
author = {Hilz, M J and Liu, M and Koehn, J and Wang, R and Ammon, F and Flanagan, S R and Hosl, K M},
year = {2016},
date = {2016-01-01},
journal = {BMC Neurology},
volume = {16},
pages = {61},
abstract = {BACKGROUND: Patients with a history of mild TBI (post-mTBI-patients) have an unexplained increase in long-term mortality which might be related to central autonomic dysregulation (CAD). We investigated whether standardized baroreflex-loading, induced by a Valsalva maneuver (VM), unveils CAD in otherwise healthy post-mTBI-patients. METHODS: In 29 healthy persons (31.3+/-12.2 years; 9 women) and 25 post-mTBI-patients (35.0+/-13.2 years, 7 women, 4-98 months post-injury), we monitored respiration (RESP), RR-intervals (RRI) and systolic blood pressure (BP) at rest and during three VMs. At rest, we calculated parameters of total autonomic modulation [RRI-coefficient-of-variation (CV), RRI-standard-deviation (RRI-SD), RRI-total-powers], of sympathetic [RRI-low-frequency-powers (LF), BP-LF-powers] and parasympathetic modulation [square-root-of-mean-squared-differences-of-successive-RRIs (RMSSD), RRI-high-frequency-powers (HF)], the index of sympatho-vagal balance (RRI LF/HF-ratios), and baroreflex sensitivity (BRS). We calculated Valsalva-ratios (VR) and times from lowest to highest RRIs after strain (VR-time) as indices of parasympathetic activation, intervals from highest systolic BP-values after strain-release to the time when systolic BP had fallen by 90 % of the differences between peak-phase-IV-BP and baseline-BP (90 %-BP-normalization-times), and velocities of BP-normalization (90 %-BP-normalization-velocities) as indices of sympathetic withdrawal. We compared patient- and control-parameters before and during VM (Mann-Whitney-U-tests or t-tests; significance: P\<0.05). RESULTS: At rest, RRI-CVs, RRI-SDs, RRI-total-powers, RRI-LF-powers, BP-LF-powers, RRI-RMSSDs, RRI-HF-powers, and BRS were lower in patients than controls. During VMs, 90 %-BP-normalization-times were longer, and 90 %-BP-normalization-velocities were lower in patients than controls (P\<0.05). CONCLUSIONS: Reduced autonomic modulation at rest and delayed BP-decrease after VM-induced baroreflex-loading indicate subtle CAD with altered baroreflex adjustment to challenge. More severe autonomic challenge might trigger more prominent cardiovascular dysregulation and thus contribute to increased mortality risk in post-mTBI-patients.},
keywords = {*Autonomic Nervous System Diseases/pp [Physiopatho, *Baroreflex, *Blood Pressure, *Brain Concussion/pp [Physiopathology], *Valsalva Maneuver, adult, Case-Control Studies, Female, Heart Rate/ph [Physiology], Humans, Male, Respiration},
pubstate = {published},
tppubtype = {article}
}
Astafiev, S V; Zinn, K L; Shulman, G L; Corbetta, M
Exploring the physiological correlates of chronic mild traumatic brain injury symptoms Journal Article
In: NeuroImage Clinical, vol. 11, pp. 10–19, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Brain Concussion/pp [Physiopathology], *Post-Concussion Syndrome/pp [Physiopathology], *White Matter/pp [Physiopathology], anisotropy, chronic disease, Diffusion Tensor Imaging/mt [Methods], Female, Humans, Magnetic Resonance Imaging/mt [Methods], Male, Neuropsychological Tests
@article{Astafiev2016,
title = {Exploring the physiological correlates of chronic mild traumatic brain injury symptoms},
author = {Astafiev, S V and Zinn, K L and Shulman, G L and Corbetta, M},
year = {2016},
date = {2016-01-01},
journal = {NeuroImage Clinical},
volume = {11},
pages = {10--19},
abstract = {We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.},
keywords = {*Brain Concussion/di [Diagnosis], *Brain Concussion/pp [Physiopathology], *Post-Concussion Syndrome/pp [Physiopathology], *White Matter/pp [Physiopathology], anisotropy, chronic disease, Diffusion Tensor Imaging/mt [Methods], Female, Humans, Magnetic Resonance Imaging/mt [Methods], Male, Neuropsychological Tests},
pubstate = {published},
tppubtype = {article}
}
van der Horn, H J; Liemburg, E J; Scheenen, M E; de Koning, M E; Marsman, J B; Spikman, J M; van der Naalt, J
Brain network dysregulation, emotion, and complaints after mild traumatic brain injury Journal Article
In: Human Brain Mapping, vol. 37, no. 4, pp. 1645–1654, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], *Emotions, *MAGNETIC resonance imaging, *Nerve Net/pp [Physiopathology], Adolescent, adult, Brain Concussion/px [Psychology], Emotions/ph [Physiology], Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging/mt [Methods], Male, middle aged, Prospective Studies, Young Adult
@article{VanderHorn2016,
title = {Brain network dysregulation, emotion, and complaints after mild traumatic brain injury},
author = {van der Horn, H J and Liemburg, E J and Scheenen, M E and de Koning, M E and Marsman, J B and Spikman, J M and van der Naalt, J},
year = {2016},
date = {2016-01-01},
journal = {Human Brain Mapping},
volume = {37},
number = {4},
pages = {1645--1654},
