McDevitt, J; Tierney, R T; Phillips, J; Gaughan, J P; Torg, J S; Krynetskiy, E
Association between GRIN2A promoter polymorphism and recovery from concussion Journal Article
In: Brain Injury, vol. 29, no. 13-14, pp. 1674–1681, 2015.
Abstract | Links | BibTeX | Tags: adult, Article, athlete, brain concussion, Brain Injury, calcium, capillary electrophoresis, CONVALESCENCE, DNA, Female, gene frequency, genetic association, genetic polymorphism, genetic variability, GENOTYPE, heterozygote, human, inheritance, major clinical study, Male, n methyl dextro aspartic acid receptor 2A, NR2A sub-unit, pedigree analysis, promoter region, sport injury, variable number of tandem repeat
@article{McDevitt2015,
title = {Association between GRIN2A promoter polymorphism and recovery from concussion},
author = {McDevitt, J and Tierney, R T and Phillips, J and Gaughan, J P and Torg, J S and Krynetskiy, E},
doi = {10.3109/02699052.2015.1075252},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {13-14},
pages = {1674--1681},
abstract = {Objective: To determine genetic variability within the N-methyl-D-aspartate receptor 2A sub-unit (GRIN2A) gene promoter and its association with concussion recovery time. The hypothesis tested was that there would be a difference in allele and/or genotype distribution between two groups of athletes with normal and prolonged recovery.Methods: DNA was extracted from saliva collected from a total of 87 athletes with a physician-diagnosed concussion. The (GT) variable number tandem repeats (VNTR) within the promoter region of GRIN2A was genotyped. The long (L) allele was an allele with ≥25 repeats and the short (S) allele was an allele with \<25 repeats in the GT tract. Participants recovery time was followed prospectively and was categorized as normal (≤60 days) or prolonged (\>60 days).Results: LL carriers were 6-times more likely to recover longer than 60 days following the concussive event (p = 0.0433) when compared to SS carriers. Additionally, L allele carriers were found more frequently in the prolonged recovery group (p = 0.048).Conclusion: Determining genetic influence on concussion recovery will aid in future development of genetic counselling. The clinical relevance of genotyping athletes could improve management of athletes who experience concussion injuries. © 2015 Taylor \& Francis Group, LLC.},
keywords = {adult, Article, athlete, brain concussion, Brain Injury, calcium, capillary electrophoresis, CONVALESCENCE, DNA, Female, gene frequency, genetic association, genetic polymorphism, genetic variability, GENOTYPE, heterozygote, human, inheritance, major clinical study, Male, n methyl dextro aspartic acid receptor 2A, NR2A sub-unit, pedigree analysis, promoter region, sport injury, variable number of tandem repeat},
pubstate = {published},
tppubtype = {article}
}
McDevitt, J; Tierney, R T; Phillips, J; Gaughan, J P; Torg, J S; Krynetskiy, E
Association between GRIN2A promoter polymorphism and recovery from concussion Journal Article
In: Brain Injury, vol. 29, no. 13-14, pp. 1674–1681, 2015.
@article{McDevitt2015,
title = {Association between GRIN2A promoter polymorphism and recovery from concussion},
author = {McDevitt, J and Tierney, R T and Phillips, J and Gaughan, J P and Torg, J S and Krynetskiy, E},
doi = {10.3109/02699052.2015.1075252},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {13-14},
pages = {1674--1681},
abstract = {Objective: To determine genetic variability within the N-methyl-D-aspartate receptor 2A sub-unit (GRIN2A) gene promoter and its association with concussion recovery time. The hypothesis tested was that there would be a difference in allele and/or genotype distribution between two groups of athletes with normal and prolonged recovery.Methods: DNA was extracted from saliva collected from a total of 87 athletes with a physician-diagnosed concussion. The (GT) variable number tandem repeats (VNTR) within the promoter region of GRIN2A was genotyped. The long (L) allele was an allele with ≥25 repeats and the short (S) allele was an allele with \<25 repeats in the GT tract. Participants recovery time was followed prospectively and was categorized as normal (≤60 days) or prolonged (\>60 days).Results: LL carriers were 6-times more likely to recover longer than 60 days following the concussive event (p = 0.0433) when compared to SS carriers. Additionally, L allele carriers were found more frequently in the prolonged recovery group (p = 0.048).Conclusion: Determining genetic influence on concussion recovery will aid in future development of genetic counselling. The clinical relevance of genotyping athletes could improve management of athletes who experience concussion injuries. © 2015 Taylor \& Francis Group, LLC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
McDevitt, J; Tierney, R T; Phillips, J; Gaughan, J P; Torg, J S; Krynetskiy, E
Association between GRIN2A promoter polymorphism and recovery from concussion Journal Article
In: Brain Injury, vol. 29, no. 13-14, pp. 1674–1681, 2015.
Abstract | Links | BibTeX | Tags: adult, Article, athlete, brain concussion, Brain Injury, calcium, capillary electrophoresis, CONVALESCENCE, DNA, Female, gene frequency, genetic association, genetic polymorphism, genetic variability, GENOTYPE, heterozygote, human, inheritance, major clinical study, Male, n methyl dextro aspartic acid receptor 2A, NR2A sub-unit, pedigree analysis, promoter region, sport injury, variable number of tandem repeat
@article{McDevitt2015,
title = {Association between GRIN2A promoter polymorphism and recovery from concussion},
author = {McDevitt, J and Tierney, R T and Phillips, J and Gaughan, J P and Torg, J S and Krynetskiy, E},
doi = {10.3109/02699052.2015.1075252},
year = {2015},
date = {2015-01-01},
journal = {Brain Injury},
volume = {29},
number = {13-14},
pages = {1674--1681},
abstract = {Objective: To determine genetic variability within the N-methyl-D-aspartate receptor 2A sub-unit (GRIN2A) gene promoter and its association with concussion recovery time. The hypothesis tested was that there would be a difference in allele and/or genotype distribution between two groups of athletes with normal and prolonged recovery.Methods: DNA was extracted from saliva collected from a total of 87 athletes with a physician-diagnosed concussion. The (GT) variable number tandem repeats (VNTR) within the promoter region of GRIN2A was genotyped. The long (L) allele was an allele with ≥25 repeats and the short (S) allele was an allele with \<25 repeats in the GT tract. Participants recovery time was followed prospectively and was categorized as normal (≤60 days) or prolonged (\>60 days).Results: LL carriers were 6-times more likely to recover longer than 60 days following the concussive event (p = 0.0433) when compared to SS carriers. Additionally, L allele carriers were found more frequently in the prolonged recovery group (p = 0.048).Conclusion: Determining genetic influence on concussion recovery will aid in future development of genetic counselling. The clinical relevance of genotyping athletes could improve management of athletes who experience concussion injuries. © 2015 Taylor \& Francis Group, LLC.},
keywords = {adult, Article, athlete, brain concussion, Brain Injury, calcium, capillary electrophoresis, CONVALESCENCE, DNA, Female, gene frequency, genetic association, genetic polymorphism, genetic variability, GENOTYPE, heterozygote, human, inheritance, major clinical study, Male, n methyl dextro aspartic acid receptor 2A, NR2A sub-unit, pedigree analysis, promoter region, sport injury, variable number of tandem repeat},
pubstate = {published},
tppubtype = {article}
}