References

2017

Dickson, T J; Trathen, S; Terwiel, F A; Waddington, G; Adams, R

Head injury trends and helmet use in skiers and snowboarders in Western Canada, 2008-2009 to 2012-2013: an ecological study Journal Article

In: Scandinavian Journal of Medicine & Science in Sports, vol. 27, no. 2, pp. 236–244, 2017, ISBN: 09057188.

Abstract | Links | BibTeX | Tags: CANADA, CHI-squared test, Concussion, CONTENT mining, DATA analysis -- Software, DESCRIPTIVE statistics, Ecological research, Head Injuries, Helmets, Injury prevention, LOGISTIC regression analysis, ODDS ratio, PROBABILITY theory, SAFETY hats, SEVERITY of illness index, skiing, Skiing injuries, Snowboarding, Snowboarding injuries

@article{Dickson2017,

title = {Head injury trends and helmet use in skiers and snowboarders in Western Canada, 2008-2009 to 2012-2013: an ecological study},

author = {Dickson, T J and Trathen, S and Terwiel, F A and Waddington, G and Adams, R},

doi = {10.1111/sms.12642},

isbn = {09057188},

year  = {2017},

date = {2017-01-01},

journal = {Scandinavian Journal of Medicine \& Science in Sports},

volume = {27},

number = {2},

pages = {236--244},

abstract = {This research explored associations between helmet use and head injuries in snowsports by investigating reported snowsport injuries in Western Canada from 2008-2009 to 2012-2013. The key finding was that increased helmet use (from 69% to 80%) was not associated with a reduction in reported head injuries. Over the study period, the average rate of reported head injuries was 0.2/1000 skier visits, with a statistically significant variation ( P \< 0.001). The line of best fit showed an non-significant upward trend ( P = 0.13). Lacerations were the only subcategory of head injuries that decreased significantly with helmet use. A higher proportion of people who reported a head injury were wearing a helmet than for injuries other than to the head. Skiers were more likely to report a head injury when wearing a helmet than snowboarders ( P \< 0.001 cf. P = 0.22). There were significant differences in characteristics of helmet and non-helmet wearers. Helmet wearers were more likely to be: young adults ( P \< 0.001); beginner/novices ( P = 0.004); and snowboarders ( P \< 0.001), but helmet wearing was not associated with gender ( P = 0.191). Further research is needed to explore the possible reasons for the failure of helmets to reduce head injuries, for example, increased reporting of head injuries and increased risk-taking combined with over-rating of the helmets' protection.},

keywords = {CANADA, CHI-squared test, Concussion, CONTENT mining, DATA analysis -- Software, DESCRIPTIVE statistics, Ecological research, Head Injuries, Helmets, Injury prevention, LOGISTIC regression analysis, ODDS ratio, PROBABILITY theory, SAFETY hats, SEVERITY of illness index, skiing, Skiing injuries, Snowboarding, Snowboarding injuries},

pubstate = {published},

tppubtype = {article}

}

2016

Hugentobler, Jason A; Gupta, Resmi; Slater, Robert; Paterno, Mark V; Riley, Michael A; Quatman-Yates, Catherine

Influence of Age on Postconcussive Postural Control Measures and Future Implications for Assessment Journal Article

In: Clinical Journal of Sport Medicine, vol. 26, no. 6, pp. 510–517, 2016, ISBN: 1050642X.

Abstract | BibTeX | Tags: ADOLESCENCE, AGE distribution (Demography), ATTENTION-deficit hyperactivity disorder, CORRELATION (Statistics), DATA analysis, DATA analysis -- Software, DESCRIPTIVE statistics, DISEASE complications, EQUILIBRIUM (Physiology), LONGITUDINAL method, MEDICAL history taking, MULTIPLE regression analysis, postconcussion syndrome, PROBABILITY theory, Questionnaires, SEVERITY of illness index, SEX distribution (Demography), STATISTICS

@article{Hugentobler2016,

title = {Influence of Age on Postconcussive Postural Control Measures and Future Implications for Assessment},

author = {Hugentobler, Jason A and Gupta, Resmi and Slater, Robert and Paterno, Mark V and Riley, Michael A and Quatman-Yates, Catherine},

isbn = {1050642X},

year  = {2016},

date = {2016-01-01},

journal = {Clinical Journal of Sport Medicine},

volume = {26},

number = {6},

pages = {510--517},

abstract = {Objective: To examine the influence of age, sex, attention-deficit hyperactivity disorder (ADHD) status, previous history of concussion, and days since injury on postconcussion postural control assessment in adolescents who have suffered a concussion. Design: Prospective cohort study. Setting: Hospital-based outpatient clinic. Participants: Seventy-one participants (42 males; 29 females) with mean age 14.14 ± 2.44. Independent Variables: Age, sex, previous concussion history, ADHD status, total and severity of postconcussion symptoms, and days since injury. Main Outcome Measures: Total Balance Error Scoring System score, path length, center-of-pressure (COP) area, sample entropy, and Romberg quotient. Results: Pearson product-moment correlation coefficients were calculated to test for potential associations between the continuous participant characteristics and the postural control variables. Spearman correlation was used to test the association between symptom severity and the postural control variables. Standard multiple regression was used to model the extent to which participant characteristics accounted for the variance in the postural sway variables. Age was significantly associated with all of the postural sway variables except COP area for the eyes open condition and sample entropy in the anterior-posterior direction for the eyes closed condition. Sex, ADHD status, and previous concussion history did not significantly predict postural control scores. Conclusions: Age significantly influences scores on common postconcussion postural control assessments. Clinical Relevance: This study demonstrates that age is a critical factor that needs to be accounted for to improve the clinical appropriateness and utility of current postconcussion postural control assessments. [ABSTRACT FROM AUTHOR]},