abstract = {OBJECTIVES: To assess the role of brain networks in emotion regulation and post-traumatic complaints in the sub-acute phase after non-complicated mild traumatic brain injury (mTBI). EXPERIMENTAL DESIGN: Fifty-four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group-matched for age, sex, education, and handedness) were included. Resting-state fMRI was performed at four weeks post-injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS-A) and depression (HADS-D). PRINCIPAL OBSERVATIONS: Regarding within-network functional connectivity, none of the selected brain networks were different between groups. Regarding between-network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS-D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS-D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS-A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network. CONCLUSIONS: Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.Copyright © 2016 Wiley Periodicals, Inc.},
keywords = {*Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], *Emotions, *MAGNETIC resonance imaging, *Nerve Net/pp [Physiopathology], Adolescent, adult, Brain Concussion/px [Psychology], Emotions/ph [Physiology], Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging/mt [Methods], Male, middle aged, Prospective Studies, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Wood, H
Traumatic brain injury: Cerebral blood flow is linked to sports-related concussion outcomes Journal Article
In: Nature Reviews Neurology, vol. 11, no. 4, pp. 185, 2015.
BibTeX | Tags: *Brain Concussion/pp [Physiopathology], *Cerebral Cortex, *Cerebrovascular Circulation/ph [Physiology], *Football/in [Injuries], *Recovery of Function/ph [Physiology], Humans, Male
@article{Wood2015a,
title = {Traumatic brain injury: Cerebral blood flow is linked to sports-related concussion outcomes},
author = {Wood, H},
year = {2015},
date = {2015-01-01},
journal = {Nature Reviews Neurology},
volume = {11},
number = {4},
pages = {185},
keywords = {*Brain Concussion/pp [Physiopathology], *Cerebral Cortex, *Cerebrovascular Circulation/ph [Physiology], *Football/in [Injuries], *Recovery of Function/ph [Physiology], Humans, Male},
pubstate = {published},
tppubtype = {article}
}
Raukar, N; Chao, L
Concussion: a primer for the physician Journal Article
In: Rhode Island Medicine, vol. 98, no. 6, pp. 27–29, 2015.
BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Concussion/pp [Physiopathology], *Brain Concussion/th [Therapy], *Sports Medicine/st [Standards], Alzheimer Disease/ep [Epidemiology], Athletes, Brain/pp [Physiopathology], Humans, Schools
@article{Raukar2015,
title = {Concussion: a primer for the physician},
author = {Raukar, N and Chao, L},
year = {2015},
date = {2015-01-01},
journal = {Rhode Island Medicine},
volume = {98},
number = {6},
pages = {27--29},
keywords = {*Brain Concussion/co [Complications], *Brain Concussion/pp [Physiopathology], *Brain Concussion/th [Therapy], *Sports Medicine/st [Standards], Alzheimer Disease/ep [Epidemiology], Athletes, Brain/pp [Physiopathology], Humans, Schools},
pubstate = {published},
tppubtype = {article}
}
Nauman, E A; Breedlove, K M; Breedlove, E L; Talavage, T M; Robinson, M E; Leverenz, L J
Post-Season Neurophysiological Deficits Assessed by ImPACT and fMRI in Athletes Competing in American Football Journal Article
In: Developmental Neuropsychology, vol. 40, no. 2, pp. 85–91, 2015.
Abstract | BibTeX | Tags: *Athletes, *Brain Concussion/pp [Physiopathology], *Football/in [Injuries], *MAGNETIC resonance imaging, Adolescent, Brain Concussion/pa [Pathology], Head, Humans, Male, Neurophysiology, Neuropsychological Tests, Schools, Seasons, Surveys and Questionnaires, UNITED States, Young Adult
@article{Nauman2015,
title = {Post-Season Neurophysiological Deficits Assessed by ImPACT and fMRI in Athletes Competing in American Football},
author = {Nauman, E A and Breedlove, K M and Breedlove, E L and Talavage, T M and Robinson, M E and Leverenz, L J},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {2},
pages = {85--91},
abstract = {Neurocognitive assessment, functional magnetic resonance imaging, and head impact monitoring were used to evaluate neurological changes in high school football players throughout competitive seasons. A substantial number of asymptomatic athletes exhibited neurophysiological changes that persisted post-season, with abnormal measures significantly more common in athletes receiving 50 or more hits per week during the season.},
keywords = {*Athletes, *Brain Concussion/pp [Physiopathology], *Football/in [Injuries], *MAGNETIC resonance imaging, Adolescent, Brain Concussion/pa [Pathology], Head, Humans, Male, Neurophysiology, Neuropsychological Tests, Schools, Seasons, Surveys and Questionnaires, UNITED States, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Svaldi, D O; Joshi, C; Robinson, M E; Shenk, T E; Abbas, K; Nauman, E A; Leverenz, L J; Talavage, T M
Cerebrovascular reactivity alterations in asymptomatic high school football players Journal Article
In: Developmental Neuropsychology, vol. 40, no. 2, pp. 80–84, 2015.
