Vagnozzi, Roberto; Signoretti, Stefano; Cristofori, Luciano; Alessandrini, Franco; Floris, Roberto; Isgrò, Eugenio; Ria, Antonio; Marziali, Simone; Zoccatelli, Giada; Tavazzi, Barbara; Del Bolgia, Franco; Sorge, Roberto; Broglio, Steven P; McIntosh, Tracy K; Lazzarino, Giuseppe
Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum Journal Article
In: Brain: A Journal of Neurology, vol. 136, no. 11, pp. e262–e262, 2013, ISBN: 0006-8950 1460-2156.
Abstract | BibTeX | Tags: 2013, Athletes, brain concussion, BRAIN damage, Concussion, Magnetic Resonance Spectroscopy, metabolic brain damage, mild traumatic brain injury, NEUROCHEMISTRY, Recovery, Recovery (Disorders), Spectroscopy, traumatic brain injury
@article{Vagnozzi2013a,
title = {Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum},
author = {Vagnozzi, Roberto and Signoretti, Stefano and Cristofori, Luciano and Alessandrini, Franco and Floris, Roberto and Isgr\`{o}, Eugenio and Ria, Antonio and Marziali, Simone and Zoccatelli, Giada and Tavazzi, Barbara and {Del Bolgia}, Franco and Sorge, Roberto and Broglio, Steven P and McIntosh, Tracy K and Lazzarino, Giuseppe},
isbn = {0006-8950
1460-2156},
year = {2013},
date = {2013-01-01},
journal = {Brain: A Journal of Neurology},
volume = {136},
number = {11},
pages = {e262--e262},
abstract = {Reports an error in 'Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients' by Roberto Vagnozzi, Stefano Signoretti, Luciano Cristofori, Franco Alessandrini, Roberto Floris, Eugenio Isgr\`{o}, Antonio Ria, Simone Marziale, Giada Zoccatelli, Barbara Tavazzi, Franco Del Bolgia, Roberto Sorge, Steven P. Broglio, Tracy K. McIntosh and Giuseppe Lazzarino (Brain: A Journal of Neurology, 2010[Nov], Vol 133[11], 3232-3242). In the original article, the eighth author’s surname was incorrectly given as ‘Marziale’. The corrected surname of the eighth author is present in the erratum. (The following abstract of the original article appeared in record [rid]2010-23062-009[/rid]). Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16\textendash35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: −17.6%, N-acetylaspartate/choline: −21.4%; P \< 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2013, Athletes, brain concussion, BRAIN damage, Concussion, Magnetic Resonance Spectroscopy, metabolic brain damage, mild traumatic brain injury, NEUROCHEMISTRY, Recovery, Recovery (Disorders), Spectroscopy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Barr, William B
Recovering from mild traumatic brain injury: What psychology has learned from sports concussion research Journal Article
In: NYS Psychologist, vol. 19, no. 5, pp. 24–29, 2007, ISBN: 1048-6925.
Abstract | BibTeX | Tags: 2007, brain concussion, disorder recovery, mild traumatic brain injury, psychology, Recovery (Disorders), Sports, sports concussion, traumatic brain injury
@article{Barr2007,
title = {Recovering from mild traumatic brain injury: What psychology has learned from sports concussion research},
author = {Barr, William B},
isbn = {1048-6925},
year = {2007},
date = {2007-01-01},
journal = {NYS Psychologist},
volume = {19},
number = {5},
pages = {24--29},
publisher = {New York State Psychological Assn},
address = {US},
abstract = {Research on sports concussion has contributed significantly to our knowledge on the characteristics and course of recovery from mild traumatic brain injury (MTBI). Findings from research studies on injured athletes indicate that most symptoms of concussion resolve within 7-10 days of the injury. Results from studies examining the development of more persistent symptoms have found relationships with a number of psychological factors, including expectation and maladaptive coping styles. Systematic reviews of intervention strategies have indicated that psychological approaches to treatment of MTBI, such as early education and support, are more effective than any form of drug treatment. Psychologists should be aware of these findings and the potential for playing a significant role in treating individuals with MTBI. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2007, brain concussion, disorder recovery, mild traumatic brain injury, psychology, Recovery (Disorders), Sports, sports concussion, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Vagnozzi, Roberto; Signoretti, Stefano; Cristofori, Luciano; Alessandrini, Franco; Floris, Roberto; Isgrò, Eugenio; Ria, Antonio; Marziali, Simone; Zoccatelli, Giada; Tavazzi, Barbara; Del Bolgia, Franco; Sorge, Roberto; Broglio, Steven P; McIntosh, Tracy K; Lazzarino, Giuseppe
Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum Journal Article
In: Brain: A Journal of Neurology, vol. 136, no. 11, pp. e262–e262, 2013, ISBN: 0006-8950 1460-2156.