keywords = {ADOLESCENCE, AGE distribution (Demography), ATTENTION-deficit hyperactivity disorder, CORRELATION (Statistics), DATA analysis, DATA analysis -- Software, DESCRIPTIVE statistics, DISEASE complications, EQUILIBRIUM (Physiology), LONGITUDINAL method, MEDICAL history taking, MULTIPLE regression analysis, postconcussion syndrome, PROBABILITY theory, Questionnaires, SEVERITY of illness index, SEX distribution (Demography), STATISTICS},

pubstate = {published},

tppubtype = {article}

}

Abbassi, Ensie; Brassil, Heather E; Salvatore, Anthony P

NIDILRR: Duration of Neurocognitive Impairments and Symptom Resolution in Mild Traumatic Brain injury (MTBI) Journal Article

In: Archives of Physical Medicine & Rehabilitation, vol. 97, no. 12, pp. e3–e3, 2016, ISBN: 00039993.

BibTeX | Tags: *BRAIN -- Concussion, *COGNITION, *Convalescence, *SPORTS injuries, *SYMPTOMS, PROBABILITY theory, Retrospective Studies, SEVERITY of illness index, time

2015

Lucas, S

Posttraumatic Headache: Clinical Characterization and Management Journal Article

In: Current Pain & Headache Reports, vol. 19, no. 10, 2015.

Abstract | Links | BibTeX | Tags: amitriptyline, botulinum toxin A, Brain Injuries, chiropractic, clinical feature, complication, Concussion, diagnostic approach route, disease association, disease classification, disease predisposition, drug efficacy, drug induced headache, evidence based medicine, human, Humans, migraine, neuropsychological test, Neuropsychological Tests, nonsteroid antiinflammatory agent, paracetamol, physiotherapy, Post-traumatic headache, postconcussion syndrome, posttraumatic headache, practice guideline, Prevalence, primary headache, Review, risk factor, Risk Factors, SEVERITY of illness index, sports concussion, symptomatology, tension headache, Tension-type headache, topiramate, traumatic brain injury, treatment response, UNITED States, valproate semisodium

@article{Lucas2015,

title = {Posttraumatic Headache: Clinical Characterization and Management},

author = {Lucas, S},

doi = {10.1007/s11916-015-0520-1},

year  = {2015},

date = {2015-01-01},

journal = {Current Pain \& Headache Reports},

volume = {19},

number = {10},

abstract = {Headache is the most common symptom after traumatic brain injury (TBI). TBI has become a global health concern with an estimated 2.5 million reported TBIs per year in the USA alone. Recent longitudinal studies of posttraumatic headache (PTH) show a high cumulative incidence of 71 % after moderate or severe TBI and an even higher cumulative incidence of 91 % after mild TBI (mTBI) at 1 year after injury. Prevalence remains high at over 44 % throughout the year after moderate or severe TBI and over 54 % after mTBI. A prior history of headache is associated with a higher risk for PTH, whereas older age appears to be protective. Gender does not appear to be a risk factor for PTH. Most PTH has clinical diagnostic criteria meeting that of migraine or probable migraine when primary headache disorder classification criteria are used, followed by tension-type headache. There are no evidence-based treatment guidelines for PTH management; however, expert opinion has suggested treating the PTH using primary headache disorder treatment recommendations according to its type. © 2015, Springer Science+Business Media New York.},

keywords = {amitriptyline, botulinum toxin A, Brain Injuries, chiropractic, clinical feature, complication, Concussion, diagnostic approach route, disease association, disease classification, disease predisposition, drug efficacy, drug induced headache, evidence based medicine, human, Humans, migraine, neuropsychological test, Neuropsychological Tests, nonsteroid antiinflammatory agent, paracetamol, physiotherapy, Post-traumatic headache, postconcussion syndrome, posttraumatic headache, practice guideline, Prevalence, primary headache, Review, risk factor, Risk Factors, SEVERITY of illness index, sports concussion, symptomatology, tension headache, Tension-type headache, topiramate, traumatic brain injury, treatment response, UNITED States, valproate semisodium},

pubstate = {published},

tppubtype = {article}

}

Merritt, V C; Meyer, J E; Arnett, P A

A novel approach to classifying postconcussion symptoms: The application of a new framework to the Post-Concussion Symptom Scale Journal Article

In: Journal of Clinical and Experimental Neuropsychology, vol. 37, no. 7, pp. 764–775, 2015.