Abstract | BibTeX | Tags: *Athletes, *Brain Concussion/pp [Physiopathology], *Brain Injury, *Cerebrovascular Disorders/pp [Physiopathology], *Football/in [Injuries], Adolescent, Chronic/pp [Physiopathology], Humans, RISK assessment, Schools
@article{Svaldi2015,
title = {Cerebrovascular reactivity alterations in asymptomatic high school football players},
author = {Svaldi, D O and Joshi, C and Robinson, M E and Shenk, T E and Abbas, K and Nauman, E A and Leverenz, L J and Talavage, T M},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {2},
pages = {80--84},
abstract = {Cerebrovascular reactivity (CVR) is impaired following brain injury, increasing susceptibility to subsequent injury. CVR was tracked in football and non-collision athletes throughout one season. CVR transiently decreased in football athletes during the first half of the season. Results indicate the brain adapts slowly to increases in loading, increasing risk for injury.},
keywords = {*Athletes, *Brain Concussion/pp [Physiopathology], *Brain Injury, *Cerebrovascular Disorders/pp [Physiopathology], *Football/in [Injuries], Adolescent, Chronic/pp [Physiopathology], Humans, RISK assessment, Schools},
pubstate = {published},
tppubtype = {article}
}
Czerniak, S M; Sikoglu, E M; Liso Navarro, A A; McCafferty, J; Eisenstock, J; Stevenson, J H; King, J A; Moore, C M
A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270] Journal Article
In: Brain Imaging & Behavior, vol. 9, no. 2, pp. 323–332, 2015.
Abstract | BibTeX | Tags: *Athletic Injuries/pp [Physiopathology], *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], Adolescent, Athletes, BRAIN mapping, Female, Humans, interview, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychological, rest, Young Adult
@article{Czerniak2015b,
title = {A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270]},
author = {Czerniak, S M and Sikoglu, E M and {Liso Navarro}, A A and McCafferty, J and Eisenstock, J and Stevenson, J H and King, J A and Moore, C M},
year = {2015},
date = {2015-01-01},
journal = {Brain Imaging \& Behavior},
volume = {9},
number = {2},
pages = {323--332},
abstract = {Sports-related concussions are currently diagnosed through multi-domain assessment by a medical professional and may utilize neurocognitive testing as an aid. However, these tests have only been able to detect differences in the days to week post-concussion. Here, we investigate a measure of brain function, namely resting state functional connectivity, which may detect residual brain differences in the weeks to months after concussion. Twenty-one student athletes (9 concussed within 6 months of enrollment; 12 non-concussed; between ages 18 and 22 years) were recruited for this study. All participants completed the Wisconsin Card Sorting Task and the Color-Word Interference Test. Neuroimaging data, specifically resting state functional Magnetic Resonance Imaging data, were acquired to examine resting state functional connectivity. Two sample t-tests were used to compare the neurocognitive scores and resting state functional connectivity patterns among concussed and non-concussed participants. Correlations between neurocognitive scores and resting state functional connectivity measures were also determined across all subjects. There were no significant differences in neurocognitive performance between concussed and non-concussed groups. Concussed subjects had significantly increased connections between areas of the brain that underlie executive function. Across all subjects, better neurocognitive performance corresponded to stronger brain connectivity. Even at rest, brains of concussed athletes may have to 'work harder' than their healthy peers to achieve similar neurocognitive results. Resting state brain connectivity may be able to detect prolonged brain differences in concussed athletes in a more quantitative manner than neurocognitive test scores.},
keywords = {*Athletic Injuries/pp [Physiopathology], *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], Adolescent, Athletes, BRAIN mapping, Female, Humans, interview, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychological, rest, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Hilz, M J; Liu, M; Koehn, J; Wang, R; Ammon, F; Flanagan, S R; Hosl, K M
Valsalva maneuver unveils central baroreflex dysfunction with altered blood pressure control in persons with a history of mild traumatic brain injury Journal Article
In: BMC Neurology, vol. 16, pp. 61, 2016.