@article{Vagnozzi2013a,
title = {Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum},
author = {Vagnozzi, Roberto and Signoretti, Stefano and Cristofori, Luciano and Alessandrini, Franco and Floris, Roberto and Isgr\`{o}, Eugenio and Ria, Antonio and Marziali, Simone and Zoccatelli, Giada and Tavazzi, Barbara and {Del Bolgia}, Franco and Sorge, Roberto and Broglio, Steven P and McIntosh, Tracy K and Lazzarino, Giuseppe},
isbn = {0006-8950
1460-2156},
year = {2013},
date = {2013-01-01},
journal = {Brain: A Journal of Neurology},
volume = {136},
number = {11},
pages = {e262--e262},
abstract = {Reports an error in 'Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients' by Roberto Vagnozzi, Stefano Signoretti, Luciano Cristofori, Franco Alessandrini, Roberto Floris, Eugenio Isgr\`{o}, Antonio Ria, Simone Marziale, Giada Zoccatelli, Barbara Tavazzi, Franco Del Bolgia, Roberto Sorge, Steven P. Broglio, Tracy K. McIntosh and Giuseppe Lazzarino (Brain: A Journal of Neurology, 2010[Nov], Vol 133[11], 3232-3242). In the original article, the eighth author’s surname was incorrectly given as ‘Marziale’. The corrected surname of the eighth author is present in the erratum. (The following abstract of the original article appeared in record [rid]2010-23062-009[/rid]). Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16\textendash35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: −17.6%, N-acetylaspartate/choline: −21.4%; P \< 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Barr, William B
Recovering from mild traumatic brain injury: What psychology has learned from sports concussion research Journal Article
In: NYS Psychologist, vol. 19, no. 5, pp. 24–29, 2007, ISBN: 1048-6925.
@article{Barr2007,
title = {Recovering from mild traumatic brain injury: What psychology has learned from sports concussion research},
author = {Barr, William B},
isbn = {1048-6925},
year = {2007},
date = {2007-01-01},
journal = {NYS Psychologist},
volume = {19},
number = {5},
pages = {24--29},
publisher = {New York State Psychological Assn},
address = {US},
abstract = {Research on sports concussion has contributed significantly to our knowledge on the characteristics and course of recovery from mild traumatic brain injury (MTBI). Findings from research studies on injured athletes indicate that most symptoms of concussion resolve within 7-10 days of the injury. Results from studies examining the development of more persistent symptoms have found relationships with a number of psychological factors, including expectation and maladaptive coping styles. Systematic reviews of intervention strategies have indicated that psychological approaches to treatment of MTBI, such as early education and support, are more effective than any form of drug treatment. Psychologists should be aware of these findings and the potential for playing a significant role in treating individuals with MTBI. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Vagnozzi, Roberto; Signoretti, Stefano; Cristofori, Luciano; Alessandrini, Franco; Floris, Roberto; Isgrò, Eugenio; Ria, Antonio; Marziali, Simone; Zoccatelli, Giada; Tavazzi, Barbara; Del Bolgia, Franco; Sorge, Roberto; Broglio, Steven P; McIntosh, Tracy K; Lazzarino, Giuseppe
Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum Journal Article
In: Brain: A Journal of Neurology, vol. 136, no. 11, pp. e262–e262, 2013, ISBN: 0006-8950 1460-2156.