Abstract | Links | BibTeX | Tags: Adolescent, Athletic Injuries, brain concussion, CLASSIFICATION, collegiate athletes, Female, human, Humans, Male, neuropsychological test, Neuropsychological Tests, Post-Concussion Syndrome, postconcussion symptoms, self report, SEVERITY of illness index, Sports-related concussion, symptom assessment, Young Adult

@article{Merritt2015b,

title = {A novel approach to classifying postconcussion symptoms: The application of a new framework to the Post-Concussion Symptom Scale},

author = {Merritt, V C and Meyer, J E and Arnett, P A},

doi = {10.1080/13803395.2015.1060950},

year  = {2015},

date = {2015-01-01},

journal = {Journal of Clinical and Experimental Neuropsychology},

volume = {37},

number = {7},

pages = {764--775},

abstract = {Introduction: Self-report measures such as the Post-Concussion Symptom Scale (PCSS) are frequently used during baseline and postconcussion testing to evaluate athletes symptom profiles. However, the common approach of evaluating the total symptom score and/or symptom clusters may not allow for a complete understanding of the nature of athletes symptom reporting patterns. The primary objective of this study was to apply three "global indices of distress" variables, derived from the Symptom Checklist-90-Revised (SCL-90-R) framework, to the PCSS at baseline and postconcussion. We aimed to evaluate the utility of these symptom indices in relation to four PCSS symptom clusters and the total PCSS symptom score. Method: Participants included college athletes evaluated at baseline (N = 846) and postconcussion (N = 86). Athletes underwent neuropsychological testing at both time points, including completion of the PCSS and a paper/pencil and computerized test battery. Eight symptom indices were derived from the PCSS, and a postconcussion neurocognitive composite score was calculated. Results: Results showed that there were significant mean increases from baseline to postconcussion on four of the eight symptom indices evaluated. Furthermore, a significant proportion of athletes showed no change from baseline to postconcussion when evaluating the total symptom score, but showed at least a one standard deviation increase in symptom reporting from baseline to postconcussion when evaluating at least one other symptom index (i.e., a global index of distress or symptom cluster). Finally, the three global indices of distress variables, two of the four symptom clusters, and the total symptom score significantly predicted a postconcussion neurocognitive composite score, such that greater postconcussion symptoms were associated with lower postconcussion neurocognitive performance. Conclusions: These findings suggest that, in addition to evaluating the postconcussion total symptom score, there may be value in examining more specific symptom indices such as the global indices of distress variables and symptom clusters. © 2015 Taylor \& Francis.},

keywords = {Adolescent, Athletic Injuries, brain concussion, CLASSIFICATION, collegiate athletes, Female, human, Humans, Male, neuropsychological test, Neuropsychological Tests, Post-Concussion Syndrome, postconcussion symptoms, self report, SEVERITY of illness index, Sports-related concussion, symptom assessment, Young Adult},

pubstate = {published},

tppubtype = {article}

}

Introduction: Self-report measures such as the Post-Concussion Symptom Scale (PCSS) are frequently used during baseline and postconcussion testing to evaluate athletes symptom profiles. However, the common approach of evaluating the total symptom score and/or symptom clusters may not allow for a complete understanding of the nature of athletes symptom reporting patterns. The primary objective of this study was to apply three "global indices of distress" variables, derived from the Symptom Checklist-90-Revised (SCL-90-R) framework, to the PCSS at baseline and postconcussion. We aimed to evaluate the utility of these symptom indices in relation to four PCSS symptom clusters and the total PCSS symptom score. Method: Participants included college athletes evaluated at baseline (N = 846) and postconcussion (N = 86). Athletes underwent neuropsychological testing at both time points, including completion of the PCSS and a paper/pencil and computerized test battery. Eight symptom indices were derived from the PCSS, and a postconcussion neurocognitive composite score was calculated. Results: Results showed that there were significant mean increases from baseline to postconcussion on four of the eight symptom indices evaluated. Furthermore, a significant proportion of athletes showed no change from baseline to postconcussion when evaluating the total symptom score, but showed at least a one standard deviation increase in symptom reporting from baseline to postconcussion when evaluating at least one other symptom index (i.e., a global index of distress or symptom cluster). Finally, the three global indices of distress variables, two of the four symptom clusters, and the total symptom score significantly predicted a postconcussion neurocognitive composite score, such that greater postconcussion symptoms were associated with lower postconcussion neurocognitive performance. Conclusions: These findings suggest that, in addition to evaluating the postconcussion total symptom score, there may be value in examining more specific symptom indices such as the global indices of distress variables and symptom clusters. © 2015 Taylor & Francis.

Stein, T D; Montenigro, P H; Alvarez, V E; Xia, W; Crary, J F; Tripodis, Y; Daneshvar, D H; Mez, J; Solomon, T; Meng, G; Kubilus, C A; Cormier, K A; Meng, S; Babcock, K; Kiernan, P; Murphy, L; Nowinski, C J; Martin, B; Dixon, D; Stern, R A; Cantu, R C; Kowall, N W; McKee, A C

Beta-amyloid deposition in chronic traumatic encephalopathy Journal Article

In: Acta Neuropathologica, vol. 130, no. 1, pp. 21–34, 2015.