@article{Hilz2016,
title = {Valsalva maneuver unveils central baroreflex dysfunction with altered blood pressure control in persons with a history of mild traumatic brain injury},
author = {Hilz, M J and Liu, M and Koehn, J and Wang, R and Ammon, F and Flanagan, S R and Hosl, K M},
year = {2016},
date = {2016-01-01},
journal = {BMC Neurology},
volume = {16},
pages = {61},
abstract = {BACKGROUND: Patients with a history of mild TBI (post-mTBI-patients) have an unexplained increase in long-term mortality which might be related to central autonomic dysregulation (CAD). We investigated whether standardized baroreflex-loading, induced by a Valsalva maneuver (VM), unveils CAD in otherwise healthy post-mTBI-patients. METHODS: In 29 healthy persons (31.3+/-12.2 years; 9 women) and 25 post-mTBI-patients (35.0+/-13.2 years, 7 women, 4-98 months post-injury), we monitored respiration (RESP), RR-intervals (RRI) and systolic blood pressure (BP) at rest and during three VMs. At rest, we calculated parameters of total autonomic modulation [RRI-coefficient-of-variation (CV), RRI-standard-deviation (RRI-SD), RRI-total-powers], of sympathetic [RRI-low-frequency-powers (LF), BP-LF-powers] and parasympathetic modulation [square-root-of-mean-squared-differences-of-successive-RRIs (RMSSD), RRI-high-frequency-powers (HF)], the index of sympatho-vagal balance (RRI LF/HF-ratios), and baroreflex sensitivity (BRS). We calculated Valsalva-ratios (VR) and times from lowest to highest RRIs after strain (VR-time) as indices of parasympathetic activation, intervals from highest systolic BP-values after strain-release to the time when systolic BP had fallen by 90 % of the differences between peak-phase-IV-BP and baseline-BP (90 %-BP-normalization-times), and velocities of BP-normalization (90 %-BP-normalization-velocities) as indices of sympathetic withdrawal. We compared patient- and control-parameters before and during VM (Mann-Whitney-U-tests or t-tests; significance: P\<0.05). RESULTS: At rest, RRI-CVs, RRI-SDs, RRI-total-powers, RRI-LF-powers, BP-LF-powers, RRI-RMSSDs, RRI-HF-powers, and BRS were lower in patients than controls. During VMs, 90 %-BP-normalization-times were longer, and 90 %-BP-normalization-velocities were lower in patients than controls (P\<0.05). CONCLUSIONS: Reduced autonomic modulation at rest and delayed BP-decrease after VM-induced baroreflex-loading indicate subtle CAD with altered baroreflex adjustment to challenge. More severe autonomic challenge might trigger more prominent cardiovascular dysregulation and thus contribute to increased mortality risk in post-mTBI-patients.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Astafiev, S V; Zinn, K L; Shulman, G L; Corbetta, M
Exploring the physiological correlates of chronic mild traumatic brain injury symptoms Journal Article
In: NeuroImage Clinical, vol. 11, pp. 10–19, 2016.
@article{Astafiev2016,
title = {Exploring the physiological correlates of chronic mild traumatic brain injury symptoms},
author = {Astafiev, S V and Zinn, K L and Shulman, G L and Corbetta, M},
year = {2016},
date = {2016-01-01},
journal = {NeuroImage Clinical},
volume = {11},
pages = {10--19},
abstract = {We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
van der Horn, H J; Liemburg, E J; Scheenen, M E; de Koning, M E; Marsman, J B; Spikman, J M; van der Naalt, J
Brain network dysregulation, emotion, and complaints after mild traumatic brain injury Journal Article
In: Human Brain Mapping, vol. 37, no. 4, pp. 1645–1654, 2016.
@article{VanderHorn2016,
title = {Brain network dysregulation, emotion, and complaints after mild traumatic brain injury},
author = {van der Horn, H J and Liemburg, E J and Scheenen, M E and de Koning, M E and Marsman, J B and Spikman, J M and van der Naalt, J},
year = {2016},
date = {2016-01-01},
journal = {Human Brain Mapping},
volume = {37},
number = {4},
pages = {1645--1654},
abstract = {OBJECTIVES: To assess the role of brain networks in emotion regulation and post-traumatic complaints in the sub-acute phase after non-complicated mild traumatic brain injury (mTBI). EXPERIMENTAL DESIGN: Fifty-four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group-matched for age, sex, education, and handedness) were included. Resting-state fMRI was performed at four weeks post-injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS-A) and depression (HADS-D). PRINCIPAL OBSERVATIONS: Regarding within-network functional connectivity, none of the selected brain networks were different between groups. Regarding between-network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS-D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS-D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS-A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network. CONCLUSIONS: Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.Copyright © 2016 Wiley Periodicals, Inc.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wood, H
Traumatic brain injury: Cerebral blood flow is linked to sports-related concussion outcomes Journal Article
In: Nature Reviews Neurology, vol. 11, no. 4, pp. 185, 2015.
@article{Wood2015a,
title = {Traumatic brain injury: Cerebral blood flow is linked to sports-related concussion outcomes},
author = {Wood, H},
year = {2015},
date = {2015-01-01},
journal = {Nature Reviews Neurology},
volume = {11},
number = {4},
pages = {185},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Raukar, N; Chao, L
Concussion: a primer for the physician Journal Article
In: Rhode Island Medicine, vol. 98, no. 6, pp. 27–29, 2015.