Abstract | BibTeX | Tags: 2013, Athletes, brain concussion, BRAIN damage, Concussion, Magnetic Resonance Spectroscopy, metabolic brain damage, mild traumatic brain injury, NEUROCHEMISTRY, Recovery, Recovery (Disorders), Spectroscopy, traumatic brain injury
@article{Vagnozzi2013a,
title = {Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients: Corrigendum},
author = {Vagnozzi, Roberto and Signoretti, Stefano and Cristofori, Luciano and Alessandrini, Franco and Floris, Roberto and Isgr\`{o}, Eugenio and Ria, Antonio and Marziali, Simone and Zoccatelli, Giada and Tavazzi, Barbara and {Del Bolgia}, Franco and Sorge, Roberto and Broglio, Steven P and McIntosh, Tracy K and Lazzarino, Giuseppe},
isbn = {0006-8950
1460-2156},
year = {2013},
date = {2013-01-01},
journal = {Brain: A Journal of Neurology},
volume = {136},
number = {11},
pages = {e262--e262},
abstract = {Reports an error in 'Assessment of metabolic brain damage and recovery following mild traumatic brain injury: A multicentre, proton magnetic resonance spectroscopic study in concussed patients' by Roberto Vagnozzi, Stefano Signoretti, Luciano Cristofori, Franco Alessandrini, Roberto Floris, Eugenio Isgr\`{o}, Antonio Ria, Simone Marziale, Giada Zoccatelli, Barbara Tavazzi, Franco Del Bolgia, Roberto Sorge, Steven P. Broglio, Tracy K. McIntosh and Giuseppe Lazzarino (Brain: A Journal of Neurology, 2010[Nov], Vol 133[11], 3232-3242). In the original article, the eighth author’s surname was incorrectly given as ‘Marziale’. The corrected surname of the eighth author is present in the erratum. (The following abstract of the original article appeared in record [rid]2010-23062-009[/rid]). Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16\textendash35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: −17.6%, N-acetylaspartate/choline: −21.4%; P \< 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2013, Athletes, brain concussion, BRAIN damage, Concussion, Magnetic Resonance Spectroscopy, metabolic brain damage, mild traumatic brain injury, NEUROCHEMISTRY, Recovery, Recovery (Disorders), Spectroscopy, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}
Barr, William B
Recovering from mild traumatic brain injury: What psychology has learned from sports concussion research Journal Article
In: NYS Psychologist, vol. 19, no. 5, pp. 24–29, 2007, ISBN: 1048-6925.
Abstract | BibTeX | Tags: 2007, brain concussion, disorder recovery, mild traumatic brain injury, psychology, Recovery (Disorders), Sports, sports concussion, traumatic brain injury
@article{Barr2007,
title = {Recovering from mild traumatic brain injury: What psychology has learned from sports concussion research},
author = {Barr, William B},
isbn = {1048-6925},
year = {2007},
date = {2007-01-01},
journal = {NYS Psychologist},
volume = {19},
number = {5},
pages = {24--29},
publisher = {New York State Psychological Assn},
address = {US},
abstract = {Research on sports concussion has contributed significantly to our knowledge on the characteristics and course of recovery from mild traumatic brain injury (MTBI). Findings from research studies on injured athletes indicate that most symptoms of concussion resolve within 7-10 days of the injury. Results from studies examining the development of more persistent symptoms have found relationships with a number of psychological factors, including expectation and maladaptive coping styles. Systematic reviews of intervention strategies have indicated that psychological approaches to treatment of MTBI, such as early education and support, are more effective than any form of drug treatment. Psychologists should be aware of these findings and the potential for playing a significant role in treating individuals with MTBI. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
keywords = {2007, brain concussion, disorder recovery, mild traumatic brain injury, psychology, Recovery (Disorders), Sports, sports concussion, traumatic brain injury},
pubstate = {published},
tppubtype = {article}
}