Abstract | BibTeX | Tags: *Amyloid beta-Peptides/me [Metabolism], *Brain Injury, *Brain/pa [Pathology], *Neurodegenerative Diseases/pa [Pathology], *tau Proteins/me [Metabolism], 0 (Amyloid beta-Peptides), 0 (Apolipoprotein E4), 0 (MAPT protein, 0 (tau Proteins), 80 and over, adult, Age Factors, aged, Amyloid/et [Etiology], Amyloid/me [Metabolism], Amyloid/pa [Pathology], Apolipoprotein E4/ge [Genetics], Athletes, Athletic Injuries/ep [Epidemiology], Athletic Injuries/ge [Genetics], Athletic Injuries/me [Metabolism], Athletic Injuries/pa [Pathology], Brain Injury, Brain/me [Metabolism], Chronic/ep [Epidemiology], Chronic/ge [Genetics], Chronic/me [Metabolism], Chronic/pa [Pathology], Cohort Studies, comorbidity, human), Humans, middle aged, Neurodegenerative Diseases/ep [Epidemiology], Neurodegenerative Diseases/ge [Genetics], Neurodegenerative Diseases/me [Metabolism], Plaque, SEVERITY of illness index, veterans, War-Related Injuries/ep [Epidemiology], War-Related Injuries/ge [Genetics], War-Related Injuries/me [Metabolism], War-Related Injuries/pa [Pathology]

@article{Stein2015b,

title = {Beta-amyloid deposition in chronic traumatic encephalopathy},

author = {Stein, T D and Montenigro, P H and Alvarez, V E and Xia, W and Crary, J F and Tripodis, Y and Daneshvar, D H and Mez, J and Solomon, T and Meng, G and Kubilus, C A and Cormier, K A and Meng, S and Babcock, K and Kiernan, P and Murphy, L and Nowinski, C J and Martin, B and Dixon, D and Stern, R A and Cantu, R C and Kowall, N W and McKee, A C},

year  = {2015},

date = {2015-01-01},

journal = {Acta Neuropathologica},

volume = {130},

number = {1},

pages = {21--34},

abstract = {Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. It is defined pathologically by the abnormal accumulation of tau in a unique pattern that is distinct from other tauopathies, including Alzheimer's disease (AD). Although trauma has been suggested to increase amyloid beta peptide (Abeta) levels, the extent of Abeta deposition in CTE has not been thoroughly characterized. We studied a heterogeneous cohort of deceased athletes and military veterans with neuropathologically diagnosed CTE (n = 114, mean age at death = 60) to test the hypothesis that Abeta deposition is altered in CTE and associated with more severe pathology and worse clinical outcomes. We found that Abeta deposition, either as diffuse or neuritic plaques, was present in 52 % of CTE subjects. Moreover, Abeta deposition in CTE occurred at an accelerated rate and with altered dynamics in CTE compared to a normal aging population (OR = 3.8, p \< 0.001). We also found a clear pathological and clinical dichotomy between those CTE cases with Abeta plaques and those without. Abeta deposition was significantly associated with the presence of the APOE epsilon4 allele (p = 0.035), older age at symptom onset (p \< 0.001), and older age at death (p \< 0.001). In addition, when controlling for age, neuritic plaques were significantly associated with increased CTE tauopathy stage (beta = 2.43},

keywords = {*Amyloid beta-Peptides/me [Metabolism], *Brain Injury, *Brain/pa [Pathology], *Neurodegenerative Diseases/pa [Pathology], *tau Proteins/me [Metabolism], 0 (Amyloid beta-Peptides), 0 (Apolipoprotein E4), 0 (MAPT protein, 0 (tau Proteins), 80 and over, adult, Age Factors, aged, Amyloid/et [Etiology], Amyloid/me [Metabolism], Amyloid/pa [Pathology], Apolipoprotein E4/ge [Genetics], Athletes, Athletic Injuries/ep [Epidemiology], Athletic Injuries/ge [Genetics], Athletic Injuries/me [Metabolism], Athletic Injuries/pa [Pathology], Brain Injury, Brain/me [Metabolism], Chronic/ep [Epidemiology], Chronic/ge [Genetics], Chronic/me [Metabolism], Chronic/pa [Pathology], Cohort Studies, comorbidity, human), Humans, middle aged, Neurodegenerative Diseases/ep [Epidemiology], Neurodegenerative Diseases/ge [Genetics], Neurodegenerative Diseases/me [Metabolism], Plaque, SEVERITY of illness index, veterans, War-Related Injuries/ep [Epidemiology], War-Related Injuries/ge [Genetics], War-Related Injuries/me [Metabolism], War-Related Injuries/pa [Pathology]},

pubstate = {published},

tppubtype = {article}

}

Reference Search

Dickson, T J; Trathen, S; Terwiel, F A; Waddington, G; Adams, R

Head injury trends and helmet use in skiers and snowboarders in Western Canada, 2008-2009 to 2012-2013: an ecological study Journal Article

In: Scandinavian Journal of Medicine & Science in Sports, vol. 27, no. 2, pp. 236–244, 2017, ISBN: 09057188.

Abstract | Links | BibTeX

Hugentobler, Jason A; Gupta, Resmi; Slater, Robert; Paterno, Mark V; Riley, Michael A; Quatman-Yates, Catherine

Influence of Age on Postconcussive Postural Control Measures and Future Implications for Assessment Journal Article

In: Clinical Journal of Sport Medicine, vol. 26, no. 6, pp. 510–517, 2016, ISBN: 1050642X.