@article{Raukar2015,
title = {Concussion: a primer for the physician},
author = {Raukar, N and Chao, L},
year = {2015},
date = {2015-01-01},
journal = {Rhode Island Medicine},
volume = {98},
number = {6},
pages = {27--29},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Nauman, E A; Breedlove, K M; Breedlove, E L; Talavage, T M; Robinson, M E; Leverenz, L J
Post-Season Neurophysiological Deficits Assessed by ImPACT and fMRI in Athletes Competing in American Football Journal Article
In: Developmental Neuropsychology, vol. 40, no. 2, pp. 85–91, 2015.
@article{Nauman2015,
title = {Post-Season Neurophysiological Deficits Assessed by ImPACT and fMRI in Athletes Competing in American Football},
author = {Nauman, E A and Breedlove, K M and Breedlove, E L and Talavage, T M and Robinson, M E and Leverenz, L J},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {2},
pages = {85--91},
abstract = {Neurocognitive assessment, functional magnetic resonance imaging, and head impact monitoring were used to evaluate neurological changes in high school football players throughout competitive seasons. A substantial number of asymptomatic athletes exhibited neurophysiological changes that persisted post-season, with abnormal measures significantly more common in athletes receiving 50 or more hits per week during the season.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Svaldi, D O; Joshi, C; Robinson, M E; Shenk, T E; Abbas, K; Nauman, E A; Leverenz, L J; Talavage, T M
Cerebrovascular reactivity alterations in asymptomatic high school football players Journal Article
In: Developmental Neuropsychology, vol. 40, no. 2, pp. 80–84, 2015.
@article{Svaldi2015,
title = {Cerebrovascular reactivity alterations in asymptomatic high school football players},
author = {Svaldi, D O and Joshi, C and Robinson, M E and Shenk, T E and Abbas, K and Nauman, E A and Leverenz, L J and Talavage, T M},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {2},
pages = {80--84},
abstract = {Cerebrovascular reactivity (CVR) is impaired following brain injury, increasing susceptibility to subsequent injury. CVR was tracked in football and non-collision athletes throughout one season. CVR transiently decreased in football athletes during the first half of the season. Results indicate the brain adapts slowly to increases in loading, increasing risk for injury.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Czerniak, S M; Sikoglu, E M; Liso Navarro, A A; McCafferty, J; Eisenstock, J; Stevenson, J H; King, J A; Moore, C M
A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270] Journal Article
In: Brain Imaging & Behavior, vol. 9, no. 2, pp. 323–332, 2015.
@article{Czerniak2015b,
title = {A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270]},
author = {Czerniak, S M and Sikoglu, E M and {Liso Navarro}, A A and McCafferty, J and Eisenstock, J and Stevenson, J H and King, J A and Moore, C M},
year = {2015},
date = {2015-01-01},
journal = {Brain Imaging \& Behavior},
volume = {9},
number = {2},
pages = {323--332},
abstract = {Sports-related concussions are currently diagnosed through multi-domain assessment by a medical professional and may utilize neurocognitive testing as an aid. However, these tests have only been able to detect differences in the days to week post-concussion. Here, we investigate a measure of brain function, namely resting state functional connectivity, which may detect residual brain differences in the weeks to months after concussion. Twenty-one student athletes (9 concussed within 6 months of enrollment; 12 non-concussed; between ages 18 and 22 years) were recruited for this study. All participants completed the Wisconsin Card Sorting Task and the Color-Word Interference Test. Neuroimaging data, specifically resting state functional Magnetic Resonance Imaging data, were acquired to examine resting state functional connectivity. Two sample t-tests were used to compare the neurocognitive scores and resting state functional connectivity patterns among concussed and non-concussed participants. Correlations between neurocognitive scores and resting state functional connectivity measures were also determined across all subjects. There were no significant differences in neurocognitive performance between concussed and non-concussed groups. Concussed subjects had significantly increased connections between areas of the brain that underlie executive function. Across all subjects, better neurocognitive performance corresponded to stronger brain connectivity. Even at rest, brains of concussed athletes may have to 'work harder' than their healthy peers to achieve similar neurocognitive results. Resting state brain connectivity may be able to detect prolonged brain differences in concussed athletes in a more quantitative manner than neurocognitive test scores.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hilz, M J; Liu, M; Koehn, J; Wang, R; Ammon, F; Flanagan, S R; Hosl, K M
Valsalva maneuver unveils central baroreflex dysfunction with altered blood pressure control in persons with a history of mild traumatic brain injury Journal Article
In: BMC Neurology, vol. 16, pp. 61, 2016.