Abstract | BibTeX

@article{Hugentobler2016,

title = {Influence of Age on Postconcussive Postural Control Measures and Future Implications for Assessment},

author = {Hugentobler, Jason A and Gupta, Resmi and Slater, Robert and Paterno, Mark V and Riley, Michael A and Quatman-Yates, Catherine},

isbn = {1050642X},

year  = {2016},

date = {2016-01-01},

journal = {Clinical Journal of Sport Medicine},

volume = {26},

number = {6},

pages = {510--517},

abstract = {Objective: To examine the influence of age, sex, attention-deficit hyperactivity disorder (ADHD) status, previous history of concussion, and days since injury on postconcussion postural control assessment in adolescents who have suffered a concussion. Design: Prospective cohort study. Setting: Hospital-based outpatient clinic. Participants: Seventy-one participants (42 males; 29 females) with mean age 14.14 ± 2.44. Independent Variables: Age, sex, previous concussion history, ADHD status, total and severity of postconcussion symptoms, and days since injury. Main Outcome Measures: Total Balance Error Scoring System score, path length, center-of-pressure (COP) area, sample entropy, and Romberg quotient. Results: Pearson product-moment correlation coefficients were calculated to test for potential associations between the continuous participant characteristics and the postural control variables. Spearman correlation was used to test the association between symptom severity and the postural control variables. Standard multiple regression was used to model the extent to which participant characteristics accounted for the variance in the postural sway variables. Age was significantly associated with all of the postural sway variables except COP area for the eyes open condition and sample entropy in the anterior-posterior direction for the eyes closed condition. Sex, ADHD status, and previous concussion history did not significantly predict postural control scores. Conclusions: Age significantly influences scores on common postconcussion postural control assessments. Clinical Relevance: This study demonstrates that age is a critical factor that needs to be accounted for to improve the clinical appropriateness and utility of current postconcussion postural control assessments. [ABSTRACT FROM AUTHOR]},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

Abbassi, Ensie; Brassil, Heather E; Salvatore, Anthony P

NIDILRR: Duration of Neurocognitive Impairments and Symptom Resolution in Mild Traumatic Brain injury (MTBI) Journal Article

In: Archives of Physical Medicine & Rehabilitation, vol. 97, no. 12, pp. e3–e3, 2016, ISBN: 00039993.

BibTeX

Lucas, S

Posttraumatic Headache: Clinical Characterization and Management Journal Article

In: Current Pain & Headache Reports, vol. 19, no. 10, 2015.

Abstract | Links | BibTeX

Merritt, V C; Meyer, J E; Arnett, P A

A novel approach to classifying postconcussion symptoms: The application of a new framework to the Post-Concussion Symptom Scale Journal Article

In: Journal of Clinical and Experimental Neuropsychology, vol. 37, no. 7, pp. 764–775, 2015.

Abstract | Links | BibTeX

@article{Merritt2015b,

title = {A novel approach to classifying postconcussion symptoms: The application of a new framework to the Post-Concussion Symptom Scale},

author = {Merritt, V C and Meyer, J E and Arnett, P A},

doi = {10.1080/13803395.2015.1060950},

year  = {2015},

date = {2015-01-01},

journal = {Journal of Clinical and Experimental Neuropsychology},

volume = {37},

number = {7},

pages = {764--775},

abstract = {Introduction: Self-report measures such as the Post-Concussion Symptom Scale (PCSS) are frequently used during baseline and postconcussion testing to evaluate athletes symptom profiles. However, the common approach of evaluating the total symptom score and/or symptom clusters may not allow for a complete understanding of the nature of athletes symptom reporting patterns. The primary objective of this study was to apply three "global indices of distress" variables, derived from the Symptom Checklist-90-Revised (SCL-90-R) framework, to the PCSS at baseline and postconcussion. We aimed to evaluate the utility of these symptom indices in relation to four PCSS symptom clusters and the total PCSS symptom score. Method: Participants included college athletes evaluated at baseline (N = 846) and postconcussion (N = 86). Athletes underwent neuropsychological testing at both time points, including completion of the PCSS and a paper/pencil and computerized test battery. Eight symptom indices were derived from the PCSS, and a postconcussion neurocognitive composite score was calculated. Results: Results showed that there were significant mean increases from baseline to postconcussion on four of the eight symptom indices evaluated. Furthermore, a significant proportion of athletes showed no change from baseline to postconcussion when evaluating the total symptom score, but showed at least a one standard deviation increase in symptom reporting from baseline to postconcussion when evaluating at least one other symptom index (i.e., a global index of distress or symptom cluster). Finally, the three global indices of distress variables, two of the four symptom clusters, and the total symptom score significantly predicted a postconcussion neurocognitive composite score, such that greater postconcussion symptoms were associated with lower postconcussion neurocognitive performance. Conclusions: These findings suggest that, in addition to evaluating the postconcussion total symptom score, there may be value in examining more specific symptom indices such as the global indices of distress variables and symptom clusters. © 2015 Taylor \& Francis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

Beta-amyloid deposition in chronic traumatic encephalopathy Journal Article

In: Acta Neuropathologica, vol. 130, no. 1, pp. 21–34, 2015.

Abstract | BibTeX

@article{Stein2015b,

title = {Beta-amyloid deposition in chronic traumatic encephalopathy},

author = {Stein, T D and Montenigro, P H and Alvarez, V E and Xia, W and Crary, J F and Tripodis, Y and Daneshvar, D H and Mez, J and Solomon, T and Meng, G and Kubilus, C A and Cormier, K A and Meng, S and Babcock, K and Kiernan, P and Murphy, L and Nowinski, C J and Martin, B and Dixon, D and Stern, R A and Cantu, R C and Kowall, N W and McKee, A C},

year  = {2015},

date = {2015-01-01},

journal = {Acta Neuropathologica},

volume = {130},

number = {1},

pages = {21--34},

abstract = {Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. It is defined pathologically by the abnormal accumulation of tau in a unique pattern that is distinct from other tauopathies, including Alzheimer's disease (AD). Although trauma has been suggested to increase amyloid beta peptide (Abeta) levels, the extent of Abeta deposition in CTE has not been thoroughly characterized. We studied a heterogeneous cohort of deceased athletes and military veterans with neuropathologically diagnosed CTE (n = 114, mean age at death = 60) to test the hypothesis that Abeta deposition is altered in CTE and associated with more severe pathology and worse clinical outcomes. We found that Abeta deposition, either as diffuse or neuritic plaques, was present in 52 % of CTE subjects. Moreover, Abeta deposition in CTE occurred at an accelerated rate and with altered dynamics in CTE compared to a normal aging population (OR = 3.8, p \< 0.001). We also found a clear pathological and clinical dichotomy between those CTE cases with Abeta plaques and those without. Abeta deposition was significantly associated with the presence of the APOE epsilon4 allele (p = 0.035), older age at symptom onset (p \< 0.001), and older age at death (p \< 0.001). In addition, when controlling for age, neuritic plaques were significantly associated with increased CTE tauopathy stage (beta = 2.43},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

Most Referenced Keywords

Show all

2017

Dickson, T J; Trathen, S; Terwiel, F A; Waddington, G; Adams, R

Head injury trends and helmet use in skiers and snowboarders in Western Canada, 2008-2009 to 2012-2013: an ecological study Journal Article

In: Scandinavian Journal of Medicine & Science in Sports, vol. 27, no. 2, pp. 236–244, 2017, ISBN: 09057188.

@article{Dickson2017,

title = {Head injury trends and helmet use in skiers and snowboarders in Western Canada, 2008-2009 to 2012-2013: an ecological study},

author = {Dickson, T J and Trathen, S and Terwiel, F A and Waddington, G and Adams, R},

doi = {10.1111/sms.12642},

isbn = {09057188},

year  = {2017},

date = {2017-01-01},

journal = {Scandinavian Journal of Medicine \& Science in Sports},

volume = {27},

number = {2},

pages = {236--244},

abstract = {This research explored associations between helmet use and head injuries in snowsports by investigating reported snowsport injuries in Western Canada from 2008-2009 to 2012-2013. The key finding was that increased helmet use (from 69% to 80%) was not associated with a reduction in reported head injuries. Over the study period, the average rate of reported head injuries was 0.2/1000 skier visits, with a statistically significant variation ( P \< 0.001). The line of best fit showed an non-significant upward trend ( P = 0.13). Lacerations were the only subcategory of head injuries that decreased significantly with helmet use. A higher proportion of people who reported a head injury were wearing a helmet than for injuries other than to the head. Skiers were more likely to report a head injury when wearing a helmet than snowboarders ( P \< 0.001 cf. P = 0.22). There were significant differences in characteristics of helmet and non-helmet wearers. Helmet wearers were more likely to be: young adults ( P \< 0.001); beginner/novices ( P = 0.004); and snowboarders ( P \< 0.001), but helmet wearing was not associated with gender ( P = 0.191). Further research is needed to explore the possible reasons for the failure of helmets to reduce head injuries, for example, increased reporting of head injuries and increased risk-taking combined with over-rating of the helmets' protection.},

keywords = {CANADA, CHI-squared test, Concussion, CONTENT mining, DATA analysis -- Software, DESCRIPTIVE statistics, Ecological research, Head Injuries, Helmets, Injury prevention, LOGISTIC regression analysis, ODDS ratio, PROBABILITY theory, SAFETY hats, SEVERITY of illness index, skiing, Skiing injuries, Snowboarding, Snowboarding injuries},

pubstate = {published},

tppubtype = {article}

}

2016

Hugentobler, Jason A; Gupta, Resmi; Slater, Robert; Paterno, Mark V; Riley, Michael A; Quatman-Yates, Catherine

Influence of Age on Postconcussive Postural Control Measures and Future Implications for Assessment Journal Article

In: Clinical Journal of Sport Medicine, vol. 26, no. 6, pp. 510–517, 2016, ISBN: 1050642X.

@article{Hugentobler2016,

title = {Influence of Age on Postconcussive Postural Control Measures and Future Implications for Assessment},

author = {Hugentobler, Jason A and Gupta, Resmi and Slater, Robert and Paterno, Mark V and Riley, Michael A and Quatman-Yates, Catherine},