Abstract | BibTeX | Tags: *Autonomic Nervous System Diseases/pp [Physiopatho, *Baroreflex, *Blood Pressure, *Brain Concussion/pp [Physiopathology], *Valsalva Maneuver, adult, Case-Control Studies, Female, Heart Rate/ph [Physiology], Humans, Male, Respiration
@article{Hilz2016,
title = {Valsalva maneuver unveils central baroreflex dysfunction with altered blood pressure control in persons with a history of mild traumatic brain injury},
author = {Hilz, M J and Liu, M and Koehn, J and Wang, R and Ammon, F and Flanagan, S R and Hosl, K M},
year = {2016},
date = {2016-01-01},
journal = {BMC Neurology},
volume = {16},
pages = {61},
abstract = {BACKGROUND: Patients with a history of mild TBI (post-mTBI-patients) have an unexplained increase in long-term mortality which might be related to central autonomic dysregulation (CAD). We investigated whether standardized baroreflex-loading, induced by a Valsalva maneuver (VM), unveils CAD in otherwise healthy post-mTBI-patients. METHODS: In 29 healthy persons (31.3+/-12.2 years; 9 women) and 25 post-mTBI-patients (35.0+/-13.2 years, 7 women, 4-98 months post-injury), we monitored respiration (RESP), RR-intervals (RRI) and systolic blood pressure (BP) at rest and during three VMs. At rest, we calculated parameters of total autonomic modulation [RRI-coefficient-of-variation (CV), RRI-standard-deviation (RRI-SD), RRI-total-powers], of sympathetic [RRI-low-frequency-powers (LF), BP-LF-powers] and parasympathetic modulation [square-root-of-mean-squared-differences-of-successive-RRIs (RMSSD), RRI-high-frequency-powers (HF)], the index of sympatho-vagal balance (RRI LF/HF-ratios), and baroreflex sensitivity (BRS). We calculated Valsalva-ratios (VR) and times from lowest to highest RRIs after strain (VR-time) as indices of parasympathetic activation, intervals from highest systolic BP-values after strain-release to the time when systolic BP had fallen by 90 % of the differences between peak-phase-IV-BP and baseline-BP (90 %-BP-normalization-times), and velocities of BP-normalization (90 %-BP-normalization-velocities) as indices of sympathetic withdrawal. We compared patient- and control-parameters before and during VM (Mann-Whitney-U-tests or t-tests; significance: P\<0.05). RESULTS: At rest, RRI-CVs, RRI-SDs, RRI-total-powers, RRI-LF-powers, BP-LF-powers, RRI-RMSSDs, RRI-HF-powers, and BRS were lower in patients than controls. During VMs, 90 %-BP-normalization-times were longer, and 90 %-BP-normalization-velocities were lower in patients than controls (P\<0.05). CONCLUSIONS: Reduced autonomic modulation at rest and delayed BP-decrease after VM-induced baroreflex-loading indicate subtle CAD with altered baroreflex adjustment to challenge. More severe autonomic challenge might trigger more prominent cardiovascular dysregulation and thus contribute to increased mortality risk in post-mTBI-patients.},
keywords = {*Autonomic Nervous System Diseases/pp [Physiopatho, *Baroreflex, *Blood Pressure, *Brain Concussion/pp [Physiopathology], *Valsalva Maneuver, adult, Case-Control Studies, Female, Heart Rate/ph [Physiology], Humans, Male, Respiration},
pubstate = {published},
tppubtype = {article}
}
Astafiev, S V; Zinn, K L; Shulman, G L; Corbetta, M
Exploring the physiological correlates of chronic mild traumatic brain injury symptoms Journal Article
In: NeuroImage Clinical, vol. 11, pp. 10–19, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/di [Diagnosis], *Brain Concussion/pp [Physiopathology], *Post-Concussion Syndrome/pp [Physiopathology], *White Matter/pp [Physiopathology], anisotropy, chronic disease, Diffusion Tensor Imaging/mt [Methods], Female, Humans, Magnetic Resonance Imaging/mt [Methods], Male, Neuropsychological Tests
@article{Astafiev2016,
title = {Exploring the physiological correlates of chronic mild traumatic brain injury symptoms},
author = {Astafiev, S V and Zinn, K L and Shulman, G L and Corbetta, M},
year = {2016},
date = {2016-01-01},
journal = {NeuroImage Clinical},
volume = {11},
pages = {10--19},
abstract = {We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.},
keywords = {*Brain Concussion/di [Diagnosis], *Brain Concussion/pp [Physiopathology], *Post-Concussion Syndrome/pp [Physiopathology], *White Matter/pp [Physiopathology], anisotropy, chronic disease, Diffusion Tensor Imaging/mt [Methods], Female, Humans, Magnetic Resonance Imaging/mt [Methods], Male, Neuropsychological Tests},
pubstate = {published},
tppubtype = {article}
}
van der Horn, H J; Liemburg, E J; Scheenen, M E; de Koning, M E; Marsman, J B; Spikman, J M; van der Naalt, J
Brain network dysregulation, emotion, and complaints after mild traumatic brain injury Journal Article
In: Human Brain Mapping, vol. 37, no. 4, pp. 1645–1654, 2016.
Abstract | BibTeX | Tags: *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], *Emotions, *MAGNETIC resonance imaging, *Nerve Net/pp [Physiopathology], Adolescent, adult, Brain Concussion/px [Psychology], Emotions/ph [Physiology], Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging/mt [Methods], Male, middle aged, Prospective Studies, Young Adult
@article{VanderHorn2016,
title = {Brain network dysregulation, emotion, and complaints after mild traumatic brain injury},
author = {van der Horn, H J and Liemburg, E J and Scheenen, M E and de Koning, M E and Marsman, J B and Spikman, J M and van der Naalt, J},
year = {2016},
date = {2016-01-01},
journal = {Human Brain Mapping},
volume = {37},
number = {4},
pages = {1645--1654},
abstract = {OBJECTIVES: To assess the role of brain networks in emotion regulation and post-traumatic complaints in the sub-acute phase after non-complicated mild traumatic brain injury (mTBI). EXPERIMENTAL DESIGN: Fifty-four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group-matched for age, sex, education, and handedness) were included. Resting-state fMRI was performed at four weeks post-injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS-A) and depression (HADS-D). PRINCIPAL OBSERVATIONS: Regarding within-network functional connectivity, none of the selected brain networks were different between groups. Regarding between-network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS-D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS-D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS-A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network. CONCLUSIONS: Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.Copyright © 2016 Wiley Periodicals, Inc.},
keywords = {*Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], *Emotions, *MAGNETIC resonance imaging, *Nerve Net/pp [Physiopathology], Adolescent, adult, Brain Concussion/px [Psychology], Emotions/ph [Physiology], Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging/mt [Methods], Male, middle aged, Prospective Studies, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Wood, H
Traumatic brain injury: Cerebral blood flow is linked to sports-related concussion outcomes Journal Article
In: Nature Reviews Neurology, vol. 11, no. 4, pp. 185, 2015.
BibTeX | Tags: *Brain Concussion/pp [Physiopathology], *Cerebral Cortex, *Cerebrovascular Circulation/ph [Physiology], *Football/in [Injuries], *Recovery of Function/ph [Physiology], Humans, Male
@article{Wood2015a,
title = {Traumatic brain injury: Cerebral blood flow is linked to sports-related concussion outcomes},
author = {Wood, H},
year = {2015},
date = {2015-01-01},
journal = {Nature Reviews Neurology},
volume = {11},
number = {4},
pages = {185},
keywords = {*Brain Concussion/pp [Physiopathology], *Cerebral Cortex, *Cerebrovascular Circulation/ph [Physiology], *Football/in [Injuries], *Recovery of Function/ph [Physiology], Humans, Male},
pubstate = {published},
tppubtype = {article}
}
Raukar, N; Chao, L
Concussion: a primer for the physician Journal Article
In: Rhode Island Medicine, vol. 98, no. 6, pp. 27–29, 2015.
BibTeX | Tags: *Brain Concussion/co [Complications], *Brain Concussion/pp [Physiopathology], *Brain Concussion/th [Therapy], *Sports Medicine/st [Standards], Alzheimer Disease/ep [Epidemiology], Athletes, Brain/pp [Physiopathology], Humans, Schools
@article{Raukar2015,
title = {Concussion: a primer for the physician},
author = {Raukar, N and Chao, L},
year = {2015},
date = {2015-01-01},
journal = {Rhode Island Medicine},
volume = {98},
number = {6},
pages = {27--29},
keywords = {*Brain Concussion/co [Complications], *Brain Concussion/pp [Physiopathology], *Brain Concussion/th [Therapy], *Sports Medicine/st [Standards], Alzheimer Disease/ep [Epidemiology], Athletes, Brain/pp [Physiopathology], Humans, Schools},
pubstate = {published},
tppubtype = {article}
}
Nauman, E A; Breedlove, K M; Breedlove, E L; Talavage, T M; Robinson, M E; Leverenz, L J
Post-Season Neurophysiological Deficits Assessed by ImPACT and fMRI in Athletes Competing in American Football Journal Article
In: Developmental Neuropsychology, vol. 40, no. 2, pp. 85–91, 2015.