isbn = {1050642X},

year  = {2016},

date = {2016-01-01},

journal = {Clinical Journal of Sport Medicine},

volume = {26},

number = {6},

pages = {510--517},

abstract = {Objective: To examine the influence of age, sex, attention-deficit hyperactivity disorder (ADHD) status, previous history of concussion, and days since injury on postconcussion postural control assessment in adolescents who have suffered a concussion. Design: Prospective cohort study. Setting: Hospital-based outpatient clinic. Participants: Seventy-one participants (42 males; 29 females) with mean age 14.14 ± 2.44. Independent Variables: Age, sex, previous concussion history, ADHD status, total and severity of postconcussion symptoms, and days since injury. Main Outcome Measures: Total Balance Error Scoring System score, path length, center-of-pressure (COP) area, sample entropy, and Romberg quotient. Results: Pearson product-moment correlation coefficients were calculated to test for potential associations between the continuous participant characteristics and the postural control variables. Spearman correlation was used to test the association between symptom severity and the postural control variables. Standard multiple regression was used to model the extent to which participant characteristics accounted for the variance in the postural sway variables. Age was significantly associated with all of the postural sway variables except COP area for the eyes open condition and sample entropy in the anterior-posterior direction for the eyes closed condition. Sex, ADHD status, and previous concussion history did not significantly predict postural control scores. Conclusions: Age significantly influences scores on common postconcussion postural control assessments. Clinical Relevance: This study demonstrates that age is a critical factor that needs to be accounted for to improve the clinical appropriateness and utility of current postconcussion postural control assessments. [ABSTRACT FROM AUTHOR]},

keywords = {ADOLESCENCE, AGE distribution (Demography), ATTENTION-deficit hyperactivity disorder, CORRELATION (Statistics), DATA analysis, DATA analysis -- Software, DESCRIPTIVE statistics, DISEASE complications, EQUILIBRIUM (Physiology), LONGITUDINAL method, MEDICAL history taking, MULTIPLE regression analysis, postconcussion syndrome, PROBABILITY theory, Questionnaires, SEVERITY of illness index, SEX distribution (Demography), STATISTICS},

pubstate = {published},

tppubtype = {article}

}

Abbassi, Ensie; Brassil, Heather E; Salvatore, Anthony P

NIDILRR: Duration of Neurocognitive Impairments and Symptom Resolution in Mild Traumatic Brain injury (MTBI) Journal Article

In: Archives of Physical Medicine & Rehabilitation, vol. 97, no. 12, pp. e3–e3, 2016, ISBN: 00039993.

BibTeX | Tags: *BRAIN -- Concussion, *COGNITION, *Convalescence, *SPORTS injuries, *SYMPTOMS, PROBABILITY theory, Retrospective Studies, SEVERITY of illness index, time

2015

Lucas, S

Posttraumatic Headache: Clinical Characterization and Management Journal Article

In: Current Pain & Headache Reports, vol. 19, no. 10, 2015.

@article{Lucas2015,

title = {Posttraumatic Headache: Clinical Characterization and Management},

author = {Lucas, S},

doi = {10.1007/s11916-015-0520-1},

year  = {2015},

date = {2015-01-01},

journal = {Current Pain \& Headache Reports},

volume = {19},

number = {10},

abstract = {Headache is the most common symptom after traumatic brain injury (TBI). TBI has become a global health concern with an estimated 2.5 million reported TBIs per year in the USA alone. Recent longitudinal studies of posttraumatic headache (PTH) show a high cumulative incidence of 71 % after moderate or severe TBI and an even higher cumulative incidence of 91 % after mild TBI (mTBI) at 1 year after injury. Prevalence remains high at over 44 % throughout the year after moderate or severe TBI and over 54 % after mTBI. A prior history of headache is associated with a higher risk for PTH, whereas older age appears to be protective. Gender does not appear to be a risk factor for PTH. Most PTH has clinical diagnostic criteria meeting that of migraine or probable migraine when primary headache disorder classification criteria are used, followed by tension-type headache. There are no evidence-based treatment guidelines for PTH management; however, expert opinion has suggested treating the PTH using primary headache disorder treatment recommendations according to its type. © 2015, Springer Science+Business Media New York.},

keywords = {amitriptyline, botulinum toxin A, Brain Injuries, chiropractic, clinical feature, complication, Concussion, diagnostic approach route, disease association, disease classification, disease predisposition, drug efficacy, drug induced headache, evidence based medicine, human, Humans, migraine, neuropsychological test, Neuropsychological Tests, nonsteroid antiinflammatory agent, paracetamol, physiotherapy, Post-traumatic headache, postconcussion syndrome, posttraumatic headache, practice guideline, Prevalence, primary headache, Review, risk factor, Risk Factors, SEVERITY of illness index, sports concussion, symptomatology, tension headache, Tension-type headache, topiramate, traumatic brain injury, treatment response, UNITED States, valproate semisodium},

pubstate = {published},

tppubtype = {article}

}

Merritt, V C; Meyer, J E; Arnett, P A

A novel approach to classifying postconcussion symptoms: The application of a new framework to the Post-Concussion Symptom Scale Journal Article

In: Journal of Clinical and Experimental Neuropsychology, vol. 37, no. 7, pp. 764–775, 2015.

@article{Merritt2015b,

title = {A novel approach to classifying postconcussion symptoms: The application of a new framework to the Post-Concussion Symptom Scale},