Abstract | BibTeX | Tags: *Athletes, *Brain Concussion/pp [Physiopathology], *Football/in [Injuries], *MAGNETIC resonance imaging, Adolescent, Brain Concussion/pa [Pathology], Head, Humans, Male, Neurophysiology, Neuropsychological Tests, Schools, Seasons, Surveys and Questionnaires, UNITED States, Young Adult
@article{Nauman2015,
title = {Post-Season Neurophysiological Deficits Assessed by ImPACT and fMRI in Athletes Competing in American Football},
author = {Nauman, E A and Breedlove, K M and Breedlove, E L and Talavage, T M and Robinson, M E and Leverenz, L J},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {2},
pages = {85--91},
abstract = {Neurocognitive assessment, functional magnetic resonance imaging, and head impact monitoring were used to evaluate neurological changes in high school football players throughout competitive seasons. A substantial number of asymptomatic athletes exhibited neurophysiological changes that persisted post-season, with abnormal measures significantly more common in athletes receiving 50 or more hits per week during the season.},
keywords = {*Athletes, *Brain Concussion/pp [Physiopathology], *Football/in [Injuries], *MAGNETIC resonance imaging, Adolescent, Brain Concussion/pa [Pathology], Head, Humans, Male, Neurophysiology, Neuropsychological Tests, Schools, Seasons, Surveys and Questionnaires, UNITED States, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Svaldi, D O; Joshi, C; Robinson, M E; Shenk, T E; Abbas, K; Nauman, E A; Leverenz, L J; Talavage, T M
Cerebrovascular reactivity alterations in asymptomatic high school football players Journal Article
In: Developmental Neuropsychology, vol. 40, no. 2, pp. 80–84, 2015.
Abstract | BibTeX | Tags: *Athletes, *Brain Concussion/pp [Physiopathology], *Brain Injury, *Cerebrovascular Disorders/pp [Physiopathology], *Football/in [Injuries], Adolescent, Chronic/pp [Physiopathology], Humans, RISK assessment, Schools
@article{Svaldi2015,
title = {Cerebrovascular reactivity alterations in asymptomatic high school football players},
author = {Svaldi, D O and Joshi, C and Robinson, M E and Shenk, T E and Abbas, K and Nauman, E A and Leverenz, L J and Talavage, T M},
year = {2015},
date = {2015-01-01},
journal = {Developmental Neuropsychology},
volume = {40},
number = {2},
pages = {80--84},
abstract = {Cerebrovascular reactivity (CVR) is impaired following brain injury, increasing susceptibility to subsequent injury. CVR was tracked in football and non-collision athletes throughout one season. CVR transiently decreased in football athletes during the first half of the season. Results indicate the brain adapts slowly to increases in loading, increasing risk for injury.},
keywords = {*Athletes, *Brain Concussion/pp [Physiopathology], *Brain Injury, *Cerebrovascular Disorders/pp [Physiopathology], *Football/in [Injuries], Adolescent, Chronic/pp [Physiopathology], Humans, RISK assessment, Schools},
pubstate = {published},
tppubtype = {article}
}
Czerniak, S M; Sikoglu, E M; Liso Navarro, A A; McCafferty, J; Eisenstock, J; Stevenson, J H; King, J A; Moore, C M
A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270] Journal Article
In: Brain Imaging & Behavior, vol. 9, no. 2, pp. 323–332, 2015.
Abstract | BibTeX | Tags: *Athletic Injuries/pp [Physiopathology], *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], Adolescent, Athletes, BRAIN mapping, Female, Humans, interview, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychological, rest, Young Adult
@article{Czerniak2015b,
title = {A resting state functional magnetic resonance imaging study of concussion in collegiate athletes.[Erratum appears in Brain Imaging Behav. 2015 Sep;9(3):650; PMID: 25326270]},
author = {Czerniak, S M and Sikoglu, E M and {Liso Navarro}, A A and McCafferty, J and Eisenstock, J and Stevenson, J H and King, J A and Moore, C M},
year = {2015},
date = {2015-01-01},
journal = {Brain Imaging \& Behavior},
volume = {9},
number = {2},
pages = {323--332},
abstract = {Sports-related concussions are currently diagnosed through multi-domain assessment by a medical professional and may utilize neurocognitive testing as an aid. However, these tests have only been able to detect differences in the days to week post-concussion. Here, we investigate a measure of brain function, namely resting state functional connectivity, which may detect residual brain differences in the weeks to months after concussion. Twenty-one student athletes (9 concussed within 6 months of enrollment; 12 non-concussed; between ages 18 and 22 years) were recruited for this study. All participants completed the Wisconsin Card Sorting Task and the Color-Word Interference Test. Neuroimaging data, specifically resting state functional Magnetic Resonance Imaging data, were acquired to examine resting state functional connectivity. Two sample t-tests were used to compare the neurocognitive scores and resting state functional connectivity patterns among concussed and non-concussed participants. Correlations between neurocognitive scores and resting state functional connectivity measures were also determined across all subjects. There were no significant differences in neurocognitive performance between concussed and non-concussed groups. Concussed subjects had significantly increased connections between areas of the brain that underlie executive function. Across all subjects, better neurocognitive performance corresponded to stronger brain connectivity. Even at rest, brains of concussed athletes may have to 'work harder' than their healthy peers to achieve similar neurocognitive results. Resting state brain connectivity may be able to detect prolonged brain differences in concussed athletes in a more quantitative manner than neurocognitive test scores.},
keywords = {*Athletic Injuries/pp [Physiopathology], *Brain Concussion/pp [Physiopathology], *Brain/pp [Physiopathology], Adolescent, Athletes, BRAIN mapping, Female, Humans, interview, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychological, rest, Young Adult},
pubstate = {published},
tppubtype = {article}
}