author = {Merritt, V C and Meyer, J E and Arnett, P A},

doi = {10.1080/13803395.2015.1060950},

year  = {2015},

date = {2015-01-01},

journal = {Journal of Clinical and Experimental Neuropsychology},

volume = {37},

number = {7},

pages = {764--775},

abstract = {Introduction: Self-report measures such as the Post-Concussion Symptom Scale (PCSS) are frequently used during baseline and postconcussion testing to evaluate athletes symptom profiles. However, the common approach of evaluating the total symptom score and/or symptom clusters may not allow for a complete understanding of the nature of athletes symptom reporting patterns. The primary objective of this study was to apply three "global indices of distress" variables, derived from the Symptom Checklist-90-Revised (SCL-90-R) framework, to the PCSS at baseline and postconcussion. We aimed to evaluate the utility of these symptom indices in relation to four PCSS symptom clusters and the total PCSS symptom score. Method: Participants included college athletes evaluated at baseline (N = 846) and postconcussion (N = 86). Athletes underwent neuropsychological testing at both time points, including completion of the PCSS and a paper/pencil and computerized test battery. Eight symptom indices were derived from the PCSS, and a postconcussion neurocognitive composite score was calculated. Results: Results showed that there were significant mean increases from baseline to postconcussion on four of the eight symptom indices evaluated. Furthermore, a significant proportion of athletes showed no change from baseline to postconcussion when evaluating the total symptom score, but showed at least a one standard deviation increase in symptom reporting from baseline to postconcussion when evaluating at least one other symptom index (i.e., a global index of distress or symptom cluster). Finally, the three global indices of distress variables, two of the four symptom clusters, and the total symptom score significantly predicted a postconcussion neurocognitive composite score, such that greater postconcussion symptoms were associated with lower postconcussion neurocognitive performance. Conclusions: These findings suggest that, in addition to evaluating the postconcussion total symptom score, there may be value in examining more specific symptom indices such as the global indices of distress variables and symptom clusters. © 2015 Taylor \& Francis.},

keywords = {Adolescent, Athletic Injuries, brain concussion, CLASSIFICATION, collegiate athletes, Female, human, Humans, Male, neuropsychological test, Neuropsychological Tests, Post-Concussion Syndrome, postconcussion symptoms, self report, SEVERITY of illness index, Sports-related concussion, symptom assessment, Young Adult},

pubstate = {published},

tppubtype = {article}

}

Beta-amyloid deposition in chronic traumatic encephalopathy Journal Article

In: Acta Neuropathologica, vol. 130, no. 1, pp. 21–34, 2015.

@article{Stein2015b,

title = {Beta-amyloid deposition in chronic traumatic encephalopathy},

author = {Stein, T D and Montenigro, P H and Alvarez, V E and Xia, W and Crary, J F and Tripodis, Y and Daneshvar, D H and Mez, J and Solomon, T and Meng, G and Kubilus, C A and Cormier, K A and Meng, S and Babcock, K and Kiernan, P and Murphy, L and Nowinski, C J and Martin, B and Dixon, D and Stern, R A and Cantu, R C and Kowall, N W and McKee, A C},

year  = {2015},

date = {2015-01-01},

journal = {Acta Neuropathologica},

volume = {130},

number = {1},

pages = {21--34},

abstract = {Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. It is defined pathologically by the abnormal accumulation of tau in a unique pattern that is distinct from other tauopathies, including Alzheimer's disease (AD). Although trauma has been suggested to increase amyloid beta peptide (Abeta) levels, the extent of Abeta deposition in CTE has not been thoroughly characterized. We studied a heterogeneous cohort of deceased athletes and military veterans with neuropathologically diagnosed CTE (n = 114, mean age at death = 60) to test the hypothesis that Abeta deposition is altered in CTE and associated with more severe pathology and worse clinical outcomes. We found that Abeta deposition, either as diffuse or neuritic plaques, was present in 52 % of CTE subjects. Moreover, Abeta deposition in CTE occurred at an accelerated rate and with altered dynamics in CTE compared to a normal aging population (OR = 3.8, p \< 0.001). We also found a clear pathological and clinical dichotomy between those CTE cases with Abeta plaques and those without. Abeta deposition was significantly associated with the presence of the APOE epsilon4 allele (p = 0.035), older age at symptom onset (p \< 0.001), and older age at death (p \< 0.001). In addition, when controlling for age, neuritic plaques were significantly associated with increased CTE tauopathy stage (beta = 2.43},

keywords = {*Amyloid beta-Peptides/me [Metabolism], *Brain Injury, *Brain/pa [Pathology], *Neurodegenerative Diseases/pa [Pathology], *tau Proteins/me [Metabolism], 0 (Amyloid beta-Peptides), 0 (Apolipoprotein E4), 0 (MAPT protein, 0 (tau Proteins), 80 and over, adult, Age Factors, aged, Amyloid/et [Etiology], Amyloid/me [Metabolism], Amyloid/pa [Pathology], Apolipoprotein E4/ge [Genetics], Athletes, Athletic Injuries/ep [Epidemiology], Athletic Injuries/ge [Genetics], Athletic Injuries/me [Metabolism], Athletic Injuries/pa [Pathology], Brain Injury, Brain/me [Metabolism], Chronic/ep [Epidemiology], Chronic/ge [Genetics], Chronic/me [Metabolism], Chronic/pa [Pathology], Cohort Studies, comorbidity, human), Humans, middle aged, Neurodegenerative Diseases/ep [Epidemiology], Neurodegenerative Diseases/ge [Genetics], Neurodegenerative Diseases/me [Metabolism], Plaque, SEVERITY of illness index, veterans, War-Related Injuries/ep [Epidemiology], War-Related Injuries/ge [Genetics], War-Related Injuries/me [Metabolism], War-Related Injuries/pa [Pathology]},

pubstate = {published},

tppubtype = {article}

}

2017

2016

2015

Reference Search

Most Referenced Keywords

2017

2016

2015

About Us

Information